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Journal Articles

Genetic Evidence of Causal Relation Between Intestinal Glucose Absorption and Early Postprandial Glucose Response: A Mendelian Randomization Study

Simon Peschard, Violeta Raverdy, Pierre Bauvin, Rebecca Goutchtat, Veronique Touche, Bruno Derudas, Celine Gheeraert, Julie Dubois-Chevalier, Robert Caiazzo, Gregory Baud, Camille Marciniak, Helene Verkindt, Naima Oukhouya Daoud, Carel W. Le Roux, Philippe Lefebvre, Bart Staels, Sophie Lestavel, François Pattou
Journal: Diabetes
Diabetes 2024;73(6):983–992
https://doi.org/10.2337/db23-0805
Published: 18 March 2024
View article titled, Genetic Evidence of Causal Relation Between Intestinal Glucose Absorption and Early Postprandial Glucose Response: A Mendelian Randomization Study
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Meeting Abstracts

1817-P: Elafibranor and Glucagon-Like Peptide-1 Receptor Agonists Synergize to Attenuate Hepatic Inflammation and Fibrosis in a Rodent Model of Obesity, Insulin Resistance, and NASH

VANESSA LEGRY, EMELINE DESCAMPS, SIMON DEBAECKER, NICOLAS STANKOVIC-VALENTIN, PEGGY PARROCHE, NATHALIE DEGALLAIX, PHILIPPE POULAIN, BART STAELS, ROBERT WALCZAK
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1817-P
https://doi.org/10.2337/db20-1817-P
Published: 01 June 2020
View article titled, 1817-P: Elafibranor and Glucagon-Like Peptide-1 Receptor Agonists Synergize to Attenuate Hepatic Inflammation and Fibrosis in a Rodent Model of Obesity, Insulin Resistance, and NASH
Journal Articles

Interindividual Heterogeneity of SGLT2 Expression and Function in Human Pancreatic Islets

Chiara Saponaro, Markus Mühlemann, Ana Acosta-Montalvo, Anthony Piron, Valery Gmyr, Nathalie Delalleau, Ericka Moerman, Julien Thévenet, Gianni Pasquetti, Anais Coddeville, Miriam Cnop, Julie Kerr-Conte, Bart Staels, François Pattou, Caroline Bonner
Journal: Diabetes
Diabetes 2020;69(5):902–914
https://doi.org/10.2337/db19-0888
Published: 02 January 2020
View article titled, Interindividual Heterogeneity of SGLT2 Expression and Function in Human Pancreatic Islets
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Includes: Supplementary data
Meeting Abstracts

23-OR: The Effect of 14-Day Atorvastatin Treatment on Postprandial Glucose Metabolism in Healthy Males—A Link to Why Statin Therapy Increases the Risk of Type 2 Diabetes?

MARTIN L. THOMASEN, DAVID P. SONNE, MARTIN L. KÅRHUS, ANDREAS BRØNDEN, BART STAELS, JENS J. HOLST, TINA VILSBØLL, FILIP K. KNOP
Journal: Diabetes
Diabetes 2019;68(Supplement_1):23-OR
https://doi.org/10.2337/db19-23-OR
Published: 01 June 2019
View article titled, 23-OR: The Effect of 14-Day Atorvastatin Treatment on Postprandial Glucose Metabolism in Healthy Males—A Link to Why Statin Therapy Increases the Risk of Type 2 Diabetes?
Meeting Abstracts

279-LB: NIS4, a Novel Blood Test, Can Identify "At-Risk" NASH (NAS>4 and Fibrosis>2) in T2D Patients

BART STAELS, VLAD RATZIU, SVEN FRANCQUE, STEPHEN A. HARRISON, PIERRE BEDOSSA, ALICE ROUDOT, ZOUHER MAJD, JOHN BROZEK, FOUAD BEN-SUDRIK, PASCAL BIRMAN, DEAN W. HUM, SUNEIL HOSMANE, PIERRE CHAUMAT, RéMY HANF, BERTRAND CARIOU, ARUN SANYAL
Journal: Diabetes
Diabetes 2019;68(Supplement_1):279-LB
https://doi.org/10.2337/db19-279-LB
Published: 01 June 2019
View article titled, 279-LB: NIS4, a Novel Blood Test, Can Identify "At-Risk" NASH (NAS>4 and Fibrosis>2) in T2D Patients
Meeting Abstracts

