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Alexandra Chadt
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Journal Articles

Depletion of TBC1D4 Improves the Metabolic Exercise Response by Overcoming Genetically Induced Peripheral Insulin Resistance

Christian Springer, Christian Binsch, Deborah Weide, Laura Toska, Anna L. Cremer, Heiko Backes, Anna K. Scheel, Lena Espelage, Jörg Kotzka, Sebastian Sill, Anette Kurowski, Daebin Kim, Sandra Karpinski, Theresia M. Schnurr, Torben Hansen, Sonja Hartwig, Stefan Lehr, Sandra Cames, Jens C. Brüning, Matthias Lienhard, Ralf Herwig, Stefan Börno, Bernd Timmermann, Hadi Al-Hasani, Alexandra Chadt
Journal: Diabetes
Diabetes 2024;73(7):1058–1071
https://doi.org/10.2337/db23-0463
Published: 12 April 2024
View article titled, Depletion of TBC1D4 Improves the Metabolic Exercise Response by Overcoming Genetically Induced Peripheral Insulin Resistance
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Journal Articles

Response to Comment on Wendt et al. Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1. Diabetes 2021;70:2796–2809

Alexandra Chadt, Hadi Al-Hasani
Journal: Diabetes
Diabetes 2022;71(3):e5
https://doi.org/10.2337/dbi21-0038
Published: 23 February 2022
View article titled, Response to Comment on Wendt et al. Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1. Diabetes 2021;70:2796–2809
Open the PDF for Response to Comment on Wendt et al. Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1. Diabetes 2021;70:2796–2809 in another window
Journal Articles

Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome in Human Skeletal Muscle

Jeppe K. Larsen, Magnus R. Larsen, Jesper B. Birk, Dorte E. Steenberg, Janne R. Hingst, Kurt Højlund, Alexandra Chadt, Hadi Al-Hasani, Atul S. Deshmukh, Jørgen F.P. Wojtaszewski, Rasmus Kjøbsted
Journal: Diabetes
Diabetes 2022;71(5):906–920
https://doi.org/10.2337/db21-0855
Published: 22 February 2022
View article titled, Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome in Human Skeletal Muscle
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Journal Articles

Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1

Christian de Wendt, Lena Espelage, Samaneh Eickelschulte, Christian Springer, Laura Toska, Anna Scheel, Awovi Didi Bedou, Tim Benninghoff, Sandra Cames, Torben Stermann, Alexandra Chadt, Hadi Al-Hasani
Journal: Diabetes
Diabetes 2021;70(12):2796–2809
https://doi.org/10.2337/db21-0587
Published: 24 September 2021
View article titled, Contraction-Mediated Glucose Transport in Skeletal Muscle Is Regulated by a Framework of AMPK, TBC1D1/4, and Rac1
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Journal Articles

The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Fatty Acids Into Skeletal Muscle via Fatty Acid Transporter SLC27A4/FATP4

Tim Benninghoff, Lena Espelage, Samaneh Eickelschulte, Isabel Zeinert, Isabelle Sinowenka, Frank Müller, Christina Schöndeling, Hannah Batchelor, Sandra Cames, Zhou Zhou, Jörg Kotzka, Alexandra Chadt, Hadi Al-Hasani
Journal: Diabetes
Diabetes 2020;69(11):2281–2293
https://doi.org/10.2337/db20-0180
Published: 31 August 2020
View article titled, The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Fatty Acids Into Skeletal Muscle via Fatty Acid Transporter SLC27A4/FATP4
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Journal Articles

TBC1D4 Is Necessary for Enhancing Muscle Insulin Sensitivity in Response to AICAR and Contraction

Rasmus Kjøbsted, Alexandra Chadt, Nicolas O. Jørgensen, Kohei Kido, Jeppe K. Larsen, Christian de Wendt, Hadi Al-Hasani, Jørgen F.P. Wojtaszewski
Journal: Diabetes
Diabetes 2019;68(9):1756–1766
https://doi.org/10.2337/db18-0769
Published: 07 June 2019
View article titled, TBC1D4 Is Necessary for Enhancing Muscle Insulin Sensitivity in Response to AICAR and Contraction
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Includes: Supplementary data
Journal Articles

AMPK and TBC1D1 Regulate Muscle Glucose Uptake After, but Not During, Exercise and Contraction

Rasmus Kjøbsted, Julie L.W. Roll, Nicolas O. Jørgensen, Jesper B. Birk, Marc Foretz, Benoit Viollet, Alexandra Chadt, Hadi Al-Hasani, Jørgen F.P. Wojtaszewski
Journal: Diabetes
Diabetes 2019;68(7):1427–1440
https://doi.org/10.2337/db19-0050
Published: 22 April 2019
View article titled, AMPK and TBC1D1 Regulate Muscle Glucose Uptake After, but Not During, Exercise and Contraction
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Includes: Supplementary data
Journal Articles

Hypoxia in Combination With Muscle Contraction Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle via the HIF-1α Pathway

Sven W. Görgens, Tim Benninghoff, Kristin Eckardt, Christian Springer, Alexandra Chadt, Anita Melior, Jakob Wefers, Andrea Cramer, Jørgen Jensen, Kåre I. Birkeland, Christian A. Drevon, Hadi Al-Hasani, Jürgen Eckel
Journal: Diabetes
Diabetes 2017;66(11):2800–2807
https://doi.org/10.2337/db16-1488
Published: 15 August 2017
View article titled, Hypoxia in Combination With Muscle Contraction Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle via the HIF-1α Pathway
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Includes: Supplementary data
Journal Articles

Deletion of Both Rab-GTPase–Activating Proteins TBC14KO and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport. Diabetes 2015;64: 746–759

Alexandra Chadt, Anja Immisch, Christian de Wendt, Christian Springer, Zhou Zhou, Torben Stermann, Geoffrey D. Holman, Dominique Loffing-Cueni, Johannes Loffing, Hans-Georg Joost, Hadi Al-Hasani
Journal: Diabetes
Diabetes 2015;64(4):1492
https://doi.org/10.2337/db15-er04
Published: 17 March 2015
View article titled, Deletion of Both Rab-GTPase–Activating Proteins TBC14KO and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport. Diabetes 2015;64: 746–759
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Journal Articles

Deletion of Both Rab-GTPase–Activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport

Alexandra Chadt, Anja Immisch, Christian de Wendt, Christian Springer, Zhou Zhou, Torben Stermann, Geoffrey D. Holman, Dominique Loffing-Cueni, Johannes Loffing, Hans-Georg Joost, Hadi Al-Hasani
Journal: Diabetes
Diabetes 2015;64(3):746–759
https://doi.org/10.2337/db14-0368
Published: 22 September 2014
View article titled, Deletion of Both Rab-GTPase–Activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport
Open the PDF for Deletion of Both Rab-GTPase–Activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport in another window
Includes: Supplementary data