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Meeting Abstracts

1559-P: Heterogeneity of Trajectories of Metabolic Parameters after 50% Beta-Cell Mass Loss by Pancreatectomy

ROBERTO BIZZOTTO, GIANFRANCO DI GIUSEPPE, LAURA SOLDOVIERI, FRANCESCA CINTI, SIMONA MOFFA, MICHELA BRUNETTI, GEA CICCARELLI, SERGIO ALFIERI, GIUSEPPE QUERO, ANDREA MARI, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2024;73(Supplement_1):1559-P

https://doi.org/10.2337/db24-1559-P

Published: 14 June 2024

View article titled, 1559-P: Heterogeneity of Trajectories of Metabolic Parameters after 50% Beta-Cell Mass Loss by Pancreatectomy

Meeting Abstracts

1555-P: Effects of 80% Pancreas Reduction on Beta-Cell Function and Glucose Metabolism

LAURA SOLDOVIERI, GIANFRANCO DI GIUSEPPE, GEA CICCARELLI, MICHELA BRUNETTI, ANDREA MARI, GIUSEPPE QUERO, SERGIO ALFIERI, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2024;73(Supplement_1):1555-P

https://doi.org/10.2337/db24-1555-P

Published: 14 June 2024

View article titled, 1555-P: Effects of 80% Pancreas Reduction on Beta-Cell Function and Glucose Metabolism

Journal Articles

β-Cell Glucose Sensitivity to Assess Changes in β-Cell Function in Recent-Onset Stage 3 Type 1 Diabetes

Stephen E. Gitelman, Carmella Evans-Molina, Annamaria Guolo, Andrea Mari, Ele Ferrannini

Diabetes 2023;72(9):1289–1296

https://doi.org/10.2337/db23-0196

Published: 27 June 2023

View article titled, β-Cell Glucose Sensitivity to Assess Changes in β-Cell Function in Recent-Onset Stage 3 Type 1 Diabetes

Meeting Abstracts

234-OR: Succinate Potentiates Insulin Secretion through SUCNR1

JOAN SABADELL-BASALLOTE, BRENNO D. ASTIARRAGA, MIRIAM EJARQUE, MARIA REPOLLÉS-DE-DALMAU, FRANCESC X. SUREDA, DARIO F. DE JESUS, CATALINA NÚÑEZ ROA, ANDREA MARI, ROHIT KULKARNI, JOAN J. VENDRELL, SONIA FERNANDEZ-VELEDO

Diabetes 2023;72(Supplement_1):234-OR

https://doi.org/10.2337/db23-234-OR

Published: 20 June 2023

View article titled, 234-OR: Succinate Potentiates Insulin Secretion through SUCNR1

Meeting Abstracts

1754-P: Reduced Incretin Effect Predicts Diabetes Appearance in a Cohort of Nondiabetic Subjects after Acute Beta-Cell Mass Reduction

GIANFRANCO DI GIUSEPPE, CHIARA MARIA ASSUNTA CEFALO, SIMONA MOFFA, GEA CICCARELLI, LAURA SOLDOVIERI, FRANCESCA CINTI, UMBERTO CAPECE, FLAVIA IMPRONTA, ANDREA MARI, JENS J. HOLST, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2023;72(Supplement_1):1754-P

https://doi.org/10.2337/db23-1754-P

Published: 20 June 2023

View article titled, 1754-P: Reduced Incretin Effect Predicts Diabetes Appearance in a Cohort of Nondiabetic Subjects after Acute Beta-Cell Mass Reduction

Meeting Abstracts

376-OR: Chronic Pancreatitis Does Not Induce Specific Alterations in Beta-Cell Function

GEA CICCARELLI, GIANFRANCO DI GIUSEPPE, FRANCESCA CINTI, ANDREA MARI, TERESA MEZZA, ANDREA GIACCARI

Diabetes 2023;72(Supplement_1):376-OR

https://doi.org/10.2337/db23-376-OR

Published: 20 June 2023

View article titled, 376-OR: Chronic Pancreatitis Does Not Induce Specific Alterations in Beta-Cell Function

Journal Articles

Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes

Elaine Chow, Ke Wang, Cadmon K.P. Lim, Sandra T.F. Tsoi, Baoqi Fan, Emily Poon, Andrea O.Y. Luk, Ronald C.W. Ma, Ele Ferrannini, Andrea Mari, Li Chen, Juliana C.N. Chan

