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Meeting Abstracts

287-OR: M6A mRNA Methylation Regulates the Innate Immune Response in Human ß-Cells

DARIO F. DE JESUS, ZIJIE ZHANG, NATALIE K. BROWN, JIANG HU, SEVIM KAHRAMAN, CLAYTON E. MATHEWS, ALVIN C. POWERS, MARK A. ATKINSON, DECIO L. EIZIRIK, CHUAN HE, ROHIT KULKARNI

Diabetes 2021;70(Supplement_1):287-OR

DOI: https://doi.org/10.2337/db21-287-OR

Published: 01 June 2021

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Journal Articles

Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health

Xin Tong, Chunhua Dai, John T. Walker, Gopika G. Nair, Arion Kennedy, Rotonya M. Carr, Matthias Hebrok, Alvin C. Powers, Roland Stein

Diabetes 2020;69(3):342–354

DOI: https://doi.org/10.2337/db19-0281

Published: 13 December 2020

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Includes: Supplementary data

Meeting Abstracts

1312-P: Pancreas Volume in Individuals with MODY 1, 2, 3, and 5

JORDAN J. WRIGHT, JONATHAN M. WILLIAMS, JOHN VIROSTKO, MELISSA A. HILMES, LIPING DU, HAKMOOK KANG, SIRI ATMA W. GREELEY, WILLIAM E. RUSSELL, DANIEL J. MOORE, ALVIN C. POWERS

Diabetes 2020;69(Supplement_1):1312-P

DOI: https://doi.org/10.2337/db20-1312-P

Published: 01 June 2020

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Meeting Abstracts

349-OR: Pancreas Volume Is Smaller in Individuals with Stage 1 Type 1 Diabetes (T1D) and Correlates with Disease Progression

JOHN VIROSTKO, JONATHAN M. WILLIAMS, MELISSA A. HILMES, JORDAN J. WRIGHT, BRENNA D. HAMMEL, LIPING DU, HAKMOOK KANG, WILLIAM E. RUSSELL, ALVIN C. POWERS, DANIEL J. MOORE

Diabetes 2020;69(Supplement_1):349-OR

DOI: https://doi.org/10.2337/db20-349-OR

Published: 01 June 2020

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Meeting Abstracts

255-OR: ADA Presidents’ Select Abstract: Glucagon Receptor Antagonism Stimulates Beta-Cell Proliferation in Mouse and Human Islets

KATIE C. COATE, ERICK SPEARS, CHUNHUA DAI, SCOTT WISNIEWSKI, GREG POFFENBERGER, LEONARD D. SHULTZ, DALE L. GREINER, DANIEL J. DRUCKER, HAI YAN, KYLE SLOOP, ALVIN C. POWERS, DANIELLE DEAN

Diabetes 2020;69(Supplement_1):255-OR

DOI: https://doi.org/10.2337/db20-255-OR

Published: 01 June 2020

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Meeting Abstracts

1894-P: Interruption of Glucagon Signaling Increases Pancreas Mass

CHUNHUA DAI, AMBER BRADLEY, KATIE C. COATE, GREG POFFENBERGER, ERICK SPEARS, JORDAN J. WRIGHT, SHRISTI SHRESTHA, DANIELLE DEAN, MARCELA BRISSOVA, ALVIN C. POWERS

Diabetes 2020;69(Supplement_1):1894-P

DOI: https://doi.org/10.2337/db20-1894-P

Published: 01 June 2020

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Meeting Abstracts

111-OR: MODY3 Diagnosis from Deidentified Pancreatic Tissue Leads to Variant Identification in Living Relatives

DAVID SPARLING, RACHANA HALIYUR, JILL LINDNER, LINDA WEBER, ANDREA RAMIREZ, MARCELA BRISSOVA, ALVIN C. POWERS

Diabetes 2020;69(Supplement_1):111-OR

DOI: https://doi.org/10.2337/db20-111-OR

Published: 01 June 2020

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Meeting Abstracts

1283-P: Multicenter Assessment of the Pancreas in Type 1 Diabetes (MAP-T1D)

