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Meeting Abstracts

10-OR: Combination Therapy with Anti-CD3 Antibody and Harmine plus Exendin-4 Enhances Remission from Recent-Onset Type 1 Diabetes.

GEMING LU, RANDY KANG, YANSUI LI, PENG WANG, CAROLINA ROSSELOT, ROBERT J. DEVITA, ANDREW F. STEWART, ADOLFO GARCIA-OCANA

Diabetes 2022;71(Supplement_1):10-OR

DOI: https://doi.org/10.2337/db22-10-OR

Published: 01 June 2022

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Meeting Abstracts

744-P: Effects of a Novel Long-Acting GIP/GLP-1/Glucagon Trireceptor Agonist, HISHS-3001, on HbA1c, Body Weight, and Lipid Metabolism

VINOD S. BURADE, ADOLFO GARCIA-OCANA, RICHARD E. PRATLEY, GUY A. RUTTER, TINA VILSBØLL, BERNARD THORENS, RAJAMANNAR THENNATI

Diabetes 2022;71(Supplement_1):744-P

DOI: https://doi.org/10.2337/db22-744-P

Published: 01 June 2022

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Meeting Abstracts

12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

LIORA S. KATZ, GABRIEL BRILL, MARK A. HERMAN, ADOLFO GARCIA-OCANA, DONALD SCOTT

Diabetes 2022;71(Supplement_1):12-OR

DOI: https://doi.org/10.2337/db22-12-OR

Published: 01 June 2022

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Meeting Abstracts

248-LB: Nrf2 Is Essential for Expanding Neonatal Pancreatic Beta-Cell Mass

SHARON BAUMEL-ALTERZON, ADOLFO GARCIA-OCANA, DONALD SCOTT

Diabetes 2022;71(Supplement_1):248-LB

DOI: https://doi.org/10.2337/db22-248-LB

Published: 01 June 2022

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Meeting Abstracts

14-OR: Harmine and Exenatide Combination Increases Human ß-Cell Survival

CAROLINA ROSSELOT, YANSUI LI, DANIELA GUEVARA, KARA A. BELIARD, RANDY KANG, PENG WANG, KEYA THAKKAR, GEMING LU, ROBERT J. DEVITA, ANDREW F. STEWART, ADOLFO GARCIA-OCANA

Diabetes 2022;71(Supplement_1):14-OR

DOI: https://doi.org/10.2337/db22-14-OR

Published: 01 June 2022

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Meeting Abstracts

822-P: The Harmine and Exendin4 Combination Markedly Expands Human Beta-Cell Mass In Vivo in Diabetic Mice

KARA A. BELIARD, CAROLINA ROSSELOT, YANSUI LI, ALEXANDRA ALVARSSON, PENG WANG, KEYA THAKKAR, DANIELA GUEVARA, ROBERT J. DEVITA, ANDREW F. STEWART, SARAH STANLEY, ADOLFO GARCIA-OCANA

Diabetes 2022;71(Supplement_1):822-P

DOI: https://doi.org/10.2337/db22-822-P

Published: 01 June 2022

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Meeting Abstracts

1459-P: Human Islet Cell Transcriptome Analysis Using Single Nucleus RNA-seq Reveals New Beta-Cell Markers and Define Distinct Beta-Cell Subpopulations with Different Transcriptional Activity

RANDY KANG, YANSUI LI, CAROLINA ROSSELOT, DONALD SCOTT, ADOLFO GARCIA-OCANA, GEMING LU

Diabetes 2022;71(Supplement_1):1459-P

DOI: https://doi.org/10.2337/db22-1459-P

Published: 01 June 2022

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Journal Articles

Nrf2 Regulates β-Cell Mass by Suppressing β-Cell Death and Promoting β-Cell Proliferation

Sharon Baumel-Alterzon, Liora S. Katz, Gabriel Brill, Clairete Jean-Pierre, Yansui Li, Isabelle Tse, Shyam Biswal, Adolfo Garcia-Ocaña, Donald K. Scott

Diabetes 2022;71(5):989–1011

DOI: https://doi.org/10.2337/db21-0581

Published: 22 February 2022

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Meeting Abstracts

638-P: A Novel, Long-Acting Dual Agonist for GIPR/GLP-1R, HISHS-2001, Demonstrates Effects on HbA1c and Weight Loss in the db/db Mouse Model of Type 2 Diabetes

