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Meeting Abstracts

362-OR: The Role of Intraislet Glucagon in Pulsatile Insulin Secretion

KINGA SUBA, YATEEN S. PATEL, ANNA ROBERTS, JED V. SHREWSBURY, SHIQIAN CHEN, RACHEL KWOK, VASILIKI KALOGIANNI, XIAOXUAN LIU, GUY A. RUTTER, BEN JONES, TRICIA M. TAN, BRYN OWEN, DANIEL J. DRUCKER, STEPHEN BLOOM, KEVIN MURPHY, VICTORIA SALEM
Journal: Diabetes
Diabetes 2022;71(Supplement_1):362-OR
DOI: https://doi.org/10.2337/db22-362-OR
Published: 01 June 2022
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Journal Articles

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion

Eleni Georgiadou, Charanya Muralidharan, Michelle Martinez, Pauline Chabosseau, Elina Akalestou, Alejandra Tomas, Fiona Yong Su Wern, Theodoros Stylianides, Asger Wretlind, Cristina Legido-Quigley, Ben Jones, Livia Lopez-Noriega, Yanwen Xu, Guoqiang Gu, Nour Alsabeeh, Céline Cruciani-Guglielmacci, Christophe Magnan, Mark Ibberson, Isabelle Leclerc, Yusuf Ali, Scott A. Soleimanpour, Amelia K. Linnemann, Tristan A. Rodriguez, Guy A. Rutter
Journal: Diabetes
Diabetes 2022;71(7):1472–1489
DOI: https://doi.org/10.2337/db21-0800
Published: 26 April 2022
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Meeting Abstracts

228-LB: ß-arrestin-2 Deletion Influences GLP-1 Receptor Signaling in Pancreatic ß Cells In Vivo

STAVROULA BITSI, KINGA SUBA, NIMCO MOHAMED, ISABELLE LECLERC, GUY A. RUTTER, VICTORIA SALEM, BEN JONES, ALEJANDRA TOMAS
Journal: Diabetes
Diabetes 2021;70(Supplement_1):228-LB
DOI: https://doi.org/10.2337/db21-228-LB
Published: 01 June 2021
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Meeting Abstracts

87-LB: Binding Kinetics, Bias, Receptor Internalization, and Effects on Insulin Secretion for a Novel GLP1R-GIPR Dual Agonist, HISHS-2001

YUSMAN MANCHANDA, BEN JONES, GAELLE CARRAT, ZENOUSKA RAMCHUNDER, PIERO MARCHETTI, ISABELLE LECLERC, RAJAMANNAR THENNATI, VINOD S. BURADE, ALEJANDRA TOMAS, GUY A. RUTTER
Journal: Diabetes
Diabetes 2021;70(Supplement_1):87-LB
DOI: https://doi.org/10.2337/db21-87-LB
Published: 01 June 2021
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Meeting Abstracts

2100-P: Binding Kinetics, GLP-1 Receptor Internalization, and Effects on Insulin Secretion for GL0034 and Related GLP-1R Agonists

GAELLE CARRAT, MARIE-SOPHIE NGUYEN-TU, ISABELLE LECLERC, RAJAMANNAR THENNATI, BEN JONES, ALEJANDRA TOMAS, GUY A. RUTTER
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2100-P
DOI: https://doi.org/10.2337/db20-2100-P
Published: 01 June 2020
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Meeting Abstracts

Effect of Biased GLP-1/Glucagon Receptor Co-agonists on Insulin Secretion

GALA FAROOQ, BEN JONES, JAMES S. MINNION, STEPHEN R. BLOOM
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1100-P
DOI: https://doi.org/10.2337/db18-1100-P
Published: 01 July 2018
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Journal Articles

A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells

Teresa Buenaventura, Nisha Kanda, Phoebe C. Douzenis, Ben Jones, Stephen R. Bloom, Pauline Chabosseau, Ivan R. Corrêa, Jr., Domenico Bosco, Lorenzo Piemonti, Piero Marchetti, Paul R. Johnson, A.M. James Shapiro, Guy A. Rutter, Alejandra Tomas
Journal: Diabetes
Diabetes 2018;67(3):385–399
DOI: https://doi.org/10.2337/db17-0639
Published: 28 December 2017
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Includes: Supplementary data
Journal Articles

Coinfusion of Low-Dose GLP-1 and Glucagon in Man Results in a Reduction in Food Intake

Jaimini Cegla, Rachel C. Troke, Ben Jones, George Tharakan, Julia Kenkre, Katherine A. McCullough, Chung Thong Lim, Nassim Parvizi, Mohamed Hussein, Edward S. Chambers, James Minnion, Joyceline Cuenco, Mohammad A. Ghatei, Karim Meeran, Tricia M. Tan, Stephen R. Bloom
Journal: Diabetes
Diabetes 2014;63(11):3711–3720
DOI: https://doi.org/10.2337/db14-0242
Published: 13 October 2014
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Includes: Supplementary data