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Meeting Abstracts

1563-P: High Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness but Not Insulin Action Under Euglycemic Conditions

DALE S. EDGERTON, GUILLAUME KRAFT, HANNAH L. WATERMAN, BEN FARMER, KALISHA YANKEY, MARTA S. SMITH, JON R. HASTINGS, MELANIE SCOTT, ALAN D. CHERRINGTON

Diabetes 2024;73(Supplement_1):1563-P

https://doi.org/10.2337/db24-1563-P

Published: 14 June 2024

View article titled, 1563-P: High Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness but Not Insulin Action Under Euglycemic Conditions

Meeting Abstracts

1565-P: Morning Hyperglucagonemia Disrupts the Priming Action of AM Insulin

HANNAH L. WATERMAN, MARY C. MOORE, MARTA S. SMITH, BEN FARMER, KALISHA YANKEY, DALE S. EDGERTON, ALAN D. CHERRINGTON

Diabetes 2024;73(Supplement_1):1565-P

https://doi.org/10.2337/db24-1565-P

Published: 14 June 2024

View article titled, 1565-P: Morning Hyperglucagonemia Disrupts the Priming Action of AM Insulin

Meeting Abstracts

1597-P: High Fat and Fructose Diet Dysregulates Postprandial Gut and Hepatic Metabolism in a Canine Model

GUILLAUME KRAFT, MELANIE SCOTT, BEN FARMER, KALISHA YANKEY, DALE S. EDGERTON, HARITH RAJAGOPALAN, EMILY COZZI, KATHERINE GIBSON-CORLEY, CHARLES R. FLYNN, ALAN D. CHERRINGTON

Diabetes 2024;73(Supplement_1):1597-P

https://doi.org/10.2337/db24-1597-P

Published: 14 June 2024

View article titled, 1597-P: High Fat and Fructose Diet Dysregulates Postprandial Gut and Hepatic Metabolism in a Canine Model

Meeting Abstracts

1600-P: Duration of Morning Hyperinsulinemia Is Key to the Enhancement of Hepatic Glucose Uptake Later in the Day

HANNAH L. WATERMAN, MARTA S. SMITH, BEN FARMER, GUILLAUME KRAFT, MELANIE SCOTT, DALE S. EDGERTON, ALAN D. CHERRINGTON, MARY C. MOORE

Diabetes 2023;72(Supplement_1):1600-P

https://doi.org/10.2337/db23-1600-P

Published: 20 June 2023

View article titled, 1600-P: Duration of Morning Hyperinsulinemia Is Key to the Enhancement of Hepatic Glucose Uptake Later in the Day

Meeting Abstracts

1560-P: Combining Glucagon with Insulin Can Lessen the Hypoglycemic Potential of Insulin

GUILLAUME KRAFT, MELANIE SCOTT, MARTA S. SMITH, BEN FARMER, DALE S. EDGERTON, ALAN D. CHERRINGTON

Diabetes 2023;72(Supplement_1):1560-P

https://doi.org/10.2337/db23-1560-P

Published: 20 June 2023

View article titled, 1560-P: Combining Glucagon with Insulin Can Lessen the Hypoglycemic Potential of Insulin

Journal Articles

Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog

Guillaume Kraft, Katie C. Coate, Marta Smith, Ben Farmer, Melanie Scott, Jon Hastings, Alan D. Cherrington, Dale S. Edgerton

Diabetes 2023;72(2):196–209

https://doi.org/10.2337/db22-0471

Published: 24 October 2022

View article titled, Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog

Meeting Abstracts

1341-P: Dietary Fat and Fructose Impair Glucagon-Stimulated Liver Glucose Metabolism

DALE S. EDGERTON, GUILLAUME KRAFT, KATIE C. COATE, BEN FARMER, MARTA S. SMITH, MELANIE SCOTT, JON R. HASTINGS, MARY C. MOORE, ALAN D. CHERRINGTON

Diabetes 2022;71(Supplement_1):1341-P

https://doi.org/10.2337/db22-1341-P

Published: 01 June 2022

View article titled, 1341-P: Dietary Fat and Fructose Impair Glucagon-Stimulated Liver Glucose Metabolism

Journal Articles

The Importance of the Mechanisms by Which Insulin Regulates Meal-Associated Liver Glucose Uptake in the Dog

Guillaume Kraft, Katie C. Coate, Marta Smith, Ben Farmer, Melanie Scott, Alan D. Cherrington, Dale S. Edgerton

Diabetes 2021;70(6):1292–1302

https://doi.org/10.2337/db20-1271

Published: 23 March 2021

View article titled, The Importance of the Mechanisms by Which Insulin Regulates Meal-Associated Liver Glucose Uptake in the Dog

