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Meeting Abstracts

1795-P: RIPK1 Mediates Nucleic Acid Sensor Expression and IFNγ+dsRNA-Induced β-Cell Death

RENATO C.S. BRANCO, CHRISTOPHER J. CONTRERAS, NOYONIKA MUKHERJEE, EGAN MATHER, LI LIN, KAITLYN A. COLGLAZIER, ERICA P. CAI, ANDREW T. TEMPLIN

Diabetes 2025;74(Supplement_1):1795-P

https://doi.org/10.2337/db25-1795-P

Published: 20 June 2025

View articletitled, 1795-P: RIPK1 Mediates Nucleic Acid Sensor Expression and IFNγ+dsRNA-Induced β-Cell Death

Meeting Abstracts

82-OR: RIPK1 Kinase Activity Regulates Cytokine-Induced β-Cell Cytotoxicity

CHRISTOPHER J. CONTRERAS, NOYONIKA MUKHERJEE, KAITLYN A. COLGLAZIER, EGAN MATHER, RENATO C. BRANCO, ERICA P. CAI, ANDREW T. TEMPLIN

Diabetes 2025;74(Supplement_1):82-OR

https://doi.org/10.2337/db25-82-OR

Published: 20 June 2025

View articletitled, 82-OR: RIPK1 Kinase Activity Regulates Cytokine-Induced β-Cell Cytotoxicity

Meeting Abstracts

1724-P: Caspase 3/7 Activation and RIPK3 Are Dispensable for Synthetic hIAPP-Induced ß-Cell Death

NOYONIKA MUKHERJEE, CHRISTOPHER J. CONTRERAS, LI LIN, ERICA P. CAI, STEVEN E. KAHN, ANDREW T. TEMPLIN

Diabetes 2023;72(Supplement_1):1724-P

https://doi.org/10.2337/db23-1724-P

Published: 20 June 2023

View articletitled, 1724-P: Caspase 3/7 Activation and RIPK3 Are Dispensable for Synthetic hIAPP-Induced ß-Cell Death

Meeting Abstracts

1722-P: RIPK1 Promotes Thapsigargin-Induced ß-Cell Death Independent of Caspase 3/7 Activity In Vitro

NOYONIKA MUKHERJEE, CHRISTOPHER J. CONTRERAS, LI LIN, ERICA P. CAI, ANDREW T. TEMPLIN

Diabetes 2023;72(Supplement_1):1722-P

https://doi.org/10.2337/db23-1722-P

Published: 20 June 2023

View articletitled, 1722-P: RIPK1 Promotes Thapsigargin-Induced ß-Cell Death Independent of Caspase 3/7 Activity In Vitro

Meeting Abstracts

1238-P: The Proinflammatory but Not Cytotoxic Effect of Aggregated IAPP on Islet Endothelial Cells Requires TLR2/4 Signaling

JOSEPH J. CASTILLO, ALFRED APLIN, MEGHAN F. HOGAN, ANDREW T. TEMPLIN, NATHALIE ESSER, REHANA AKTER, REBECCA L. HULL

Diabetes 2021;70(Supplement_1):1238-P

https://doi.org/10.2337/db21-1238-P

Published: 01 June 2021

View articletitled, 1238-P: The Proinflammatory but Not Cytotoxic Effect of Aggregated IAPP on Islet Endothelial Cells Requires TLR2/4 Signaling

Meeting Abstracts

130-OR: Statin Exposure Increases Star (Steroidogenic Acute Regulatory Protein) Expression in Islets: A Novel Mechanism for ß-Cell Dysfunction and Increased Diabetes Risk?

MEGHAN F. HOGAN, NATHALIE ESSER, ANDREW T. TEMPLIN, JOSEPH J. CASTILLO, REHANA AKTER, REBECCA L. HULL, STEVEN E. KAHN, SAKENEH ZRAIKA

Diabetes 2021;70(Supplement_1):130-OR

https://doi.org/10.2337/db21-130-OR

Published: 01 June 2021

View articletitled, 130-OR: Statin Exposure Increases Star (Steroidogenic Acute Regulatory Protein) Expression in Islets: A Novel Mechanism for ß-Cell Dysfunction and Increased Diabetes Risk?

