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Meeting Abstracts

339-OR: Enhanced Expression of Zinc Finger Protein 385D Leads to Type 2 Diabetes Phenotype in Human Beta Cells

GEMING LU, RANDY KANG, MIGUEL A. VARELA, EUNJIN OH, DEBBIE C. THURMOND, ADOLFO GARCIA-OCANA

Diabetes 2024;73(Supplement_1):339-OR

https://doi.org/10.2337/db24-339-OR

Published: 14 June 2024

View article titled, 339-OR: Enhanced Expression of Zinc Finger Protein 385D Leads to Type 2 Diabetes Phenotype in Human Beta Cells

Meeting Abstracts

1720-P: Single Nucleus Transcriptome Profiling of Human Islet Cells under Metabolic Stress In Vivo

RANDY KANG, JUNGEUN LEE, MIGUEL A. VARELA, ESRA KARAKOSE, ANDREW F. STEWART, DONALD SCOTT, ADOLFO GARCIA-OCANA, GEMING LU

Diabetes 2024;73(Supplement_1):1720-P

https://doi.org/10.2337/db24-1720-P

Published: 14 June 2024

View article titled, 1720-P: Single Nucleus Transcriptome Profiling of Human Islet Cells under Metabolic Stress In Vivo

Meeting Abstracts

121-OR: Safety, Tolerability, and Metabolic Effects of Once-Weekly GL0034 (Utreglutide) in Individuals with Obesity—A Multiple Ascending Dose Study

RAJAMANNAR THENNATI, VINOD S. BURADE, MUTHUKUMARAN NATARAJAN, PRADEEP SHAHI, RAVISHANKARA NAGARAJA, SUDEEP K. AGRAWAL, THIERRY DUVAUCHELLE, ADOLFO GARCIA-OCANA, GUY A. RUTTER, RICHARD E. PRATLEY, BERNARD THORENS, TINA VILSBØLL

Diabetes 2024;73(Supplement_1):121-OR

https://doi.org/10.2337/db24-121-OR

Published: 14 June 2024

View article titled, 121-OR: Safety, Tolerability, and Metabolic Effects of Once-Weekly GL0034 (Utreglutide) in Individuals with Obesity—A Multiple Ascending Dose Study

Meeting Abstracts

116-OR: GL0034 (Utreglutide), a Novel GLP-1RA, Increases Liver FGF-21 and Demonstrates Significant Efficacy on Weight Loss, HbA1c, and Triglycerides in db/db Mice

RAJAMANNAR THENNATI, VINOD S. BURADE, MUTHUKUMARAN NATARAJAN, ADOLFO GARCIA-OCANA, GUY A. RUTTER, RICHARD E. PRATLEY, BERNARD THORENS, TINA VILSBØLL

Diabetes 2024;73(Supplement_1):116-OR

https://doi.org/10.2337/db24-116-OR

Published: 14 June 2024

View article titled, 116-OR: GL0034 (Utreglutide), a Novel GLP-1RA, Increases Liver FGF-21 and Demonstrates Significant Efficacy on Weight Loss, HbA1c, and Triglycerides in db/db Mice

Meeting Abstracts

349-OR: Selected DYRK1A Inhibitors Simultaneously Drive Both Human Beta-Cell Proliferation and Differentiation

PENG WANG, KUNAL KUMAR, HONGTAO LIU, OLIVIA WOOD, ESRA KARAKOSE, LAURYN CHOLEVA, LUCA LAMBERTINI, ADOLFO GARCIA-OCANA, ROBERT J. DEVITA, ANDREW F. STEWART

Diabetes 2023;72(Supplement_1):349-OR

https://doi.org/10.2337/db23-349-OR

Published: 20 June 2023

View article titled, 349-OR: Selected DYRK1A Inhibitors Simultaneously Drive Both Human Beta-Cell Proliferation and Differentiation

Meeting Abstracts

82-OR: NRF2 Regulates Neonatal ß-Cell Mass Expansion

SHARON BAUMEL-ALTERZON, LIORA S. KATZ, LUCA LAMBERTINI, ADOLFO GARCIA-OCANA, DONALD SCOTT

Diabetes 2023;72(Supplement_1):82-OR

https://doi.org/10.2337/db23-82-OR

Published: 20 June 2023

View article titled, 82-OR: NRF2 Regulates Neonatal ß-Cell Mass Expansion

Meeting Abstracts

350-OR: Transcriptomics Identification of a-Cell Subpopulations in Human Islets Using Integrated scRNA-seq and snRNA-seq

