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Meeting Abstracts

1846-P: Human α-Cell Heterogeneity and Trajectory Inference Analyses of Human Islets Reveal SMOC1 as a β-Cell Dedifferentiation Gene

RANDY KANG, MIGUEL A. VARELA, EUNJIN OH, JUNGEUN LEE, ESRA KARAKOSE, ANDREW F. STEWART, DONALD SCOTT, DEBBIE C. THURMOND, ADOLFO GARCIA-OCANA, GEMING LU

Diabetes 2025;74(Supplement_1):1846-P

https://doi.org/10.2337/db25-1846-P

Published: 20 June 2025

View articletitled, 1846-P: Human α-Cell Heterogeneity and Trajectory Inference Analyses of Human Islets Reveal SMOC1 as a β-Cell Dedifferentiation Gene

Meeting Abstracts

321-OR: ADA Presidents' Select Abstract: FOXO1 Is Vital for Gestational Beta-Cell Compensation to Protect Against Gestational Diabetes

TAOFEEK USMAN, TING ZHANG, GOMA CHHETRI, HSUAN YEH, GEMING LU, ADOLFO GARCIA-OCANA, H. HENRY DONG

Diabetes 2025;74(Supplement_1):321-OR

https://doi.org/10.2337/db25-321-OR

Published: 20 June 2025

View articletitled, 321-OR: ADA Presidents' Select Abstract: FOXO1 Is Vital for Gestational Beta-Cell Compensation to Protect Against Gestational Diabetes

Meeting Abstracts

1831-P: Selective Induction of Spliced XBP1 in Pancreatic Islet Beta Cells Causes Reversible Diabetes

YUNQIAN PENG, GEMING LU, ADOLFO GARCIA-OCANA, YINGFENG DENG

Diabetes 2025;74(Supplement_1):1831-P

https://doi.org/10.2337/db25-1831-P

Published: 20 June 2025

View articletitled, 1831-P: Selective Induction of Spliced XBP1 in Pancreatic Islet Beta Cells Causes Reversible Diabetes

Meeting Abstracts

77-OR: BNIP3-Mediated Mitophagy Protects Human β-Cells by Regulating Mitochondrial Integrity and Immunogenicity in Type 1 Diabetes (T1D)

GEMING LU, RANDY KANG, EUNJIN OH, MIGUEL A. VARELA, JUAN ALDACO, DEBBIE C. THURMOND, ADOLFO GARCIA-OCANA

Diabetes 2025;74(Supplement_1):77-OR

https://doi.org/10.2337/db25-77-OR

Published: 20 June 2025

View articletitled, 77-OR: BNIP3-Mediated Mitophagy Protects Human β-Cells by Regulating Mitochondrial Integrity and Immunogenicity in Type 1 Diabetes (T1D)

Meeting Abstracts

339-OR: Enhanced Expression of Zinc Finger Protein 385D Leads to Type 2 Diabetes Phenotype in Human Beta Cells

GEMING LU, RANDY KANG, MIGUEL A. VARELA, EUNJIN OH, DEBBIE C. THURMOND, ADOLFO GARCIA-OCANA

Diabetes 2024;73(Supplement_1):339-OR

https://doi.org/10.2337/db24-339-OR

Published: 14 June 2024

View articletitled, 339-OR: Enhanced Expression of Zinc Finger Protein 385D Leads to Type 2 Diabetes Phenotype in Human Beta Cells

Meeting Abstracts

1720-P: Single Nucleus Transcriptome Profiling of Human Islet Cells under Metabolic Stress In Vivo

RANDY KANG, JUNGEUN LEE, MIGUEL A. VARELA, ESRA KARAKOSE, ANDREW F. STEWART, DONALD SCOTT, ADOLFO GARCIA-OCANA, GEMING LU

Diabetes 2024;73(Supplement_1):1720-P

https://doi.org/10.2337/db24-1720-P

Published: 14 June 2024

View articletitled, 1720-P: Single Nucleus Transcriptome Profiling of Human Islet Cells under Metabolic Stress In Vivo

Meeting Abstracts

121-OR: Safety, Tolerability, and Metabolic Effects of Once-Weekly GL0034 (Utreglutide) in Individuals with Obesity—A Multiple Ascending Dose Study

