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Journal Articles

Genetic Variations in GCKR and PNPLA3 Regulate Metabolic Balance Across the Liver

Available to Purchase
Yunyun Ma, Shiqi Zuo, Therlinder Lo, David Phan, Tyler Finley, Adrienne Mackay, Enrique Trigo, Jaana A. Hartiala, Hooman Allayee, Anny H. Xiang, Thomas A. Buchanan, Richard M. Watanabe
Journal: Diabetes
Diabetes 2025;74(7):1300–1309
https://doi.org/10.2337/db24-0923
Published: 24 April 2025
View articletitled, Genetic Variations in GCKR and PNPLA3 Regulate Metabolic Balance Across the Liver
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Journal Articles

What Is Gestational Diabetes—Really?

Free
Thomas A. Buchanan, Anny H. Xiang, Kathleen A. Page, Richard M. Watanabe
Journal: Diabetes
Diabetes 2025;74(7):1037–1046
https://doi.org/10.2337/dbi24-0041
Published: 08 April 2025
View articletitled, What Is Gestational Diabetes—Really?
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Journal Articles

Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on β-Cell Function: Comparison of Responses In Youth And Adults

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RISE Consortium Investigators, David A. Ehrmann, Karla A. Temple, Abby Rue, Elena Barengolts, Babak Mokhlesi, Eve Van Cauter, Susan Sam, M. Annette Miller, Steven E. Kahn, Karen M. Atkinson, Jerry P. Palmer, Kristina M. Utzschneider, Tsige Gebremedhin, Abigail Kernan-Schloss, Alexandra Kozedub, Brenda K. Montgomery, Emily J. Morse, Kieren J. Mather, Tammy Garrett, Tamara S. Hannon, Amale Lteif, Aniket Patel, Robin Chisholm, Karen Moore, Vivian Pirics, Linda Pratt, Kristen J. Nadeau, Susan Gross, Philip S. Zeitler, Jayne Williams, Melanie Cree-Green, Yesenia Garcia Reyes, Krista Vissat, Silva A. Arslanian, Kathleen Brown, Nancy Guerra, Kristin Porter, Sonia Caprio, Mary Savoye, Bridget Pierpont, Thomas A. Buchanan, Anny H. Xiang, Enrique Trigo, Elizabeth Beale, Ting Chow, Fadi N. Hendee, Namir Katkhouda, Krishan Nayak, Mayra Martinez, Cortney Montgomery, Xinhui Wang, Jun Wu, Sharon L. Edelstein, John M. Lachin, Ashley Hogan Tjaden, Mark T. Tripputi, Santica Marcovina, Jessica Harting, John Albers, Dave Hill, Peter J. Savage, Ellen W. Leschek
Journal: Diabetes
Diabetes 2019;68(8):1670–1680
https://doi.org/10.2337/db19-0299
Published: 09 June 2019
View articletitled, Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on β-Cell Function: Comparison of Responses In Youth And Adults
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Includes: Supplementary data
Journal Articles

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

Free
Andrew R. Wood, Anna Jonsson, Anne U. Jackson, Nan Wang, Nienke van Leewen, Nicholette D. Palmer, Sayuko Kobes, Joris Deelen, Lorena Boquete-Vilarino, Jussi Paananen, Alena Stančáková, Dorret I. Boomsma, Eco J.C. de Geus, Elisabeth M.W. Eekhoff, Andreas Fritsche, Mark Kramer, Giel Nijpels, Annemarie Simonis-Bik, Timon W. van Haeften, Anubha Mahajan, Michael Boehnke, Richard N. Bergman, Jaakko Tuomilehto, Francis S. Collins, Karen L. Mohlke, Karina Banasik, Christopher J. Groves, Mark I. McCarthy, Diabetes Research on Patient Stratification (DIRECT), Ewan R. Pearson, Andrea Natali, Andrea Mari, Thomas A. Buchanan, Kent D. Taylor, Anny H. Xiang, Anette P. Gjesing, Niels Grarup, Hans Eiberg, Oluf Pedersen, Yii-Derr Chen, Markku Laakso, Jill M. Norris, Ulf Smith, Lynne E. Wagenknecht, Leslie Baier, Donald W. Bowden, Torben Hansen, Mark Walker, Richard M. Watanabe, Leen M. ‘t Hart, Robert L. Hanson, Timothy M. Frayling
Journal: Diabetes
Diabetes 2017;66(8):2296–2309
https://doi.org/10.2337/db16-1452
Published: 10 May 2017
View articletitled, A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants
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Includes: Supplementary data
Journal Articles

Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium

Free
Nicholette D. Palmer, Lynne E. Wagenknecht, Carl D. Langefeld, Nan Wang, Thomas A. Buchanan, Anny H. Xiang, Hooman Allayee, Richard N. Bergman, Leslie J. Raffel, Yii-Der Ida Chen, Talin Haritunians, Tasha Fingerlin, Mark O. Goodarzi, Kent D. Taylor, Jerome I. Rotter, Richard M. Watanabe, Donald W. Bowden
Journal: Diabetes
Diabetes 2016;65(7):2072–2080
https://doi.org/10.2337/db15-1543
Published: 03 May 2016
View articletitled, Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium
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Includes: Supplementary data
Journal Articles

Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium

Free
Nicholette D. Palmer, Mark O. Goodarzi, Carl D. Langefeld, Nan Wang, Xiuqing Guo, Kent D. Taylor, Tasha E. Fingerlin, Jill M. Norris, Thomas A. Buchanan, Anny H. Xiang, Talin Haritunians, Julie T. Ziegler, Adrienne H. Williams, Darko Stefanovski, Jinrui Cui, Adrienne W. Mackay, Leora F. Henkin, Richard N. Bergman, Xiaoyi Gao, James Gauderman, Rohit Varma, Craig L. Hanis, Nancy J. Cox, Heather M. Highland, Jennifer E. Below, Amy L. Williams, Noel P. Burtt, Carlos A. Aguilar-Salinas, Alicia Huerta-Chagoya, Clicerio Gonzalez-Villalpando, Lorena Orozco, Christopher A. Haiman, Michael Y. Tsai, W. Craig Johnson, Jie Yao, Laura Rasmussen-Torvik, James Pankow, Beverly Snively, Rebecca D. Jackson, Simin Liu, Jerry L. Nadler, Fouad Kandeel, Yii-Der I. Chen, Donald W. Bowden, Stephen S. Rich, Leslie J. Raffel, Jerome I. Rotter, Richard M. Watanabe, Lynne E. Wagenknecht
Journal: Diabetes
Diabetes 2015;64(5):1853–1866
https://doi.org/10.2337/db14-0732
Published: 18 December 2014
View articletitled, Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium
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Includes: Supplementary data
Journal Articles

Detailed Physiological Characterization of the Development of Type 2 Diabetes in Hispanic Women With Prior Gestational Diabetes Mellitus

Open Access
Anny H. Xiang, Siri L. Kjos, Miwa Takayanagi, Enrique Trigo, Thomas A. Buchanan
Journal: Diabetes
Diabetes 2010;59(10):2625–2630
https://doi.org/10.2337/db10-0521
Published: 03 August 2010
View articletitled, Detailed Physiological Characterization of the Development of Type 2 Diabetes in Hispanic Women With Prior Gestational Diabetes Mellitus
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Journal Articles

Additive Effects of Genetic Variation in GCK and G6PC2 on Insulin Secretion and Fasting Glucose

Open Access
Xia Li, Yu-Hsiang Shu, Anny H. Xiang, Enrique Trigo, Johanna Kuusisto, Jaana Hartiala, Amy J. Swift, Miwa Kawakubo, Heather M. Stringham, Lori L. Bonnycastle, Jean M. Lawrence, Markku Laakso, Hooman Allayee, Thomas A. Buchanan, Richard M. Watanabe
Journal: Diabetes
Diabetes 2009;58(12):2946–2953
https://doi.org/10.2337/db09-0228
Published: 09 September 2009
View articletitled, Additive Effects of Genetic Variation in GCK and G6PC2 on Insulin Secretion and Fasting Glucose
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Journal Articles

