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Journal Articles

Cardiovascular Autonomic Neuropathy and Risk of Kidney Function Decline in Type 1 and Type 2 Diabetes: Findings From the PERL and ACCORD Cohorts

Yaling Tang, Lynn Ang, Mamta Jaiswal, Brendan R. Dillon, Nazanene H. Esfandiari, Hetal S. Shah, Cathie Spino, Cindy Plunkett, Bruce A. Perkins, Rodica Pop-Busui, Alessandro Doria

Diabetes 2024;73(5):751–762

https://doi.org/10.2337/db23-0247

Published: 19 July 2023

View article titled, Cardiovascular Autonomic Neuropathy and Risk of Kidney Function Decline in Type 1 and Type 2 Diabetes: Findings From the PERL and ACCORD Cohorts

Meeting Abstracts

1226-P: A Rapid Rate of Kidney Function Decline Is Associated with Increased Risk of Heart Failure in Patients with Type 2 Diabetes—Results from ACCORD Study

ARJOLA BANO, CARLOS BUENO, JUNIOR, YALING TANG, XIUQIN SUN, ELIZABETH HALL, JOANNA MITRI, MARIO LUCA MORIERI, HETAL SHAH, ALESSANDRO DORIA

Diabetes 2023;72(Supplement_1):1226-P

https://doi.org/10.2337/db23-1226-P

Published: 20 June 2023

View article titled, 1226-P: A Rapid Rate of Kidney Function Decline Is Associated with Increased Risk of Heart Failure in Patients with Type 2 Diabetes—Results from ACCORD Study

Meeting Abstracts

398-P: KIM-1 and TNFR 1 and Associations with Early Diabetic Nephropathy Histology

FRANCES TIAN, DAVID PRINCE, ALESSANDRO DORIA, MICHAEL MAUER, BRYAN KESTENBAUM

Diabetes 2022;71(Supplement_1):398-P

https://doi.org/10.2337/db22-398-P

Published: 01 June 2022

View article titled, 398-P: KIM-1 and TNFR 1 and Associations with Early Diabetic Nephropathy Histology

Meeting Abstracts

41-OR: ADA President's Select Abstract: The Beneficial Effect of Fenofibrate on Diabetic Retinopathy Is Influenced by PPARA Genetic Variability and Is Mediated by an Increase in FGF21 Levels

MARIO LUCA MORIERI, HETAL SHAH, YALING TANG, CHRISTINE MENDONCA, JENNY MARIE JOBE, JOSYF MYCHALECKYJ, ALESSANDRO DORIA

Diabetes 2022;71(Supplement_1):41-OR

https://doi.org/10.2337/db22-41-OR

Published: 01 June 2022

View article titled, 41-OR: ADA President's Select Abstract: The Beneficial Effect of Fenofibrate on Diabetic Retinopathy Is Influenced by PPARA Genetic Variability and Is Mediated by an Increase in FGF21 Levels

Meeting Abstracts

1276-P: Transancestral Genomic Analysis Links Dysregulation of Valine Metabolism to the Development of Heart Failure in Type 2 Diabetes

YALING TANG, MARIE PIGEYRE, XIUQIN SUN, MARIO LUCA MORIERI, HETAL SHAH, GUILLAUME PARE, HERTZEL C. GERSTEIN, KENT TAYLOR, VASAN S. RAMACHANDRAN, JEROME I. ROTTER, STEPHEN S. RICH, JAMES B. MEIGS, ALISA MANNING, JOSYF MYCHALECKYJ, ALESSANDRO DORIA, CONSORTIUM NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED)

Diabetes 2022;71(Supplement_1):1276-P

https://doi.org/10.2337/db22-1276-P

Published: 01 June 2022

View article titled, 1276-P: Transancestral Genomic Analysis Links Dysregulation of Valine Metabolism to the Development of Heart Failure in Type 2 Diabetes

Meeting Abstracts

405-P: Glycemic Control Impacts Renal Function Decline among People with Type 1 Diabetes after the Onset of Diabetic Kidney Disease

HETAL SHAH, JANET B. MCGILL, IRL B. HIRSCH, CHUN-YI WU, ANDRZEJ GALECKI, MICHAEL MAUER, ALESSANDRO DORIA, PERL CONSORTIUM

