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Meeting Abstracts

140-OR: The Coronary Flow Reserve Increase after Dapagliflozin Treatment in Patients with Type 2 Diabetes Is Maintained after Four Years—A Four-Year DAPAHEART Follow-up Study

CASSANDRA MORCIANO, FRANCESCA CINTI, GIAN PIO SORICE, LUCIA LECCISOTTI, SHAWN GUGLIANDOLO, UMBERTO CAPECE, LUIGI CAPPANNOLI, DOMENICO D'AMARIO, TERESA MEZZA, GIANFRANCO DI GIUSEPPE, GEA CICCARELLI, LAURA SOLDOVIERI, ANDREA GIACCARI

Diabetes 2024;73(Supplement_1):140-OR

https://doi.org/10.2337/db24-140-OR

Published: 14 June 2024

View article titled, 140-OR: The Coronary Flow Reserve Increase after Dapagliflozin Treatment in Patients with Type 2 Diabetes Is Maintained after Four Years—A Four-Year DAPAHEART Follow-up Study

Meeting Abstracts

1559-P: Heterogeneity of Trajectories of Metabolic Parameters after 50% Beta-Cell Mass Loss by Pancreatectomy

ROBERTO BIZZOTTO, GIANFRANCO DI GIUSEPPE, LAURA SOLDOVIERI, FRANCESCA CINTI, SIMONA MOFFA, MICHELA BRUNETTI, GEA CICCARELLI, SERGIO ALFIERI, GIUSEPPE QUERO, ANDREA MARI, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2024;73(Supplement_1):1559-P

https://doi.org/10.2337/db24-1559-P

Published: 14 June 2024

View article titled, 1559-P: Heterogeneity of Trajectories of Metabolic Parameters after 50% Beta-Cell Mass Loss by Pancreatectomy

Meeting Abstracts

1555-P: Effects of 80% Pancreas Reduction on Beta-Cell Function and Glucose Metabolism

LAURA SOLDOVIERI, GIANFRANCO DI GIUSEPPE, GEA CICCARELLI, MICHELA BRUNETTI, ANDREA MARI, GIUSEPPE QUERO, SERGIO ALFIERI, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2024;73(Supplement_1):1555-P

https://doi.org/10.2337/db24-1555-P

Published: 14 June 2024

View article titled, 1555-P: Effects of 80% Pancreas Reduction on Beta-Cell Function and Glucose Metabolism

Meeting Abstracts

108-OR: Insulin Resistance Is Associated with Alterations in the Dynamics of Incretin Secretion

GIANFRANCO DI GIUSEPPE, LAURA SOLDOVIERI, GEA CICCARELLI, MICHELA BRUNETTI, FRANCESCA CINTI, SIMONA MOFFA, JENS J. HOLST, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2024;73(Supplement_1):108-OR

https://doi.org/10.2337/db24-108-OR

Published: 14 June 2024

View article titled, 108-OR: Insulin Resistance Is Associated with Alterations in the Dynamics of Incretin Secretion

Meeting Abstracts

1068-P: Reassessing Insulin Therapy In Diabetes of the Exocrine Pancreas—A Pilot Study

GEA CICCARELLI, GIANFRANCO DI GIUSEPPE, MICHELA BRUNETTI, LAURA SOLDOVIERI, NICOLETTA DI GIORGI, CHIARA IACOMINI, CARLOTTA MASCIOCCHI, STEFANO PATARNELLO, UMBERTO CAPECE, CASSANDRA MORCIANO, SHAWN GUGLIANDOLO, ADRIANA AVOLIO, SIMONA MOFFA, FRANCESCA CINTI, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2024;73(Supplement_1):1068-P

https://doi.org/10.2337/db24-1068-P

Published: 14 June 2024

View article titled, 1068-P: Reassessing Insulin Therapy In Diabetes of the Exocrine Pancreas—A Pilot Study

Meeting Abstracts

1535-P: Type 2 Diabetes Remission after Roux-en-Y Gastric Bypass Is Related to a Reduction of Pancreatic Noradrenergic Innervation and Beta-Cell Redifferentiation

FRANCESCA CINTI, ADRIANA AVOLIO, CASSANDRA MORCIANO, SHAWN GUGLIANDOLO, UMBERTO CAPECE, TERESA MEZZA, LAURA SOLDOVIERI, GEA CICCARELLI, GIANFRANCO DI GIUSEPPE, SIMONA MOFFA, ANDREA GIACCARI

