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Journal Articles

Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function

Diabetes 2022;71(7):1525–1545

https://doi.org/10.2337/db21-0803

Published: 27 April 2022

View articletitled, Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function

Journal Articles

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion

Diabetes 2022;71(7):1472–1489

https://doi.org/10.2337/db21-0800

Published: 26 April 2022

View articletitled, Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion

Meeting Abstracts

38-OR: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) from the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Impairs Glucose-, but Not Incretin-, Stimulated Insulin Secretion

ELENI GEORGIADOU, CHARANYA MURALIDHARAN, PAULINE L. CHABOSSEAU, ALEJANDRA TOMAS, THEODOROS STYLIANIDES, CRISTINA LEGIDO-QUIGLEY, NOUR ALSABEEH, CÉLINE CRUCIANI-GUGLIELMACCI, CHRISTOPHE MAGNAN, MARK IBBERSON, ISABELLE LECLERC, AMELIA K. LINNEMANN, YUSUF ALI, TRISTAN RODRIGUEZ, GUY A. RUTTER

Diabetes 2021;70(Supplement_1):38-OR

https://doi.org/10.2337/db21-38-OR

Published: 01 June 2021

View articletitled, 38-OR: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) from the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Impairs Glucose-, but Not Incretin-, Stimulated Insulin Secretion

Meeting Abstracts

87-LB: Binding Kinetics, Bias, Receptor Internalization, and Effects on Insulin Secretion for a Novel GLP1R-GIPR Dual Agonist, HISHS-2001

YUSMAN MANCHANDA, BEN JONES, GAELLE CARRAT, ZENOUSKA RAMCHUNDER, PIERO MARCHETTI, ISABELLE LECLERC, RAJAMANNAR THENNATI, VINOD S. BURADE, ALEJANDRA TOMAS, GUY A. RUTTER

Diabetes 2021;70(Supplement_1):87-LB

https://doi.org/10.2337/db21-87-LB

Published: 01 June 2021

View articletitled, 87-LB: Binding Kinetics, Bias, Receptor Internalization, and Effects on Insulin Secretion for a Novel GLP1R-GIPR Dual Agonist, HISHS-2001

Meeting Abstracts

228-LB: ß-arrestin-2 Deletion Influences GLP-1 Receptor Signaling in Pancreatic ß Cells In Vivo

STAVROULA BITSI, KINGA SUBA, NIMCO MOHAMED, ISABELLE LECLERC, GUY A. RUTTER, VICTORIA SALEM, BEN JONES, ALEJANDRA TOMAS

Diabetes 2021;70(Supplement_1):228-LB

https://doi.org/10.2337/db21-228-LB

Published: 01 June 2021

View articletitled, 228-LB: ß-arrestin-2 Deletion Influences GLP-1 Receptor Signaling in Pancreatic ß Cells In Vivo

Meeting Abstracts

1683-P: Upregulation of Pancreatic Islet EGF Receptor Improves Beta-Cell Identity and In Vivo Vascularisation in a Directly Observed Transplant Model

VICTORIA SALEM, USAMA ALI, KINGA SUBA, STAVROULA BITSI, TATIANA LOPES, ALDARA MARTIN ALONSO, YATEEN S. PATEL, ISABELLE LECLERC, BRYN OWEN, GUY A. RUTTER, STEPHEN M. ROTHERY, ALEJANDRA TOMAS

Diabetes 2020;69(Supplement_1):1683-P

https://doi.org/10.2337/db20-1683-P

Published: 01 June 2020

View articletitled, 1683-P: Upregulation of Pancreatic Islet EGF Receptor Improves Beta-Cell Identity and In Vivo Vascularisation in a Directly Observed Transplant Model

Meeting Abstracts

2072-P: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) in the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Function In Vitro and Strongly Impairs Glucose-Stimulated Insulin Secretion In Vivo

ELENI GEORGIADOU, PAULINE L. CHABOSSEAU, ALEJANDRA TOMAS, ISABELLE LECLERC, GUY A. RUTTER

Diabetes 2020;69(Supplement_1):2072-P

https://doi.org/10.2337/db20-2072-P

Published: 01 June 2020

View articletitled, 2072-P: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) in the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Function In Vitro and Strongly Impairs Glucose-Stimulated Insulin Secretion In Vivo

Meeting Abstracts

2100-P: Binding Kinetics, GLP-1 Receptor Internalization, and Effects on Insulin Secretion for GL0034 and Related GLP-1R Agonists

GAELLE CARRAT, MARIE-SOPHIE NGUYEN-TU, ISABELLE LECLERC, RAJAMANNAR THENNATI, BEN JONES, ALEJANDRA TOMAS, GUY A. RUTTER

Diabetes 2020;69(Supplement_1):2100-P

https://doi.org/10.2337/db20-2100-P

Published: 01 June 2020

View articletitled, 2100-P: Binding Kinetics, GLP-1 Receptor Internalization, and Effects on Insulin Secretion for GL0034 and Related GLP-1R Agonists

Meeting Abstracts

343-LB: The Type 2 Diabetes-Associated Lipid Binding Protein STARD10 Controls Insulin Secretory Granule Biogenesis

