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Journal Articles

Differential DNA Methylation and Expression of miRNAs in Adipose Tissue From Twin Pairs Discordant for Type 2 Diabetes

Emma Nilsson, Magdalena Vavakova, Alexander Perfilyev, Johanna Säll, Per-Anders Jansson, Pernille Poulsen, Jonathan Lou S. Esguerra, Lena Eliasson, Allan Vaag, Olga Göransson, Charlotte Ling
Journal: Diabetes
Diabetes 2021;70(10):2402–2418
https://doi.org/10.2337/db20-0324
Published: 27 July 2021
View article titled, Differential DNA Methylation and Expression of miRNAs in Adipose Tissue From Twin Pairs Discordant for Type 2 Diabetes
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Journal Articles

Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation, Which Associates With Body Composition in the Offspring

Josefine Jönsson, Kristina M. Renault, Sonia García-Calzón, Alexander Perfilyev, Angela C. Estampador, Kirsten Nørgaard, Mads Vendelbo Lind, Allan Vaag, Line Hjort, Kim F. Michaelsen, Emma Malchau Carlsen, Paul W. Franks, Charlotte Ling
Journal: Diabetes
Diabetes 2021;70(4):854–866
https://doi.org/10.2337/db20-0487
Published: 11 January 2021
View article titled, Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation, Which Associates With Body Composition in the Offspring
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Journal Articles

Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study

Alexia Cardona, Felix R. Day, John R.B. Perry, Marie Loh, Audrey Y. Chu, Benjamin Lehne, Dirk S. Paul, Luca A. Lotta, Isobel D. Stewart, Nicola D. Kerrison, Robert A. Scott, Kay-Tee Khaw, Nita G. Forouhi, Claudia Langenberg, Chunyu Liu, Michael M. Mendelson, Daniel Levy, Stephan Beck, R. David Leslie, Josée Dupuis, James B. Meigs, Jaspal S. Kooner, Jussi Pihlajamäki, Allan Vaag, Alexander Perfilyev, Charlotte Ling, Marie-France Hivert, John C. Chambers, Nicholas J. Wareham, Ken K. Ong
Journal: Diabetes
Diabetes 2019;68(12):2315–2326
https://doi.org/10.2337/db18-0290
Published: 10 September 2019
View article titled, Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study
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Includes: Supplementary data
Journal Articles

ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations

Anne-Sofie Graae, Niels Grarup, Rasmus Ribel-Madsen, Sara H. Lystbæk, Trine Boesgaard, Harald Staiger, Andreas Fritsche, Niels Wellner, Karolina Sulek, Mads Kjolby, Marie Balslev Backe, Sabina Chubanava, Clara Prats, Annette K. Serup, Jesper B. Birk, Johanne Dubail, Linn Gillberg, Sara G. Vienberg, Anders Nykjær, Bente Kiens, Jørgen F.P. Wojtaszewski, Steen Larsen, Suneel S. Apte, Hans-Ulrich Häring, Allan Vaag, Björn Zethelius, Oluf Pedersen, Jonas T. Treebak, Torben Hansen, Birgitte Holst
Journal: Diabetes
Diabetes 2019;68(3):502–514
https://doi.org/10.2337/db18-0418
Published: 09 January 2019
View article titled, ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations
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Includes: Supplementary data
Journal Articles

Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB

Lisa M. Berglund, Valeriya Lyssenko, Claes Ladenvall, Olga Kotova, Andreas Edsfeldt, Kasper Pilgaard, Sami Alkayyali, Charlotte Brøns, Carol Forsblom, Anna Jonsson, Anna V. Zetterqvist, Mihaela Nitulescu, Christian Ruiz McDavitt, Pontus Dunér, Alena Stancáková, Johanna Kuusisto, Emma Ahlqvist, Maria Lajer, Lise Tarnow, Sten Madsbad, Peter Rossing, Timothy J. Kieffer, Olle Melander, Marju Orho-Melander, Peter Nilsson, Per-Henrik Groop, Allan Vaag, Bengt Lindblad, Anders Gottsäter, Markku Laakso, Isabel Goncalves, Leif Groop, Maria F. Gomez
Journal: Diabetes
Diabetes 2016;65(1):239–254
https://doi.org/10.2337/db15-0122
Published: 22 September 2015
View article titled, Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB
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Includes: Supplementary data
Journal Articles

Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes

Emma Nilsson, Per Anders Jansson, Alexander Perfilyev, Petr Volkov, Maria Pedersen, Maria K. Svensson, Pernille Poulsen, Rasmus Ribel-Madsen, Nancy L. Pedersen, Peter Almgren, João Fadista, Tina Rönn, Bente Klarlund Pedersen, Camilla Scheele, Allan Vaag, Charlotte Ling
Journal: Diabetes
Diabetes 2014;63(9):2962–2976
https://doi.org/10.2337/db13-1459
Published: 16 August 2014
View article titled, Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

Impaired Leptin Gene Expression and Release in Cultured Preadipocytes Isolated From Individuals Born With Low Birth Weight

Ninna S. Schultz, Christa Broholm, Linn Gillberg, Brynjulf Mortensen, Sine W. Jørgensen, Heidi S. Schultz, Camilla Scheele, Jørgen F.P. Wojtaszewski, Bente K. Pedersen, Allan Vaag
Journal: Diabetes
Diabetes 2014;63(1):111–121
https://doi.org/10.2337/db13-0621
Published: 13 December 2013
View article titled, Impaired Leptin Gene Expression and Release in Cultured Preadipocytes Isolated From Individuals Born With Low Birth Weight
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Includes: Supplementary data
Journal Articles

Link Between GIP and Osteopontin in Adipose Tissue and Insulin Resistance

Emma Ahlqvist, Peter Osmark, Tiina Kuulasmaa, Kasper Pilgaard, Bilal Omar, Charlotte Brøns, Olga Kotova, Anna V. Zetterqvist, Alena Stančáková, Anna Jonsson, Ola Hansson, Johanna Kuusisto, Timothy J. Kieffer, Tiinamaija Tuomi, Bo Isomaa, Sten Madsbad, Maria F. Gomez, Pernille Poulsen, Markku Laakso, Eva Degerman, Jussi Pihlajamäki, Nils Wierup, Allan Vaag, Leif Groop, Valeriya Lyssenko
Journal: Diabetes
Diabetes 2013;62(6):2088–2094
https://doi.org/10.2337/db12-0976
Published: 17 May 2013
View article titled, Link Between GIP and Osteopontin in Adipose Tissue and Insulin Resistance
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Includes: Supplementary data
Journal Articles

Pleiotropic Effects of GIP on Islet Function Involve Osteopontin

Valeriya Lyssenko, Lena Eliasson, Olga Kotova, Kasper Pilgaard, Nils Wierup, Albert Salehi, Anna Wendt, Anna Jonsson, Yang Z. De Marinis, Lisa M. Berglund, Jalal Taneera, Alexander Balhuizen, Ola Hansson, Peter Osmark, Pontus Dunér, Charlotte Brøns, Alena Stančáková, Johanna Kuusisto, Marco Bugliani, Richa Saxena, Emma Ahlqvist, Timothy J. Kieffer, Tiinamaija Tuomi, Bo Isomaa, Olle Melander, Emily Sonestedt, Marju Orho-Melander, Peter Nilsson, Sara Bonetti, Riccardo Bonadonna, Roberto Miccoli, Stefano DelPrato, Piero Marchetti, Sten Madsbad, Pernille Poulsen, Allan Vaag, Markku Laakso, Maria F. Gomez, Leif Groop
Journal: Diabetes
Diabetes 2011;60(9):2424–2433
https://doi.org/10.2337/db10-1532
Published: 20 August 2011
View article titled, Pleiotropic Effects of GIP on Islet Function Involve Osteopontin
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Includes: Supplementary data
Journal Articles