Diabetes 2023;72(2):299–308

https://doi.org/10.2337/db22-0708

Published: 28 October 2022

View article titled, Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes

Meeting Abstracts

722-P: Tirzepatide Improves Multiple Aspects of Beta-Cell Function

ANDREA MARI, JING LI, SHWETA URVA, TIM HEISE, J. HANS DE VRIES, EDWARD J. PRATT, ROBERT J. HEINE, MELISSA K. THOMAS, ZVONKO MILICEVIC, KIEREN J. MATHER

Diabetes 2022;71(Supplement_1):722-P

https://doi.org/10.2337/db22-722-P

Published: 01 June 2022

View article titled, 722-P: Tirzepatide Improves Multiple Aspects of Beta-Cell Function

Meeting Abstracts

714-P: Greater Improvement in Insulin Sensitivity Per Unit Weight Loss with Tirzepatide Compared with Selective GLP-1 Receptor Agonism

KIEREN J. MATHER, ANDREA MARI, JING LI, TIM HEISE, J. HANS DE VRIES, SHWETA URVA, TAMER COSKUN, ZVONKO MILICEVIC, AXEL HAUPT, MELISSA K. THOMAS

Diabetes 2022;71(Supplement_1):714-P

https://doi.org/10.2337/db22-714-P

Published: 01 June 2022

View article titled, 714-P: Greater Improvement in Insulin Sensitivity Per Unit Weight Loss with Tirzepatide Compared with Selective GLP-1 Receptor Agonism

Meeting Abstracts

261-OR: Dorzagliatin, a Dual-Acting Glucokinase Activator. Improves Insulin Secretion and Glucose Sensitivity in Glucokinase-Maturity-Onset Diabetes of the Young (GCK-MODY)

ELAINE CHOW, KE WANG, CADMON K.P. LIM, SANDRA TSOI, BAOQI FAN, ANDREA LUK, RONALD C. MA, ELE FERRANNINI, ANDREA MARI, LI CHEN, JULIANA C. CHAN

Diabetes 2022;71(Supplement_1):261-OR

https://doi.org/10.2337/db22-261-OR

Published: 01 June 2022

View article titled, 261-OR: Dorzagliatin, a Dual-Acting Glucokinase Activator. Improves Insulin Secretion and Glucose Sensitivity in Glucokinase-Maturity-Onset Diabetes of the Young (GCK-MODY)

