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Archana Vijayakumar
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Meeting Abstracts

1694-P: De Novo or Sequential Combination of the Mitochondrial Protonophore TLC-1180 with Semaglutide Improves Weight Loss and Preserves Lean Mass in Dio Mice

Free
MONIKA SHARMA, NATALIE SRODA, EISUKE MURAKAMI, CHRISTOPHER LOGAN, STEVE WENG, BRIAN J. KIRBY, ROBERT P. MYERS, MANI SUBRAMANIAN, GERALD I. SHULMAN, ARCHANA VIJAYAKUMAR
Journal: Diabetes
Diabetes 2025;74(Supplement_1):1694-P
https://doi.org/10.2337/db25-1694-P
Published: 20 June 2025
View article titled, 1694-P: De Novo or Sequential Combination of the Mitochondrial Protonophore TLC-1180 with Semaglutide Improves Weight Loss and Preserves Lean Mass in Dio Mice
Meeting Abstracts

1687-P: Sequential Combination of the Mitochondrial Protonophore (MP) TLC-6740 with Semaglutide Normalizes Body Weight and Preserves Lean Mass in DIO Mice

Free
NATALIE SRODA, MONIKA SHARMA, EISUKE MURAKAMI, CHRISTOPHER LOGAN, STEVE WENG, BRIAN J. KIRBY, ROBERT P. MYERS, MANI SUBRAMANIAN, GERALD I. SHULMAN, ARCHANA VIJAYAKUMAR
Journal: Diabetes
Diabetes 2025;74(Supplement_1):1687-P
https://doi.org/10.2337/db25-1687-P
Published: 20 June 2025
View article titled, 1687-P: Sequential Combination of the Mitochondrial Protonophore (MP) TLC-6740 with Semaglutide Normalizes Body Weight and Preserves Lean Mass in DIO Mice
Meeting Abstracts

1686-P: Novel Combination of a Mitochondrial Protonophore (MP) and an Acetyl-CoA Carboxylase 2 (ACC2) Inhibitor Causes Weight Loss and Preserves Lean Mass in Obese Mice

Free
NATALIE SRODA, MONIKA SHARMA, EISUKE MURAKAMI, CHRISTOPHER LOGAN, STEVE WENG, BRIAN J. KIRBY, ROBERT P. MYERS, MANI SUBRAMANIAN, GERALD I. SHULMAN, ARCHANA VIJAYAKUMAR
Journal: Diabetes
Diabetes 2025;74(Supplement_1):1686-P
https://doi.org/10.2337/db25-1686-P
Published: 20 June 2025
View article titled, 1686-P: Novel Combination of a Mitochondrial Protonophore (MP) and an Acetyl-CoA Carboxylase 2 (ACC2) Inhibitor Causes Weight Loss and Preserves Lean Mass in Obese Mice
Meeting Abstracts

1637-P: TLC-6740, a Liver-Targeted Mitochondrial Protonophore, Increases Energy Expenditure and Lipid Utilization in Obese Mice

Free
NATALIE SRODA, ARCHANA VIJAYAKUMAR, EISUKE MURAKAMI, STEVE WENG, GERALD I. SHULMAN, ROBERT P. MYERS, MANI SUBRAMANIAN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1637-P
https://doi.org/10.2337/db24-1637-P
Published: 14 June 2024
View article titled, 1637-P: TLC-6740, a Liver-Targeted Mitochondrial Protonophore, Increases Energy Expenditure and Lipid Utilization in Obese Mice
Meeting Abstracts

899-P: Combinations of the Mitochondrial Protonophore TLC-6740 and/or the ACC2 Inhibitor TLC-3595 Provide Additive Glycemic Benefits to Semaglutide (SEMA) in db/db Mice

Free
ARCHANA VIJAYAKUMAR, NATALIE SRODA, EISUKE MURAKAMI, STEVE WENG, ROBERT P. MYERS, MANI SUBRAMANIAN, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):899-P
https://doi.org/10.2337/db24-899-P
Published: 14 June 2024
View article titled, 899-P: Combinations of the Mitochondrial Protonophore TLC-6740 and/or the ACC2 Inhibitor TLC-3595 Provide Additive Glycemic Benefits to Semaglutide (SEMA) in db/db Mice
Meeting Abstracts