Impact of Physical Inactivity on Subcutaneous Adipose Tissue Metabolism in Healthy Young Male Offspring of Patients With Type 2 Diabetes

Lise Højbjerre, Mette Paulli Sonne, Amra Ciric Alibegovic, Flemming Dela, Allan Vaag, Jens Bruun Meldgaard, Karl Bang Christensen, Bente Stallknecht
Journal: Diabetes
Diabetes 2010;59(11):2790–2798
https://doi.org/10.2337/db10-0320
Published: 07 September 2010
View article titled, Impact of Physical Inactivity on Subcutaneous Adipose Tissue Metabolism in Healthy Young Male Offspring of Patients With Type 2 Diabetes
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Journal Articles

Impact of rs361072 in the Phosphoinositide 3-Kinase p110β Gene on Whole-Body Glucose Metabolism and Subunit Protein Expression in Skeletal Muscle

Rasmus Ribel-Madsen, Pernille Poulsen, Johan Holmkvist, Brynjulf Mortensen, Niels Grarup, Martin Friedrichsen, Torben Jørgensen, Torsten Lauritzen, Jørgen F.P. Wojtaszewski, Oluf Pedersen, Torben Hansen, Allan Vaag
Journal: Diabetes
Diabetes 2010;59(4):1108–1112
https://doi.org/10.2337/db09-1359
Published: 27 January 2010
View article titled, Impact of rs361072 in the Phosphoinositide 3-Kinase p110β Gene on Whole-Body Glucose Metabolism and Subunit Protein Expression in Skeletal Muscle
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Includes: Supplementary data
Journal Articles

The T-Allele of TCF7L2 rs7903146 Associates With a Reduced Compensation of Insulin Secretion for Insulin Resistance Induced by 9 Days of Bed Rest

Amra C. Alibegovic, Mette P. Sonne, Lise Højbjerre, Torben Hansen, Oluf Pedersen, Gerrit van Hall, Jens J. Holst, Bente Stallknecht, Flemming Dela, Allan Vaag
Journal: Diabetes
Diabetes 2010;59(4):836–843
https://doi.org/10.2337/db09-0918
Published: 27 January 2010
View article titled, The T-Allele of <em>TCF7L2</em> rs7903146 Associates With a Reduced Compensation of Insulin Secretion for Insulin Resistance Induced by 9 Days of Bed Rest
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Journal Articles

Impact of 9 Days of Bed Rest on Hepatic and Peripheral Insulin Action, Insulin Secretion, and Whole-Body Lipolysis in Healthy Young Male Offspring of Patients With Type 2 Diabetes

Amra C. Alibegovic, Lise Højbjerre, Mette P. Sonne, Gerrit van Hall, Bente Stallknecht, Flemming Dela, Allan Vaag
Journal: Diabetes
Diabetes 2009;58(12):2749–2756
https://doi.org/10.2337/db09-0369
Published: 31 August 2009
View article titled, Impact of 9 Days of Bed Rest on Hepatic and Peripheral Insulin Action, Insulin Secretion, and Whole-Body Lipolysis in Healthy Young Male Offspring of Patients With Type 2 Diabetes
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Journal Articles

Regulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue

Louise G. Grunnet, Emma Nilsson, Charlotte Ling, Torben Hansen, Oluf Pedersen, Leif Groop, Allan Vaag, Pernille Poulsen
Journal: Diabetes
Diabetes 2009;58(10):2402–2408
https://doi.org/10.2337/db09-0205
Published: 08 July 2009
View article titled, Regulation and Function of <em>FTO</em> mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue
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Journal Articles

Increased Risk of Type 2 Diabetes in Elderly Twins

Pernille Poulsen, Louise G. Grunnet, Kasper Pilgaard, Heidi Storgaard, Amra Alibegovic, Mette P. Sonne, Bendix Carstensen, Henning Beck-Nielsen, Allan Vaag
Journal: Diabetes
Diabetes 2009;58(6):1350–1355
https://doi.org/10.2337/db08-1714
Published: 31 March 2009
View article titled, Increased Risk of Type 2 Diabetes in Elderly Twins
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Journal Articles

