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Alisa Manning
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Meeting Abstracts

215-OR: Polygenic Scores for Metabolic Diseases Are Associated with Gene Expression Networks across Tissues

Free
CHRISTOPHER BRYAN, KIRK SMITH, ALISA MANNING, JOSEP M. MERCADER, MIRIAM UDLER
Journal: Diabetes
Diabetes 2024;73(Supplement_1):215-OR
https://doi.org/10.2337/db24-215-OR
Published: 14 June 2024
View articletitled, 215-OR: Polygenic Scores for Metabolic Diseases Are Associated with Gene Expression Networks across Tissues
Meeting Abstracts

277-OR: Whole-Genome Sequencing Identifies a Rare Noncoding Variant Proximal to METRN Associated with HbA1c Levels

Free
GARETH HAWKES, KASHYAP A. PATEL, INÊS BARROSO, TIMOTHY M. FRAYLING, ALISA MANNING, MICHAEL N. WEEDON
Journal: Diabetes
Diabetes 2024;73(Supplement_1):277-OR
https://doi.org/10.2337/db24-277-OR
Published: 14 June 2024
View articletitled, 277-OR: Whole-Genome Sequencing Identifies a Rare Noncoding Variant Proximal to METRN Associated with HbA1c Levels
Meeting Abstracts

276-OR: Common Variant Polygenic Risk Score Influences Penetrance of Rare Variants in Monogenic Diabetes Genes

Free
ALICIA HUERTA, RAVI MANDLA, DORKA NAGY, LUKASZ SZCZERBINSKI, JESPER G.S. MADSEN, JOANNE B. COLE, BIANCA PORNEALA, KENNETH E. WESTERMAN, JOSEPHINE H. LI, TONI I. POLLIN, JOSE C. FLOREZ, ANNA L. GLOYN, INES CEBOLA, ALISA MANNING, AARON LEONG, MIRIAM UDLER, JOSEP M. MERCADER
Journal: Diabetes
Diabetes 2024;73(Supplement_1):276-OR
https://doi.org/10.2337/db24-276-OR
Published: 14 June 2024
View articletitled, 276-OR: Common Variant Polygenic Risk Score Influences Penetrance of Rare Variants in Monogenic Diabetes Genes
Meeting Abstracts

1480-P: TOPMed Metabolomics Association Analysis of Cardiovascular Disease in Participants with Type 2 Diabetes

Free
YIXIN ZHANG, DANIEL A. DICORPO, MARK O. GOODARZI, XIUQING GUO, JEFFREY HAESSLER, PAUL A. HANSON, CHARLES L. KOOPERBERG, NGOC QUYNH H. NGUYEN, ALEX REINER, CHLOE SARNOWSKI, MAGDALENA SEVILLA-GONZALEZ, KENT TAYLOR, BING YU, JOSÉE DUPUIS, ALISA MANNING, JAMES B. MEIGS, CHING-TI LIU
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1480-P
https://doi.org/10.2337/db24-1480-P
Published: 14 June 2024
View articletitled, 1480-P: TOPMed Metabolomics Association Analysis of Cardiovascular Disease in Participants with Type 2 Diabetes
Meeting Abstracts

1479-P: The Association between Race and Ethnicity and Type 2 Diabetes Is Partially Mediated by Circulating Proteins—A Meta-analysis of 2,339 Individuals from Two Multiethnic Cohorts of the TOPMed Program

Free
MAGDALENA SEVILLA-GONZALEZ, KENNETH E. WESTERMAN, NINGYUAN WANG, SARA JANE CROMER, ZSU-ZSU CHEN, JEROME I. ROTTER, CHARLES L. KOOPERBERG, JAMES B. MEIGS, ALISA MANNING
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1479-P
https://doi.org/10.2337/db24-1479-P
Published: 14 June 2024
View articletitled, 1479-P: The Association between Race and Ethnicity and Type 2 Diabetes Is Partially Mediated by Circulating Proteins—A Meta-analysis of 2,339 Individuals from Two Multiethnic Cohorts of the TOPMed Program
Meeting Abstracts

