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Assam El-Osta
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Journal Articles

Targeting SETD7 Rescues Diabetes-induced Impairment of Angiogenic Response by Transcriptional Repression of Semaphorin 3G

Shafeeq A. Mohammed, PhD, Era Gorica, PhD, Mattia Albiero, PhD, Gergely Karsai, PhD, Alessandro Mengozzi, MD, PhD, Carlo Maria Caravaggi, MD, Samuele Ambrosini, PhD, Stefano Masi, MD, PhD, Maria Cristina Vinci, PhD, Omer Dzemali, Gaia Spinetti, PhD, Sanjay Rajagopalan, MD, Assam El-Osta, PhD, Jaroslav Pelisek, Frank Ruschitzka, MD, Gian Paolo Fadini, MD, PhD, Sarah Costantino, PhD, Francesco Paneni, MD, PhD
Journal: Diabetes
Diabetes db240997
https://doi.org/10.2337/db24-0997
Published: 27 February 2025
View articletitled, Targeting SETD7 Rescues Diabetes-induced Impairment of Angiogenic Response by Transcriptional Repression of Semaphorin 3G
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Journal Articles

Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility

Sih Min Tan, Mark Ziemann, Vicki Thallas-Bonke, Matthew Snelson, Vinod Kumar, Adrienne Laskowski, Tuong-Vi Nguyen, Kevin Huynh, Michele V. Clarke, Renata Libianto, Scott T. Baker, Alison Skene, David A. Power, Richard J. MacIsaac, Darren C. Henstridge, Rick A. Wetsel, Assam El-Osta, Peter J. Meikle, Scott G. Wilson, Josephine M. Forbes, Mark E. Cooper, Elif I. Ekinci, Trent M. Woodruff, Melinda T. Coughlan
Journal: Diabetes
Diabetes 2020;69(1):83–98
https://doi.org/10.2337/db19-0043
Published: 17 October 2019
View articletitled, Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility
Open the PDF for Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility in another window
Includes: Supplementary data
Meeting Abstracts

Tissue Plasminogen Activator (tPA) Expression Is Increased by Islet Amyloid Formation In Vitro

NATHALIE ESSER, MEGHAN F. HOGAN, ANDREW T. TEMPLIN, MARK ZIEMANN, ASSAM EL-OSTA, SAKENEH ZRAIKA, REBECCA L. HULL, STEVEN E. KAHN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2107-P
https://doi.org/10.2337/db18-2107-P
Published: 01 July 2018
View articletitled, Tissue Plasminogen Activator (tPA) Expression Is Increased by Islet Amyloid Formation In Vitro
Journal Articles

Metabolic Karma—The Atherogenic Legacy of Diabetes: The 2017 Edwin Bierman Award Lecture

Mark Emmanuel Cooper, Assam El-Osta, Terri Jean Allen, Anna Margareta Dorothea Watson, Merlin Christopher Thomas, Karin Agnes Maria Jandeleit-Dahm
Journal: Diabetes
Diabetes 2018;67(5):785–790
https://doi.org/10.2337/dbi18-0010
Published: 13 April 2018
View articletitled, Metabolic Karma—The Atherogenic Legacy of Diabetes: The 2017 Edwin Bierman Award Lecture
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Journal Articles

RAGE Deletion Confers Renoprotection by Reducing Responsiveness to Transforming Growth Factor-β and Increasing Resistance to Apoptosis

Shinji Hagiwara, Karly Sourris, Mark Ziemann, Wu Tieqiao, Muthukumar Mohan, Aaron D. McClelland, Eoin Brennan, Josephine Forbes, Melinda Coughlan, Brooke Harcourt, Sally Penfold, Bo Wang, Gavin Higgins, Raelene Pickering, Assam El-Osta, Merlin C. Thomas, Mark E. Cooper, Phillip Kantharidis
Journal: Diabetes
Diabetes 2018;67(5):960–973
https://doi.org/10.2337/db17-0538
Published: 15 February 2018
View articletitled, RAGE Deletion Confers Renoprotection by Reducing Responsiveness to Transforming Growth Factor-β and Increasing Resistance to Apoptosis
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Includes: Supplementary data
Journal Articles

Genetic Examination of SETD7 and SUV39H1/H2 Methyltransferases and the Risk of Diabetes Complications in Patients With Type 1 Diabetes

Anna Syreeni, Assam El-Osta, Carol Forsblom, Niina Sandholm, Maikki Parkkonen, Lise Tarnow, Hans-Henrik Parving, Amy J. McKnight, Alexander P. Maxwell, Mark E. Cooper, Per-Henrik Groop, on behalf of the FinnDiane Study Group
Journal: Diabetes
Diabetes 2011;60(11):3073–3080
https://doi.org/10.2337/db11-0073
Published: 17 October 2011
View articletitled, Genetic Examination of SETD7 and SUV39H1/H2 Methyltransferases and the Risk of Diabetes Complications in Patients With Type 1 Diabetes
Open the PDF for Genetic Examination of SETD7 and SUV39H1/H2 Methyltransferases and the Risk of Diabetes Complications in Patients With Type 1 Diabetes in another window
Includes: Supplementary data
Journal Articles

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

Daniella Brasacchio, Jun Okabe, Christos Tikellis, Aneta Balcerczyk, Prince George, Emma K. Baker, Anna C. Calkin, Michael Brownlee, Mark E. Cooper, Assam El-Osta
Journal: Diabetes
Diabetes 2009;58(5):1229–1236
https://doi.org/10.2337/db08-1666
Published: 10 February 2009
View articletitled, Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail
Open the PDF for Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail in another window