G-allele of Intronic rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release: Studies Involving 19,605 Europeans

Thomas Sparsø, Amélie Bonnefond, Ehm Andersson, Nabila Bouatia-Naji, Johan Holmkvist, Lise Wegner, Niels Grarup, Anette P. Gjesing, Karina Banasik, Christine Cavalcanti-Proença, Marion Marchand, Martine Vaxillaire, Guillaume Charpentier, Marjo-Riitta Jarvelin, Jean Tichet, Beverley Balkau, Michel Marre, Claire Lévy-Marchal, Kristine Færch, Knut Borch-Johnsen, Torben Jørgensen, Sten Madsbad, Pernille Poulsen, Allan Vaag, Christian Dina, Torben Hansen, Oluf Pedersen, Philippe Froguel
Journal: Diabetes
Diabetes 2009;58(6):1450–1456
https://doi.org/10.2337/db08-1660
Published: 26 March 2009
View article titled, G-allele of Intronic rs10830963 in <em>MTNR1B</em> Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release: <subtitle>Studies Involving 19,605 Europeans</subtitle>
Open the PDF for G-allele of Intronic rs10830963 in <em>MTNR1B</em> Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release: <subtitle>Studies Involving 19,605 Europeans</subtitle> in another window
Includes: Supplementary data
Journal Articles

Retinol-Binding Protein 4 in Twins: Regulatory Mechanisms and Impact of Circulating and Tissue Expression Levels on Insulin Secretion and Action

Rasmus Ribel-Madsen, Martin Friedrichsen, Allan Vaag, Pernille Poulsen
Journal: Diabetes
Diabetes 2009;58(1):54–60
https://doi.org/10.2337/db08-1019
Published: 01 January 2009
View article titled, Retinol-Binding Protein 4 in Twins: <subtitle>Regulatory Mechanisms and Impact of Circulating and Tissue Expression Levels on Insulin Secretion and Action</subtitle>
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Journal Articles

Low Birth Weight and Zygosity Status Is Associated With Defective Muscle Glycogen and Glycogen Synthase Regulation in Elderly Twins

Pernille Poulsen, Jørgen F.P. Wojtaszewski, Erik A. Richter, Henning Beck-Nielsen, Allan Vaag
Journal: Diabetes
Diabetes 2007;56(11):2710–2714
https://doi.org/10.2337/db07-0155
Published: 01 November 2007
View article titled, Low Birth Weight and Zygosity Status Is Associated With Defective Muscle Glycogen and Glycogen Synthase Regulation in Elderly Twins
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Journal Articles

The Intrauterine Environment as Reflected by Birth Size and Twin and Zygosity Status Influences Insulin Action and Intracellular Glucose Metabolism in an Age- or Time-Dependent Manner

Pernille Poulsen, Allan Vaag
Journal: Diabetes
Diabetes 2006;55(6):1819–1825
https://doi.org/10.2337/db05-1462
Published: 01 June 2006
View article titled, The Intrauterine Environment as Reflected by Birth Size and Twin and Zygosity Status Influences Insulin Action and Intracellular Glucose Metabolism in an Age- or Time-Dependent Manner
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Journal Articles

Genetic and Nongenetic Regulation of CAPN10 mRNA Expression in Skeletal Muscle

Emma Carlsson, Pernille Poulsen, Heidi Storgaard, Peter Almgren, Charlotte Ling, Christine Bjørn Jensen, Sten Madsbad, Leif Groop, Allan Vaag, Martin Ridderstråle
Journal: Diabetes
Diabetes 2005;54(10):3015–3020
https://doi.org/10.2337/diabetes.54.10.3015
Published: 01 October 2005
View article titled, Genetic and Nongenetic Regulation of <em>CAPN10</em> mRNA Expression in Skeletal Muscle
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