1886-LB: Safety, PK, and Preliminary Efficacy of the Liver-Targeted Mitochondrial Protonophore TLC-6740—A Phase 1 Study

Free
EDWARD GANE, RYAN S. HUSS, JANE SUR, EISUKE MURAKAMI, STEVE WENG, BRIAN J. KIRBY, AMRIK SHAH, GERALD I. SHULMAN, MANI SUBRAMANIAN, ARCHANA VIJAYAKUMAR, ROBERT P. MYERS
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1886-LB
https://doi.org/10.2337/db24-1886-LB
Published: 14 June 2024
View article titled, 1886-LB: Safety, PK, and Preliminary Efficacy of the Liver-Targeted Mitochondrial Protonophore TLC-6740—A Phase 1 Study
Meeting Abstracts

849-P: Antidiabetic Effects of TLC-3595, a Selective ACC2 Inhibitor, in ZDF Rats

Free
ARCHANA VIJAYAKUMAR, EISUKE MURAKAMI, RYAN S. HUSS, NATALIE SRODA, ATSUYUKI SHIMAZAKI, YUTO KASHIWAGI, ROBERT P. MYERS, MANI SUBRAMANIAN, GERALD I. SHULMAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):849-P
https://doi.org/10.2337/db23-849-P
Published: 20 June 2023
View article titled, 849-P: Antidiabetic Effects of TLC-3595, a Selective ACC2 Inhibitor, in ZDF Rats
Meeting Abstracts

361-OR: ER Stress Attenuation Is Involved in PAHSA-Induced Reduction of T1D in Nonobese Diabetic (NOD) Mice

Free
ISMAIL SYED, MARIA FERNANDEZ RUBIN DE CELIS, JAMES F. MOHAN, PEDRO M. MORAES-VIERIA, ARCHANA VIJAYAKUMAR, ANDREW T. NELSON, DIONICIO SIEGEL, ALAN SAGHATELIAN, DIANE MATHIS, BARBARA KAHN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):361-OR
https://doi.org/10.2337/db19-361-OR
Published: 01 June 2019
View article titled, 361-OR: ER Stress Attenuation Is Involved in PAHSA-Induced Reduction of T1D in Nonobese Diabetic (NOD) Mice
Journal Articles

Targeted Loss of GHR Signaling in Mouse Skeletal Muscle Protects Against High-Fat Diet–Induced Metabolic Deterioration

Open Access
Archana Vijayakumar, YingJie Wu, Hui Sun, Xiaosong Li, Zuha Jeddy, Chengyu Liu, Gary J. Schwartz, Shoshana Yakar, Derek LeRoith
Journal: Diabetes
Diabetes 2012;61(1):94–103
https://doi.org/10.2337/db11-0814
Published: 12 December 2011
View article titled, Targeted Loss of GHR Signaling in Mouse Skeletal Muscle Protects Against High-Fat Diet–Induced Metabolic Deterioration
Open the PDF for Targeted Loss of GHR Signaling in Mouse Skeletal Muscle Protects Against High-Fat Diet–Induced Metabolic Deterioration in another window
Includes: Supplementary data
Journal Articles

Insulin-Sensitizing Therapy Attenuates Type 2 Diabetes–Mediated Mammary Tumor Progression

Open Access
Yvonne Fierz, Ruslan Novosyadlyy, Archana Vijayakumar, Shoshana Yakar, Derek LeRoith
Journal: Diabetes
Diabetes 2010;59(3):686–693
https://doi.org/10.2337/db09-1291
Published: 03 December 2009
View article titled, Insulin-Sensitizing Therapy Attenuates Type 2 Diabetes–Mediated Mammary Tumor Progression
Open the PDF for Insulin-Sensitizing Therapy Attenuates Type 2 Diabetes–Mediated Mammary Tumor Progression in another window
Includes: Supplementary data