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Alexandra E. Butler
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Journal Articles

Erratum. DNA Methylation–Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-Cell Heterogeneity. Diabetes 2023;72:575–589

Nazia Parveen, Jean Kimi Wang, Supriyo Bhattacharya, Janielle Cuala, Mohan Singh Rajkumar, Alexandra E. Butler, Xiwei Wu, Hung-Ping Shih, Senta K. Georgia, Sangeeta Dhawan
Journal: Diabetes
Diabetes 2023;72(12):1882
https://doi.org/10.2337/db23-er12a
Published: 08 September 2023
View article titled, Erratum. DNA Methylation–Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-Cell Heterogeneity. Diabetes 2023;72:575–589
Open the PDF for Erratum. DNA Methylation–Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-Cell Heterogeneity. Diabetes 2023;72:575–589 in another window
Journal Articles

Erratum. β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide–Induced UCH-L1 Deficiency. Diabetes 2011;60:227–238

Safia Costes, Chang-jiang Huang, Tatyana Gurlo, Marie Daval, Aleksey V. Matveyenko, Robert A. Rizza, Alexandra E. Butler, Peter C. Butler
Journal: Diabetes
Diabetes 2023;72(12):1881
https://doi.org/10.2337/db23-er12
Published: 08 September 2023
View article titled, Erratum. β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide–Induced UCH-L1 Deficiency. Diabetes 2011;60:227–238
Open the PDF for Erratum. β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide–Induced UCH-L1 Deficiency. Diabetes 2011;60:227–238 in another window
Meeting Abstracts

393-P: Acute Hypoglycemia Alters Serum Immune Mediators Associated with Macrophage and T-Cell Activation in Type 2 Diabetes

ABU S. MOIN, THOZHUKAT SATHYAPALAN, STEPHEN ATKIN, ALEXANDRA E. BUTLER
Journal: Diabetes
Diabetes 2023;72(Supplement_1):393-P
https://doi.org/10.2337/db23-393-P
Published: 20 June 2023
View article titled, 393-P: Acute Hypoglycemia Alters Serum Immune Mediators Associated with Macrophage and T-Cell Activation in Type 2 Diabetes
Meeting Abstracts

495-P: Comparing Detection of Diabetic Retinopathy by Three Artificial Intelligence Platforms in Subjects Not Known to Have Diabetes

ALEXANDRA E. BUTLER, ERIC S. KILPATRICK, STEVEN C. HUNT, STEPHEN ATKIN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):495-P
https://doi.org/10.2337/db23-495-P
Published: 20 June 2023
View article titled, 495-P: Comparing Detection of Diabetic Retinopathy by Three Artificial Intelligence Platforms in Subjects Not Known to Have Diabetes
Journal Articles

DNA Methylation–Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-Cell Heterogeneity

Nazia Parveen, Jean Kimi Wang, Supriyo Bhattacharya, Janielle Cuala, Mohan Singh Rajkumar, Alexandra E. Butler, Xiwei Wu, Hung-Ping Shih, Senta K. Georgia, Sangeeta Dhawan
Journal: Diabetes
Diabetes 2023;72(5):575–589
https://doi.org/10.2337/db22-0506
Published: 06 January 2023
View article titled, DNA Methylation–Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-Cell Heterogeneity
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Meeting Abstracts

237-OR: Platelet-Derived Protein Responses Differ According to Severity of Hypoglycemia

ABU MOIN, HASSAN KAHAL, AHMED AL-QAISSI, THOZHUKAT SATHYAPALAN, STEPHEN ATKIN, ALEXANDRA E. BUTLER
Journal: Diabetes
Diabetes 2022;71(Supplement_1):237-OR
https://doi.org/10.2337/db22-237-OR
Published: 01 June 2022
View article titled, 237-OR: Platelet-Derived Protein Responses Differ According to Severity of Hypoglycemia
Meeting Abstracts

132-OR: Prolonged Mild Hypoglycemia Elicits Greater Heat Shock Protein Responses than Severe Transient Hypoglycemia