Diabetes 2022;71(Supplement_1):405-P

https://doi.org/10.2337/db22-405-P

Published: 01 June 2022

View article titled, 405-P: Glycemic Control Impacts Renal Function Decline among People with Type 1 Diabetes after the Onset of Diabetic Kidney Disease

Meeting Abstracts

143-OR: Mapping Genetic Determinants of Blood Glucose Control in the Action to Control Cardiovascular Risk in Diabetes Study Group (ACCORD)

JOHN S. HOUSE, DANIEL M. ROTROFF, VIVIAN FONSECA, JAMES M. HEMPE, JOSYF MYCHALECKYJ, ALESSANDRO DORIA, JOHN B. BUSE, ALISON MOTSINGER-REIF

Diabetes 2022;71(Supplement_1):143-OR

https://doi.org/10.2337/db22-143-OR

Published: 01 June 2022

View article titled, 143-OR: Mapping Genetic Determinants of Blood Glucose Control in the Action to Control Cardiovascular Risk in Diabetes Study Group (ACCORD)

Meeting Abstracts

204-OR: ADA Presidents’ Select Abstract: Cardiovascular Autonomic Neuropathy Is Associated with Rapid Kidney Function Decline in Type 2 Diabetes: Findings from the ACCORD Trial

YALING TANG, CARLOS BUENO JUNIOR, HETAL SHAH, LYNN ANG, RODICA POP-BUSUI, ALESSANDRO DORIA

Diabetes 2021;70(Supplement_1):204-OR

https://doi.org/10.2337/db21-204-OR

Published: 01 June 2021

View article titled, 204-OR: ADA Presidents’ Select Abstract: Cardiovascular Autonomic Neuropathy Is Associated with Rapid Kidney Function Decline in Type 2 Diabetes: Findings from the ACCORD Trial

Journal Articles

Association of the 1q25 Diabetes-Specific Coronary Heart Disease Locus With Alterations of the γ-Glutamyl Cycle and Increased Methylglyoxal Levels in Endothelial Cells

Caterina Pipino, Hetal Shah, Sabrina Prudente, Natalia Di Pietro, Lixia Zeng, Kyoungmin Park, Vincenzo Trischitta, Subramanian Pennathur, Assunta Pandolfi, Alessandro Doria

Diabetes 2020;69(10):2206–2216

https://doi.org/10.2337/db20-0475

Published: 10 July 2020

View article titled, Association of the 1q25 Diabetes-Specific Coronary Heart Disease Locus With Alterations of the γ-Glutamyl Cycle and Increased Methylglyoxal Levels in Endothelial Cells

Meeting Abstracts

130-OR: Effects of Intensive Risk Factor Management on Cardiovascular Autonomic Neuropathy in Type 2 Diabetes: Findings from the ACCORD Trial

YALING TANG, HETAL SHAH, CARLOS BUENO JUNIOR, XIUQIN SUN, JOANNA MITRI, MARIA SAMBATARO, LUISA SAMBADO, HERTZEL C. GERSTEIN, VIVIAN FONSECA, ALESSANDRO DORIA, RODICA POP-BUSUI

Diabetes 2020;69(Supplement_1):130-OR

https://doi.org/10.2337/db20-130-OR

Published: 01 June 2020

View article titled, 130-OR: Effects of Intensive Risk Factor Management on Cardiovascular Autonomic Neuropathy in Type 2 Diabetes: Findings from the ACCORD Trial

Meeting Abstracts

305-OR: Glycemic Variability and Progression of CKD: PERL Substudy

JANET B. MCGILL, IRL B. HIRSCH, PETER CALHOUN, ANDRZEJ GALECKI, KATRINA RUEDY, CHUN-YI WU, ALESSANDRO DORIA

Diabetes 2020;69(Supplement_1):305-OR

https://doi.org/10.2337/db20-305-OR

Published: 01 June 2020

View article titled, 305-OR: Glycemic Variability and Progression of CKD: PERL Substudy

Journal Articles

PPARA Polymorphism Influences the Cardiovascular Benefit of Fenofibrate in Type 2 Diabetes: Findings From ACCORD-Lipid

