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Journal Articles

Type 1 Diabetes Genetic Risk Contributes to Phenotypic Presentation in Monogenic Autoimmune Diabetes

Amber M. Luckett, Gareth Hawkes, Harry D. Green, Elisa De Franco, William A. Hagopian, Bart O. Roep, Michael N. Weedon, Richard A. Oram, Matthew B. Johnson, EXE-T1D consortium, Rebecca A Dobbs, Clara Domingo-Vila, Kathleen M Gillespie, Andrew T Hattersley, Michelle Hudson, Timothy J McDonald, Noel G Morgan, Kathryn Murrall, Sarah J Richardson, Megan E Smithmyer, Cate Speake, Timothy IM Tree
Journal: Diabetes
Diabetes db240485
https://doi.org/10.2337/db24-0485
Published: 12 November 2024
View article titled, Type 1 Diabetes Genetic Risk Contributes to Phenotypic Presentation in Monogenic Autoimmune Diabetes
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Journal Articles

Methylglyoxal Adducts Are Prognostic Biomarkers for Diabetic Kidney Disease in Patients With Type 1 Diabetes

Seigmund Wai Tsuen Lai, Carlos Hernandez-Castillo, Edwin De Jesus Lopez Gonzalez, Tala Zoukari, Min Talley, Nadia Paquin, Zhuo Chen, Bart O. Roep, John S. Kaddis, Rama Natarajan, John Termini, Sarah C. Shuck
Journal: Diabetes
Diabetes 2024;73(4):611–617
https://doi.org/10.2337/db23-0277
Published: 15 November 2023
View article titled, Methylglyoxal Adducts Are Prognostic Biomarkers for Diabetic Kidney Disease in Patients With Type 1 Diabetes
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Meeting Abstracts

27-OR: Residual Beta-Cell Function Associates with Lower Glycaemic Variability and More Time in Range in Individuals with Type 1 Diabetes

COCO FUHRI SNETHAGE, TIMOTHY J. MCDONALD, ELENA RAMPANELLI, PLEUN DE GROEN, ALINDA W.M. SCHIMMEL, DANIËL VAN RAALTE, CATHERINE B. BROUWER, RICHARD A. ORAM, BART O. ROEP, MAX NIEUWDORP, NORDIN HANSSEN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):27-OR
https://doi.org/10.2337/db23-27-OR
Published: 20 June 2023
View article titled, 27-OR: Residual Beta-Cell Function Associates with Lower Glycaemic Variability and More Time in Range in Individuals with Type 1 Diabetes
Journal Articles

Syntaxin 4 Enrichment in β-Cells Prevents Conversion to Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice

Eunjin Oh, Erika M. McCown, Miwon Ahn, Pablo A. Garcia, Sergio Branciamore, Shanshan Tang, De-Fu Zeng, Bart O. Roep, Debbie C. Thurmond
Journal: Diabetes
Diabetes 2021;70(12):2837–2849
https://doi.org/10.2337/db21-0170
Published: 23 September 2021
View article titled, Syntaxin 4 Enrichment in β-Cells Prevents Conversion to Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice
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Journal Articles

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape

Sofia Thomaidou, Roderick C. Slieker, Arno R. van der Slik, Jasper Boom, Flip Mulder, Amadeo Munoz-Garcia, Leen M. ‘t Hart, Bobby Koeleman, Françoise Carlotti, Rob C. Hoeben, Bart O. Roep, Hailiang Mei, Arnaud Zaldumbide
Journal: Diabetes
Diabetes 2021;70(10):2299–2312
https://doi.org/10.2337/db20-1122
Published: 15 June 2021
View article titled, Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape
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Journal Articles

There Is Something About Insulin Granules

Bart O. Roep
Journal: Diabetes
Diabetes 2020;69(12):2575–2577
https://doi.org/10.2337/dbi20-0039
Published: 16 November 2020
View article titled, There Is Something About Insulin Granules
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Journal Articles

β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1

Sofia Thomaidou, Maria J.L. Kracht, Arno van der Slik, Sandra Laban, Eelco J. de Koning, Francoise Carlotti, Rob C. Hoeben, Bart O. Roep, Arnaud Zaldumbide
Journal: Diabetes
Diabetes 2020;69(4):670–680
https://doi.org/10.2337/db19-0984
Published: 02 January 2020
View article titled, β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1
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Includes: Supplementary data
Journal Articles

Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances

Simi Ahmed, Karen Cerosaletti, Eddie James, S. Alice Long, Stuart Mannering, Cate Speake, Maki Nakayama, Timothy Tree, Bart O. Roep, Kevan C. Herold, Todd M. Brusko
Journal: Diabetes
Diabetes 2019;68(7):1366–1379
https://doi.org/10.2337/db19-0119
Published: 13 June 2019
View article titled, Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances
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Includes: Supplementary data
Journal Articles

Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 Diabetes

Menno van Lummel, David T.P. Buis, Cherish Ringeling, Arnoud H. de Ru, Jos Pool, George K. Papadopoulos, Peter A. van Veelen, Helena Reijonen, Jan W. Drijfhout, Bart O. Roep
Journal: Diabetes
Diabetes 2019;68(4):787–795
https://doi.org/10.2337/db18-0501
Published: 09 January 2019
View article titled, Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass

Eunjin Oh, Miwon Ahn, Solomon Afelik, Thomas C. Becker, Bart O. Roep, Debbie C. Thurmond
Journal: Diabetes
Diabetes 2018;67(12):2626–2639
https://doi.org/10.2337/db18-0259
Published: 10 October 2018
View article titled, Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass
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Includes: Supplementary data
Journal Articles

Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes

Aaron W. Michels, Laurie G. Landry, Kristen A. McDaniel, Liping Yu, Martha Campbell-Thompson, William W. Kwok, Kenneth L. Jones, Peter A. Gottlieb, John W. Kappler, Qizhi Tang, Bart O. Roep, Mark A. Atkinson, Clayton E. Mathews, Maki Nakayama
Journal: Diabetes
Diabetes 2017;66(3):722–734
https://doi.org/10.2337/db16-1025
Published: 05 December 2016
View article titled, Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes
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Includes: Supplementary data
Journal Articles

Insulitis Revisited

Bart O. Roep
Journal: Diabetes
Diabetes 2016;65(3):545–547
https://doi.org/10.2337/dbi15-0040
Published: 13 February 2016
View article titled, Insulitis Revisited
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Journal Articles

Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8trans Molecule

Menno van Lummel, Peter A. van Veelen, Arnoud H. de Ru, Jos Pool, Tatjana Nikolic, Sandra Laban, Antoinette Joosten, Jan W. Drijfhout, Iria Gómez-Touriño, Sefina Arif, Henk J. Aanstoot, Mark Peakman, Bart O. Roep
Journal: Diabetes
Diabetes 2016;65(3):732–741
https://doi.org/10.2337/db15-1031
Published: 30 December 2015
View article titled, Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8<em>trans</em> Molecule
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Includes: Supplementary data
Journal Articles

Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes

Menno van Lummel, Gaby Duinkerken, Peter A. van Veelen, Arnoud de Ru, Robert Cordfunke, Arnaud Zaldumbide, Iria Gomez-Touriño, Sefina Arif, Mark Peakman, Jan W. Drijfhout, Bart O. Roep
Journal: Diabetes
Diabetes 2014;63(1):237–247
https://doi.org/10.2337/db12-1214
Published: 13 December 2013
View article titled, Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

β-Cells, Autoimmunity, and the Innate Immune System: “un Ménage á Trois”?

Bart O. Roep
Journal: Diabetes
Diabetes 2013;62(6):1821–1822
https://doi.org/10.2337/db13-0276
Published: 17 May 2013
View article titled, β-Cells, Autoimmunity, and the Innate Immune System: “un Ménage á Trois”?
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Journal Articles

Local Autoantigen Expression as Essential Gatekeeper of Memory T-Cell Recruitment to Islet Grafts in Diabetic Hosts

Gonnie M. Alkemade, Xavier Clemente-Casares, Zhenguo Yu, Bao-You Xu, Jinguo Wang, Sue Tsai, James R. Wright, Jr., Bart O. Roep, Pere Santamaria
Journal: Diabetes
Diabetes 2013;62(3):905–911
https://doi.org/10.2337/db12-0600
Published: 14 February 2013
View article titled, Local Autoantigen Expression as Essential Gatekeeper of Memory T-Cell Recruitment to Islet Grafts in Diabetic Hosts
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Includes: Supplementary data
Journal Articles

Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers

Jurjen H. Velthuis, Wendy W. Unger, Joana R.F. Abreu, Gaby Duinkerken, Kees Franken, Mark Peakman, Arnold H. Bakker, Sine Reker-Hadrup, Bart Keymeulen, Jan Wouter Drijfhout, Ton N. Schumacher, Bart O. Roep
Journal: Diabetes
Diabetes 2010;59(7):1721–1730
https://doi.org/10.2337/db09-1486
Published: 31 March 2010
View article titled, Simultaneous Detection of Circulating Autoreactive CD8<sup>+</sup> T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers
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Includes: Supplementary data
Journal Articles

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

Timothy I.M. Tree, Jennifer Lawson, Hannah Edwards, Ania Skowera, Sefina Arif, Bart O. Roep, Mark Peakman
Journal: Diabetes
Diabetes 2010;59(6):1451–1460
https://doi.org/10.2337/db09-0503
Published: 18 March 2010
View article titled, Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression
Open the PDF for Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression in another window
Includes: Supplementary data
Journal Articles

Current Advances and Travails in Islet Transplantation

David M. Harlan, Norma Sue Kenyon, Olle Korsgren, Bart O. Roep, for the Immunology of Diabetes Society
Journal: Diabetes
Diabetes 2009;58(10):2175–2184
https://doi.org/10.2337/db09-0476
Published: 01 October 2009
View article titled, Current Advances and Travails in Islet Transplantation
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Journal Articles

Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients

Robert Hilbrands, Volkert A.L. Huurman, Pieter Gillard, Jurjen H.L. Velthuis, Marc De Waele, Chantal Mathieu, Leonard Kaufman, Miriam Pipeleers-Marichal, Zhidong Ling, Babak Movahedi, Daniel Jacobs-Tulleneers-Thevissen, Diethard Monbaliu, Dirk Ysebaert, Frans K. Gorus, Bart O. Roep, Daniel G. Pipeleers, Bart Keymeulen
Journal: Diabetes
Diabetes 2009;58(10):2267–2276
https://doi.org/10.2337/db09-0160
Published: 14 July 2009
View article titled, Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients
Open the PDF for Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients in another window
Includes: Supplementary data