Journal Articles

Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study

Andrea Tura, Eleonora Grespan, Christian S. Göbl, Robert W. Koivula, Paul W. Franks, Ewan R. Pearson, Mark Walker, Ian M. Forgie, Giuseppe N. Giordano, Imre Pavo, Hartmut Ruetten, Emmanouil T. Dermitzakis, Mark I. McCarthy, Oluf Pedersen, Jochen M. Schwenk, Jerzy Adamski, Federico De Masi, Konstantinos D. Tsirigos, Søren Brunak, Ana Viñuela, Anubha Mahajan, Timothy J. McDonald, Tarja Kokkola, Jagadish Vangipurapu, Henna Cederberg, Markku Laakso, Femke Rutters, Petra J.M. Elders, Anitra D.M. Koopman, Joline W. Beulens, Martin Ridderstråle, Tue H. Hansen, Kristine H. Allin, Torben Hansen, Henrik Vestergaard, Andrea Mari, IMI DIRECT Consortium, Leen M. 't Hart, Moustafa Abdalla, Jonathan Adam, Jerzy Adamski, Kofi Adragni, Rosa L. Allesøe, Kristine H. Allin, Manimozhiyan Arumugam, Naeimeh Atabaki Pasdar, Tania Baltauss, Karina Banasik, Patrick Baum, Jimmy D. Bell, Margit Bergstrom, Joline W. Beulens, Susaana Bianzano, Roberto Bizzotto, Amelie Bonneford, Caroline Anna Brorsson, Andrew A. Brown, Søren Brunak, Louise Cabrelli, Robert Caiazzo, Mickael Canouil, Henna Cederberg, Matilda Dale, David Davtian, Adem Y. Dawed, Federico De Masi, Nathalie de Preville, Koen F. Dekkers, Emmanouil T. Dermitzakis, Harshal A. Deshmukh, Christiane Dings, Louise Donnelly, Avirup Dutta, Beate Ehrhardt, Petra J. M. Elders, Line Engelbrechtsen, Rebeca Eriksen, Yong Fan, Juan Fernandez, Jorge Ferrer, Hugo Fitipaldi, Ian M. Forgie, Annemette Forman, Paul W. Franks, Francesca Frau, Andreas Fritsche, Philippe Froguel, Gary Frost, Johann Gassenhuber, Giuseppe N. Giordano, Toni Giorgino, Stephen Gough, Ulrike Graefe-Mody, Harald Grallert, Rolf Grempler, Lenka Groeneveld, Leif Groop, Valborg Gudmundsdóttir, Ramneek Gupta, Mark Haid, Torben Hansen, Tue H. Hansen, Andrew T. Hattersley, Ragna Haussler, Alison J. Heggie, Anita M. Hennige, Anita V. Hill, Reinhard W. Holl, Mun-gwan Hong, Michelle Hudson, Bernd Jablonka, Christopher Jennison, Yunlong Jiao, Joachim Johansen, Angus G. Jones, Anna Jonsson, Tugce Karaderi, Jane Kaye, Maria Klintenberg, Robert W. Koivula, Tarja Kokkola, Anitra D. M. Koopman, Azra Kurbasic, Teemu Kuulasmaa, Markku Laakso, Thorsten Lehr, Heather Loftus, Agnete T. Lundgaard, Anubha Mahajan, Andrea Mari, Gianluca Mazzoni, Mark I. McCarthy, Timothy J. McDonald, Donna McEvoy, Nicky McRobert, Ian McVittie, Miranda Mourby, Petra Musholt, Pascal Mutie, Rachel Nice, Claudia Nicolay, Agnes Martine Nielsen, Birgitte Nilsson, Giel Nijpels, Colin N. Palmer, Francois Pattou, Imre Pavo, Ewan R. Pearson, Oluf Pedersen, Helle K. Pedersen, Mandy H. Perry, Hugo Pomares-Millan, Anna Ramisch, Simon Rasmussen, Violeta Raverdi, Martin Ridderstråle, Neil Robertson, Slieker Roderick, Marianne Rodriquez, Hartmut Ruetten, Femke Rutters, Peter Sackett, Nina Scherer, Jochen M. Schwenk, Nisha Shah, Sapna Sharma, Iryna Sihinevich, Nadja B. Sondertoft, Hans-Henrik Staerfeldt, Birgit Steckel-Hamann, Harriet Teare, Cecilia Engel Thomas, Melissa K. Thomas, Louise Thomas, Henrik S. Thomsen, Barbara Thorand, Claire E. Thorne, Joachim Tillner, Martina Troll, Konstantinos D. Tsirigos, Andrea Tura, Mathias Uhlen, Jagadish Vangipurapu, Nienke van Leeuwen, Sabine van Oort, Helene Verkindt, Henrik Vestergaard, Ana Viñuela, Josef K. Vogt, Peter Wad Sackett, Dianne Wake, Mark Walker, Agata Wesolowska-Andersen, Brandon Whitcher, Margaret W. White, Han Wu

Diabetes 2021;70(9):2092–2106

https://doi.org/10.2337/db21-0227

Published: 07 July 2021

View article titled, Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study

Meeting Abstracts

1186-P: Mechanisms of Glucose Intolerance Induced by Excess Triglycerides and Free Fatty Acids

DOMENICO TRICO, BRENNO D. ASTIARRAGA, MARTA SEGHIERI, ALESSANDRO MENGOZZI, SIMONA BALDI, ANDREA MARI, ANDREA NATALI

Diabetes 2021;70(Supplement_1):1186-P

https://doi.org/10.2337/db21-1186-P

Published: 01 June 2021

View article titled, 1186-P: Mechanisms of Glucose Intolerance Induced by Excess Triglycerides and Free Fatty Acids

Meeting Abstracts

290-OR: Altered In-Situ Expression of Proinsulin-Insulin in Pancreatic Islets Reflects Metabolic and Molecular Defects in Type 2 Diabetic and Glucose-Intolerant Living Donors

NOEMI BRUSCO, GUIDO SEBASTIANI, GIADA LICATA, GIUSEPPINA E. GRIECO, GIANFRANCO DI GIUSEPPE, LAURA NIGI, DANIELA FIGNANI, SIMONA MOFFA, FRANCESCA CINTI, CHIARA MARIA ASSUNTA CEFALO, UMBERTO CAPECE, FLAVIA IMPRONTA, ANDREA MARI, FRANCESCO DOTTA, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2021;70(Supplement_1):290-OR

https://doi.org/10.2337/db21-290-OR

Published: 01 June 2021

View article titled, 290-OR: Altered In-Situ Expression of Proinsulin-Insulin in Pancreatic Islets Reflects Metabolic and Molecular Defects in Type 2 Diabetic and Glucose-Intolerant Living Donors

