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Journal Articles

Activation of the HPA Axis Does Not Explain Nonresponsiveness to GLP-1R Agonist Treatment in Individuals With Type 2 Diabetes

Sevilay Tokgöz, Marti Boss, Theodorus J.P. Jansen, Rick Meijer, Cathelijne Frielink, Arianne C. van Bon, Cees J. Tack, Bastiaan E. de Galan, Martin Gotthardt

Diabetes 2025;74(2):212–222

https://doi.org/10.2337/db24-0463

Published: 19 November 2024

View article titled, Activation of the HPA Axis Does Not Explain Nonresponsiveness to GLP-1R Agonist Treatment in Individuals With Type 2 Diabetes

Meeting Abstracts

251-OR: The Impact of Identifying Sleep with a Fitbit on Calculated Rates of Nocturnal Hypoglycemia—The Hypo-Metrics Study

GILBERTE MARTINE-EDITH, PATRICK DIVILLY, NATALIE ZAREMBA, UFFE SOEHOLM, ANDREW KINGSNORTH, ZEINAB MAHMOUDI, MIKEL GOMES, BASTIAAN E. DE GALAN, ULRIK PEDERSEN-BJERGAARD, RORY J. MCCRIMMON, ERIC RENARD, SIMON R. HELLER, MARK EVANS, JULIA K. MADER, STEPHANIE A. AMIEL, PRATIK CHOUDHARY, HYPO-RESOLVE CONSORTIUM

Diabetes 2023;72(Supplement_1):251-OR

https://doi.org/10.2337/db23-251-OR

Published: 20 June 2023

View article titled, 251-OR: The Impact of Identifying Sleep with a Fitbit on Calculated Rates of Nocturnal Hypoglycemia—The Hypo-Metrics Study

Meeting Abstracts

250-OR: Majority of Sensor Hypoglycemia Is Not Detected by People Living with Diabetes—Hypo-METRICS Study

PATRICK DIVILLY, GILBERTE MARTINE-EDITH, ZEINAB MAHMOUDI, NATALIE ZAREMBA, UFFE SOEHOLM, BASTIAAN E. DE GALAN, ULRIK PEDERSEN-BJERGAARD, RORY J. MCCRIMMON, ERIC RENARD, SIMON R. HELLER, MARK EVANS, JULIA K. MADER, STEPHANIE A. AMIEL, PRATIK CHOUDHARY, HYPO-RESOLVE CONSORTIUM

Diabetes 2023;72(Supplement_1):250-OR

https://doi.org/10.2337/db23-250-OR

Published: 20 June 2023

View article titled, 250-OR: Majority of Sensor Hypoglycemia Is Not Detected by People Living with Diabetes—Hypo-METRICS Study

Meeting Abstracts

392-P: Optimizing Duration and Threshold of Sensor Glucose for Identifying Symptomatic Hypoglycemia in Insulin-Treated Diabetes—Hypo-METRICS Study

PATRICK DIVILLY, ZEINAB MAHMOUDI, GILBERTE MARTINE-EDITH, DIMITRI BOIROUX, NATALIE ZAREMBA, UFFE SOEHOLM, MIKEL GOMES, ALLAN A. VAAG, BASTIAAN E. DE GALAN, ULRIK PEDERSEN-BJERGAARD, RORY J. MCCRIMMON, JULIA K. MADER, MARK EVANS, STEPHANIE A. AMIEL, PRATIK CHOUDHARY, HYPO-RESOLVE CONSORTIUM

Diabetes 2023;72(Supplement_1):392-P

https://doi.org/10.2337/db23-392-P

Published: 20 June 2023

View article titled, 392-P: Optimizing Duration and Threshold of Sensor Glucose for Identifying Symptomatic Hypoglycemia in Insulin-Treated Diabetes—Hypo-METRICS Study

Meeting Abstracts

391-P: Individualized Optimization of Duration and Threshold of Sensor Hypoglycemia Improves Identification of Symptomatic Hypoglycemia Episodes—Hypo-METRICS Study