Diabetes 2024;73(Supplement_1):1535-P

https://doi.org/10.2337/db24-1535-P

Published: 14 June 2024

View article titled, 1535-P: Type 2 Diabetes Remission after Roux-en-Y Gastric Bypass Is Related to a Reduction of Pancreatic Noradrenergic Innervation and Beta-Cell Redifferentiation

Meeting Abstracts

1619-P: Insulin Resistance Stimulates Intraislet GLP-1 Secretion from a-Cells in Diet-Induced Obese Mice

GIANFRANCO DI GIUSEPPE, SARA L. JEPSEN, JON VERGARA UCIN, BOLETTE HARTMANN, ANDREA GIACCARI, JENS J. HOLST, TERESA MEZZA

Diabetes 2024;73(Supplement_1):1619-P

https://doi.org/10.2337/db24-1619-P

Published: 14 June 2024

View article titled, 1619-P: Insulin Resistance Stimulates Intraislet GLP-1 Secretion from a-Cells in Diet-Induced Obese Mice

Journal Articles

Lysophosphatidylinositols Are Upregulated After Human β-Cell Loss and Potentiate Insulin Release

Diabetes 2024;73(1):93–107

https://doi.org/10.2337/db23-0205

Published: 20 October 2023

View article titled, Lysophosphatidylinositols Are Upregulated After Human β-Cell Loss and Potentiate Insulin Release

Meeting Abstracts

1754-P: Reduced Incretin Effect Predicts Diabetes Appearance in a Cohort of Nondiabetic Subjects after Acute Beta-Cell Mass Reduction

GIANFRANCO DI GIUSEPPE, CHIARA MARIA ASSUNTA CEFALO, SIMONA MOFFA, GEA CICCARELLI, LAURA SOLDOVIERI, FRANCESCA CINTI, UMBERTO CAPECE, FLAVIA IMPRONTA, ANDREA MARI, JENS J. HOLST, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2023;72(Supplement_1):1754-P

https://doi.org/10.2337/db23-1754-P

Published: 20 June 2023

View article titled, 1754-P: Reduced Incretin Effect Predicts Diabetes Appearance in a Cohort of Nondiabetic Subjects after Acute Beta-Cell Mass Reduction

Meeting Abstracts

376-OR: Chronic Pancreatitis Does Not Induce Specific Alterations in Beta-Cell Function

GEA CICCARELLI, GIANFRANCO DI GIUSEPPE, FRANCESCA CINTI, ANDREA MARI, TERESA MEZZA, ANDREA GIACCARI

Diabetes 2023;72(Supplement_1):376-OR

https://doi.org/10.2337/db23-376-OR

Published: 20 June 2023

View article titled, 376-OR: Chronic Pancreatitis Does Not Induce Specific Alterations in Beta-Cell Function

Meeting Abstracts

290-OR: Altered In-Situ Expression of Proinsulin-Insulin in Pancreatic Islets Reflects Metabolic and Molecular Defects in Type 2 Diabetic and Glucose-Intolerant Living Donors

NOEMI BRUSCO, GUIDO SEBASTIANI, GIADA LICATA, GIUSEPPINA E. GRIECO, GIANFRANCO DI GIUSEPPE, LAURA NIGI, DANIELA FIGNANI, SIMONA MOFFA, FRANCESCA CINTI, CHIARA MARIA ASSUNTA CEFALO, UMBERTO CAPECE, FLAVIA IMPRONTA, ANDREA MARI, FRANCESCO DOTTA, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2021;70(Supplement_1):290-OR

https://doi.org/10.2337/db21-290-OR

Published: 01 June 2021

View article titled, 290-OR: Altered In-Situ Expression of Proinsulin-Insulin in Pancreatic Islets Reflects Metabolic and Molecular Defects in Type 2 Diabetic and Glucose-Intolerant Living Donors

Meeting Abstracts

1795-P: Proinsulin-Insulin Pancreatic Islets In-situ Expression Mirrors Metabolic Defects Observed in Type 2 Diabetic and Glucose Intolerant Living Donors

NOEMI BRUSCO, GUIDO SEBASTIANI, GIADA LICATA, GIUSEPPINA E. GRIECO, LAURA NIGI, DANIELA FIGNANI, SIMONA MOFFA, GIAN PIO SORICE, GIANFRANCO DI GIUSEPPE, CHIARA MARIA ASSUNTA CEFALO, JR., ANDREA MARI, FRANCESCO DOTTA, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2020;69(Supplement_1):1795-P

https://doi.org/10.2337/db20-1795-P

Published: 01 June 2020

View article titled, 1795-P: Proinsulin-Insulin Pancreatic Islets In-situ Expression Mirrors Metabolic Defects Observed in Type 2 Diabetic and Glucose Intolerant Living Donors