JOHN VIROSTKO, JONATHAN M. WILLIAMS, MELISSA A. HILMES, LIPING DU, HAKMOOK KANG, WILLIAM E. RUSSELL, TAYLOR M. TRIOLO, LOUIS H. PHILIPSON, EMILY K. SIMS, CARMELLA EVANS-MOLINA, HELEN E. THOMAS, THOMAS KAY, SIRI ATMA W. GREELEY, ANDREA STECK, ALVIN C. POWERS, DANIEL J. MOORE

Diabetes 2020;69(Supplement_1):1283-P

DOI: https://doi.org/10.2337/db20-1283-P

Published: 01 June 2020

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Meeting Abstracts

1282-P: Assessment of Pancreas Volume and Shape Dynamics Longitudinally after T1D Diagnosis

JOHN VIROSTKO, JONATHAN M. WILLIAMS, MELISSA A. HILMES, JORDAN J. WRIGHT, LIPING DU, HAKMOOK KANG, WILLIAM E. RUSSELL, DANIEL J. MOORE, ALVIN C. POWERS

Diabetes 2020;69(Supplement_1):1282-P

DOI: https://doi.org/10.2337/db20-1282-P

Published: 01 June 2020

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Journal Articles

Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation

Joon Ho Moon, Yeong Gi Kim, Kyuho Kim, Sho Osonoi, Shuang Wang, Diane C. Saunders, Juehu Wang, Katherine Yang, Hyeongseok Kim, Junguee Lee, Ji-Seon Jeong, Ronadip R. Banerjee, Seung K. Kim, Yingjie Wu, Hiroki Mizukami, Alvin C. Powers, Michael S. German, Hail Kim

Diabetes 2020;69(2):205–214

DOI: https://doi.org/10.2337/db19-0546

Published: 05 December 2019

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Includes: Supplementary data

Meeting Abstracts

185-LB: Repeatability and Reproducibility of Pancreas Volume Measurements Using MRI

JONATHAN M. WILLIAMS, MELISSA A. HILMES, BRANCH T. ARCHER, LIPING DU, HAKMOOK KANG, WILLIAM E. RUSSELL, DANIEL J. MOORE, ALVIN C. POWERS, JOHN VIROSTKO

Diabetes 2019;68(Supplement_1):185-LB

DOI: https://doi.org/10.2337/db19-185-LB

Published: 01 June 2019

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Meeting Abstracts

198-OR: Role for the Cationic Amino Acid Transporter Slc7a2 in Alpha-Cell Proliferation and Islet Hormone Secretion

ERICK SPEARS, MATTHEW SHOU, WALTER A. SIV, CHUNHUA DAI, WENBIAO CHEN, ALVIN C. POWERS, DANIELLE DEAN

Diabetes 2019;68(Supplement_1):198-OR

DOI: https://doi.org/10.2337/db19-198-OR

Published: 01 June 2019

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Meeting Abstracts

2140-P: Pancreatic Islet and Exocrine Tissue Innervation Is Not Altered in Type 1 Diabetes

TIFFANY M. RICHARDSON, RACHANA HALIYUR, RADHIKA ARAMANDLA, RITA BOTTINO, ALVIN C. POWERS, MARCELA BRISSOVA

Diabetes 2019;68(Supplement_1):2140-P

DOI: https://doi.org/10.2337/db19-2140-P

Published: 01 June 2019

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Meeting Abstracts

2138-P: Pancreatic Exocrine Changes in Longstanding Type 1 Diabetes

JORDAN J. WRIGHT, DIANE C. SAUNDERS, JILL LINDNER, MARIKA BOGDANI, MARCELA BRISSOVA, RITA BOTTINO, ALVIN C. POWERS

Diabetes 2019;68(Supplement_1):2138-P

DOI: https://doi.org/10.2337/db19-2138-P

Published: 01 June 2019

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Meeting Abstracts

107-OR: Profiling of Human Pancreatic Islets by Single Cell Transcriptomics Reveals α- and ß-Cell Subpopulations

SHRISTI SHRESTHA, DIANE C. SAUNDERS, JOHN T. WALKER, RACHANA HALIYUR, GREG POFFENBERGER, RADHIKA ARAMANDLA, ANGELA JONES, NRIPESH PRASAD, SHAWN E. LEVY, ALVIN C. POWERS, MARCELA BRISSOVA