RANDY KANG, JUNGEUN LEE, ADOLFO GARCIA-OCANA, GEMING LU

Diabetes 2023;72(Supplement_1):350-OR

https://doi.org/10.2337/db23-350-OR

Published: 20 June 2023

View article titled, 350-OR: Transcriptomics Identification of a-Cell Subpopulations in Human Islets Using Integrated scRNA-seq and snRNA-seq

Meeting Abstracts

766-P: Safety and Tolerability of Once-Weekly GL0034 (Utreglutide) in Healthy Individuals—A Multiple Ascending Dose Study

RAJAMANNAR THENNATI, VINOD S. BURADE, MUTHUKUMARAN NATARAJAN, PRADEEP SHAHI, RAVISHANKARA NAGARAJA, SATISH T. PANCHAL, SUDEEP K. AGRAWAL, BERNARD JANDRAIN, THIERRY DUVAUCHELLE, ADOLFO GARCIA-OCANA, GUY A. RUTTER, RICHARD E. PRATLEY, BERNARD THORENS, TINA VILSBØLL

Diabetes 2023;72(Supplement_1):766-P

https://doi.org/10.2337/db23-766-P

Published: 20 June 2023

View article titled, 766-P: Safety and Tolerability of Once-Weekly GL0034 (Utreglutide) in Healthy Individuals—A Multiple Ascending Dose Study

Meeting Abstracts

765-P: A Single Ascending Dose Study of the Novel GLP-1 Receptor Agonist GL0034 (Utreglutide) in Obese Individuals without Diabetes

Diabetes 2023;72(Supplement_1):765-P

https://doi.org/10.2337/db23-765-P

Published: 20 June 2023

View article titled, 765-P: A Single Ascending Dose Study of the Novel GLP-1 Receptor Agonist GL0034 (Utreglutide) in Obese Individuals without Diabetes

Meeting Abstracts

1728-P: Transcriptional Activation of Myc by Glucose Requires Recruitment of ChREBP to the Pvt1 Promoter Regulating Proliferation in ß-Cells

LIORA S. KATZ, PENG WANG, GABRIEL BRILL, PILI ZHANG, JONATHAN HALDEMAN, CHRISTOPHER B. NEWGARD, ANDREW F. STEWART, ADOLFO GARCIA-OCANA, DONALD SCOTT

Diabetes 2023;72(Supplement_1):1728-P

https://doi.org/10.2337/db23-1728-P

Published: 20 June 2023

View article titled, 1728-P: Transcriptional Activation of Myc by Glucose Requires Recruitment of ChREBP to the Pvt1 Promoter Regulating Proliferation in ß-Cells

Meeting Abstracts

235-OR: Myc Activity Is Required for Mitochondrial Function and Glucose-Stimulated Insulin Secretion (GSIS) in Pancreatic ß-Cells

GEMING LU, RANDY KANG, PEDRO DIAZ-POZO, JUNGEUN LEE, MINGPEI LI, VICTOR M. VICTOR, DONALD SCOTT, ADOLFO GARCIA-OCANA

Diabetes 2023;72(Supplement_1):235-OR

https://doi.org/10.2337/db23-235-OR

Published: 20 June 2023

View article titled, 235-OR: Myc Activity Is Required for Mitochondrial Function and Glucose-Stimulated Insulin Secretion (GSIS) in Pancreatic ß-Cells

Meeting Abstracts

14-OR: Harmine and Exenatide Combination Increases Human ß-Cell Survival

CAROLINA ROSSELOT, YANSUI LI, DANIELA GUEVARA, KARA A. BELIARD, RANDY KANG, PENG WANG, KEYA THAKKAR, GEMING LU, ROBERT J. DEVITA, ANDREW F. STEWART, ADOLFO GARCIA-OCANA