Meeting Abstracts

2295-PUB: Impaired First-Phase Insulin Secretion Predicts the Development of Hyperglycemia in a Human Model of Acute Beta-Cell Mass Reduction

TERESA MEZZA, PIETRO MANUEL FERRARO, GIANFRANCO DI GIUSEPPE, CHIARA MARIA ASSUNTA CEFALO, JR., SIMONA MOFFA, GIUSEPPE QUERO, FRANCESCA CINTI, FLAVIA IMPRONTA, UMBERTO CAPECE, SERGIO ALFIERI, ANDREA MARI, ANDREA GIACCARI

Diabetes 2020;69(Supplement_1):2295-PUB

https://doi.org/10.2337/db20-2295-PUB

Published: 01 June 2020

View article titled, 2295-PUB: Impaired First-Phase Insulin Secretion Predicts the Development of Hyperglycemia in a Human Model of Acute Beta-Cell Mass Reduction

Meeting Abstracts

1100-P: Efficacy and Safety of Sotagliflozin by Baseline Renal Function in Adults with Type 1 Diabetes

YEHUDA HANDELSMAN, ANDREA GIACCARI, SANGEETA SAWHNEY, PHILLIP L. BANKS, MICHAEL J. DAVIES, PABLO LAPUERTA

Diabetes 2020;69(Supplement_1):1100-P

https://doi.org/10.2337/db20-1100-P

Published: 01 June 2020

View article titled, 1100-P: Efficacy and Safety of Sotagliflozin by Baseline Renal Function in Adults with Type 1 Diabetes

Meeting Abstracts

2090-P: Noradrenergic Stimulus as a Potential Inducer of Human ß-Cell Dedifferentiation

FRANCESCA CINTI, FEDERICA FANTUZZI, ANDREA CARFÍ, TERESA MEZZA, CHIARA MARIA ASSUNTA CEFALO, JR., SIMONA MOFFA, GIAN PIO SORICE, ANDREA GIACCARI, MIRIAM CNOP

Diabetes 2020;69(Supplement_1):2090-P

https://doi.org/10.2337/db20-2090-P

Published: 01 June 2020

View article titled, 2090-P: Noradrenergic Stimulus as a Potential Inducer of Human ß-Cell Dedifferentiation

Meeting Abstracts

2110-P: Correlation between Ex Vivo Islet Proteomic Analysis and In Vivo Secretory Function in Humans

CHIARA MARIA ASSUNTA CEFALO, TERESA MEZZA, FRANCESCA CINTI, SIMONA MOFFA, UMBERTO CAPECE, ROHIT KULKARNI, ANDREA GIACCARI

Diabetes 2020;69(Supplement_1):2110-P

https://doi.org/10.2337/db20-2110-P

Published: 01 June 2020

View article titled, 2110-P: Correlation between Ex Vivo Islet Proteomic Analysis and In Vivo Secretory Function in Humans

Meeting Abstracts

134-OR: Effects of PCSK9 Inhibitors on Glucose Metabolism and ß-Cell Function in Humans

SIMONA MOFFA, TERESA MEZZA, CHIARA MARIA ASSUNTA CEFALO, JR., FRANCESCA CINTI, GIAN PIO SORICE, FLAVIA IMPRONTA, UMBERTO CAPECE, ANDREA MARI, ANDREA GIACCARI

Diabetes 2020;69(Supplement_1):134-OR

https://doi.org/10.2337/db20-134-OR

Published: 01 June 2020

View article titled, 134-OR: Effects of PCSK9 Inhibitors on Glucose Metabolism and ß-Cell Function in Humans

Meeting Abstracts

999-P: Liraglutide Treatment in Obese Diabetic Patients Modulates Gut Microbiota

SIMONA MOFFA, VALENTINA TESORI, TERESA MEZZA, CHIARA MARIA ASSUNTA CEFALO, JR., FRANCESCA CINTI, GIAN PIO SORICE, ANDREA GIACCARI

Diabetes 2019;68(Supplement_1):999-P

https://doi.org/10.2337/db19-999-P

Published: 01 June 2019

View article titled, 999-P: Liraglutide Treatment in Obese Diabetic Patients Modulates Gut Microbiota

