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Meeting Abstracts

1507-P: Mixed-Meal Tolerance Test (MMTT) C-Peptide and BETA-2 Score Predict Underlying ß-Cell Secretory Capacity following Islet Transplantation for Type 1 Diabetes (T1D)

ANNELIESE FLATT, AUSTIN M. MATUS, ROBERT J. GALLOP, EILEEN M. MARKMANN, CORNELIA V. DALTON-BAKES, AMY PELECKIS, CHENGYANG LIU, ALI NAJI, MICHAEL R. RICKELS

Diabetes 2024;73(Supplement_1):1507-P

https://doi.org/10.2337/db24-1507-P

Published: 14 June 2024

View article titled, 1507-P: Mixed-Meal Tolerance Test (MMTT) C-Peptide and BETA-2 Score Predict Underlying ß-Cell Secretory Capacity following Islet Transplantation for Type 1 Diabetes (T1D)

Meeting Abstracts

1736-P: Exploring Intrinsic Features of Human Pancreatic a- and ß-Cell Physiology Using Pseudoislets

ANDREA V. ROZO, JEFFEREY ROMAN, WEI QIN, CHENGYANG LIU, ALI NAJI, KLAUS H. KAESTNER, TOSHINORI HOSHI, DORIS A. STOFFERS, NICOLAI M. DOLIBA

Diabetes 2024;73(Supplement_1):1736-P

https://doi.org/10.2337/db24-1736-P

Published: 14 June 2024

View article titled, 1736-P: Exploring Intrinsic Features of Human Pancreatic a- and ß-Cell Physiology Using Pseudoislets

Meeting Abstracts

836-P: Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell–Derived, Fully Differentiated Islet Cells—Updated Data from the VX-880 Clinical Trial

TREVOR W. REICHMAN, CAMILLO RICORDI, ALI NAJI, JAMES F. MARKMANN, BRUCE A. PERKINS, MARTIN WIJKSTROM, STEVEN PARASKEVAS, BOTE BRUINSMA, GAUTHAM MARIGOWDA, JUDY L. SHIH, CHENKUN WANG, DOUGLAS MELTON, FELICIA PAGLIUCA, BASTIANO SANNA, LESLIE S. KEAN, ANNE L. PETERS, PIOTR WITKOWSKI, MICHAEL R. RICKELS

Diabetes 2023;72(Supplement_1):836-P

https://doi.org/10.2337/db23-836-P

Published: 23 June 2023

View article titled, 836-P: Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell–Derived, Fully Differentiated Islet Cells—Updated Data from the VX-880 Clinical Trial

Meeting Abstracts

253-LB: Ethnic Differences in Pancreatic Hormone Secretion in Health and T2D

NICOLAI M. DOLIBA, JEFFREY ROMAN, ANDREA V. ROZO, WEI QIN, CHENGYANG LIU, ALI NAJI, MICHAEL R. RICKELS, MARK A. ATKINSON, ALVIN C. POWERS, MARCELA BRISSOVA, KLAUS H. KAESTNER, DORIS A. STOFFERS

Diabetes 2022;71(Supplement_1):253-LB

https://doi.org/10.2337/db22-253-LB

Published: 01 June 2022

View article titled, 253-LB: Ethnic Differences in Pancreatic Hormone Secretion in Health and T2D

Meeting Abstracts

259-OR: Stem Cell–Derived, Fully Differentiated Islet Cells for Type 1 Diabetes

JAMES F. MARKMANN, ALI NAJI, MICHAEL R. RICKELS, MARIA ALBA, GAUTHAM MARIGOWDA, LEORAH ROSS, CHENKUN WANG, FELICIA PAGLIUCA, BASTIANO SANNA, LESLIE S. KEAN, ANNE L. PETERS, PIOTR WITKOWSKI, CAMILLO RICORDI

Diabetes 2022;71(Supplement_1):259-OR

https://doi.org/10.2337/db22-259-OR

Published: 01 June 2022

View article titled, 259-OR: Stem Cell–Derived, Fully Differentiated Islet Cells for Type 1 Diabetes

Meeting Abstracts

359-OR: a- or ß-Adrenergic Blockade Does Not Affect Transplanted Islet Responses to Hypoglycemia in Type 1 Diabetes (T1D)

MICHAEL R. RICKELS, MELENA BELLIN, DARKO STEFANOVSKI, AMY J. PELECKIS, CORNELIA V. DALTON-BAKES, EILEEN MARKMANN, HUONG-LAN T. NGUYEN, ALI NAJI

Diabetes 2020;69(Supplement_1):359-OR

https://doi.org/10.2337/db20-359-OR

Published: 01 June 2020

View article titled, 359-OR: a- or ß-Adrenergic Blockade Does Not Affect Transplanted Islet Responses to Hypoglycemia in Type 1 Diabetes (T1D)