Diabetes 2020;69(4):771–783

https://doi.org/10.2337/db19-0973

Published: 23 January 2020

View article titled, <em>PPARA</em> Polymorphism Influences the Cardiovascular Benefit of Fenofibrate in Type 2 Diabetes: Findings From ACCORD-Lipid

Includes: Supplementary data

Meeting Abstracts

321-OR: A Genetic Locus on Chromosome 1p36 Associated with Cardiovascular Autonomic Neuropathy in Type 2 Diabetes

YALING TANG, HETAL SHAH, XIUQIN SUN, BRUCE A. PERKINS, MICHAEL J. WAGNER, ALISON MOTSINGER-REIF, JOHN B. BUSE, JOSYF MYCHALECKYJ, RODICA POP-BUSUI, ALESSANDRO DORIA

Diabetes 2019;68(Supplement_1):321-OR

https://doi.org/10.2337/db19-321-OR

Published: 01 June 2019

View article titled, 321-OR: A Genetic Locus on Chromosome 1p36 Associated with Cardiovascular Autonomic Neuropathy in Type 2 Diabetes

Meeting Abstracts

61-OR: ADA Presidents' Select Abstract: Characterization of Beta-Cell Function with Autoantibodies, Islet Pathology, and Genetics after 50 Years of Insulin Dependence

MARC GREGORY YU, MARCUS G. PEZZOLESI, HILLARY A. KEENAN, DAVID M. POBER, ZHIHENG HE, LIANE J. TINSLEY, ALESSANDRO DORIA, SUSAN BONNER-WEIR, GEORGE L. KING

Diabetes 2019;68(Supplement_1):61-OR

https://doi.org/10.2337/db19-61-OR

Published: 01 June 2019

View article titled, 61-OR: ADA Presidents' Select Abstract: Characterization of Beta-Cell Function with Autoantibodies, Islet Pathology, and Genetics after 50 Years of Insulin Dependence

Meeting Abstracts

20-LB: Endothelial Cell Metabolomics Identifies ?-glutamyl Cycle Alterations Associated with the 1q25 T2D-Specific Cardiovascular Locus

CATERINA PIPINO, HETAL SHAH, KYOUNGMIN PARK, STEFANO MONTI, CHRISTINE MENDONCA, GEORGE L. KING, ASSUNTA PANDOLFI, ALESSANDRO DORIA

Diabetes 2019;68(Supplement_1):20-LB

https://doi.org/10.2337/db19-20-LB

Published: 01 June 2019

View article titled, 20-LB: Endothelial Cell Metabolomics Identifies ?-glutamyl Cycle Alterations Associated with the 1q25 T2D-Specific Cardiovascular Locus

Journal Articles

A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes: Results From the ACCORD and BARI 2D Studies

Yaling Tang, Petra A. Lenzini, Rodica Pop-Busui, Pradipta R. Ray, Hannah Campbell, Bruce A. Perkins, Brian Callaghan, Michael J. Wagner, Alison A. Motsinger-Reif, John B. Buse, Theodore J. Price, Josyf C. Mychaleckyj, Sharon Cresci, Hetal Shah, Alessandro Doria

Diabetes 2019;68(8):1649–1662

https://doi.org/10.2337/db19-0109

Published: 24 May 2019

View article titled, A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes: Results From the ACCORD and BARI 2D Studies

Includes: Supplementary data

Journal Articles

Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes

Prapaporn Jungtrakoon, Jun Shirakawa, Patinut Buranasupkajorn, Manoj K. Gupta, Dario F. De Jesus, Marcus G. Pezzolesi, Aussara Panya, Timothy Hastings, Chutima Chanprasert, Christine Mendonca, Rohit N. Kulkarni, Alessandro Doria

Diabetes 2019;68(5):1084–1093

https://doi.org/10.2337/db17-0821

Published: 04 March 2019

View article titled, Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes

Includes: Supplementary data

Journal Articles

Leveraging Genetics to Improve Cardiovascular Health in Diabetes: The 2018 Edwin Bierman Award Lecture