278-LB: Type 2 Diabetes (T2D) as a Risk Factor for NASH and Significant Liver Fibrosis (F>2) in an International Cohort of 2,363 Patients with Metabolic Steatosis

BART STAELS, VLAD RATZIU, ARUN J. SANYAL, SVEN FRANCQUE, STEPHEN A. HARRISON, ALICE ROUDOT, JOHN BROZEK, YACINE HAJJI, SOPHIE MEGNIEN, DEAN W. HUM, PASCAL BIRMAN, RéMY HANF, BERTRAND CARIOU
Journal: Diabetes
Diabetes 2019;68(Supplement_1):278-LB
https://doi.org/10.2337/db19-278-LB
Published: 01 June 2019
View article titled, 278-LB: Type 2 Diabetes (T2D) as a Risk Factor for NASH and Significant Liver Fibrosis (F>2) in an International Cohort of 2,363 Patients with Metabolic Steatosis
Journal Articles

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes

Amar Abderrahmani, Loïc Yengo, Robert Caiazzo, Mickaël Canouil, Stéphane Cauchi, Violeta Raverdy, Valérie Plaisance, Valérie Pawlowski, Stéphane Lobbens, Julie Maillet, Laure Rolland, Raphael Boutry, Gurvan Queniat, Maxime Kwapich, Mathie Tenenbaum, Julien Bricambert, Sophie Saussenthaler, Elodie Anthony, Pooja Jha, Julien Derop, Olivier Sand, Iandry Rabearivelo, Audrey Leloire, Marie Pigeyre, Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin, Tasnim Dayeh, Guillaume Lassailly, Philippe Mathurin, Bart Staels, Johan Auwerx, Annette Schürmann, Catherine Postic, Clemens Schafmayer, Jochen Hampe, Amélie Bonnefond, François Pattou, Philippe Froguel
Journal: Diabetes
Diabetes 2018;67(7):1310–1321
https://doi.org/10.2337/db17-1539
Published: 04 May 2018
View article titled, Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

The Sodium–Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model

Michael Joubert, Benoît Jagu, David Montaigne, Xavier Marechal, Angela Tesse, Audrey Ayer, Lucile Dollet, Cédric Le May, Gilles Toumaniantz, Alain Manrique, Flavien Charpentier, Bart Staels, Jocelyne Magré, Bertrand Cariou, Xavier Prieur
Journal: Diabetes
Diabetes 2017;66(4):1030–1040
https://doi.org/10.2337/db16-0733
Published: 04 January 2017
View article titled, The Sodium–Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model
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Includes: Supplementary data
Journal Articles

Comment on Patel et al. ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity. Diabetes 2016;65:85–95

David Montaigne, Augustin Coisne, Xavier Marechal, Bart Staels
Journal: Diabetes
Diabetes 2016;65(2):e1–e2
https://doi.org/10.2337/db15-1425
Published: 13 January 2016
View article titled, Comment on Patel et al. ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity. Diabetes 2016;65:85–95
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Journal Articles

Cdkn2a/p16Ink4a Regulates Fasting-Induced Hepatic Gluconeogenesis Through the PKA-CREB-PGC1α Pathway

Kadiombo Bantubungi, Sarah-Anissa Hannou, Sandrine Caron-Houde, Emmanuelle Vallez, Morgane Baron, Anthony Lucas, Emmanuel Bouchaert, Réjane Paumelle, Anne Tailleux, Bart Staels
Journal: Diabetes
Diabetes 2014;63(10):3199–3209
https://doi.org/10.2337/db13-1921
Published: 15 September 2014
View article titled, <em>Cdkn2a</em>/p16<em><sup>Ink4a</sup></em> Regulates Fasting-Induced Hepatic Gluconeogenesis Through the PKA-CREB-PGC1α Pathway
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Includes: Supplementary data
Journal Articles

Soaping Up Type 2 Diabetes With Bile Acids?: The Link Between Glucose and Bile Acid Metabolism in Humans Tightens: Quality Matters!