VINOD S. BURADE, ADOLFO GARCIA-OCANA, RICHARD E. PRATLEY, GUY A. RUTTER, TINA VILSBØLL, BERNARD THORENS, RAJAMANNAR THENNATI

Diabetes 2021;70(Supplement_1):638-P

DOI: https://doi.org/10.2337/db21-638-P

Published: 01 June 2021

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Meeting Abstracts

1784-P: Liraglutide Treatment Stimulates Alpha Cells to Produce Glucagon-Like Peptide-1 via Expression of Prohormone Convertase 1/3 in Mice and Human

MRIDUSMITA SAIKIA, MARLENA M. HOLTER, DARLINE GARIBAY, ADOLFO GARCIA-OCANA, CHARLES G. DANKO, BETHANY CUMMINGS

Diabetes 2020;69(Supplement_1):1784-P

DOI: https://doi.org/10.2337/db20-1784-P

Published: 01 June 2020

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Journal Articles

Dextran Sulfate Protects Pancreatic β-Cells, Reduces Autoimmunity, and Ameliorates Type 1 Diabetes

Geming Lu, Francisco Rausell-Palamos, Jiamin Zhang, Zihan Zheng, Tuo Zhang, Shelley Valle, Carolina Rosselot, Cecilia Berrouet, Patricia Conde, Matthew P. Spindler, John G. Graham, Dirk Homann, Adolfo Garcia-Ocaña

Diabetes 2020;69(8):1692–1707

DOI: https://doi.org/10.2337/db19-0725

Published: 07 May 2020

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Journal Articles

Lactogens Reduce Endoplasmic Reticulum Stress–Induced Rodent and Human β-Cell Death and Diabetes Incidence in Akita Mice

Rosemary Li, Nagesha Guthalu Kondegowda, Joanna Filipowska, Rollie F. Hampton, Silvia Leblanc, Adolfo Garcia-Ocana, Rupangi C. Vasavada

Diabetes 2020;69(7):1463–1475

DOI: https://doi.org/10.2337/db19-0909

Published: 24 April 2020

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Journal Articles

Myc Is Required for Adaptive β-Cell Replication in Young Mice but Is Not Sufficient in One-Year-Old Mice Fed With a High-Fat Diet

Carolina Rosselot, Anil Kumar, Jayalakshmi Lakshmipathi, Pili Zhang, Geming Lu, Liora S. Katz, Edward V. Prochownik, Andrew F. Stewart, Luca Lambertini, Donald K. Scott, Adolfo Garcia-Ocaña

Diabetes 2019;68(10):1934–1949

DOI: https://doi.org/10.2337/db18-1368

Published: 10 July 2019

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Includes: Supplementary data

Meeting Abstracts

44-OR: Human Pseudo Islets Reveal Differential Effects of Gq Signaling in ß Cells in Low and High Glucose

JOHN T. WALKER, RACHANA HALIYUR, RADHIKA ARAMANDLA, GREG POFFENBERGER, HEATHER A. NELSON, JOSEPH LUCHSINGER, PENG WANG, ADOLFO GARCIA-OCAÑA, MARCELA BRISSOVA, ALVIN C. POWERS

Diabetes 2019;68(Supplement_1):44-OR

DOI: https://doi.org/10.2337/db19-44-OR

Published: 01 June 2019

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Meeting Abstracts

2131-P: Dextran Sulfate and HGF Ameliorate Type 1 Diabetes

GEMING LU, TUO ZHANG, DIRK HOMANN, ADOLFO GARCIA-OCAÑA

Diabetes 2019;68(Supplement_1):2131-P

DOI: https://doi.org/10.2337/db19-2131-P

Published: 01 June 2019

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Meeting Abstracts

2141-P: Nrf2 Mediates Glucose-Stimulated Beta-Cell Proliferation

SHARON BAUMEL-ALTERZON, LIORA S. KATZ, GABRIEL BRILL, ADOLFO GARCIA-OCAÑA, DONALD SCOTT

Diabetes 2019;68(Supplement_1):2141-P

DOI: https://doi.org/10.2337/db19-2141-P

Published: 01 June 2019

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Meeting Abstracts

Altering ß-Cell Proliferation In Vivo by Pharmacological Manipulation of the Nrf2 Pathway