ZEINAB MAHMOUDI, PATRICK DIVILLY, GILBERTE MARTINE-EDITH, DIMITRI BOIROUX, NATALIE ZAREMBA, UFFE SOEHOLM, MIKEL GOMES, ALLAN A. VAAG, JANE SPEIGHT, BASTIAAN E. DE GALAN, ULRIK PEDERSEN-BJERGAARD, RORY J. MCCRIMMON, ERIC RENARD, SIMON R. HELLER, MARK EVANS, JULIA K. MADER, STEPHANIE A. AMIEL, PRATIK CHOUDHARY, HYPO-RESOLVE CONSORTIUM

Diabetes 2023;72(Supplement_1):391-P

https://doi.org/10.2337/db23-391-P

Published: 20 June 2023

View article titled, 391-P: Individualized Optimization of Duration and Threshold of Sensor Hypoglycemia Improves Identification of Symptomatic Hypoglycemia Episodes—Hypo-METRICS Study

Meeting Abstracts

388-P: The Impact of Routine CGM on Hypoglycemia Rates and Psychological Outcomes in the Hypo-METRICS Study

NATALIE ZAREMBA, PATRICK DIVILLY, GILBERTE MARTINE-EDITH, ZEINAB MAHMOUDI, UFFE SOEHOLM, BASTIAAN E. DE GALAN, ULRIK PEDERSEN-BJERGAARD, RORY J. MCCRIMMON, JULIA K. MADER, MARK EVANS, ERIC RENARD, SIMON R. HELLER, JANE SPEIGHT, STEPHANIE A. AMIEL, PRATIK CHOUDHARY

Diabetes 2023;72(Supplement_1):388-P

https://doi.org/10.2337/db23-388-P

Published: 20 June 2023

View article titled, 388-P: The Impact of Routine CGM on Hypoglycemia Rates and Psychological Outcomes in the Hypo-METRICS Study

Journal Articles

Monitoring β-Cell Survival After Intrahepatic Islet Transplantation Using Dynamic Exendin PET Imaging: A Proof-of-Concept Study in Individuals With Type 1 Diabetes

Theodorus J.P. Jansen, Mijke Buitinga, Marti Boss, Michiel F. Nijhoff, Maarten Brom, Bastiaan E. de Galan, Marinette van der Graaf, Sebastiaan van Koeverden, Marie-Christine Vantyghem, Amandine Beron, François Pattou, Marten A. Engelse, Irina Velikyan, Olof Eriksson, Eelco J.P. de Koning, Martin Gotthardt

Diabetes 2023;72(7):898–907

https://doi.org/10.2337/db22-0884

Published: 17 April 2023

View article titled, Monitoring β-Cell Survival After Intrahepatic Islet Transplantation Using Dynamic Exendin PET Imaging: A Proof-of-Concept Study in Individuals With Type 1 Diabetes

Journal Articles

Sustained Proinflammatory Effects of Hypoglycemia in People With Type 2 Diabetes and in People Without Diabetes

Clementine E.M. Verhulst, Julia I.P. van Heck, Therese W. Fabricius, Rinke Stienstra, Steven Teerenstra, Rory J. McCrimmon, Cees J. Tack, Ulrik Pedersen-Bjergaard, Bastiaan E. de Galan

Diabetes 2022;71(12):2716–2727

https://doi.org/10.2337/db22-0246

Published: 18 July 2022

View article titled, Sustained Proinflammatory Effects of Hypoglycemia in People With Type 2 Diabetes and in People Without Diabetes

Meeting Abstracts

233-OR: Impact of Nocturnal Hypoglycemia on Daily Sleep Quality, Mood, and Alertness among Adults with Type 1 Diabetes: The Hypo-METRICS (Hypoglycaemia Measurement, Thresholds, and Impacts) Study

Diabetes 2022;71(Supplement_1):233-OR

https://doi.org/10.2337/db22-233-OR

Published: 01 June 2022

View article titled, 233-OR: Impact of Nocturnal Hypoglycemia on Daily Sleep Quality, Mood, and Alertness among Adults with Type 1 Diabetes: The Hypo-METRICS (Hypoglycaemia Measurement, Thresholds, and Impacts) Study

Meeting Abstracts

238-OR: A Single Hypoglycemic Event Causes a Prolonged Immune Response

CLEMENTINE E. VERHULST, JULIA VAN HECK, THERESE W. FABRICIUS, RINKE STIENSTRA, CORNELIS TACK, ULRIK PEDERSEN-BJERGAARD, BASTIAAN E. DE GALAN, HYPO-RESOLVE CONSORTIUM