Bart Staels, Janne Prawitt
Journal: Diabetes
Diabetes 2013;62(12):3987–3989
https://doi.org/10.2337/db13-1278
Published: 16 November 2013
View article titled, Soaping Up Type 2 Diabetes With Bile Acids?: <subtitle>The Link Between Glucose and Bile Acid Metabolism in Humans Tightens: Quality Matters!</subtitle>
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Journal Articles

Detrimental Effects of Diet-Induced Obesity on τ Pathology Are Independent of Insulin Resistance in τ Transgenic Mice

Antoine Leboucher, Cyril Laurent, Francisco-José Fernandez-Gomez, Sylvie Burnouf, Laetitia Troquier, Sabiha Eddarkaoui, Dominique Demeyer, Raphaëlle Caillierez, Nadège Zommer, Emmanuelle Vallez, Kadiombo Bantubungi, Christophe Breton, Pascal Pigny, Valérie Buée-Scherrer, Bart Staels, Malika Hamdane, Anne Tailleux, Luc Buée, David Blum
Journal: Diabetes
Diabetes 2013;62(5):1681–1688
https://doi.org/10.2337/db12-0866
Published: 16 April 2013
View article titled, Detrimental Effects of Diet-Induced Obesity on τ Pathology Are Independent of Insulin Resistance in τ Transgenic Mice
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Includes: Supplementary data
Journal Articles

Impaired Expression of the Inducible cAMP Early Repressor Accounts for Sustained Adipose CREB Activity in Obesity

Dimitri Favre, Eric Le Gouill, Denis Fahmi, Chantal Verdumo, Giulia Chinetti-Gbaguidi, Bart Staels, Robert Caiazzo, François Pattou, Kim-Anne Lê, Luc Tappy, Romano Regazzi, Vittorio Giusti, Peter Vollenweider, Gérard Waeber, Amar Abderrahmani
Journal: Diabetes
Diabetes 2011;60(12):3169–3174
https://doi.org/10.2337/db10-1743
Published: 13 November 2011
View article titled, Impaired Expression of the Inducible cAMP Early Repressor Accounts for Sustained Adipose CREB Activity in Obesity
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Includes: Supplementary data
Journal Articles

Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity

Janne Prawitt, Mouaadh Abdelkarim, Johanna H.M. Stroeve, Iuliana Popescu, Helene Duez, Vidya R. Velagapudi, Julie Dumont, Emmanuel Bouchaert, Theo H. van Dijk, Anthony Lucas, Emilie Dorchies, Mehdi Daoudi, Sophie Lestavel, Frank J. Gonzalez, Matej Oresic, Bertrand Cariou, Folkert Kuipers, Sandrine Caron, Bart Staels
Journal: Diabetes
Diabetes 2011;60(7):1861–1871
https://doi.org/10.2337/db11-0030
Published: 20 June 2011
View article titled, Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity
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Includes: Supplementary data
Journal Articles

The Natural Protective Mechanism Against Hyperglycemia in Vascular Endothelial Cells: Roles of the Lipid Peroxidation Product 4-Hydroxydodecadienal and Peroxisome Proliferator–Activated Receptor δ

Yael Riahi, Yoav Sin-Malia, Guy Cohen, Evgenia Alpert, Arie Gruzman, Juergen Eckel, Bart Staels, Michel Guichardant, Shlomo Sasson
Journal: Diabetes
Diabetes 2010;59(4):808–818
https://doi.org/10.2337/db09-1207
Published: 27 January 2010
View article titled, The Natural Protective Mechanism Against Hyperglycemia in Vascular Endothelial Cells: <subtitle>Roles of the Lipid Peroxidation Product 4-Hydroxydodecadienal and Peroxisome Proliferator–Activated Receptor δ</subtitle>
Open the PDF for The Natural Protective Mechanism Against Hyperglycemia in Vascular Endothelial Cells: <subtitle>Roles of the Lipid Peroxidation Product 4-Hydroxydodecadienal and Peroxisome Proliferator–Activated Receptor δ</subtitle> in another window
Includes: Supplementary data
Journal Articles

Liver-Specific Peroxisome Proliferator–Activated Receptor α Target Gene Regulation by the Angiotensin Type 1 Receptor Blocker Telmisartan