Meeting Abstracts

1851-P: Renal Denervation Attenuates Endogenous Glucose Production Increase with SGLT2 Inhibition in Patients with Renal Transplant Recipients and Impaired Fasting Glucose

GIUSEPPE DANIELE, CAROLINA SOLIS-HERRERA, ANGELA DARDANO, ANDREA MARI, ANDREA TURA, LAURA GIUSTI, JANCY J. KURUMTHODATHU, ALEX A.G. BROCCHI, BEATRICE CAMPI, ALESSANDRO SABA, ANNA MARIA BIANCHI, CARLA TREGNAGHI, MARIA FRANCESCA EGIDI, MUHAMMAD ABDUL-GHANI, RALPH A. DEFRONZO, STEFANO DELPRATO

Diabetes 2020;69(Supplement_1):1851-P

https://doi.org/10.2337/db20-1851-P

Published: 01 June 2020

View article titled, 1851-P: Renal Denervation Attenuates Endogenous Glucose Production Increase with SGLT2 Inhibition in Patients with Renal Transplant Recipients and Impaired Fasting Glucose

Meeting Abstracts

1795-P: Proinsulin-Insulin Pancreatic Islets In-situ Expression Mirrors Metabolic Defects Observed in Type 2 Diabetic and Glucose Intolerant Living Donors

NOEMI BRUSCO, GUIDO SEBASTIANI, GIADA LICATA, GIUSEPPINA E. GRIECO, LAURA NIGI, DANIELA FIGNANI, SIMONA MOFFA, GIAN PIO SORICE, GIANFRANCO DI GIUSEPPE, CHIARA MARIA ASSUNTA CEFALO, JR., ANDREA MARI, FRANCESCO DOTTA, ANDREA GIACCARI, TERESA MEZZA

Diabetes 2020;69(Supplement_1):1795-P

https://doi.org/10.2337/db20-1795-P

Published: 01 June 2020

View article titled, 1795-P: Proinsulin-Insulin Pancreatic Islets In-situ Expression Mirrors Metabolic Defects Observed in Type 2 Diabetic and Glucose Intolerant Living Donors

Meeting Abstracts

1780-P: Differential Effects of Medications and Gastric Banding on OGTT-Modeled Measures of ß-Cell Function in Adults with IGT or Recent-Onset Type 2 Diabetes (T2D)

KRISTINA UTZSCHNEIDER, LAURE EL GHORMLI, SUSAN SAM, DAVID A. EHRMANN, KIEREN J. MATHER, ELENA BARENGOLTS, TAMARA S. HANNON, MARK TRIPPUTI, SHARON EDELSTEIN, ANDREA MARI, THE RISE CONSORTIUM

Diabetes 2020;69(Supplement_1):1780-P

https://doi.org/10.2337/db20-1780-P

Published: 01 June 2020

View article titled, 1780-P: Differential Effects of Medications and Gastric Banding on OGTT-Modeled Measures of ß-Cell Function in Adults with IGT or Recent-Onset Type 2 Diabetes (T2D)

Meeting Abstracts

2295-PUB: Impaired First-Phase Insulin Secretion Predicts the Development of Hyperglycemia in a Human Model of Acute Beta-Cell Mass Reduction

TERESA MEZZA, PIETRO MANUEL FERRARO, GIANFRANCO DI GIUSEPPE, CHIARA MARIA ASSUNTA CEFALO, JR., SIMONA MOFFA, GIUSEPPE QUERO, FRANCESCA CINTI, FLAVIA IMPRONTA, UMBERTO CAPECE, SERGIO ALFIERI, ANDREA MARI, ANDREA GIACCARI

Diabetes 2020;69(Supplement_1):2295-PUB

https://doi.org/10.2337/db20-2295-PUB

Published: 01 June 2020

View article titled, 2295-PUB: Impaired First-Phase Insulin Secretion Predicts the Development of Hyperglycemia in a Human Model of Acute Beta-Cell Mass Reduction

Meeting Abstracts

1261-P: OGTT Model–Derived ß-Cell Function Reveals Differential Loss in Youth vs. Adults during and following Treatment Withdrawal in the Restoring Insulin Secretion (RISE) Study

KRISTINA UTZSCHNEIDER, MARK TRIPPUTI, MELANIE CREE-GREEN, TAMARA S. HANNON, KRISTEN J. NADEAU, ELENA BARENGOLTS, JERRY P. PALMER, KIEREN J. MATHER, SONIA CAPRIO, SHARON EDELSTEIN, ANDREA MARI, THE RISE CONSORTIUM