2006-LB: Polygenic Scores for Metabolic Diseases Are Associated with Gene Expression Networks across Tissues

Free
CHRISTOPHER BRYAN, KIRK SMITH, HESAM DASHTI, MELINA CLAUSSNITZER, ALISA MANNING, JOSEP M. MERCADER, MIRIAM UDLER, YI HUANG
Journal: Diabetes
Diabetes 2024;73(Supplement_1):2006-LB
https://doi.org/10.2337/db24-2006-LB
Published: 14 June 2024
View articletitled, 2006-LB: Polygenic Scores for Metabolic Diseases Are Associated with Gene Expression Networks across Tissues
Meeting Abstracts

74-OR: Improving Performance of Type 2 Diabetes Polygenic Scores in African and Hispanic Ancestries

Free
ALICIA HUERTA, JOOHYUN KIM, RAVI MANDLA, YINGCHANG LU, LAUREN E. PETTY, KEN SUZUKI, SIMON S. LEE, HONG KIAT NG, MARIE LOH, MARIJANA VUJKOVIC, BENJAMIN F. VOIGHT, XUELING SIM, RUTH J. LOOS, JENNIFER E. BELOW, TIAN GE, VA MILLION VETERAN PROGRAM, JOSE C. FLOREZ, ALISA MANNING, MAGGIE NG, JOSEP M. MERCADER, DIABETES POLYGENIC RISK SCORES IN MULTIPLE ANCESTRIES (D-PRISM)
Journal: Diabetes
Diabetes 2023;72(Supplement_1):74-OR
https://doi.org/10.2337/db23-74-OR
Published: 20 June 2023
View articletitled, 74-OR: Improving Performance of Type 2 Diabetes Polygenic Scores in African and Hispanic Ancestries
Meeting Abstracts

73-OR: Multiancestry Genetic Clustering of Type 2 Diabetes Loci Highlights the Contribution of Non-European Variants to Disease Heterogeneity

Free
KIRK SMITH, HYUNKYUNG KIM, KENNETH E. WESTERMAN, SARAH HSU, RAVI MANDLA, PHILIP H. SCHROEDER, TIM MAJARIAN, VARINDERPAL KAUR, JOSE C. FLOREZ, ALISA MANNING, JOSEP M. MERCADER, MIRIAM UDLER
Journal: Diabetes
Diabetes 2023;72(Supplement_1):73-OR
https://doi.org/10.2337/db23-73-OR
Published: 20 June 2023
View articletitled, 73-OR: Multiancestry Genetic Clustering of Type 2 Diabetes Loci Highlights the Contribution of Non-European Variants to Disease Heterogeneity
Meeting Abstracts

1091-P: Genetic Ancestry Influences Metformin Treatment Response in Youth with Type 2 Diabetes

Free
SHYLAJA SRINIVASAN, LING CHEN, MEGAN M. KELSEY, JENNIFER TODD, SILVA A. ARSLANIAN, NANCY T. CHANG, LORI M. LAFFEL, LYNNE L. LEVITSKY, JENNIFER E. SPRAGUE, TONI I. POLLIN, ALISA MANNING, JOSE C. FLOREZ
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1091-P
https://doi.org/10.2337/db23-1091-P
Published: 20 June 2023
View articletitled, 1091-P: Genetic Ancestry Influences Metformin Treatment Response in Youth with Type 2 Diabetes
Meeting Abstracts

1471-P: Metabolomic Profiling of Type 2 Diabetes Pathway-Partitioned Polygenic Risk Scores Offers Insights into Disease Etiology

Free
MAGDALENA SEVILLA, ITZIAR LAMIQUIZ-MONEO, KIRK SMITH, MARINA CANYELLES, JOSE C. FLOREZ, ALISA MANNING, FERNANDO CIVEIRA, JORDI MERINO, MIRIAM UDLER
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1471-P
https://doi.org/10.2337/db23-1471-P
Published: 20 June 2023
View articletitled, 1471-P: Metabolomic Profiling of Type 2 Diabetes Pathway-Partitioned Polygenic Risk Scores Offers Insights into Disease Etiology
Meeting Abstracts

