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Meeting Abstracts

1322-P: Role of Macrophage NOD1 in Fat-Induced ß-Cell Dysfunction

S.M. NIAZUR RAHMAN, JUSTIN HOU MING YUNG, YIHE ZHANG, ADRIA GIACCA

Diabetes 2022;71(Supplement_1):1322-P

DOI: https://doi.org/10.2337/db22-1322-P

Published: 01 June 2022

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Meeting Abstracts

452-P: Liraglutide Decreases Neointimal Growth in Control and Western Diet–Fed Mice, and Its Effect Is Insulin Dependent

MAREL GONZALEZ, ZHIWEI LIU, ADRIA GIACCA

Diabetes 2022;71(Supplement_1):452-P

DOI: https://doi.org/10.2337/db22-452-P

Published: 01 June 2022

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Meeting Abstracts

324-OR: Pathway-Specific Role of Insulin in an In Vivo Model of Restenosis

ZHIWEI LIU, MAREL GONZALEZ, SONGXIAN OU, LANHUI QIU, ADRIA GIACCA

Diabetes 2022;71(Supplement_1):324-OR

DOI: https://doi.org/10.2337/db22-324-OR

Published: 01 June 2022

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Meeting Abstracts

1329-P: A RIPK2 Inhibitor Protects against Saturated-Fat–Induced Glucose Intolerance in Mice

NICOLE TSAKIRIDIS, ALEKSANDAR IVOVIC, S M NIAZUR RAHMAN, YAO TAN, ADRIA GIACCA

Diabetes 2022;71(Supplement_1):1329-P

DOI: https://doi.org/10.2337/db22-1329-P

Published: 01 June 2022

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Meeting Abstracts

101-OR: Cell-Specific Role of Insulin in a Model of Restenosis in Insulin-Sensitive and Insulin-Resistant Conditions

MAREL GONZALEZ, ZHIWEI LIU, JOHNY Z. WANG, CINDY X. ZHANG, ADRIA GIACCA

Diabetes 2022;71(Supplement_1):101-OR

DOI: https://doi.org/10.2337/db22-101-OR

Published: 01 June 2022

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Meeting Abstracts

1161-P: NOD1-JNK1 Axis Plays a Causal Role in Palmitate-Induced ß-Cell Dysfunction

JUSTIN HOU MING YUNG, ALEKSANDAR IVOVIC, ISABEL CLARK, FIONA LI, BRIAN LIN, YAO TAN, ADRIA GIACCA

Diabetes 2021;70(Supplement_1):1161-P

DOI: https://doi.org/10.2337/db21-1161-P

Published: 01 June 2021

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Meeting Abstracts

453-P: Cell-Specific Role of Insulin in an In Vivo Model of Restenosis

MAREL GONZALEZ, YUSAKU MORI, JUNE GUO, LUKE S. DINGWELL, ADRIA GIACCA

Diabetes 2020;69(Supplement_1):453-P

DOI: https://doi.org/10.2337/db20-453-P

Published: 01 June 2020

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Meeting Abstracts

1858-P: P38 MAPK Inhibition Protects against FFA-Induced Insulin Resistance and Hepatic Fat Accumulation

DEBORAH Y. JOSEPH, SYDNEY L. RIVERS, ADRIA GIACCA

Diabetes 2020;69(Supplement_1):1858-P

DOI: https://doi.org/10.2337/db20-1858-P

Published: 01 June 2020

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Meeting Abstracts

1875-P: Liver-Specific p38 MAPK Stimulates Hepatic Fat Accumulation and Reduces Insulin Sensitivity In Vivo