Diabetes 2020;69(Supplement_1):1261-P

https://doi.org/10.2337/db20-1261-P

Published: 01 June 2020

View article titled, 1261-P: OGTT Model–Derived ß-Cell Function Reveals Differential Loss in Youth vs. Adults during and following Treatment Withdrawal in the Restoring Insulin Secretion (RISE) Study

Meeting Abstracts

134-OR: Effects of PCSK9 Inhibitors on Glucose Metabolism and ß-Cell Function in Humans

SIMONA MOFFA, TERESA MEZZA, CHIARA MARIA ASSUNTA CEFALO, JR., FRANCESCA CINTI, GIAN PIO SORICE, FLAVIA IMPRONTA, UMBERTO CAPECE, ANDREA MARI, ANDREA GIACCARI

Diabetes 2020;69(Supplement_1):134-OR

https://doi.org/10.2337/db20-134-OR

Published: 01 June 2020

View article titled, 134-OR: Effects of PCSK9 Inhibitors on Glucose Metabolism and ß-Cell Function in Humans

Meeting Abstracts

173-OR: Effects of Mild Acute Hypertriglyceridemia on Fasting and Post-Load Glucose Homeostasis

DOMENICO TRICO, ALESSANDRO MENGOZZI, MARTA SEGHIERI, ANDREA MARI, ANDREA NATALI

Diabetes 2019;68(Supplement_1):173-OR

https://doi.org/10.2337/db19-173-OR

Published: 01 June 2019

View article titled, 173-OR: Effects of Mild Acute Hypertriglyceridemia on Fasting and Post-Load Glucose Homeostasis

NARROW

1559-P: Heterogeneity of Trajectories of Metabolic Parameters after 50% Beta-Cell Mass Loss by Pancreatectomy

1555-P: Effects of 80% Pancreas Reduction on Beta-Cell Function and Glucose Metabolism

β-Cell Glucose Sensitivity to Assess Changes in β-Cell Function in Recent-Onset Stage 3 Type 1 Diabetes

234-OR: Succinate Potentiates Insulin Secretion through SUCNR1

1754-P: Reduced Incretin Effect Predicts Diabetes Appearance in a Cohort of Nondiabetic Subjects after Acute Beta-Cell Mass Reduction

376-OR: Chronic Pancreatitis Does Not Induce Specific Alterations in Beta-Cell Function

Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes

722-P: Tirzepatide Improves Multiple Aspects of Beta-Cell Function

714-P: Greater Improvement in Insulin Sensitivity Per Unit Weight Loss with Tirzepatide Compared with Selective GLP-1 Receptor Agonism

261-OR: Dorzagliatin, a Dual-Acting Glucokinase Activator. Improves Insulin Secretion and Glucose Sensitivity in Glucokinase-Maturity-Onset Diabetes of the Young (GCK-MODY)

Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study

1186-P: Mechanisms of Glucose Intolerance Induced by Excess Triglycerides and Free Fatty Acids

290-OR: Altered In-Situ Expression of Proinsulin-Insulin in Pancreatic Islets Reflects Metabolic and Molecular Defects in Type 2 Diabetic and Glucose-Intolerant Living Donors

1851-P: Renal Denervation Attenuates Endogenous Glucose Production Increase with SGLT2 Inhibition in Patients with Renal Transplant Recipients and Impaired Fasting Glucose

1795-P: Proinsulin-Insulin Pancreatic Islets In-situ Expression Mirrors Metabolic Defects Observed in Type 2 Diabetic and Glucose Intolerant Living Donors

1780-P: Differential Effects of Medications and Gastric Banding on OGTT-Modeled Measures of ß-Cell Function in Adults with IGT or Recent-Onset Type 2 Diabetes (T2D)

2295-PUB: Impaired First-Phase Insulin Secretion Predicts the Development of Hyperglycemia in a Human Model of Acute Beta-Cell Mass Reduction

1261-P: OGTT Model–Derived ß-Cell Function Reveals Differential Loss in Youth vs. Adults during and following Treatment Withdrawal in the Restoring Insulin Secretion (RISE) Study

134-OR: Effects of PCSK9 Inhibitors on Glucose Metabolism and ß-Cell Function in Humans

173-OR: Effects of Mild Acute Hypertriglyceridemia on Fasting and Post-Load Glucose Homeostasis

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