Meeting Abstracts

322-OR: Impairment of Alpha-Cell Bioenergetics Contributes to Increased Basal Yet Decreased Glucose Stimulated Oxygen Consumption Rates of Isolated Human Pancreatic Islets in T1DM and T2DM

NICOLAI M. DOLIBA, ANDREA V. ROZO, WEI QIN, JEFFREY ROMAN, CHENGYANG LIU, ALI NAJI, KLAUS H. KAESTNER, DORIS A. STOFFERS, FRANZ MATSCHINSKY

Diabetes 2020;69(Supplement_1):322-OR

https://doi.org/10.2337/db20-322-OR

Published: 01 June 2020

View article titled, 322-OR: Impairment of Alpha-Cell Bioenergetics Contributes to Increased Basal Yet Decreased Glucose Stimulated Oxygen Consumption Rates of Isolated Human Pancreatic Islets in T1DM and T2DM

Journal Articles

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)

Klaus H. Kaestner, Alvin C. Powers, Ali Naji, HPAP Consortium, Mark A. Atkinson

Diabetes 2019;68(7):1394–1402

https://doi.org/10.2337/db19-0058

Published: 24 May 2019

View article titled, NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)

Journal Articles

Erratum. National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65: 3418–3428

Diabetes 2017;66(9):2531

https://doi.org/10.2337/db17-er09a

Published: 29 June 2017

View article titled, Erratum. National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65: 3418–3428

Journal Articles

Functional and Metabolomic Consequences of K_ATP Channel Inactivation in Human Islets

Changhong Li, Amanda M. Ackermann, Kara E. Boodhansingh, Tricia R. Bhatti, Chengyang Liu, Jonathan Schug, Nicolai Doliba, Bing Han, Karen E. Cosgrove, Indraneel Banerjee, Franz M. Matschinsky, Itzhak Nissim, Klaus H. Kaestner, Ali Naji, N. Scott Adzick, Mark J. Dunne, Charles A. Stanley, Diva D. De León

Diabetes 2017;66(7):1901–1913

https://doi.org/10.2337/db17-0029

Published: 25 April 2017

View article titled, Functional and Metabolomic Consequences of K<sub>ATP</sub> Channel Inactivation in Human Islets

Includes: Supplementary data

Journal Articles

National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities

Diabetes 2016;65(11):3418–3428

https://doi.org/10.2337/db16-0234

Published: 27 July 2016

View article titled, National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities

Includes: Supplementary data

Journal Articles

Single-Cell Transcriptomics of the Human Endocrine Pancreas

Yue J. Wang, Jonathan Schug, Kyoung-Jae Won, Chengyang Liu, Ali Naji, Dana Avrahami, Maria L. Golson, Klaus H. Kaestner

Diabetes 2016;65(10):3028–3038

https://doi.org/10.2337/db16-0405

Published: 30 June 2016

View article titled, Single-Cell Transcriptomics of the Human Endocrine Pancreas

Includes: Supplementary data

Journal Articles

Restoration of Glucose Counterregulation by Islet Transplantation in Long-standing Type 1 Diabetes

Michael R. Rickels, Carissa Fuller, Cornelia Dalton-Bakes, Eileen Markmann, Maral Palanjian, Kevin Cullison, Janice Tiao, Shiv Kapoor, Chengyang Liu, Ali Naji, Karen L. Teff

Diabetes 2015;64(5):1713–1718

https://doi.org/10.2337/db14-1620

Published: 18 December 2014

View article titled, Restoration of Glucose Counterregulation by Islet Transplantation in Long-standing Type 1 Diabetes

Includes: Supplementary data

Journal Articles

Grg3/TLE3 and Grg1/TLE1 Induce Monohormonal Pancreatic β-Cells While Repressing α-Cell Functions

David E. Metzger, Chengyang Liu, Amin Sam Ziaie, Ali Naji, Kenneth S. Zaret

Diabetes 2014;63(5):1804–1816

https://doi.org/10.2337/db13-0867

Published: 12 April 2014

View article titled, Grg3/TLE3 and Grg1/TLE1 Induce Monohormonal Pancreatic β-Cells While Repressing α-Cell Functions

Includes: Supplementary data

Journal Articles

Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting

Yang Jiao, John Le Lay, Ming Yu, Ali Naji, Klaus H. Kaestner

Diabetes 2014;63(4):1283–1288

https://doi.org/10.2337/db13-1435

Published: 13 March 2014

View article titled, Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting

Journal Articles

Improvement in β-Cell Secretory Capacity After Human Islet Transplantation According to the CIT07 Protocol