LIORA S. KATZ, ADOLFO GARCIA-OCANA, DONALD SCOTT

Diabetes 2018;67(Supplement_1):2116-P

DOI: https://doi.org/10.2337/db18-2116-P

Published: 01 July 2018

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Journal Articles

Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation

Anil Kumar, Liora S. Katz, Anna M. Schulz, Misung Kim, Lee B. Honig, Lucy Li, Bennett Davenport, Dirk Homann, Adolfo Garcia-Ocaña, Mark A. Herman, Cole M. Haynes, Jerry E. Chipuk, Donald K. Scott

Diabetes 2018;67(8):1561–1575

DOI: https://doi.org/10.2337/db17-0943

Published: 15 May 2018

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Includes: Supplementary data

Journal Articles

PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2

Jayalakshmi Lakshmipathi, Juan Carlos Alvarez-Perez, Carolina Rosselot, Gabriella P. Casinelli, Rachel E. Stamateris, Francisco Rausell-Palamos, Christopher P. O’Donnell, Rupangi C. Vasavada, Donald K. Scott, Laura C. Alonso, Adolfo Garcia-Ocaña

Diabetes 2016;65(5):1283–1296

DOI: https://doi.org/10.2337/db15-1398

Published: 11 February 2016

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Includes: Supplementary data

Journal Articles

Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor

Rachel E. Stamateris, Rohit B. Sharma, Yahui Kong, Pantea Ebrahimpour, Deepika Panday, Pavana Ranganath, Baobo Zou, Helena Levitt, Nisha Abraham Parambil, Christopher P. O’Donnell, Adolfo García-Ocaña, Laura C. Alonso

Diabetes 2016;65(4):981–995

DOI: https://doi.org/10.2337/db15-0529

Published: 06 January 2016

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Includes: Supplementary data

NARROW

10-OR: Combination Therapy with Anti-CD3 Antibody and Harmine plus Exendin-4 Enhances Remission from Recent-Onset Type 1 Diabetes.

744-P: Effects of a Novel Long-Acting GIP/GLP-1/Glucagon Trireceptor Agonist, HISHS-3001, on HbA1c, Body Weight, and Lipid Metabolism

12-OR: Preventing ß-Cell Death under Glucotoxic Conditions: The Role of ChREBPb

248-LB: Nrf2 Is Essential for Expanding Neonatal Pancreatic Beta-Cell Mass

14-OR: Harmine and Exenatide Combination Increases Human ß-Cell Survival

822-P: The Harmine and Exendin4 Combination Markedly Expands Human Beta-Cell Mass In Vivo in Diabetic Mice

1459-P: Human Islet Cell Transcriptome Analysis Using Single Nucleus RNA-seq Reveals New Beta-Cell Markers and Define Distinct Beta-Cell Subpopulations with Different Transcriptional Activity

Nrf2 Regulates β-Cell Mass by Suppressing β-Cell Death and Promoting β-Cell Proliferation

638-P: A Novel, Long-Acting Dual Agonist for GIPR/GLP-1R, HISHS-2001, Demonstrates Effects on HbA1c and Weight Loss in the db/db Mouse Model of Type 2 Diabetes

1784-P: Liraglutide Treatment Stimulates Alpha Cells to Produce Glucagon-Like Peptide-1 via Expression of Prohormone Convertase 1/3 in Mice and Human

Dextran Sulfate Protects Pancreatic β-Cells, Reduces Autoimmunity, and Ameliorates Type 1 Diabetes

Lactogens Reduce Endoplasmic Reticulum Stress–Induced Rodent and Human β-Cell Death and Diabetes Incidence in Akita Mice

Myc Is Required for Adaptive β-Cell Replication in Young Mice but Is Not Sufficient in One-Year-Old Mice Fed With a High-Fat Diet

44-OR: Human Pseudo Islets Reveal Differential Effects of Gq Signaling in ß Cells in Low and High Glucose

2131-P: Dextran Sulfate and HGF Ameliorate Type 1 Diabetes

2141-P: Nrf2 Mediates Glucose-Stimulated Beta-Cell Proliferation

Altering ß-Cell Proliferation In Vivo by Pharmacological Manipulation of the Nrf2 Pathway

Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation

PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2

Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor

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