SYDNEY L. RIVERS, HUIQI WANG, LORETTA LAM, ADRIA GIACCA

Diabetes 2019;68(Supplement_1):1875-P

DOI: https://doi.org/10.2337/db19-1875-P

Published: 01 June 2019

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Meeting Abstracts

2167-P: Gamma-Hydroxybutyrate Prevents Lipotoxicity-Induced ß-Cell Dysfunction

LUCY SHU NGA YEUNG, ALEKSANDAR IVOVIC, YAO FANG TAN, BATTSETSEG BATCHULUUN, MORTIMER MAMELAK, ADRIA GIACCA

Diabetes 2019;68(Supplement_1):2167-P

DOI: https://doi.org/10.2337/db19-2167-P

Published: 01 June 2019

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Meeting Abstracts

2472-PUB: JNK1 Plays a Causal Role in Palmitate-induced ß-Cell Dysfunction In Vivo

JUSTIN HOU MING YUNG, LUCY SHU NGA YEUNG, ASHRAF NAHLE, KHAJAG KOULAJIAN, ADRIA GIACCA

Diabetes 2019;68(Supplement_1):2472-PUB

DOI: https://doi.org/10.2337/db19-2472-PUB

Published: 01 June 2019

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Meeting Abstracts

The Effect of Resveratrol on Reducing Neointimal Growth after Femoral Artery Injury in AMPKα2 Knockout Mice Given High-Fat Diet

LIWEI ZHOU, JUNE GUO, HANGJUN ZHANG, SCOTT HEXIMER, ADRIA GIACCA

Diabetes 2018;67(Supplement_1):484-P

DOI: https://doi.org/10.2337/db18-484-P

Published: 01 July 2018

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Meeting Abstracts

NOD1 Mediates Insulin Resistance in Response to Circulating Free Fatty Acids

SYDNEY L. RIVERS, LUCY SHU NGA YEUNG, KENNY L. CHAN, YUSAKU MORI, DANA PHILPOTT, AMIRA KLIP, ADRIA GIACCA

Diabetes 2018;67(Supplement_1):148-OR

DOI: https://doi.org/10.2337/db18-148-OR

Published: 01 July 2018

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Journal Articles

Somatostatin Receptor Type 2 Antagonism Improves Glucagon and Corticosterone Counterregulatory Responses to Hypoglycemia in Streptozotocin-Induced Diabetic Rats

Jessica T.Y. Yue, Elena Burdett, David H. Coy, Adria Giacca, Suad Efendic, Mladen Vranic

Diabetes 2012;61(1):197–207

DOI: https://doi.org/10.2337/db11-0690

Published: 12 December 2011

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Includes: Supplementary data

Journal Articles

NOD1 Activators Link Innate Immunity to Insulin Resistance

Jonathan D. Schertzer, Akhilesh K. Tamrakar, Joao G. Magalhães, Sandra Pereira, Philip J. Bilan, Morgan D. Fullerton, Zhi Liu, Gregory R. Steinberg, Adria Giacca, Dana J. Philpott, Amira Klip

Diabetes 2011;60(9):2206–2215

DOI: https://doi.org/10.2337/db11-0004

Published: 20 August 2011

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Includes: Supplementary data

Journal Articles

Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans

Changting Xiao, Adria Giacca, Gary F. Lewis

Diabetes 2011;60(3):918–924

DOI: https://doi.org/10.2337/db10-1433

Published: 21 February 2011

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Journal Articles

Free Fatty Acid–Induced Reduction in Glucose-Stimulated Insulin Secretion : Evidence for a Role of Oxidative Stress In Vitro and In Vivo

Andrei I. Oprescu, George Bikopoulos, Anthony Naassan, Emma M. Allister, Christine Tang, Edward Park, Hiroshi Uchino, Gary F. Lewis, I. George Fantus, Maria Rozakis-Adcock, Michael B. Wheeler, Adria Giacca

Diabetes 2007;56(12):2927–2937

DOI: https://doi.org/10.2337/db07-0075

Published: 01 December 2007

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Includes: Supplementary data

Journal Articles

Evidence for a Role of Superoxide Generation in Glucose-Induced β-Cell Dysfunction In Vivo