ANU MOIN, ALEXANDER S. ATKIN, HASSAN KAHAL, AHMED AL-QAISSI, THOZHUKAT SATHYAPALAN, STEPHEN ATKIN, ALEXANDRA E. BUTLER
Journal: Diabetes
Diabetes 2021;70(Supplement_1):132-OR
https://doi.org/10.2337/db21-132-OR
Published: 01 June 2021
View article titled, 132-OR: Prolonged Mild Hypoglycemia Elicits Greater Heat Shock Protein Responses than Severe Transient Hypoglycemia
Meeting Abstracts

2062-P: Pancreatic Inflammation Implicates Increased Cellular Plasticity in the Pancreatic Duct Glands in Type 1 Diabetes

SHWETA S. KULKARNI, ALEXANDRA E. BUTLER, MARK A. ATKINSON
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2062-P
https://doi.org/10.2337/db20-2062-P
Published: 01 June 2020
View article titled, 2062-P: Pancreatic Inflammation Implicates Increased Cellular Plasticity in the Pancreatic Duct Glands in Type 1 Diabetes
Meeting Abstracts

386-P: Acute Hypoglycemia Does Not Alter Serum Levels of Amyloid-Related Proteins Associated with Dementia

ABU MOIN, THOZHUKAT SATHYAPALAN, STEPHEN ATKIN, ALEXANDRA E. BUTLER
Journal: Diabetes
Diabetes 2020;69(Supplement_1):386-P
https://doi.org/10.2337/db20-386-P
Published: 01 June 2020
View article titled, 386-P: Acute Hypoglycemia Does Not Alter Serum Levels of Amyloid-Related Proteins Associated with Dementia
Meeting Abstracts

2223-PUB: Association of Vitamin D Metabolites with Type 2 Diabetes Complications in Qatar

STEPHEN ATKIN, ALEXANDRA E. BUTLER
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2223-PUB
https://doi.org/10.2337/db19-2223-PUB
Published: 01 June 2019
View article titled, 2223-PUB: Association of Vitamin D Metabolites with Type 2 Diabetes Complications in Qatar
Journal Articles

β-Cell Identity in Type 2 Diabetes: Lost or Found?

Alexandra E. Butler, Sangeeta Dhawan
Journal: Diabetes
Diabetes 2015;64(8):2698–2700
https://doi.org/10.2337/db15-0550
Published: 16 July 2015
View article titled, β-Cell Identity in Type 2 Diabetes: Lost or Found?
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Journal Articles

Reponse to Comments on: Butler et al. Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors. Diabetes 2013;62:2595–2604

Alexandra E. Butler, Martha Campbell-Thompson, Tatyana Gurlo, David W. Dawson, Mark Atkinson, Peter C. Butler
Journal: Diabetes
Diabetes 2013;62(10):e19–e22
https://doi.org/10.2337/db13-0996
Published: 17 September 2013
View article titled, Reponse to Comments on: Butler et al. Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors. Diabetes 2013;62:2595–2604
Open the PDF for Reponse to Comments on: Butler et al. Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors. Diabetes 2013;62:2595–2604 in another window
Journal Articles

Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors

Alexandra E. Butler, Martha Campbell-Thompson, Tatyana Gurlo, David W. Dawson, Mark Atkinson, Peter C. Butler
Journal: Diabetes
Diabetes 2013;62(7):2595–2604
https://doi.org/10.2337/db12-1686
Published: 14 June 2013
View article titled, Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors
Open the PDF for Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors in another window
Includes: Supplementary data
Journal Articles

Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes

Yoshifumi Saisho, Erica Manesso, Alexandra E. Butler, Ryan Galasso, Kylie Kavanagh, Mickey Flynn, Li Zhang, Paige Clark, Tatyana Gurlo, Gianna M. Toffolo, Claudio Cobelli, Janice D. Wagner, Peter C. Butler
Journal: Diabetes
Diabetes 2011;60(3):848–856
https://doi.org/10.2337/db09-1368
Published: 21 February 2011
View article titled, Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes
Open the PDF for Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced Diabetes in another window
Includes: Supplementary data
Journal Articles

