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Barbara B. Kahn
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Meeting Abstracts

1765-P: Inhibition of NLRP3 Inflammasome Activation and Reduction in T-Cell Migration Are Key Mechanisms by Which PAHSAs Protect against Type 1 Diabetes

ISMAIL SYED, VENKAT G. MAGUPALLI, PRATIK ARYAL, ANNA SANTORO, DIONICIO SIEGEL, BARBARA B. KAHN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1765-P
https://doi.org/10.2337/db24-1765-P
Published: 14 June 2024
View articletitled, 1765-P: Inhibition of NLRP3 Inflammasome Activation and Reduction in T-Cell Migration Are Key Mechanisms by Which PAHSAs Protect against Type 1 Diabetes
Meeting Abstracts

1557-P: Increased PAHSA Hydrolysis Driven by Mutant Carboxyl Ester Lipase (CEL) Contributes to Beta-Cell Dysfunction in MODY8

ANNA SANTORO, SEVIM KAHRAMAN, GIORGIO BASILE, KHADIJA EL JELLAS, JIANG HU, RYAN TARPEY, BENTE B. JOHANSSON, ERCUMENT DIRICE, ISMAIL SYED, DIONICIO SIEGEL, ANDERS MOLVEN, BARBARA B. KAHN, ROHIT KULKARNI
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1557-P
https://doi.org/10.2337/db24-1557-P
Published: 14 June 2024
View articletitled, 1557-P: Increased PAHSA Hydrolysis Driven by Mutant Carboxyl Ester Lipase (CEL) Contributes to Beta-Cell Dysfunction in MODY8
Meeting Abstracts

361-OR: A Multiomics Approach to Identify Genes Important for the Regulation of Antidiabetic and Anti-inflammatory Lipids

ANNA SANTORO, MARK KELLER, ZHENLONG CHEN, ALAN D. ATTIE, DIONICIO SIEGEL, GARY A. CHURCHILL, ALAN SAGHATELIAN, BARBARA B. KAHN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):361-OR
https://doi.org/10.2337/db24-361-OR
Published: 14 June 2024
View articletitled, 361-OR: A Multiomics Approach to Identify Genes Important for the Regulation of Antidiabetic and Anti-inflammatory Lipids
Meeting Abstracts

125-OR: New Lipid Biomarkers for Worsening Glucose Tolerance in Nondiabetic Relatives of People with Type 2 Diabetes

ISMAIL SYED, KENNETH SLUIS, PRATIK ARYAL, ZACHARY SOLOMON, RUCHA PATEL, SRIHARI KONDURI, DIONICIO SIEGEL, ULF SMITH, BARBARA B. KAHN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):125-OR
https://doi.org/10.2337/db24-125-OR
Published: 14 June 2024
View articletitled, 125-OR: New Lipid Biomarkers for Worsening Glucose Tolerance in Nondiabetic Relatives of People with Type 2 Diabetes
Meeting Abstracts

1405-P: Bacteroides thetaiotaomicron Fortifies the Gut Mucosa and Improves Host Metabolism in Dietary Obese Mice

JENNIFER LEE, KERRY WELLENSTEIN, BARBARA B. KAHN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1405-P
https://doi.org/10.2337/db22-1405-P
Published: 01 June 2022
View articletitled, 1405-P: Bacteroides thetaiotaomicron Fortifies the Gut Mucosa and Improves Host Metabolism in Dietary Obese Mice
Journal Articles

Adipose Tissue, Inter-Organ Communication, and the Path to Type 2 Diabetes: The 2016 Banting Medal for Scientific Achievement Lecture

Barbara B. Kahn
Journal: Diabetes
Diabetes 2019;68(1):3–14
https://doi.org/10.2337/dbi18-0035
Published: 13 December 2018
View articletitled, Adipose Tissue, Inter-Organ Communication, and the Path to Type 2 Diabetes: The 2016 Banting Medal for Scientific Achievement Lecture
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Journal Articles

GLUT4 Is Not Necessary for Overload-Induced Glucose Uptake or Hypertrophic Growth in Mouse Skeletal Muscle