Christine Tang, Ping Han, Andrei I. Oprescu, Simon C. Lee, Armen V. Gyulkhandanyan, Gary N.Y. Chan, Michael B. Wheeler, Adria Giacca

Diabetes 2007;56(11):2722–2731

DOI: https://doi.org/10.2337/db07-0279

Published: 01 November 2007

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Journal Articles

Gene and Protein Kinase Expression Profiling of Reactive Oxygen Species-Associated Lipotoxicity in the Pancreatic β-Cell Line MIN6

Xiaolin Wang, Hui Li, Domenica De Leo, Wanbei Guo, Vasilij Koshkin, I. George Fantus, Adria Giacca, Catherine B. Chan, Sandy Der, Michael B. Wheeler

Diabetes 2004;53(1):129–140

DOI: https://doi.org/10.2337/diabetes.53.1.129

Published: 01 January 2004

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Journal Articles

Free Fatty Acid-Mediated Impairment of Glucose-Stimulated Insulin Secretion in Nondiabetic Oji-Cree Individuals From the Sandy Lake Community of Ontario, Canada: A Population at Very High Risk for Developing Type 2 Diabetes

André Carpentier, Bernard Zinman, Nathalie Leung, Adria Giacca, Anthony J.G. Hanley, Stewart B. Harris, Robert A. Hegele, Gary F. Lewis

Diabetes 2003;52(6):1485–1495

DOI: https://doi.org/10.2337/diabetes.52.6.1485

Published: 01 June 2003

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NARROW

1322-P: Role of Macrophage NOD1 in Fat-Induced ß-Cell Dysfunction

452-P: Liraglutide Decreases Neointimal Growth in Control and Western Diet–Fed Mice, and Its Effect Is Insulin Dependent

324-OR: Pathway-Specific Role of Insulin in an In Vivo Model of Restenosis

1329-P: A RIPK2 Inhibitor Protects against Saturated-Fat–Induced Glucose Intolerance in Mice

101-OR: Cell-Specific Role of Insulin in a Model of Restenosis in Insulin-Sensitive and Insulin-Resistant Conditions

1161-P: NOD1-JNK1 Axis Plays a Causal Role in Palmitate-Induced ß-Cell Dysfunction

453-P: Cell-Specific Role of Insulin in an In Vivo Model of Restenosis

1858-P: P38 MAPK Inhibition Protects against FFA-Induced Insulin Resistance and Hepatic Fat Accumulation

1875-P: Liver-Specific p38 MAPK Stimulates Hepatic Fat Accumulation and Reduces Insulin Sensitivity In Vivo

2167-P: Gamma-Hydroxybutyrate Prevents Lipotoxicity-Induced ß-Cell Dysfunction

2472-PUB: JNK1 Plays a Causal Role in Palmitate-induced ß-Cell Dysfunction In Vivo

The Effect of Resveratrol on Reducing Neointimal Growth after Femoral Artery Injury in AMPKα2 Knockout Mice Given High-Fat Diet

NOD1 Mediates Insulin Resistance in Response to Circulating Free Fatty Acids

Somatostatin Receptor Type 2 Antagonism Improves Glucagon and Corticosterone Counterregulatory Responses to Hypoglycemia in Streptozotocin-Induced Diabetic Rats

NOD1 Activators Link Innate Immunity to Insulin Resistance

Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans

Free Fatty Acid–Induced Reduction in Glucose-Stimulated Insulin Secretion : Evidence for a Role of Oxidative Stress In Vitro and In Vivo

Evidence for a Role of Superoxide Generation in Glucose-Induced β-Cell Dysfunction In Vivo

Gene and Protein Kinase Expression Profiling of Reactive Oxygen Species-Associated Lipotoxicity in the Pancreatic β-Cell Line MIN6

Free Fatty Acid-Mediated Impairment of Glucose-Stimulated Insulin Secretion in Nondiabetic Oji-Cree Individuals From the Sandy Lake Community of Ontario, Canada: A Population at Very High Risk for Developing Type 2 Diabetes

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