Diabetes 2022;71(Supplement_1):14-OR

https://doi.org/10.2337/db22-14-OR

Published: 01 June 2022

View article titled, 14-OR: Harmine and Exenatide Combination Increases Human ß-Cell Survival

Meeting Abstracts

248-LB: Nrf2 Is Essential for Expanding Neonatal Pancreatic Beta-Cell Mass

SHARON BAUMEL-ALTERZON, ADOLFO GARCIA-OCANA, DONALD SCOTT

Diabetes 2022;71(Supplement_1):248-LB

https://doi.org/10.2337/db22-248-LB

Published: 01 June 2022

View article titled, 248-LB: Nrf2 Is Essential for Expanding Neonatal Pancreatic Beta-Cell Mass

Meeting Abstracts

10-OR: Combination Therapy with Anti-CD3 Antibody and Harmine plus Exendin-4 Enhances Remission from Recent-Onset Type 1 Diabetes.

GEMING LU, RANDY KANG, YANSUI LI, PENG WANG, CAROLINA ROSSELOT, ROBERT J. DEVITA, ANDREW F. STEWART, ADOLFO GARCIA-OCANA

Diabetes 2022;71(Supplement_1):10-OR

https://doi.org/10.2337/db22-10-OR

Published: 01 June 2022

View article titled, 10-OR: Combination Therapy with Anti-CD3 Antibody and Harmine plus Exendin-4 Enhances Remission from Recent-Onset Type 1 Diabetes.

Meeting Abstracts

744-P: Effects of a Novel Long-Acting GIP/GLP-1/Glucagon Trireceptor Agonist, HISHS-3001, on HbA1c, Body Weight, and Lipid Metabolism

VINOD S. BURADE, ADOLFO GARCIA-OCANA, RICHARD E. PRATLEY, GUY A. RUTTER, TINA VILSBØLL, BERNARD THORENS, RAJAMANNAR THENNATI

Diabetes 2022;71(Supplement_1):744-P

https://doi.org/10.2337/db22-744-P

Published: 01 June 2022

View article titled, 744-P: Effects of a Novel Long-Acting GIP/GLP-1/Glucagon Trireceptor Agonist, HISHS-3001, on HbA1c, Body Weight, and Lipid Metabolism

Meeting Abstracts

12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

LIORA S. KATZ, GABRIEL BRILL, MARK A. HERMAN, ADOLFO GARCIA-OCANA, DONALD SCOTT

Diabetes 2022;71(Supplement_1):12-OR

https://doi.org/10.2337/db22-12-OR

Published: 01 June 2022

View article titled, 12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

Meeting Abstracts

822-P: The Harmine and Exendin4 Combination Markedly Expands Human Beta-Cell Mass In Vivo in Diabetic Mice

KARA A. BELIARD, CAROLINA ROSSELOT, YANSUI LI, ALEXANDRA ALVARSSON, PENG WANG, KEYA THAKKAR, DANIELA GUEVARA, ROBERT J. DEVITA, ANDREW F. STEWART, SARAH STANLEY, ADOLFO GARCIA-OCANA

Diabetes 2022;71(Supplement_1):822-P

https://doi.org/10.2337/db22-822-P

Published: 01 June 2022

View article titled, 822-P: The Harmine and Exendin4 Combination Markedly Expands Human Beta-Cell Mass In Vivo in Diabetic Mice

Meeting Abstracts

1459-P: Human Islet Cell Transcriptome Analysis Using Single Nucleus RNA-seq Reveals New Beta-Cell Markers and Define Distinct Beta-Cell Subpopulations with Different Transcriptional Activity

RANDY KANG, YANSUI LI, CAROLINA ROSSELOT, DONALD SCOTT, ADOLFO GARCIA-OCANA, GEMING LU

Diabetes 2022;71(Supplement_1):1459-P

https://doi.org/10.2337/db22-1459-P

Published: 01 June 2022

View article titled, 1459-P: Human Islet Cell Transcriptome Analysis Using Single Nucleus RNA-seq Reveals New Beta-Cell Markers and Define Distinct Beta-Cell Subpopulations with Different Transcriptional Activity

Journal Articles

Nrf2 Regulates β-Cell Mass by Suppressing β-Cell Death and Promoting β-Cell Proliferation

