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Meeting Abstracts

342-OR: Low Incretin Effect Is Associated with Longitudinal Decline of Beta-Cell Function and Insulin Sensitivity in Obese Youth

ALFONSO GALDERISI, JESSICA O. LAT, STEPHANIE SAMUELS, BRIDGET PIERPONT, MICHELLE A. VAN NAME, NICOLA SANTORO, SONIA CAPRIO

Diabetes 2022;71(Supplement_1):342-OR

DOI: https://doi.org/10.2337/db22-342-OR

Published: 01 June 2022

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Meeting Abstracts

61-OR: Genetic and Metabolic Determinants of the Incretin Effect in Obese Adolescent with Prediabetes

ALFONSO GALDERISI, STEPHANIE SAMUELS, BRIDGET PIERPONT, CHIARA DALLA MAN, NICOLA SANTORO, SONIA CAPRIO

Diabetes 2020;69(Supplement_1):61-OR

DOI: https://doi.org/10.2337/db20-61-OR

Published: 01 June 2020

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Meeting Abstracts

1273-P: Growth Differentiation Factor 15 (GDF15) Is Associated with Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Youth

BRITTANY GALUPPO, CRISTIANA AGAZZI, BRIDGET PIERPONT, STEPHANIE SAMUELS, ELENA TARABRA, SONIA CAPRIO, NICOLA SANTORO

Diabetes 2020;69(Supplement_1):1273-P

DOI: https://doi.org/10.2337/db20-1273-P

Published: 01 June 2020

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Journal Articles

Lower Insulin Clearance Parallels a Reduced Insulin Sensitivity in Obese Youths and Is Associated With a Decline in β-Cell Function Over Time

Alfonso Galderisi, David Polidori, Ram Weiss, Cosimo Giannini, Bridget Pierpont, Domenico Tricò, Sonia Caprio

Diabetes 2019;68(11):2074–2084

DOI: https://doi.org/10.2337/db19-0120

Published: 09 August 2019

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Includes: Supplementary data

Journal Articles

Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on β-Cell Function: Comparison of Responses In Youth And Adults

RISE Consortium Investigators, David A. Ehrmann, Karla A. Temple, Abby Rue, Elena Barengolts, Babak Mokhlesi, Eve Van Cauter, Susan Sam, M. Annette Miller, Steven E. Kahn, Karen M. Atkinson, Jerry P. Palmer, Kristina M. Utzschneider, Tsige Gebremedhin, Abigail Kernan-Schloss, Alexandra Kozedub, Brenda K. Montgomery, Emily J. Morse, Kieren J. Mather, Tammy Garrett, Tamara S. Hannon, Amale Lteif, Aniket Patel, Robin Chisholm, Karen Moore, Vivian Pirics, Linda Pratt, Kristen J. Nadeau, Susan Gross, Philip S. Zeitler, Jayne Williams, Melanie Cree-Green, Yesenia Garcia Reyes, Krista Vissat, Silva A. Arslanian, Kathleen Brown, Nancy Guerra, Kristin Porter, Sonia Caprio, Mary Savoye, Bridget Pierpont, Thomas A. Buchanan, Anny H. Xiang, Enrique Trigo, Elizabeth Beale, Ting Chow, Fadi N. Hendee, Namir Katkhouda, Krishan Nayak, Mayra Martinez, Cortney Montgomery, Xinhui Wang, Jun Wu, Sharon L. Edelstein, John M. Lachin, Ashley Hogan Tjaden, Mark T. Tripputi, Santica Marcovina, Jessica Harting, John Albers, Dave Hill, Peter J. Savage, Ellen W. Leschek

Diabetes 2019;68(8):1670–1680

DOI: https://doi.org/10.2337/db19-0299

Published: 09 June 2019

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Includes: Supplementary data

Meeting Abstracts

1317-P: Static, but Nondynamic, ß-Cell Responsiveness to Glucose Is Affected by the Risk Variant rs7903146 of TCF7L2 and Associated with a Delayed Time-to-Glucose-Peak in Obese Youths

ALFONSO GALDERISI, DOMENICO TRICO, CHIARA DALLA MAN, STEPHAN SIEBEL, NICOLA SANTORO, BRIDGET PIERPONT, CLAUDIO COBELLI, SONIA CAPRIO

Diabetes 2019;68(Supplement_1):1317-P

DOI: https://doi.org/10.2337/db19-1317-P

Published: 01 June 2019

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Meeting Abstracts

128-OR: Clustering of Metabolomics, Clinical Biomarkers, and Ectopic Liver Fat in Children/Adolescents: An Integrated Network Analysis

CATHERINE E. CIOFFI, K.M. VENKAT NARAYAN, KARAN UPPAL, BRIDGET PIERPONT, SONIA CAPRIO, NICOLA SANTORO, MIRIAM B. VOS

Diabetes 2019;68(Supplement_1):128-OR

DOI: https://doi.org/10.2337/db19-128-OR

Published: 01 June 2019

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Meeting Abstracts

772-P: Effect of a Low n6/n3 PUFA Diet on Intrahepatic Fat Content in Obese Adolescents

MICHELLE A. VAN NAME, JENNIFER M. CHICK, MARY SAVOYE, BRIDGET PIERPONT, BRITTANY GALUPPO, ARIEL FELDSTEIN, NICOLA SANTORO

Diabetes 2019;68(Supplement_1):772-P

DOI: https://doi.org/10.2337/db19-772-P

Published: 01 June 2019

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Journal Articles

Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls

Jessica Nouws, Mark Fitch, Mariana Mata, Nicola Santoro, Brittany Galuppo, Romy Kursawe, Deepak Narayan, Alla Vash-Margita, Bridget Pierpont, Gerald I. Shulman, Marc Hellerstein, Sonia Caprio