RAJAMANNAR THENNATI, VINOD S. BURADE, MUTHUKUMARAN NATARAJAN, PRADEEP SHAHI, RAVISHANKARA NAGARAJA, SUDEEP K. AGRAWAL, THIERRY DUVAUCHELLE, ADOLFO GARCIA-OCANA, GUY A. RUTTER, RICHARD E. PRATLEY, BERNARD THORENS, TINA VILSBØLL

Diabetes 2024;73(Supplement_1):121-OR

https://doi.org/10.2337/db24-121-OR

Published: 14 June 2024

View articletitled, 121-OR: Safety, Tolerability, and Metabolic Effects of Once-Weekly GL0034 (Utreglutide) in Individuals with Obesity—A Multiple Ascending Dose Study

Meeting Abstracts

116-OR: GL0034 (Utreglutide), a Novel GLP-1RA, Increases Liver FGF-21 and Demonstrates Significant Efficacy on Weight Loss, HbA1c, and Triglycerides in db/db Mice

RAJAMANNAR THENNATI, VINOD S. BURADE, MUTHUKUMARAN NATARAJAN, ADOLFO GARCIA-OCANA, GUY A. RUTTER, RICHARD E. PRATLEY, BERNARD THORENS, TINA VILSBØLL

Diabetes 2024;73(Supplement_1):116-OR

https://doi.org/10.2337/db24-116-OR

Published: 14 June 2024

View articletitled, 116-OR: GL0034 (Utreglutide), a Novel GLP-1RA, Increases Liver FGF-21 and Demonstrates Significant Efficacy on Weight Loss, HbA1c, and Triglycerides in db/db Mice

Meeting Abstracts

350-OR: Transcriptomics Identification of a-Cell Subpopulations in Human Islets Using Integrated scRNA-seq and snRNA-seq

RANDY KANG, JUNGEUN LEE, ADOLFO GARCIA-OCANA, GEMING LU

Diabetes 2023;72(Supplement_1):350-OR

https://doi.org/10.2337/db23-350-OR

Published: 20 June 2023

View articletitled, 350-OR: Transcriptomics Identification of a-Cell Subpopulations in Human Islets Using Integrated scRNA-seq and snRNA-seq

Meeting Abstracts

766-P: Safety and Tolerability of Once-Weekly GL0034 (Utreglutide) in Healthy Individuals—A Multiple Ascending Dose Study

RAJAMANNAR THENNATI, VINOD S. BURADE, MUTHUKUMARAN NATARAJAN, PRADEEP SHAHI, RAVISHANKARA NAGARAJA, SATISH T. PANCHAL, SUDEEP K. AGRAWAL, BERNARD JANDRAIN, THIERRY DUVAUCHELLE, ADOLFO GARCIA-OCANA, GUY A. RUTTER, RICHARD E. PRATLEY, BERNARD THORENS, TINA VILSBØLL

Diabetes 2023;72(Supplement_1):766-P

https://doi.org/10.2337/db23-766-P

Published: 20 June 2023

View articletitled, 766-P: Safety and Tolerability of Once-Weekly GL0034 (Utreglutide) in Healthy Individuals—A Multiple Ascending Dose Study

Meeting Abstracts

765-P: A Single Ascending Dose Study of the Novel GLP-1 Receptor Agonist GL0034 (Utreglutide) in Obese Individuals without Diabetes

Diabetes 2023;72(Supplement_1):765-P

https://doi.org/10.2337/db23-765-P

Published: 20 June 2023

View articletitled, 765-P: A Single Ascending Dose Study of the Novel GLP-1 Receptor Agonist GL0034 (Utreglutide) in Obese Individuals without Diabetes

Meeting Abstracts

349-OR: Selected DYRK1A Inhibitors Simultaneously Drive Both Human Beta-Cell Proliferation and Differentiation

PENG WANG, KUNAL KUMAR, HONGTAO LIU, OLIVIA WOOD, ESRA KARAKOSE, LAURYN CHOLEVA, LUCA LAMBERTINI, ADOLFO GARCIA-OCANA, ROBERT J. DEVITA, ANDREW F. STEWART

Diabetes 2023;72(Supplement_1):349-OR

https://doi.org/10.2337/db23-349-OR

Published: 20 June 2023

View articletitled, 349-OR: Selected DYRK1A Inhibitors Simultaneously Drive Both Human Beta-Cell Proliferation and Differentiation