β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide–Induced UCH-L1 Deficiency

Safia Costes, Chang-jiang Huang, Tatyana Gurlo, Marie Daval, Aleksey V. Matveyenko, Robert A. Rizza, Alexandra E. Butler, Peter C. Butler
Journal: Diabetes
Diabetes 2011;60(1):227–238
https://doi.org/10.2337/db10-0522
Published: 27 October 2010
View article titled, β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide–Induced UCH-L1 Deficiency
Open the PDF for β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide–Induced UCH-L1 Deficiency in another window
Includes: Supplementary data
Journal Articles

Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes: Interactions With Metformin

Aleksey V. Matveyenko, Sarah Dry, Heather I. Cox, Artemis Moshtaghian, Tatyana Gurlo, Ryan Galasso, Alexandra E. Butler, Peter C. Butler
Journal: Diabetes
Diabetes 2009;58(7):1604–1615
https://doi.org/10.2337/db09-0058
Published: 29 April 2009
View article titled, Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes: <subtitle>Interactions With Metformin</subtitle>
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Journal Articles

Successful Versus Failed Adaptation to High-Fat Diet–Induced Insulin Resistance: The Role of IAPP-Induced β-Cell Endoplasmic Reticulum Stress

Aleksey V. Matveyenko, Tatyana Gurlo, Marie Daval, Alexandra E. Butler, Peter C. Butler
Journal: Diabetes
Diabetes 2009;58(4):906–916
https://doi.org/10.2337/db08-1464
Published: 16 January 2009
View article titled, Successful Versus Failed Adaptation to High-Fat Diet–Induced Insulin Resistance: <subtitle>The Role of IAPP-Induced β-Cell Endoplasmic Reticulum Stress</subtitle>
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Journal Articles

β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans

Juris J. Meier, Alexandra E. Butler, Yoshifumi Saisho, Travis Monchamp, Ryan Galasso, Anil Bhushan, Robert A. Rizza, Peter C. Butler
Journal: Diabetes
Diabetes 2008;57(6):1584–1594
https://doi.org/10.2337/db07-1369
Published: 01 June 2008
View article titled, β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans
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Journal Articles

High Expression Rates of Human Islet Amyloid Polypeptide Induce Endoplasmic Reticulum Stress–Mediated β-Cell Apoptosis, a Characteristic of Humans With Type 2 but Not Type 1 Diabetes

Chang-jiang Huang, Chia-yu Lin, Leena Haataja, Tatyana Gurlo, Alexandra E. Butler, Robert A. Rizza, Peter C. Butler
Journal: Diabetes
Diabetes 2007;56(8):2016–2027
https://doi.org/10.2337/db07-0197
Published: 01 August 2007
View article titled, High Expression Rates of Human Islet Amyloid Polypeptide Induce Endoplasmic Reticulum Stress–Mediated β-Cell Apoptosis, a Characteristic of Humans With Type 2 but Not Type 1 Diabetes
Open the PDF for High Expression Rates of Human Islet Amyloid Polypeptide Induce Endoplasmic Reticulum Stress–Mediated β-Cell Apoptosis, a Characteristic of Humans With Type 2 but Not Type 1 Diabetes in another window
Journal Articles

Hematopoietic Stem Cells Derived From Adult Donors Are Not a Source of Pancreatic β-Cells in Adult Nondiabetic Humans

Alexandra E. Butler, Andrew Huang, P. Nagesh Rao, Anil Bhushan, William J. Hogan, Robert A. Rizza, Peter C. Butler
Journal: Diabetes
Diabetes 2007;56(7):1810–1816
https://doi.org/10.2337/db06-1385
Published: 01 July 2007
View article titled, Hematopoietic Stem Cells Derived From Adult Donors Are Not a Source of Pancreatic β-Cells in Adult Nondiabetic Humans
Open the PDF for Hematopoietic Stem Cells Derived From Adult Donors Are Not a Source of Pancreatic β-Cells in Adult Nondiabetic Humans in another window