Meeting Abstracts

367-OR: High-Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness

DALE S. EDGERTON, GUILLAUME KRAFT, BEN FARMER, MELANIE SCOTT, MARTA S. SMITH, ALAN D. CHERRINGTON

Diabetes 2020;69(Supplement_1):367-OR

https://doi.org/10.2337/db20-367-OR

Published: 01 June 2020

View article titled, 367-OR: High-Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness

Meeting Abstracts

7-LB: Insulin and Glucagon Coadministration in Type 1 Diabetes Prevents Hypoglycemia without Worsening Hyperglycemia

BRUCE W. BODE, JENNIFER BOYD, ANNE SHAH, DAVID PARKES, SOUMITRA GHOSH, ALAN D. CHERRINGTON

Diabetes 2020;69(Supplement_1):7-LB

https://doi.org/10.2337/db20-7-LB

Published: 01 June 2020

View article titled, 7-LB: Insulin and Glucagon Coadministration in Type 1 Diabetes Prevents Hypoglycemia without Worsening Hyperglycemia

Journal Articles

The Peripheral Peril: Injected Insulin Induces Insulin Insensitivity in Type 1 Diabetes

Justin M. Gregory, Alan D. Cherrington, Daniel J. Moore

Diabetes 2020;69(5):837–847

https://doi.org/10.2337/dbi19-0026

Published: 13 April 2020

View article titled, The Peripheral Peril: Injected Insulin Induces Insulin Insensitivity in Type 1 Diabetes

Meeting Abstracts

1801-P: Common Hepatic Artery Denervation Does Not Alter the Counterregulatory Response to Hypoglycemia in an Insulin Resistant Canine Model

GUILLAUME KRAFT, L. MERKLE MOORE, BEN FARMER, MELANIE F. SCOTT, DALE S. EDGERTON, PHILLIP E. WILLIAMS, BOBAK AZAMIAN, ALAN D. CHERRINGTON

Diabetes 2019;68(Supplement_1):1801-P

https://doi.org/10.2337/db19-1801-P

Published: 01 June 2019

View article titled, 1801-P: Common Hepatic Artery Denervation Does Not Alter the Counterregulatory Response to Hypoglycemia in an Insulin Resistant Canine Model

Meeting Abstracts

1848-P: Effect of Brain Glucagon Action on Hepatic Glucose Production

DALE S. EDGERTON, GUILLAUME KRAFT, BEN FARMER, MARTA S. SMITH, ALAN D. CHERRINGTON

Diabetes 2019;68(Supplement_1):1848-P

https://doi.org/10.2337/db19-1848-P

Published: 01 June 2019

View article titled, 1848-P: Effect of Brain Glucagon Action on Hepatic Glucose Production

Meeting Abstracts

1849-P: Importance of Insulin’s Direct and Indirect Effects on Postprandial Hepatic Glucose Uptake

DALE S. EDGERTON, GUILLAUME KRAFT, BEN FARMER, MARTA S. SMITH, PHILLIP E. WILLIAMS, ALAN D. CHERRINGTON

Diabetes 2019;68(Supplement_1):1849-P

https://doi.org/10.2337/db19-1849-P

Published: 01 June 2019

View article titled, 1849-P: Importance of Insulin’s Direct and Indirect Effects on Postprandial Hepatic Glucose Uptake

Journal Articles

Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2)

Justin M. Gregory, T. Jordan Smith, James C. Slaughter, Holly R. Mason, Curtis C. Hughey, Marta S. Smith, Balamurugan Kandasamy, Siri Atma W. Greeley, Louis H. Philipson, Rochelle N. Naylor, Lisa R. Letourneau, Naji N. Abumrad, Alan D. Cherrington, Daniel J. Moore

Diabetes 2019;68(8):1565–1576

https://doi.org/10.2337/db19-0324

Published: 15 May 2019

View article titled, Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2)

Includes: Supplementary data

Journal Articles

Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog

Guillaume Kraft, Anthony Vrba, Melanie Scott, Eric Allen, Dale S. Edgerton, Phil E. Williams, Scott B. Vafai, Bobak R. Azamian, Alan D. Cherrington

Diabetes 2019;68(6):1143–1155

https://doi.org/10.2337/db18-1209

Published: 01 April 2019

View article titled, Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog

Meeting Abstracts

Basal Oral Insulin Analog I338 Enhances Meal-Related Hepatic Glucose Disposal

MARY C. MOORE, ERICA NISHIMURA, CHRISTIAN L. BRAND, THOMAS KJELDSEN, PETER MADSEN, HANNE H. REFSGAARD, KARSTEN WASSERMANN, SANNE GRAM-NIELSEN, MARTA S. SMITH, L. MERKLE MOORE, BEN FARMER, JON R. HASTINGS, PHILLIP E. WILLIAMS, ALAN D. CHERRINGTON