Michael R. Rickels, Chengyang Liu, Richard D. Shlansky-Goldberg, Scott A. Soleimanpour, Kumar Vivek, Malek Kamoun, Zaw Min, Eileen Markmann, Maral Palangian, Cornelia Dalton-Bakes, Carissa Fuller, Allen J. Chiou, Clyde F. Barker, Eline T. Luning Prak, Ali Naji

Diabetes 2013;62(8):2890–2897

https://doi.org/10.2337/db12-1802

Published: 17 July 2013

View article titled, Improvement in β-Cell Secretory Capacity After Human Islet Transplantation According to the CIT07 Protocol

Journal Articles

MicroRNA-7 Regulates the mTOR Pathway and Proliferation in Adult Pancreatic β-Cells

You Wang, Jiangying Liu, Chengyang Liu, Ali Naji, Doris A. Stoffers

Diabetes 2013;62(3):887–895

https://doi.org/10.2337/db12-0451

Published: 14 February 2013

View article titled, MicroRNA-7 Regulates the mTOR Pathway and Proliferation in Adult Pancreatic β-Cells

Includes: Supplementary data

Journal Articles

Leucine Regulation of Glucokinase and ATP Synthase Sensitizes Glucose-Induced Insulin Secretion in Pancreatic β-Cells

Jichun Yang, Ryan K. Wong, MieJung Park, Jianmei Wu, Joshua R. Cook, David A. York, Shaoping Deng, James Markmann, Ali Naji, Bryan A. Wolf, Zhiyong Gao

Diabetes 2006;55(1):193–201

https://doi.org/10.2337/diabetes.55.01.06.db05-0938

Published: 01 January 2006

View article titled, Leucine Regulation of Glucokinase and ATP Synthase Sensitizes Glucose-Induced Insulin Secretion in Pancreatic β-Cells

Journal Articles

Islet Cell Hormonal Responses to Hypoglycemia After Human Islet Transplantation for Type 1 Diabetes

Michael R. Rickels, Mark H. Schutta, Rebecca Mueller, James F. Markmann, Clyde F. Barker, Ali Naji, Karen L. Teff

Diabetes 2005;54(11):3205–3211

https://doi.org/10.2337/diabetes.54.11.3205

Published: 01 November 2005

View article titled, Islet Cell Hormonal Responses to Hypoglycemia After Human Islet Transplantation for Type 1 Diabetes

Journal Articles

NOD B-cells Are Insufficient to Incite T-Cell-Mediated Anti-islet Autoimmunity

Daniel J. Moore, Hooman Noorchashm, Tina H. Lin, Siri A. Greeley, Ali Naji

Diabetes 2005;54(7):2019–2025

https://doi.org/10.2337/diabetes.54.7.2019

Published: 01 July 2005

View article titled, NOD B-cells Are Insufficient to Incite T-Cell-Mediated Anti-islet Autoimmunity

NARROW

1507-P: Mixed-Meal Tolerance Test (MMTT) C-Peptide and BETA-2 Score Predict Underlying ß-Cell Secretory Capacity following Islet Transplantation for Type 1 Diabetes (T1D)

1736-P: Exploring Intrinsic Features of Human Pancreatic a- and ß-Cell Physiology Using Pseudoislets

836-P: Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell–Derived, Fully Differentiated Islet Cells—Updated Data from the VX-880 Clinical Trial

253-LB: Ethnic Differences in Pancreatic Hormone Secretion in Health and T2D

259-OR: Stem Cell–Derived, Fully Differentiated Islet Cells for Type 1 Diabetes

359-OR: a- or ß-Adrenergic Blockade Does Not Affect Transplanted Islet Responses to Hypoglycemia in Type 1 Diabetes (T1D)

322-OR: Impairment of Alpha-Cell Bioenergetics Contributes to Increased Basal Yet Decreased Glucose Stimulated Oxygen Consumption Rates of Isolated Human Pancreatic Islets in T1DM and T2DM

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)

Erratum. National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65: 3418–3428

Functional and Metabolomic Consequences of K_ATP Channel Inactivation in Human Islets

National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities

Single-Cell Transcriptomics of the Human Endocrine Pancreas

Restoration of Glucose Counterregulation by Islet Transplantation in Long-standing Type 1 Diabetes

Grg3/TLE3 and Grg1/TLE1 Induce Monohormonal Pancreatic β-Cells While Repressing α-Cell Functions

Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting

Improvement in β-Cell Secretory Capacity After Human Islet Transplantation According to the CIT07 Protocol

MicroRNA-7 Regulates the mTOR Pathway and Proliferation in Adult Pancreatic β-Cells

Leucine Regulation of Glucokinase and ATP Synthase Sensitizes Glucose-Induced Insulin Secretion in Pancreatic β-Cells

Islet Cell Hormonal Responses to Hypoglycemia After Human Islet Transplantation for Type 1 Diabetes

NOD B-cells Are Insufficient to Incite T-Cell-Mediated Anti-islet Autoimmunity

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