Shawna L. McMillin, Denise L. Schmidt, Barbara B. Kahn, Carol A. Witczak
Journal: Diabetes
Diabetes 2017;66(6):1491–1500
https://doi.org/10.2337/db16-1075
Published: 09 March 2017
View articletitled, GLUT4 Is Not Necessary for Overload-Induced Glucose Uptake or Hypertrophic Growth in Mouse Skeletal Muscle
Open the PDF for GLUT4 Is Not Necessary for Overload-Induced Glucose Uptake or Hypertrophic Growth in Mouse Skeletal Muscle in another window
Includes: Supplementary data
Journal Articles

Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation

Candace M. Reno, Erwin C. Puente, Zhenyu Sheng, Dorit Daphna-Iken, Adam J. Bree, Vanessa H. Routh, Barbara B. Kahn, Simon J. Fisher
Journal: Diabetes
Diabetes 2017;66(3):587–597
https://doi.org/10.2337/db16-0917
Published: 17 October 2016
View articletitled, Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation
Open the PDF for Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation in another window
Includes: Supplementary data
Journal Articles

GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects

Pedro M. Moraes-Vieira, Alan Saghatelian, Barbara B. Kahn
Journal: Diabetes
Diabetes 2016;65(7):1808–1815
https://doi.org/10.2337/db16-0221
Published: 12 June 2016
View articletitled, GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects
Open the PDF for GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects in another window
Journal Articles

Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance

Reema P. Vazirani, Akanksha Verma, L. Amanda Sadacca, Melanie S. Buckman, Belen Picatoste, Muheeb Beg, Christopher Torsitano, Joanne H. Bruno, Rajesh T. Patel, Kotryna Simonyte, Joao P. Camporez, Gabriela Moreira, Domenick J. Falcone, Domenico Accili, Olivier Elemento, Gerald I. Shulman, Barbara B. Kahn, Timothy E. McGraw
Journal: Diabetes
Diabetes 2016;65(6):1577–1589
https://doi.org/10.2337/db15-1128
Published: 25 March 2016
View articletitled, Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance
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Includes: Supplementary data
Journal Articles

Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance

Pedro M. Moraes-Vieira, Angela Castoldi, Pratik Aryal, Kerry Wellenstein, Odile D. Peroni, Barbara B. Kahn
Journal: Diabetes
Diabetes 2016;65(5):1317–1327
https://doi.org/10.2337/db15-1696
Published: 02 March 2016
View articletitled, Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance
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Includes: Supplementary data
Journal Articles

Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice

Laura Zemany, Sanjay Bhanot, Odile D. Peroni, Susan F. Murray, Pedro M. Moraes-Vieira, Angela Castoldi, Prasad Manchem, Shuling Guo, Brett P. Monia, Barbara B. Kahn
Journal: Diabetes
Diabetes 2015;64(5):1603–1614
https://doi.org/10.2337/db14-0970
Published: 18 December 2014
View articletitled, Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice
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Journal Articles

Lessons on Conditional Gene Targeting in Mouse Adipose Tissue

Kevin Y. Lee, Steven J. Russell, Siegfried Ussar, Jeremie Boucher, Cecile Vernochet, Marcelo A. Mori, Graham Smyth, Michael Rourk, Carly Cederquist, Evan D. Rosen, Barbara B. Kahn, C. Ronald Kahn
Journal: Diabetes
Diabetes 2013;62(3):864–874
https://doi.org/10.2337/db12-1089
Published: 14 February 2013
View articletitled, Lessons on Conditional Gene Targeting in Mouse Adipose Tissue
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Includes: Supplementary data
Journal Articles

Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress

Mirela Delibegovic, Derek Zimmer, Caitlin Kauffman, Kimberly Rak, Eun-Gyoung Hong, You-Ree Cho, Jason K. Kim, Barbara B. Kahn, Benjamin G. Neel, Kendra K. Bence
Journal: Diabetes
Diabetes 2009;58(3):590–599
https://doi.org/10.2337/db08-0913
Published: 01 March 2009
View articletitled, Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress
Open the PDF for Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress in another window
Includes: Supplementary data
Journal Articles

Deletion of Cd39/Entpd1 Results in Hepatic Insulin Resistance

Keiichi Enjyoji, Ko Kotani, Chandrashekar Thukral, Benjamin Blumel, Xiaofeng Sun, Yan Wu, Masato Imai, David Friedman, Eva Csizmadia, Wissam Bleibel, Barbara B. Kahn, Simon C. Robson
Journal: Diabetes
Diabetes 2008;57(9):2311–2320
https://doi.org/10.2337/db07-1265
Published: 01 September 2008
View articletitled, Deletion of Cd39/Entpd1 Results in Hepatic Insulin Resistance
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Journal Articles