Meeting Abstracts

1212-P: Sotagliflozin Reduces Markers of Arterial Stiffness in T1D: Pooled Analysis from inTandem 1 and inTandem 2 Clinical Trials

HELENA W. RODBARD, ANDREA GIACCARI, MICHAEL J. DAVIES, SANGEETA SAWHNEY, STELLA WANG, SATISH K. GARG, BERTRAND CARIOU

Diabetes 2019;68(Supplement_1):1212-P

https://doi.org/10.2337/db19-1212-P

Published: 01 June 2019

View article titled, 1212-P: Sotagliflozin Reduces Markers of Arterial Stiffness in T1D: Pooled Analysis from inTandem 1 and inTandem 2 Clinical Trials

Meeting Abstracts

1220-P: Sotagliflozin Leads to Lower Rates of Clinically Relevant Hypoglycemic Events at Any HbA_1c Level at 52 Weeks in Adults with T1D

THOMAS DANNE, JEREMY PETTUS, ANDREA GIACCARI, BERTRAND CARIOU, HELENA W. RODBARD, STUART A. WEINZIMER, MIREILLE BONNEMAIRE, SANGEETA SAWHNEY, STELLA WANG, RITA CASTRO, SATISH K. GARG

Diabetes 2019;68(Supplement_1):1220-P

https://doi.org/10.2337/db19-1220-P

Published: 01 June 2019

View article titled, 1220-P: Sotagliflozin Leads to Lower Rates of Clinically Relevant Hypoglycemic Events at Any HbA<sub>1c</sub> Level at 52 Weeks in Adults with T1D

NARROW

140-OR: The Coronary Flow Reserve Increase after Dapagliflozin Treatment in Patients with Type 2 Diabetes Is Maintained after Four Years—A Four-Year DAPAHEART Follow-up Study

1559-P: Heterogeneity of Trajectories of Metabolic Parameters after 50% Beta-Cell Mass Loss by Pancreatectomy

1555-P: Effects of 80% Pancreas Reduction on Beta-Cell Function and Glucose Metabolism

108-OR: Insulin Resistance Is Associated with Alterations in the Dynamics of Incretin Secretion

1068-P: Reassessing Insulin Therapy In Diabetes of the Exocrine Pancreas—A Pilot Study

1535-P: Type 2 Diabetes Remission after Roux-en-Y Gastric Bypass Is Related to a Reduction of Pancreatic Noradrenergic Innervation and Beta-Cell Redifferentiation

1619-P: Insulin Resistance Stimulates Intraislet GLP-1 Secretion from a-Cells in Diet-Induced Obese Mice

Lysophosphatidylinositols Are Upregulated After Human β-Cell Loss and Potentiate Insulin Release

1754-P: Reduced Incretin Effect Predicts Diabetes Appearance in a Cohort of Nondiabetic Subjects after Acute Beta-Cell Mass Reduction

376-OR: Chronic Pancreatitis Does Not Induce Specific Alterations in Beta-Cell Function

290-OR: Altered In-Situ Expression of Proinsulin-Insulin in Pancreatic Islets Reflects Metabolic and Molecular Defects in Type 2 Diabetic and Glucose-Intolerant Living Donors

1795-P: Proinsulin-Insulin Pancreatic Islets In-situ Expression Mirrors Metabolic Defects Observed in Type 2 Diabetic and Glucose Intolerant Living Donors

2295-PUB: Impaired First-Phase Insulin Secretion Predicts the Development of Hyperglycemia in a Human Model of Acute Beta-Cell Mass Reduction

1100-P: Efficacy and Safety of Sotagliflozin by Baseline Renal Function in Adults with Type 1 Diabetes

2090-P: Noradrenergic Stimulus as a Potential Inducer of Human ß-Cell Dedifferentiation

2110-P: Correlation between Ex Vivo Islet Proteomic Analysis and In Vivo Secretory Function in Humans

134-OR: Effects of PCSK9 Inhibitors on Glucose Metabolism and ß-Cell Function in Humans

999-P: Liraglutide Treatment in Obese Diabetic Patients Modulates Gut Microbiota

1212-P: Sotagliflozin Reduces Markers of Arterial Stiffness in T1D: Pooled Analysis from inTandem 1 and inTandem 2 Clinical Trials

1220-P: Sotagliflozin Leads to Lower Rates of Clinically Relevant Hypoglycemic Events at Any HbA_1c Level at 52 Weeks in Adults with T1D

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