Sharon Baumel-Alterzon, Liora S. Katz, Gabriel Brill, Clairete Jean-Pierre, Yansui Li, Isabelle Tse, Shyam Biswal, Adolfo Garcia-Ocaña, Donald K. Scott

Diabetes 2022;71(5):989–1011

https://doi.org/10.2337/db21-0581

Published: 22 February 2022

View article titled, Nrf2 Regulates β-Cell Mass by Suppressing β-Cell Death and Promoting β-Cell Proliferation

Meeting Abstracts

638-P: A Novel, Long-Acting Dual Agonist for GIPR/GLP-1R, HISHS-2001, Demonstrates Effects on HbA1c and Weight Loss in the db/db Mouse Model of Type 2 Diabetes

VINOD S. BURADE, ADOLFO GARCIA-OCANA, RICHARD E. PRATLEY, GUY A. RUTTER, TINA VILSBØLL, BERNARD THORENS, RAJAMANNAR THENNATI

Diabetes 2021;70(Supplement_1):638-P

https://doi.org/10.2337/db21-638-P

Published: 01 June 2021

View article titled, 638-P: A Novel, Long-Acting Dual Agonist for GIPR/GLP-1R, HISHS-2001, Demonstrates Effects on HbA1c and Weight Loss in the db/db Mouse Model of Type 2 Diabetes

NARROW

339-OR: Enhanced Expression of Zinc Finger Protein 385D Leads to Type 2 Diabetes Phenotype in Human Beta Cells

1720-P: Single Nucleus Transcriptome Profiling of Human Islet Cells under Metabolic Stress In Vivo

121-OR: Safety, Tolerability, and Metabolic Effects of Once-Weekly GL0034 (Utreglutide) in Individuals with Obesity—A Multiple Ascending Dose Study

116-OR: GL0034 (Utreglutide), a Novel GLP-1RA, Increases Liver FGF-21 and Demonstrates Significant Efficacy on Weight Loss, HbA1c, and Triglycerides in db/db Mice

349-OR: Selected DYRK1A Inhibitors Simultaneously Drive Both Human Beta-Cell Proliferation and Differentiation

82-OR: NRF2 Regulates Neonatal ß-Cell Mass Expansion

350-OR: Transcriptomics Identification of a-Cell Subpopulations in Human Islets Using Integrated scRNA-seq and snRNA-seq

766-P: Safety and Tolerability of Once-Weekly GL0034 (Utreglutide) in Healthy Individuals—A Multiple Ascending Dose Study

765-P: A Single Ascending Dose Study of the Novel GLP-1 Receptor Agonist GL0034 (Utreglutide) in Obese Individuals without Diabetes

1728-P: Transcriptional Activation of Myc by Glucose Requires Recruitment of ChREBP to the Pvt1 Promoter Regulating Proliferation in ß-Cells

235-OR: Myc Activity Is Required for Mitochondrial Function and Glucose-Stimulated Insulin Secretion (GSIS) in Pancreatic ß-Cells

14-OR: Harmine and Exenatide Combination Increases Human ß-Cell Survival

248-LB: Nrf2 Is Essential for Expanding Neonatal Pancreatic Beta-Cell Mass

10-OR: Combination Therapy with Anti-CD3 Antibody and Harmine plus Exendin-4 Enhances Remission from Recent-Onset Type 1 Diabetes.

744-P: Effects of a Novel Long-Acting GIP/GLP-1/Glucagon Trireceptor Agonist, HISHS-3001, on HbA1c, Body Weight, and Lipid Metabolism

12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

822-P: The Harmine and Exendin4 Combination Markedly Expands Human Beta-Cell Mass In Vivo in Diabetic Mice

1459-P: Human Islet Cell Transcriptome Analysis Using Single Nucleus RNA-seq Reveals New Beta-Cell Markers and Define Distinct Beta-Cell Subpopulations with Different Transcriptional Activity

Nrf2 Regulates β-Cell Mass by Suppressing β-Cell Death and Promoting β-Cell Proliferation

638-P: A Novel, Long-Acting Dual Agonist for GIPR/GLP-1R, HISHS-2001, Demonstrates Effects on HbA1c and Weight Loss in the db/db Mouse Model of Type 2 Diabetes

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