Meeting Abstracts

294-OR: RIPK3-Mediated Necroptosis Is an Alternative Form of TNFa-Induced ß-Cell Death

CHRISTOPHER J. CONTRERAS, LI LIN, MEGHAN F. HOGAN, ANDREW OBERST, STEVEN E. KAHN, ANDREW T. TEMPLIN

Diabetes 2021;70(Supplement_1):294-OR

https://doi.org/10.2337/db21-294-OR

Published: 01 June 2021

View articletitled, 294-OR: RIPK3-Mediated Necroptosis Is an Alternative Form of TNFa-Induced ß-Cell Death

Meeting Abstracts

2043-P: Hyaluronan Produced by Inflamed Islet Endothelial Cells Contributes to HIAPP Aggregation

JOSEPH J. CASTILLO, MEGHAN F. HOGAN, ALFRED APLIN, NATHALIE ESSER, ANDREW T. TEMPLIN, REBECCA L. HULL

Diabetes 2020;69(Supplement_1):2043-P

https://doi.org/10.2337/db20-2043-P

Published: 01 June 2020

View articletitled, 2043-P: Hyaluronan Produced by Inflamed Islet Endothelial Cells Contributes to HIAPP Aggregation

Meeting Abstracts

2039-P: Plasmin-Mediated Cleavage of Human Islet Amyloid Polypeptide (hIAPP) Protects ß-Cells from Amyloid-Induced Toxicity

NATHALIE ESSER, MEGHAN F. HOGAN, ANDREW T. TEMPLIN, JOSEPH J. CASTILLO, DANIEL RALEIGH, JOHN S. EDGAR, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN

Diabetes 2020;69(Supplement_1):2039-P

https://doi.org/10.2337/db20-2039-P

Published: 01 June 2020

View articletitled, 2039-P: Plasmin-Mediated Cleavage of Human Islet Amyloid Polypeptide (hIAPP) Protects ß-Cells from Amyloid-Induced Toxicity

Meeting Abstracts

2042-P: Loss of Apoptosis Repressor with Caspase Recruitment Domain Promotes High-Fat Diet Induced Hyperglycemia In Vivo

ANDREW T. TEMPLIN, CHRISTINE R. SCHMIDT, MEGHAN F. HOGAN, NATHALIE ESSER, RICHARD N. KITSIS, REBECCA L. HULL, SAKENEH ZRAIKA, STEVEN E. KAHN

Diabetes 2020;69(Supplement_1):2042-P

https://doi.org/10.2337/db20-2042-P

Published: 01 June 2020

View articletitled, 2042-P: Loss of Apoptosis Repressor with Caspase Recruitment Domain Promotes High-Fat Diet Induced Hyperglycemia In Vivo

Meeting Abstracts

2040-P: Chronic Activation of CREB by Islet Amyloid Increases Star (Steroidogenic Acute Regulatory Protein) Expression in Islets

MEGHAN F. HOGAN, NATHALIE ESSER, ANDREW T. TEMPLIN, JOSEPH J. CASTILLO, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN

Diabetes 2020;69(Supplement_1):2040-P

https://doi.org/10.2337/db20-2040-P

Published: 01 June 2020

View articletitled, 2040-P: Chronic Activation of CREB by Islet Amyloid Increases Star (Steroidogenic Acute Regulatory Protein) Expression in Islets

Meeting Abstracts

2126-P: Physiological Concentrations of IL-1 Beta Promote Islet Amyloid Deposition by Increasing Beta-Cell Secretion of Human Islet Amyloid Polypeptide

ANDREW T. TEMPLIN, MAHNAZ MELLATI, DANIEL ZEMAN-MEIER, MEGHAN F. HOGAN, NATHALIE ESSER, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN

Diabetes 2019;68(Supplement_1):2126-P

https://doi.org/10.2337/db19-2126-P

Published: 01 June 2019

View articletitled, 2126-P: Physiological Concentrations of IL-1 Beta Promote Islet Amyloid Deposition by Increasing Beta-Cell Secretion of Human Islet Amyloid Polypeptide

Meeting Abstracts

2125-P: Increased StAR (Steroidogenic Acute Regulatory Protein) Is Detrimental to ß Cells and Promotes Mitochondrial Dysfunction

MEGHAN F. HOGAN, NATHALIE ESSER, ANDREW T. TEMPLIN, SAKENEH ZRAIKA, REBECCA L. HULL, SAM EL-OSTA, STEVEN E. KAHN

Diabetes 2019;68(Supplement_1):2125-P

https://doi.org/10.2337/db19-2125-P

Published: 01 June 2019

View articletitled, 2125-P: Increased StAR (Steroidogenic Acute Regulatory Protein) Is Detrimental to ß Cells and Promotes Mitochondrial Dysfunction

Meeting Abstracts

2124-P: The Tissue Plasminogen Activator (tPA)/Plasmin System Reduces Amyloid Formation by Cleaving Human Islet Amyloid Polypeptide (hIAPP)

NATHALIE ESSER, MEGHAN F. HOGAN, ALFRED APLIN, ANDREW T. TEMPLIN, SAM EL-OSTA, DANIEL RALEIGH, JOHN S. EDGAR, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN

Diabetes 2019;68(Supplement_1):2124-P

https://doi.org/10.2337/db19-2124-P

Published: 01 June 2019

View articletitled, 2124-P: The Tissue Plasminogen Activator (tPA)/Plasmin System Reduces Amyloid Formation by Cleaving Human Islet Amyloid Polypeptide (hIAPP)