Evidence of Interaction Between PPARG2 and HNF4A Contributing to Variation in Insulin Sensitivity in Mexican Americans

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Mary Helen Black, Tasha E. Fingerlin, Hooman Allayee, Weiming Zhang, Anny H. Xiang, Enrique Trigo, Jaana Hartiala, Allison B. Lehtinen, Steven M. Haffner, Richard N. Bergman, Richard C. McEachin, Siri L. Kjos, Jean M. Lawrence, Thomas A. Buchanan, Richard M. Watanabe
Journal: Diabetes
Diabetes 2008;57(4):1048–1056
https://doi.org/10.2337/db07-0848
Published: 01 April 2008
View articletitled, Evidence of Interaction Between PPARG2 and HNF4A Contributing to Variation in Insulin Sensitivity in Mexican Americans
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Includes: Supplementary data
Journal Articles

Transcription Factor 7-Like 2 (TCF7L2) Is Associated With Gestational Diabetes Mellitus and Interacts With Adiposity to Alter Insulin Secretion in Mexican Americans

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Richard M. Watanabe, Hooman Allayee, Anny H. Xiang, Enrique Trigo, Jaana Hartiala, Jean M. Lawrence, Thomas A. Buchanan
Journal: Diabetes
Diabetes 2007;56(5):1481–1485
https://doi.org/10.2337/db06-1682
Published: 01 May 2007
View articletitled, Transcription Factor 7-Like 2 (TCF7L2) Is Associated With Gestational Diabetes Mellitus and Interacts With Adiposity to Alter Insulin Secretion in Mexican Americans
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Includes: Supplementary data
Journal Articles

Coordinate Changes in Plasma Glucose and Pancreatic β-Cell Function in Latino Women at High Risk for Type 2 Diabetes

Free
Anny H. Xiang, Chengwei Wang, Ruth K. Peters, Enrique Trigo, Siri L. Kjos, Thomas A. Buchanan
Journal: Diabetes
Diabetes 2006;55(4):1074–1079
https://doi.org/10.2337/diabetes.55.04.06.db05-1109
Published: 01 April 2006
View articletitled, Coordinate Changes in Plasma Glucose and Pancreatic β-Cell Function in Latino Women at High Risk for Type 2 Diabetes
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Journal Articles

Effect of Pioglitazone on Pancreatic β-Cell Function and Diabetes Risk in Hispanic Women With Prior Gestational Diabetes

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Anny H. Xiang, Ruth K. Peters, Siri L. Kjos, Aura Marroquin, Jose Goico, Cesar Ochoa, Miwa Kawakubo, Thomas A. Buchanan
Journal: Diabetes
Diabetes 2006;55(2):517–522
https://doi.org/10.2337/diabetes.55.02.06.db05-1066
Published: 01 February 2006
View articletitled, Effect of Pioglitazone on Pancreatic β-Cell Function and Diabetes Risk in Hispanic Women With Prior Gestational Diabetes
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Journal Articles

Sequence Variation in PPARG May Underlie Differential Response to Troglitazone

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Johanna K. Wolford, Kimberly A. Yeatts, Sharanjeet K. Dhanjal, Mary Helen Black, Anny H. Xiang, Thomas A. Buchanan, Richard M. Watanabe
Journal: Diabetes
Diabetes 2005;54(11):3319–3325
https://doi.org/10.2337/diabetes.54.11.3319
Published: 01 November 2005
View articletitled, Sequence Variation in PPARG May Underlie Differential Response to Troglitazone
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Journal Articles

Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women

Free
Thomas A. Buchanan, Anny H. Xiang, Ruth K. Peters, Siri L. Kjos, Aura Marroquin, Jose Goico, Cesar Ochoa, Sylvia Tan, Kathleen Berkowitz, Howard N. Hodis, Stanley P. Azen
Journal: Diabetes
Diabetes 2002;51(9):2796–2803
https://doi.org/10.2337/diabetes.51.9.2796
Published: 01 September 2002
View articletitled, Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women
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