Diabetes 2022;71(Supplement_1):238-OR

https://doi.org/10.2337/db22-238-OR

Published: 01 June 2022

View article titled, 238-OR: A Single Hypoglycemic Event Causes a Prolonged Immune Response

Meeting Abstracts

711-P: User Acceptability of Ecological Momentary Assessment to Report Hypoglycemia over Ten Weeks Using a Novel Smartphone Application in the Hypo-METRICS Study: Hypoglycemia Measurements, Thresholds and Impacts

NATALIE ZAREMBA, GILBERTE MARTINE-EDITH, PATRICK DIVILLY, ZEINAB MAHMOUDI, UFFE SOEHOLM, MELANIE M. BROADLEY, FRANS POUWER, BASTIAAN E. DE GALAN, ULRIK PEDERSEN-BJERGAARD, RORY J. MCCRIMMON, ERIC RENARD, SIMON R. HELLER, MARK EVANS, JULIA K. MADER, ALEXANDER SEIBOLD, STEPHANIE A. AMIEL, PRATIK CHOUDHARY, HYPO-RESOLVE CONSORTIUM

Diabetes 2022;71(Supplement_1):711-P

https://doi.org/10.2337/db22-711-P

Published: 01 June 2022

View article titled, 711-P: User Acceptability of Ecological Momentary Assessment to Report Hypoglycemia over Ten Weeks Using a Novel Smartphone Application in the Hypo-METRICS Study: Hypoglycemia Measurements, Thresholds and Impacts

Meeting Abstracts

689-P: Comparing the Rates of Sensor-Detected Hypoglycaemia and Patient-Reported Hypoglycaemia by Awareness of Hypoglycaemia Using Continuous Glucose Monitoring: The Hypo-METRICS Trial

PATRICK DIVILLY, GILBERTE MARTINE-EDITH, ZEINAB MAHMOUDI, NATALIE ZAREMBA, UFFE SOEHOLM, ULRIK PEDERSEN-BJERGAARD, RORY J. MCCRIMMON, BASTIAAN E. DE GALAN, ERIC RENARD, SIMON R. HELLER, MARK EVANS, JULIA K. MADER, STEPHANIE A. AMIEL, PRATIK CHOUDHARY, ALEXANDER SEIBOLD

Diabetes 2022;71(Supplement_1):689-P

https://doi.org/10.2337/db22-689-P

Published: 01 June 2022

View article titled, 689-P: Comparing the Rates of Sensor-Detected Hypoglycaemia and Patient-Reported Hypoglycaemia by Awareness of Hypoglycaemia Using Continuous Glucose Monitoring: The Hypo-METRICS Trial

Meeting Abstracts

688-P: Comparing Rates of Sensor-Detected Hypoglycaemia and Patient-Reported Hypoglycaemia by Method of Glucose Monitoring: The Hypo-METRICS Trial

PATRICK DIVILLY, GILBERTE MARTINE-EDITH, ZEINAB MAHMOUDI, NATALIE ZAREMBA, UFFE SOEHOLM, BASTIAAN E. DE GALAN, ULRIK PEDERSEN-BJERGAARD, RORY J. MCCRIMMON, ERIC RENARD, SIMON R. HELLER, MARK EVANS, STEPHANIE A. AMIEL, PRATIK CHOUDHARY, ALEXANDER SEIBOLD

Diabetes 2022;71(Supplement_1):688-P

https://doi.org/10.2337/db22-688-P

Published: 01 June 2022

View article titled, 688-P: Comparing Rates of Sensor-Detected Hypoglycaemia and Patient-Reported Hypoglycaemia by Method of Glucose Monitoring: The Hypo-METRICS Trial

Meeting Abstracts

373-P: A Systematic Review and Meta-analysis of the Impact of Acute Hypoglycemia on Cognitive Function in Adults with Type 1 Diabetes

MELANIE M. BROADLEY, HANNAH CHATWIN, UFFE SOEHOLM, JOHANNE AXELSEN, STEPHANIE A. AMIEL, PRATIK CHOUDHARY, BASTIAAN E. DE GALAN, THERESE W. FABRICIUS, SIMON R. HELLER, CHRISTEL HENDRIECKX, RORY J. MCCRIMMON, GIESJE NEFS, ULRIK PEDERSEN-BJERGAARD, CLEMENTINE E. VERHULST, JANE SPEIGHT, FRANS POUWER, THE HYPO-RESOLVE CONSORTIUM