Meeting Abstracts

82-OR: NRF2 Regulates Neonatal ß-Cell Mass Expansion

SHARON BAUMEL-ALTERZON, LIORA S. KATZ, LUCA LAMBERTINI, ADOLFO GARCIA-OCANA, DONALD SCOTT

Diabetes 2023;72(Supplement_1):82-OR

https://doi.org/10.2337/db23-82-OR

Published: 20 June 2023

View articletitled, 82-OR: NRF2 Regulates Neonatal ß-Cell Mass Expansion

Meeting Abstracts

1728-P: Transcriptional Activation of Myc by Glucose Requires Recruitment of ChREBP to the Pvt1 Promoter Regulating Proliferation in ß-Cells

LIORA S. KATZ, PENG WANG, GABRIEL BRILL, PILI ZHANG, JONATHAN HALDEMAN, CHRISTOPHER B. NEWGARD, ANDREW F. STEWART, ADOLFO GARCIA-OCANA, DONALD SCOTT

Diabetes 2023;72(Supplement_1):1728-P

https://doi.org/10.2337/db23-1728-P

Published: 20 June 2023

View articletitled, 1728-P: Transcriptional Activation of Myc by Glucose Requires Recruitment of ChREBP to the Pvt1 Promoter Regulating Proliferation in ß-Cells

Meeting Abstracts

235-OR: Myc Activity Is Required for Mitochondrial Function and Glucose-Stimulated Insulin Secretion (GSIS) in Pancreatic ß-Cells

GEMING LU, RANDY KANG, PEDRO DIAZ-POZO, JUNGEUN LEE, MINGPEI LI, VICTOR M. VICTOR, DONALD SCOTT, ADOLFO GARCIA-OCANA

Diabetes 2023;72(Supplement_1):235-OR

https://doi.org/10.2337/db23-235-OR

Published: 20 June 2023

View articletitled, 235-OR: Myc Activity Is Required for Mitochondrial Function and Glucose-Stimulated Insulin Secretion (GSIS) in Pancreatic ß-Cells

Meeting Abstracts

14-OR: Harmine and Exenatide Combination Increases Human ß-Cell Survival

CAROLINA ROSSELOT, YANSUI LI, DANIELA GUEVARA, KARA A. BELIARD, RANDY KANG, PENG WANG, KEYA THAKKAR, GEMING LU, ROBERT J. DEVITA, ANDREW F. STEWART, ADOLFO GARCIA-OCANA

Diabetes 2022;71(Supplement_1):14-OR

https://doi.org/10.2337/db22-14-OR

Published: 01 June 2022

View articletitled, 14-OR: Harmine and Exenatide Combination Increases Human ß-Cell Survival

Meeting Abstracts

822-P: The Harmine and Exendin4 Combination Markedly Expands Human Beta-Cell Mass In Vivo in Diabetic Mice

KARA A. BELIARD, CAROLINA ROSSELOT, YANSUI LI, ALEXANDRA ALVARSSON, PENG WANG, KEYA THAKKAR, DANIELA GUEVARA, ROBERT J. DEVITA, ANDREW F. STEWART, SARAH STANLEY, ADOLFO GARCIA-OCANA

Diabetes 2022;71(Supplement_1):822-P

https://doi.org/10.2337/db22-822-P

Published: 01 June 2022

View articletitled, 822-P: The Harmine and Exendin4 Combination Markedly Expands Human Beta-Cell Mass In Vivo in Diabetic Mice

Meeting Abstracts

1459-P: Human Islet Cell Transcriptome Analysis Using Single Nucleus RNA-seq Reveals New Beta-Cell Markers and Define Distinct Beta-Cell Subpopulations with Different Transcriptional Activity

RANDY KANG, YANSUI LI, CAROLINA ROSSELOT, DONALD SCOTT, ADOLFO GARCIA-OCANA, GEMING LU

Diabetes 2022;71(Supplement_1):1459-P

https://doi.org/10.2337/db22-1459-P

Published: 01 June 2022

View articletitled, 1459-P: Human Islet Cell Transcriptome Analysis Using Single Nucleus RNA-seq Reveals New Beta-Cell Markers and Define Distinct Beta-Cell Subpopulations with Different Transcriptional Activity