Diabetes 2019;68(Supplement_1):107-OR

DOI: https://doi.org/10.2337/db19-107-OR

Published: 01 June 2019

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Meeting Abstracts

44-OR: Human Pseudo Islets Reveal Differential Effects of Gq Signaling in ß Cells in Low and High Glucose

JOHN T. WALKER, RACHANA HALIYUR, RADHIKA ARAMANDLA, GREG POFFENBERGER, HEATHER A. NELSON, JOSEPH LUCHSINGER, PENG WANG, ADOLFO GARCIA-OCAÑA, MARCELA BRISSOVA, ALVIN C. POWERS

Diabetes 2019;68(Supplement_1):44-OR

DOI: https://doi.org/10.2337/db19-44-OR

Published: 01 June 2019

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Journal Articles

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)

Klaus H. Kaestner, Alvin C. Powers, Ali Naji, HPAP Consortium, Mark A. Atkinson

Diabetes 2019;68(7):1394–1402

DOI: https://doi.org/10.2337/db19-0058

Published: 24 May 2019

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Journal Articles

HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes

Diabetes 2019;68(5):988–1001

DOI: https://doi.org/10.2337/db18-0686

Published: 04 March 2019

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Includes: Multimedia, Supplementary data

Journal Articles

Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally

Holly A. Cyphert, Emily M. Walker, Yan Hang, Sangeeta Dhawan, Rachana Haliyur, Lauren Bonatakis, Dana Avrahami, Marcela Brissova, Klaus H. Kaestner, Anil Bhushan, Alvin C. Powers, Roland Stein

Diabetes 2019;68(2):337–348

DOI: https://doi.org/10.2337/db18-0903

Published: 13 November 2018

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Includes: Supplementary data

Journal Articles

β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes

Elad Horwitz, Lars Krogvold, Sophia Zhitomirsky, Avital Swisa, Maya Fischman, Tsuria Lax, Tehila Dahan, Noa Hurvitz, Noa Weinberg-Corem, Agnes Klochendler, Alvin C. Powers, Marcela Brissova, Anne Jörns, Sigurd Lenzen, Benjamin Glaser, Knut Dahl-Jørgensen, Yuval Dor

Diabetes 2018;67(11):2305–2318

DOI: https://doi.org/10.2337/db17-1006

Published: 27 August 2018

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Includes: Supplementary data

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NARROW

287-OR: M6A mRNA Methylation Regulates the Innate Immune Response in Human ß-Cells

Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health

1312-P: Pancreas Volume in Individuals with MODY 1, 2, 3, and 5

349-OR: Pancreas Volume Is Smaller in Individuals with Stage 1 Type 1 Diabetes (T1D) and Correlates with Disease Progression

255-OR: ADA Presidents’ Select Abstract: Glucagon Receptor Antagonism Stimulates Beta-Cell Proliferation in Mouse and Human Islets

1894-P: Interruption of Glucagon Signaling Increases Pancreas Mass

111-OR: MODY3 Diagnosis from Deidentified Pancreatic Tissue Leads to Variant Identification in Living Relatives

1283-P: Multicenter Assessment of the Pancreas in Type 1 Diabetes (MAP-T1D)

1282-P: Assessment of Pancreas Volume and Shape Dynamics Longitudinally after T1D Diagnosis

Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation

185-LB: Repeatability and Reproducibility of Pancreas Volume Measurements Using MRI

198-OR: Role for the Cationic Amino Acid Transporter Slc7a2 in Alpha-Cell Proliferation and Islet Hormone Secretion

2140-P: Pancreatic Islet and Exocrine Tissue Innervation Is Not Altered in Type 1 Diabetes

2138-P: Pancreatic Exocrine Changes in Longstanding Type 1 Diabetes

107-OR: Profiling of Human Pancreatic Islets by Single Cell Transcriptomics Reveals α- and ß-Cell Subpopulations

44-OR: Human Pseudo Islets Reveal Differential Effects of Gq Signaling in ß Cells in Low and High Glucose

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)

HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes

Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally

β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes

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