Diabetes 2018;67(Supplement_1):347-OR

https://doi.org/10.2337/db18-347-OR

Published: 01 July 2018

View article titled, Basal Oral Insulin Analog I338 Enhances Meal-Related Hepatic Glucose Disposal

Meeting Abstracts

Pharmacodynamic Effect of Novel Oral Insulin Tregopil in Relation to Meal Composition in Type 2 Diabetes Mellitus Patients

ANAND P. KHEDKAR, VINU JOSE, HAROLD E. LEBOVITZ, ALAN D. CHERRINGTON, GILBERT ALEXANDER FLEMING, SANDEEP N. ATHALYE, ASHWINI VISHWESWARAMURTHY

Diabetes 2018;67(Supplement_1):346-OR

https://doi.org/10.2337/db18-346-OR

Published: 01 July 2018

View article titled, Pharmacodynamic Effect of Novel Oral Insulin Tregopil in Relation to Meal Composition in Type 2 Diabetes Mellitus Patients

Meeting Abstracts

Incretin Hormone Release Does Not Involve Hepatic Portal Vein Glucose Sensors

DALE S. EDGERTON, GUILLAUME KRAFT, MARTA S. SMITH, L. MERKLE MOORE, BEN FARMER, HEATHER SARA, MELANIE SCOTT, MARY MOORE, MICHAEL A. NAUCK, ALAN D. CHERRINGTON

Diabetes 2018;67(Supplement_1):1961-P

https://doi.org/10.2337/db18-1961-P

Published: 01 July 2018

View article titled, Incretin Hormone Release Does Not Involve Hepatic Portal Vein Glucose Sensors

Meeting Abstracts

Dosing Time of Insulin Tregopil, a Novel Oral Insulin, in Type 2 Diabetes Mellitus Patients and Its Pharmacodynamic Effect

ANAND P. KHEDKAR, VINU JOSE, HAROLD E. LEBOVITZ, ALAN D. CHERRINGTON, GILBERT ALEXANDER FLEMING, SANDEEP N. ATHALYE, ASHWINI VISHWESWARAMURTHY

Diabetes 2018;67(Supplement_1):979-P

https://doi.org/10.2337/db18-979-P

Published: 01 July 2018

View article titled, Dosing Time of Insulin Tregopil, a Novel Oral Insulin, in Type 2 Diabetes Mellitus Patients and Its Pharmacodynamic Effect

NARROW

1563-P: High Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness but Not Insulin Action Under Euglycemic Conditions

1565-P: Morning Hyperglucagonemia Disrupts the Priming Action of AM Insulin

1597-P: High Fat and Fructose Diet Dysregulates Postprandial Gut and Hepatic Metabolism in a Canine Model

1600-P: Duration of Morning Hyperinsulinemia Is Key to the Enhancement of Hepatic Glucose Uptake Later in the Day

1560-P: Combining Glucagon with Insulin Can Lessen the Hypoglycemic Potential of Insulin

Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog

1341-P: Dietary Fat and Fructose Impair Glucagon-Stimulated Liver Glucose Metabolism

The Importance of the Mechanisms by Which Insulin Regulates Meal-Associated Liver Glucose Uptake in the Dog

367-OR: High-Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness

7-LB: Insulin and Glucagon Coadministration in Type 1 Diabetes Prevents Hypoglycemia without Worsening Hyperglycemia

The Peripheral Peril: Injected Insulin Induces Insulin Insensitivity in Type 1 Diabetes

1801-P: Common Hepatic Artery Denervation Does Not Alter the Counterregulatory Response to Hypoglycemia in an Insulin Resistant Canine Model

1848-P: Effect of Brain Glucagon Action on Hepatic Glucose Production

1849-P: Importance of Insulin’s Direct and Indirect Effects on Postprandial Hepatic Glucose Uptake

Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2)

Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog

Basal Oral Insulin Analog I338 Enhances Meal-Related Hepatic Glucose Disposal

Pharmacodynamic Effect of Novel Oral Insulin Tregopil in Relation to Meal Composition in Type 2 Diabetes Mellitus Patients

Incretin Hormone Release Does Not Involve Hepatic Portal Vein Glucose Sensors

Dosing Time of Insulin Tregopil, a Novel Oral Insulin, in Type 2 Diabetes Mellitus Patients and Its Pharmacodynamic Effect

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