Meeting Abstracts

Tissue Plasminogen Activator (tPA) Expression Is Increased by Islet Amyloid Formation In Vitro

NATHALIE ESSER, MEGHAN F. HOGAN, ANDREW T. TEMPLIN, MARK ZIEMANN, ASSAM EL-OSTA, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN

Diabetes 2018;67(Supplement_1):2107-P

https://doi.org/10.2337/db18-2107-P

Published: 01 July 2018

View articletitled, Tissue Plasminogen Activator (tPA) Expression Is Increased by Islet Amyloid Formation In Vitro

Meeting Abstracts

Evidence for Necroptosis as a Mechanism of Islet Amyloid–Induced Beta-Cell Death

ANDREW T. TEMPLIN, MEGHAN F. HOGAN, NATHALIE ESSER, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN

Diabetes 2018;67(Supplement_1):82-OR

https://doi.org/10.2337/db18-82-OR

Published: 01 July 2018

View articletitled, Evidence for Necroptosis as a Mechanism of Islet Amyloid–Induced Beta-Cell Death

Journal Articles

Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation

Andrew T. Templin, Tanya Samarasekera, Daniel T. Meier, Meghan F. Hogan, Mahnaz Mellati, Michael T. Crow, Richard N. Kitsis, Sakeneh Zraika, Rebecca L. Hull, Steven E. Kahn

Diabetes 2017;66(10):2636–2645

https://doi.org/10.2337/db16-1352

Published: 20 July 2017

View articletitled, Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation

Journal Articles

Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β-Cells via Activation of the Mammalian Target of Rapamycin Pathway

Masayuki Hatanaka, Bernhard Maier, Emily K. Sims, Andrew T. Templin, Rohit N. Kulkarni, Carmella Evans-Molina, Raghavendra G. Mirmira

Diabetes 2014;63(10):3404–3415

https://doi.org/10.2337/db14-0105

Published: 15 September 2014

View articletitled, Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β-Cells via Activation of the Mammalian Target of Rapamycin Pathway

Includes: Supplementary data

Journal Articles

Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

Sarah A. Tersey, Yurika Nishiki, Andrew T. Templin, Susanne M. Cabrera, Natalie D. Stull, Stephanie C. Colvin, Carmella Evans-Molina, Jenna L. Rickus, Bernhard Maier, Raghavendra G. Mirmira

Diabetes 2012;61(4):818–827

https://doi.org/10.2337/db11-1293

Published: 14 March 2012

View articletitled, Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

Includes: Supplementary data

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1795-P: RIPK1 Mediates Nucleic Acid Sensor Expression and IFNγ+dsRNA-Induced β-Cell Death

82-OR: RIPK1 Kinase Activity Regulates Cytokine-Induced β-Cell Cytotoxicity

1724-P: Caspase 3/7 Activation and RIPK3 Are Dispensable for Synthetic hIAPP-Induced ß-Cell Death

1722-P: RIPK1 Promotes Thapsigargin-Induced ß-Cell Death Independent of Caspase 3/7 Activity In Vitro

1238-P: The Proinflammatory but Not Cytotoxic Effect of Aggregated IAPP on Islet Endothelial Cells Requires TLR2/4 Signaling

130-OR: Statin Exposure Increases Star (Steroidogenic Acute Regulatory Protein) Expression in Islets: A Novel Mechanism for ß-Cell Dysfunction and Increased Diabetes Risk?

294-OR: RIPK3-Mediated Necroptosis Is an Alternative Form of TNFa-Induced ß-Cell Death

2043-P: Hyaluronan Produced by Inflamed Islet Endothelial Cells Contributes to HIAPP Aggregation

2039-P: Plasmin-Mediated Cleavage of Human Islet Amyloid Polypeptide (hIAPP) Protects ß-Cells from Amyloid-Induced Toxicity

2042-P: Loss of Apoptosis Repressor with Caspase Recruitment Domain Promotes High-Fat Diet Induced Hyperglycemia In Vivo

2040-P: Chronic Activation of CREB by Islet Amyloid Increases Star (Steroidogenic Acute Regulatory Protein) Expression in Islets

2126-P: Physiological Concentrations of IL-1 Beta Promote Islet Amyloid Deposition by Increasing Beta-Cell Secretion of Human Islet Amyloid Polypeptide

2125-P: Increased StAR (Steroidogenic Acute Regulatory Protein) Is Detrimental to ß Cells and Promotes Mitochondrial Dysfunction

2124-P: The Tissue Plasminogen Activator (tPA)/Plasmin System Reduces Amyloid Formation by Cleaving Human Islet Amyloid Polypeptide (hIAPP)

Tissue Plasminogen Activator (tPA) Expression Is Increased by Islet Amyloid Formation In Vitro

Evidence for Necroptosis as a Mechanism of Islet Amyloid–Induced Beta-Cell Death

Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation

Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β-Cells via Activation of the Mammalian Target of Rapamycin Pathway

Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

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