Diabetes 2019;68(6):1168–1177

DOI: https://doi.org/10.2337/db18-1162

Published: 01 April 2019

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Includes: Supplementary data

Meeting Abstracts

Ethnicity and Common Genetic Variants Modulate Nonalcoholic Fatty Liver Disease (NAFLD) Metabolic Phenotype in Obese Youth

DOMENICO TRICO, SONIA CAPRIO, GIUSEPPINA R. UMANO, ALFONSO GALDERISI, MARIANA M. MATA, JESSICA NOUWS, BRIDGET PIERPONT, GRACE KIM, NICOLA SANTORO

Diabetes 2018;67(Supplement_1):313-OR

DOI: https://doi.org/10.2337/db18-313-OR

Published: 01 July 2018

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Meeting Abstracts

The TCF7L2 Variant rs7903146 Affects the Risk of Youth-Onset Type 2 Diabetes by Reducing the Incretin Effect on Insulin Secretion

ALFONSO GALDERISI, BRIDGET PIERPONT, DAVID D'ALESSIO, NICOLA SANTORO, SONIA CAPRIO

Diabetes 2018;67(Supplement_1):340-OR

DOI: https://doi.org/10.2337/db18-340-OR

Published: 01 July 2018

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Journal Articles

Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents

Ania M. Jastreboff, Rajita Sinha, Jagriti Arora, Cosimo Giannini, Jessica Kubat, Saima Malik, Michelle A. Van Name, Nicola Santoro, Mary Savoye, Elvira J. Duran, Bridget Pierpont, Gary Cline, R. Todd Constable, Robert S. Sherwin, Sonia Caprio

Diabetes 2016;65(7):1929–1939

DOI: https://doi.org/10.2337/db15-1216

Published: 05 April 2016

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Includes: Supplementary data

Journal Articles

A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents

Romy Kursawe, Vishwa D. Dixit, Philipp E. Scherer, Nicola Santoro, Deepak Narayan, Ruth Gordillo, Cosimo Giannini, Ximena Lopez, Bridget Pierpont, Jessica Nouws, Gerald I. Shulman, Sonia Caprio

Diabetes 2016;65(3):610–618

DOI: https://doi.org/10.2337/db15-1478

Published: 30 December 2015

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Includes: Supplementary data

Journal Articles

Decreased Transcription of ChREBP-α/β Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes: Associations With Insulin Resistance and Hyperglycemia

Romy Kursawe, Sonia Caprio, Cosimo Giannini, Deepak Narayan, Aiping Lin, Ebe D’Adamo, Melissa Shaw, Bridget Pierpont, Samuel W. Cushman, Gerald I. Shulman

Diabetes 2013;62(3):837–844

DOI: https://doi.org/10.2337/db12-0889

Published: 14 February 2013

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Includes: Supplementary data

Journal Articles

Evidence for Early Defects in Insulin Sensitivity and Secretion Before the Onset of Glucose Dysregulation in Obese Youths : A Longitudinal Study

Cosimo Giannini, Ram Weiss, Anna Cali, Riccardo Bonadonna, Nicola Santoro, Bridget Pierpont, Melissa Shaw, Sonia Caprio

Diabetes 2012;61(3):606–614

DOI: https://doi.org/10.2337/db11-1111

Published: 13 February 2012

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Includes: Supplementary data

Journal Articles

Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis

Romy Kursawe, Markus Eszlinger, Deepak Narayan, Teresa Liu, Merlijn Bazuine, Anna M.G. Cali, Ebe D'Adamo, Melissa Shaw, Bridget Pierpont, Gerald I. Shulman, Samuel W. Cushman, Arthur Sherman, Sonia Caprio

Diabetes 2010;59(9):2288–2296

DOI: https://doi.org/10.2337/db10-0113

Published: 01 September 2010

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Includes: Supplementary data

NARROW

342-OR: Low Incretin Effect Is Associated with Longitudinal Decline of Beta-Cell Function and Insulin Sensitivity in Obese Youth

61-OR: Genetic and Metabolic Determinants of the Incretin Effect in Obese Adolescent with Prediabetes

1273-P: Growth Differentiation Factor 15 (GDF15) Is Associated with Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Youth

Lower Insulin Clearance Parallels a Reduced Insulin Sensitivity in Obese Youths and Is Associated With a Decline in β-Cell Function Over Time

Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on β-Cell Function: Comparison of Responses In Youth And Adults

1317-P: Static, but Nondynamic, ß-Cell Responsiveness to Glucose Is Affected by the Risk Variant rs7903146 of TCF7L2 and Associated with a Delayed Time-to-Glucose-Peak in Obese Youths

128-OR: Clustering of Metabolomics, Clinical Biomarkers, and Ectopic Liver Fat in Children/Adolescents: An Integrated Network Analysis

772-P: Effect of a Low n6/n3 PUFA Diet on Intrahepatic Fat Content in Obese Adolescents

Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls

Ethnicity and Common Genetic Variants Modulate Nonalcoholic Fatty Liver Disease (NAFLD) Metabolic Phenotype in Obese Youth

The TCF7L2 Variant rs7903146 Affects the Risk of Youth-Onset Type 2 Diabetes by Reducing the Incretin Effect on Insulin Secretion

Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents

A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents

Decreased Transcription of ChREBP-α/β Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes: Associations With Insulin Resistance and Hyperglycemia

Evidence for Early Defects in Insulin Sensitivity and Secretion Before the Onset of Glucose Dysregulation in Obese Youths : A Longitudinal Study

Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis

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