1469-P: Gene-Level Gene–Mediterranean Diet Interaction Detection Influencing Inflammatory and Glycemic Biomarkers in 137,000 UK Biobank Participants

Free
KENNETH E. WESTERMAN, JAMES B. MEIGS, ALISA MANNING
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1469-P
https://doi.org/10.2337/db23-1469-P
Published: 20 June 2023
View articletitled, 1469-P: Gene-Level Gene–Mediterranean Diet Interaction Detection Influencing Inflammatory and Glycemic Biomarkers in 137,000 UK Biobank Participants
Meeting Abstracts

1468-P: Integrating Whole-Genome Sequence Analysis and eQTL Data from the TOPMed Program Improves Understanding of Type 2 Diabetes Risk Loci in Diverse Populations

Free
NINGYUAN WANG, DANIEL A. DICORPO, YIXIN ZHANG, JENNIFER WESSEL, ALISA MANNING
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1468-P
https://doi.org/10.2337/db23-1468-P
Published: 20 June 2023
View articletitled, 1468-P: Integrating Whole-Genome Sequence Analysis and eQTL Data from the TOPMed Program Improves Understanding of Type 2 Diabetes Risk Loci in Diverse Populations
Journal Articles

Nontargeted and Targeted Metabolomic Profiling Reveals Novel Metabolite Biomarkers of Incident Diabetes in African Americans

Free
Zsu-Zsu Chen, Julian Avila Pacheco, Yan Gao, Shuliang Deng, Bennet Peterson, Xu Shi, Shuning Zheng, Usman A. Tahir, Daniel H. Katz, Daniel E. Cruz, Debby Ngo, Mark D. Benson, Jeremy M. Robbins, Xiuqing Guo, Magdalena del Rocio Sevilla Gonzalez, Alisa Manning, Adolfo Correa, James B. Meigs, Kent D. Taylor, Stephen S. Rich, Mark O. Goodarzi, Jerome I. Rotter, James G. Wilson, Clary B. Clish, Robert E. Gerszten
Journal: Diabetes
Diabetes 2022;71(11):2426–2437
https://doi.org/10.2337/db22-0033
Published: 23 August 2022
View articletitled, Nontargeted and Targeted Metabolomic Profiling Reveals Novel Metabolite Biomarkers of Incident Diabetes in African Americans
Open the PDF for Nontargeted and Targeted Metabolomic Profiling Reveals Novel Metabolite Biomarkers of Incident Diabetes in African Americans in another window
Meeting Abstracts

137-OR: A Genetic Approach to Detangling the Heterogeneity of Fasting Insulin Levels

Free
MAGDALENA SEVILLA, MARK O. GOODARZI, DANIEL A. DICORPO, JEROME I. ROTTER, JAMES B. MEIGS, MIRIAM UDLER, ALISA MANNING
Journal: Diabetes
Diabetes 2022;71(Supplement_1):137-OR
https://doi.org/10.2337/db22-137-OR
Published: 01 June 2022
View articletitled, 137-OR: A Genetic Approach to Detangling the Heterogeneity of Fasting Insulin Levels
Meeting Abstracts

1276-P: Transancestral Genomic Analysis Links Dysregulation of Valine Metabolism to the Development of Heart Failure in Type 2 Diabetes

Free
YALING TANG, MARIE PIGEYRE, XIUQIN SUN, MARIO LUCA MORIERI, HETAL SHAH, GUILLAUME PARE, HERTZEL C. GERSTEIN, KENT TAYLOR, VASAN S. RAMACHANDRAN, JEROME I. ROTTER, STEPHEN S. RICH, JAMES B. MEIGS, ALISA MANNING, JOSYF MYCHALECKYJ, ALESSANDRO DORIA, CONSORTIUM NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED)
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1276-P
https://doi.org/10.2337/db22-1276-P
Published: 01 June 2022
View articletitled, 1276-P: Transancestral Genomic Analysis Links Dysregulation of Valine Metabolism to the Development of Heart Failure in Type 2 Diabetes
Journal Articles