Effects of Genetic Variation in the Human Retinol Binding Protein-4 Gene (RBP4) on Insulin Resistance and Fat Depot–Specific mRNA Expression

Peter Kovacs, Michaela Geyer, Janin Berndt, Nora Klöting, Timothy E. Graham, Yvonne Böttcher, Beate Enigk, Anke Tönjes, Dorit Schleinitz, Michael R. Schön, Barbara B. Kahn, Matthias Blüher, Michael Stumvoll
Journal: Diabetes
Diabetes 2007;56(12):3095–3100
https://doi.org/10.2337/db06-1647
Published: 01 December 2007
View articletitled, Effects of Genetic Variation in the Human Retinol Binding Protein-4 Gene (RBP4) on Insulin Resistance and Fat Depot–Specific mRNA Expression
Open the PDF for Effects of Genetic Variation in the Human Retinol Binding Protein-4 Gene (RBP4) on Insulin Resistance and Fat Depot–Specific mRNA Expression in another window
Includes: Supplementary data
Journal Articles

The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance

Qing-Wu Yan, Qin Yang, Nimesh Mody, Timothy E. Graham, Chung-Hsin Hsu, Zhao Xu, Nicholas E. Houstis, Barbara B. Kahn, Evan D. Rosen
Journal: Diabetes
Diabetes 2007;56(10):2533–2540
https://doi.org/10.2337/db07-0007
Published: 01 October 2007
View articletitled, The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance
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Journal Articles

Islet-Sparing Effects of Protein Tyrosine Phosphatase-1b Deficiency Delays Onset of Diabetes in IRS2 Knockout Mice

Jake A. Kushner, Fawaz G. Haj, Lori D. Klaman, Matthew A. Dow, Barbara B. Kahn, Benjamin G. Neel, Morris F. White
Journal: Diabetes
Diabetes 2004;53(1):61–66
https://doi.org/10.2337/diabetes.53.1.61
Published: 01 January 2004
View articletitled, Islet-Sparing Effects of Protein Tyrosine Phosphatase-1b Deficiency Delays Onset of Diabetes in IRS2 Knockout Mice
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Journal Articles

Insulin-Stimulated Protein Kinase C λ/ζ Activity Is Reduced in Skeletal Muscle of Humans With Obesity and Type 2 Diabetes: Reversal With Weight Reduction

Young-Bum Kim, Ko Kotani, Theodore P. Ciaraldi, Robert R. Henry, Barbara B. Kahn
Journal: Diabetes
Diabetes 2003;52(8):1935–1942
https://doi.org/10.2337/diabetes.52.8.1935
Published: 01 August 2003
View articletitled, Insulin-Stimulated Protein Kinase C λ/ζ Activity Is Reduced in Skeletal Muscle of Humans With Obesity and Type 2 Diabetes: Reversal With Weight Reduction
Open the PDF for Insulin-Stimulated Protein Kinase C λ/ζ Activity Is Reduced in Skeletal Muscle of Humans With Obesity and Type 2 Diabetes: Reversal With Weight Reduction in another window
Journal Articles

Troglitazone but not Metformin Restores Insulin-Stimulated Phosphoinositide 3-Kinase Activity and Increases p110β Protein Levels in Skeletal Muscle of Type 2 Diabetic Subjects

Young-Bum Kim, Theodore P. Ciaraldi, Alice Kong, Dennis Kim, Neelima Chu, Pharis Mohideen, Sunder Mudaliar, Robert R. Henry, Barbara B. Kahn
Journal: Diabetes
Diabetes 2002;51(2):443–448
https://doi.org/10.2337/diabetes.51.2.443
Published: 01 February 2002
View articletitled, Troglitazone but not Metformin Restores Insulin-Stimulated Phosphoinositide 3-Kinase Activity and Increases p110β Protein Levels in Skeletal Muscle of Type 2 Diabetic Subjects
Open the PDF for Troglitazone but not Metformin Restores Insulin-Stimulated Phosphoinositide 3-Kinase Activity and Increases p110β Protein Levels in Skeletal Muscle of Type 2 Diabetic Subjects in another window