GAELLE CARRAT, ELIZABETH HAYTHORNE, LEENA HAATAJA, PETER ARVAN, ALEJANDRA TOMAS, ALEXANDRA PIUNTI, TIMOTHY J. PULLEN, ELENI GEORGIADOU, THEODOROS STYLIANIDES, VICTORIA SALEM, WALTER DISTASO, ANDREW CAKEBREAD, DAVID HODSON, ANNIE C. FUNG, RICHARD B. SESSIONS, FABIEN ALPY, ALICE P. KONG, ISABELLE LECLERC, GUY A. RUTTER

Diabetes 2019;68(Supplement_1):343-LB

https://doi.org/10.2337/db19-343-LB

Published: 01 June 2019

View articletitled, 343-LB: The Type 2 Diabetes-Associated Lipid Binding Protein STARD10 Controls Insulin Secretory Granule Biogenesis

Journal Articles

A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells

Teresa Buenaventura, Nisha Kanda, Phoebe C. Douzenis, Ben Jones, Stephen R. Bloom, Pauline Chabosseau, Ivan R. Corrêa, Jr., Domenico Bosco, Lorenzo Piemonti, Piero Marchetti, Paul R. Johnson, A.M. James Shapiro, Guy A. Rutter, Alejandra Tomas

Diabetes 2018;67(3):385–399

https://doi.org/10.2337/db17-0639

Published: 28 December 2017

View articletitled, A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells

Includes: Supplementary data

Journal Articles

Erratum. Small Interfering RNA—Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture. Diabetes 2008;57: 3045—3055

Lucy Marzban, Alejandra Tomas, Thomas C. Becker, Lawrence Rosenberg, Jose Oberholzer, Paul E. Fraser, Philippe A. Halban, C. Bruce Verchere

Diabetes 2016;65(3):818

https://doi.org/10.2337/db16-er03

Published: 13 February 2016

View articletitled, Erratum. Small Interfering RNA—Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture. Diabetes 2008;57: 3045—3055

Journal Articles

Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin

Dieter Rondas, Alejandra Tomas, Philippe A. Halban

Diabetes 2011;60(4):1146–1157

https://doi.org/10.2337/db10-0946

Published: 22 March 2011

View articletitled, Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin

Journal Articles

Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture

Lucy Marzban, Alejandra Tomas, Thomas C. Becker, Lawrence Rosenberg, Jose Oberholzer, Paul E. Fraser, Philippe A. Halban, C. Bruce Verchere

Diabetes 2008;57(11):3045–3055

https://doi.org/10.2337/db08-0485

Published: 01 November 2008

View articletitled, Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture

Journal Articles

Rab GTPase-Activating Protein AS160 Is a Major Downstream Effector of Protein Kinase B/Akt Signaling in Pancreatic β-Cells

Karim Bouzakri, Pascale Ribaux, Alejandra Tomas, Geraldine Parnaud, Katharina Rickenbach, Philippe A. Halban

Diabetes 2008;57(5):1195–1204

https://doi.org/10.2337/db07-1469

Published: 01 May 2008

View articletitled, Rab GTPase-Activating Protein AS160 Is a Major Downstream Effector of Protein Kinase B/Akt Signaling in Pancreatic β-Cells

Includes: Supplementary data

Journal Articles

Pro-Survival Role of Gelsolin in Mouse β-Cells

Barbara Yermen, Alejandra Tomas, Philippe A. Halban

Diabetes 2007;56(1):80–87

https://doi.org/10.2337/db06-0769

Published: 01 January 2007

View articletitled, Pro-Survival Role of Gelsolin in Mouse β-Cells

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Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion

38-OR: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) from the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Impairs Glucose-, but Not Incretin-, Stimulated Insulin Secretion

87-LB: Binding Kinetics, Bias, Receptor Internalization, and Effects on Insulin Secretion for a Novel GLP1R-GIPR Dual Agonist, HISHS-2001

228-LB: ß-arrestin-2 Deletion Influences GLP-1 Receptor Signaling in Pancreatic ß Cells In Vivo

1683-P: Upregulation of Pancreatic Islet EGF Receptor Improves Beta-Cell Identity and In Vivo Vascularisation in a Directly Observed Transplant Model

2072-P: Deletion of the Mitofusins 1 and 2 (Mfn1 and Mfn2) in the Pancreatic Beta Cell Disrupts Mitochondrial Structure and Function In Vitro and Strongly Impairs Glucose-Stimulated Insulin Secretion In Vivo

2100-P: Binding Kinetics, GLP-1 Receptor Internalization, and Effects on Insulin Secretion for GL0034 and Related GLP-1R Agonists

343-LB: The Type 2 Diabetes-Associated Lipid Binding Protein STARD10 Controls Insulin Secretory Granule Biogenesis

A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells

Erratum. Small Interfering RNA—Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture. Diabetes 2008;57: 3045—3055

Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin

Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture

Rab GTPase-Activating Protein AS160 Is a Major Downstream Effector of Protein Kinase B/Akt Signaling in Pancreatic β-Cells

Pro-Survival Role of Gelsolin in Mouse β-Cells

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