Alessandro Doria

Diabetes 2019;68(3):479–489

https://doi.org/10.2337/dbi18-0036

Published: 13 February 2019

View article titled, Leveraging Genetics to Improve Cardiovascular Health in Diabetes: The 2018 Edwin Bierman Award Lecture

Meeting Abstracts

A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes

YALING TANG, JOSYF MYCHALECKYJ, BRUCE A. PERKINS, RODICA POP-BUSUI, MICHAEL J. WAGNER, ALISON MOTSINGER-REIF, JOHN B. BUSE, HETAL SHAH, ALESSANDRO DORIA

Diabetes 2018;67(Supplement_1):56-OR

https://doi.org/10.2337/db18-56-OR

Published: 01 July 2018

View article titled, A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes

Meeting Abstracts

Cardiovascular Autonomic Neuropathy and Uric Acid in Subjects with Type 1 Diabetes—Preventing Early Renal Loss (PERL) in Type 1 Diabetes Trial

MAMTA JAISWAL, ALESSANDRO DORIA, MICHAEL MAUER, RODICA POP-BUSUI

Diabetes 2018;67(Supplement_1):578-P

https://doi.org/10.2337/db18-578-P

Published: 01 July 2018

View article titled, Cardiovascular Autonomic Neuropathy and Uric Acid in Subjects with Type 1 Diabetes—Preventing Early Renal Loss (PERL) in Type 1 Diabetes Trial

NARROW

Cardiovascular Autonomic Neuropathy and Risk of Kidney Function Decline in Type 1 and Type 2 Diabetes: Findings From the PERL and ACCORD Cohorts

1226-P: A Rapid Rate of Kidney Function Decline Is Associated with Increased Risk of Heart Failure in Patients with Type 2 Diabetes—Results from ACCORD Study

398-P: KIM-1 and TNFR 1 and Associations with Early Diabetic Nephropathy Histology

41-OR: ADA President's Select Abstract: The Beneficial Effect of Fenofibrate on Diabetic Retinopathy Is Influenced by PPARA Genetic Variability and Is Mediated by an Increase in FGF21 Levels

1276-P: Transancestral Genomic Analysis Links Dysregulation of Valine Metabolism to the Development of Heart Failure in Type 2 Diabetes

405-P: Glycemic Control Impacts Renal Function Decline among People with Type 1 Diabetes after the Onset of Diabetic Kidney Disease

143-OR: Mapping Genetic Determinants of Blood Glucose Control in the Action to Control Cardiovascular Risk in Diabetes Study Group (ACCORD)

204-OR: ADA Presidents’ Select Abstract: Cardiovascular Autonomic Neuropathy Is Associated with Rapid Kidney Function Decline in Type 2 Diabetes: Findings from the ACCORD Trial

Association of the 1q25 Diabetes-Specific Coronary Heart Disease Locus With Alterations of the γ-Glutamyl Cycle and Increased Methylglyoxal Levels in Endothelial Cells

130-OR: Effects of Intensive Risk Factor Management on Cardiovascular Autonomic Neuropathy in Type 2 Diabetes: Findings from the ACCORD Trial

305-OR: Glycemic Variability and Progression of CKD: PERL Substudy

PPARA Polymorphism Influences the Cardiovascular Benefit of Fenofibrate in Type 2 Diabetes: Findings From ACCORD-Lipid

321-OR: A Genetic Locus on Chromosome 1p36 Associated with Cardiovascular Autonomic Neuropathy in Type 2 Diabetes

61-OR: ADA Presidents' Select Abstract: Characterization of Beta-Cell Function with Autoantibodies, Islet Pathology, and Genetics after 50 Years of Insulin Dependence

20-LB: Endothelial Cell Metabolomics Identifies ?-glutamyl Cycle Alterations Associated with the 1q25 T2D-Specific Cardiovascular Locus

A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes: Results From the ACCORD and BARI 2D Studies

Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes

Leveraging Genetics to Improve Cardiovascular Health in Diabetes: The 2018 Edwin Bierman Award Lecture

A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes

Cardiovascular Autonomic Neuropathy and Uric Acid in Subjects with Type 1 Diabetes—Preventing Early Renal Loss (PERL) in Type 1 Diabetes Trial

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