Meeting Abstracts

248-LB: Nrf2 Is Essential for Expanding Neonatal Pancreatic Beta-Cell Mass

SHARON BAUMEL-ALTERZON, ADOLFO GARCIA-OCANA, DONALD SCOTT

Diabetes 2022;71(Supplement_1):248-LB

https://doi.org/10.2337/db22-248-LB

Published: 01 June 2022

View articletitled, 248-LB: Nrf2 Is Essential for Expanding Neonatal Pancreatic Beta-Cell Mass

Meeting Abstracts

10-OR: Combination Therapy with Anti-CD3 Antibody and Harmine plus Exendin-4 Enhances Remission from Recent-Onset Type 1 Diabetes.

GEMING LU, RANDY KANG, YANSUI LI, PENG WANG, CAROLINA ROSSELOT, ROBERT J. DEVITA, ANDREW F. STEWART, ADOLFO GARCIA-OCANA

Diabetes 2022;71(Supplement_1):10-OR

https://doi.org/10.2337/db22-10-OR

Published: 01 June 2022

View articletitled, 10-OR: Combination Therapy with Anti-CD3 Antibody and Harmine plus Exendin-4 Enhances Remission from Recent-Onset Type 1 Diabetes.

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1846-P: Human α-Cell Heterogeneity and Trajectory Inference Analyses of Human Islets Reveal SMOC1 as a β-Cell Dedifferentiation Gene

321-OR: ADA Presidents' Select Abstract: FOXO1 Is Vital for Gestational Beta-Cell Compensation to Protect Against Gestational Diabetes

1831-P: Selective Induction of Spliced XBP1 in Pancreatic Islet Beta Cells Causes Reversible Diabetes

77-OR: BNIP3-Mediated Mitophagy Protects Human β-Cells by Regulating Mitochondrial Integrity and Immunogenicity in Type 1 Diabetes (T1D)

339-OR: Enhanced Expression of Zinc Finger Protein 385D Leads to Type 2 Diabetes Phenotype in Human Beta Cells

1720-P: Single Nucleus Transcriptome Profiling of Human Islet Cells under Metabolic Stress In Vivo

121-OR: Safety, Tolerability, and Metabolic Effects of Once-Weekly GL0034 (Utreglutide) in Individuals with Obesity—A Multiple Ascending Dose Study

116-OR: GL0034 (Utreglutide), a Novel GLP-1RA, Increases Liver FGF-21 and Demonstrates Significant Efficacy on Weight Loss, HbA1c, and Triglycerides in db/db Mice

350-OR: Transcriptomics Identification of a-Cell Subpopulations in Human Islets Using Integrated scRNA-seq and snRNA-seq

766-P: Safety and Tolerability of Once-Weekly GL0034 (Utreglutide) in Healthy Individuals—A Multiple Ascending Dose Study

765-P: A Single Ascending Dose Study of the Novel GLP-1 Receptor Agonist GL0034 (Utreglutide) in Obese Individuals without Diabetes

349-OR: Selected DYRK1A Inhibitors Simultaneously Drive Both Human Beta-Cell Proliferation and Differentiation

82-OR: NRF2 Regulates Neonatal ß-Cell Mass Expansion

1728-P: Transcriptional Activation of Myc by Glucose Requires Recruitment of ChREBP to the Pvt1 Promoter Regulating Proliferation in ß-Cells

235-OR: Myc Activity Is Required for Mitochondrial Function and Glucose-Stimulated Insulin Secretion (GSIS) in Pancreatic ß-Cells

14-OR: Harmine and Exenatide Combination Increases Human ß-Cell Survival

822-P: The Harmine and Exendin4 Combination Markedly Expands Human Beta-Cell Mass In Vivo in Diabetic Mice

1459-P: Human Islet Cell Transcriptome Analysis Using Single Nucleus RNA-seq Reveals New Beta-Cell Markers and Define Distinct Beta-Cell Subpopulations with Different Transcriptional Activity

248-LB: Nrf2 Is Essential for Expanding Neonatal Pancreatic Beta-Cell Mass

10-OR: Combination Therapy with Anti-CD3 Antibody and Harmine plus Exendin-4 Enhances Remission from Recent-Onset Type 1 Diabetes.

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