Erratum. The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium. Diabetes 2021;70:996–1005

Free
Shylaja Srinivasan, Ling Chen, Jennifer Todd, Jasmin Divers, Samuel Gidding, Steven Chernausek, Rose A. Gubitosi-Klug, Megan M. Kelsey, Rachana Shah, Mary Helen Black, Lynne E. Wagenknecht, Alisa Manning, Jason Flannick, Giuseppina Imperatore, Josep M. Mercader, Dana Dabelea, Jose C. Florez
Journal: Diabetes
Diabetes 2022;71(1):170
https://doi.org/10.2337/db22-er01a
Published: 29 October 2021
View articletitled, Erratum. The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium. Diabetes 2021;70:996–1005
Open the PDF for Erratum. The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium. Diabetes 2021;70:996–1005 in another window
Meeting Abstracts

325-OR: Genetic and Socioeconomic Factors Are Independently Associated with Type 2 Diabetes

Free
SARA JANE CROMER, CHIRAG M. LAKHANI, JOSEP M. MERCADER, TIM MAJARIAN, JOSE C. FLOREZ, ALISA MANNING, JORDI MERINO, MIRIAM UDLER
Journal: Diabetes
Diabetes 2021;70(Supplement_1):325-OR
https://doi.org/10.2337/db21-325-OR
Published: 01 June 2021
View articletitled, 325-OR: Genetic and Socioeconomic Factors Are Independently Associated with Type 2 Diabetes
Meeting Abstracts

73-OR: Clonal Hematopoiesis of Indeterminate Potential (CHIP), Glycemic Traits, and Type 2 Diabetes (T2D) Risk

Free
DEIRDRE K. TOBIAS, ALISA MANNING, JENNIFER WESSEL, KENNETH E. WESTERMAN, SRIDHARAN RAGHAVAN, LAURA RAFFIELD, JOSEE DUPUIS, ALEXANDER BICK, PEITAO WU, DANIEL A. DICORPO, BRUCE M. PSATY, ALANNA C. MORRISON, VASAN S. RAMACHANDRAN, L. ADRIENNE CUPPLES, LESLIE LANGE, ADOLFO CORREA, CHARLES L. KOOPERBERG, LESLEY F. TINKER, BARBARA V. HOWARD, ALEX REINER, JEROME I. ROTTER, JASON M. COLLINS, JAMES B. MEIGS, JOANN E. MANSON
Journal: Diabetes
Diabetes 2021;70(Supplement_1):73-OR
https://doi.org/10.2337/db21-73-OR
Published: 01 June 2021
View articletitled, 73-OR: Clonal Hematopoiesis of Indeterminate Potential (CHIP), Glycemic Traits, and Type 2 Diabetes (T2D) Risk
Journal Articles

The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium

Free
Shylaja Srinivasan, Ling Chen, Jennifer Todd, Jasmin Divers, Samuel Gidding, Steven Chernausek, Rose A. Gubitosi-Klug, Megan M. Kelsey, Rachana Shah, Mary Helen Black, Lynne E. Wagenknecht, Alisa Manning, Jason Flannick, Giuseppina Imperatore, Josep M. Mercader, Dana Dabelea, Jose C. Florez
Journal: Diabetes
Diabetes 2021;70(4):996–1005
https://doi.org/10.2337/db20-0443
Published: 21 January 2021
View articletitled, The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium
Open the PDF for The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium in another window
Meeting Abstracts

242-OR: Rare Genetic Variants in the Islet Regulome Contribute to the Heritability of Type 2 Diabetes Risk

Free
ALISA MANNING, TOPMED DIABETES WORKING GROUP
Journal: Diabetes
Diabetes 2020;69(Supplement_1):242-OR
https://doi.org/10.2337/db20-242-OR
Published: 01 June 2020
View articletitled, 242-OR: Rare Genetic Variants in the Islet Regulome Contribute to the Heritability of Type 2 Diabetes Risk