Markus Clemenz, Nikolaj Frost, Michael Schupp, Sandrine Caron, Anna Foryst-Ludwig, Christian Böhm, Martin Hartge, Ronald Gust, Bart Staels, Thomas Unger, Ulrich Kintscher
Journal: Diabetes
Diabetes 2008;57(5):1405–1413
https://doi.org/10.2337/db07-0839
Published: 01 May 2008
View article titled, Liver-Specific Peroxisome Proliferator–Activated Receptor α Target Gene Regulation by the Angiotensin Type 1 Receptor Blocker Telmisartan
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Includes: Supplementary data
Journal Articles

S 26948: a New Specific Peroxisome Proliferator–Activated Receptor γ Modulator With Potent Antidiabetes and Antiatherogenic Effects

Maria Carmen Carmona, Katie Louche, Bruno Lefebvre, Antoine Pilon, Nathalie Hennuyer, Véronique Audinot-Bouchez, Catherine Fievet, Gérard Torpier, Pierre Formstecher, Pierre Renard, Philippe Lefebvre, Catherine Dacquet, Bart Staels, Louis Casteilla, Luc Pénicaud, on behalf of the Consortium of the French Ministry of Research and Technology
Journal: Diabetes
Diabetes 2007;56(11):2797–2808
https://doi.org/10.2337/db06-1734
Published: 01 November 2007
View article titled, S 26948: <subtitle>a New Specific Peroxisome Proliferator–Activated Receptor γ Modulator With Potent Antidiabetes and Antiatherogenic Effects</subtitle>
Open the PDF for S 26948: <subtitle>a New Specific Peroxisome Proliferator–Activated Receptor γ Modulator With Potent Antidiabetes and Antiatherogenic Effects</subtitle> in another window
Journal Articles

PPARα Agonists Suppress Osteopontin Expression in Macrophages and Decrease Plasma Levels in Patients With Type 2 Diabetes

Takafumi Nakamachi, Takashi Nomiyama, Florence Gizard, Elizabeth B. Heywood, Karrie L. Jones, Yue Zhao, Lucia Fuentes, Kohzo Takebayashi, Yoshimasa Aso, Bart Staels, Toshihiko Inukai, Dennis Bruemmer
Journal: Diabetes
Diabetes 2007;56(6):1662–1670
https://doi.org/10.2337/db06-1177
Published: 01 June 2007
View article titled, PPARα Agonists Suppress Osteopontin Expression in Macrophages and Decrease Plasma Levels in Patients With Type 2 Diabetes
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Journal Articles

Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human β-Cells and Adipose Tissue and Strong Association With Type 2 Diabetes

Stéphane Cauchi, David Meyre, Christian Dina, Hélène Choquet, Chantal Samson, Sophie Gallina, Beverley Balkau, Guillaume Charpentier, François Pattou, Volodymyr Stetsyuk, Raphaël Scharfmann, Bart Staels, Gema Frühbeck, Philippe Froguel
Journal: Diabetes
Diabetes 2006;55(10):2903–2908
https://doi.org/10.2337/db06-0474
Published: 01 October 2006
View article titled, Transcription Factor <em>TCF7L2</em> Genetic Study in the French Population: <subtitle>Expression in Human β-Cells and Adipose Tissue and Strong Association With Type 2 Diabetes</subtitle>
Open the PDF for Transcription Factor <em>TCF7L2</em> Genetic Study in the French Population: <subtitle>Expression in Human β-Cells and Adipose Tissue and Strong Association With Type 2 Diabetes</subtitle> in another window
Includes: Supplementary data
Journal Articles

Peroxisome Proliferator–Activated Receptor α Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets

Fanny Lalloyer, Brigitte Vandewalle, Frédéric Percevault, Gérard Torpier, Julie Kerr-Conte, Maaike Oosterveer, Réjane Paumelle, Jean-Charles Fruchart, Folkert Kuipers, François Pattou, Catherine Fiévet, Bart Staels
Journal: Diabetes
Diabetes 2006;55(6):1605–1613
https://doi.org/10.2337/db06-0016
Published: 01 June 2006
View article titled, Peroxisome Proliferator–Activated Receptor α Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets
Open the PDF for Peroxisome Proliferator–Activated Receptor α Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets in another window
Includes: Supplementary data