Diabetes 2022;71(Supplement_1):373-P

https://doi.org/10.2337/db22-373-P

Published: 01 June 2022

View article titled, 373-P: A Systematic Review and Meta-analysis of the Impact of Acute Hypoglycemia on Cognitive Function in Adults with Type 1 Diabetes

Meeting Abstracts

46-OR: Hypoglycemia Increases the Left Ventricular Ejection Fraction in People with Diabetes and Healthy Controls

THERESE W. FABRICIUS, CLEMENTINE E. VERHULST, MALENE WIENBERG, ANTHONIE L. DUIJNHOUWER, PETER L. KRISTENSEN, BASTIAAN E. DE GALAN, ULRIK PEDERSEN-BJERGAARD

Diabetes 2021;70(Supplement_1):46-OR

https://doi.org/10.2337/db21-46-OR

Published: 01 June 2021

View article titled, 46-OR: Hypoglycemia Increases the Left Ventricular Ejection Fraction in People with Diabetes and Healthy Controls

Meeting Abstracts

Prevalence of Impaired Awareness of Hypoglycemia and Severe Hypoglycemia among People with Type 2 Diabetes Treated with Insulin—The Dutch Diabetes Pearl Cohort

LIAN VAN MEIJEL, DE VEGT FEMMIE, CORNELIS TACK, EVERTINE J. ABBINK, FEMKE RUTTERS, JACQUELINE M. DEKKER, BRUCE H. WOLFFENBUTTEL, FRITS HOLLEMAN, J. HANS DEVRIES, NATHALIE MASUREL, HANNO PIJL, BEHIYE OZCAN, BIANCA SILVIUS, BASTIAAN E. DE GALAN

Diabetes 2018;67(Supplement_1):106-OR

https://doi.org/10.2337/db18-106-OR

Published: 01 July 2018

View article titled, Prevalence of Impaired Awareness of Hypoglycemia and Severe Hypoglycemia among People with Type 2 Diabetes Treated with Insulin—The Dutch Diabetes Pearl Cohort

Journal Articles

Effect of Exercise-Induced Lactate Elevation on Brain Lactate Levels During Hypoglycemia in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia

Evita C. Wiegers, Hanne M. Rooijackers, Cees J. Tack, Hans J.M.M. Groenewoud, Arend Heerschap, Bastiaan E. de Galan, Marinette van der Graaf

Diabetes 2017;66(12):3105–3110

https://doi.org/10.2337/db17-0794

Published: 21 September 2017

View article titled, Effect of Exercise-Induced Lactate Elevation on Brain Lactate Levels During Hypoglycemia in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia

Includes: Supplementary data

Journal Articles

A Single Bout of High-Intensity Interval Training Reduces Awareness of Subsequent Hypoglycemia in Patients With Type 1 Diabetes

Hanne M. Rooijackers, Evita C. Wiegers, Marinette van der Graaf, Dick H. Thijssen, Roy P.C. Kessels, Cees J. Tack, Bastiaan E. de Galan

Diabetes 2017;66(7):1990–1998

https://doi.org/10.2337/db16-1535

Published: 18 April 2017

View article titled, A Single Bout of High-Intensity Interval Training Reduces Awareness of Subsequent Hypoglycemia in Patients With Type 1 Diabetes

Journal Articles

Proinflammatory Effects of Hypoglycemia in Humans With or Without Diabetes

Jacqueline M. Ratter, Hanne M.M. Rooijackers, Cees J. Tack, Anneke G.M. Hijmans, Mihai G. Netea, Bastiaan E. de Galan, Rinke Stienstra

Diabetes 2017;66(4):1052–1061

https://doi.org/10.2337/db16-1091

Published: 23 January 2017

View article titled, Proinflammatory Effects of Hypoglycemia in Humans With or Without Diabetes

Includes: Supplementary data

Journal Articles

Brain Lactate Concentration Falls in Response to Hypoglycemia in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia

Evita C. Wiegers, Hanne M. Rooijackers, Cees J. Tack, Arend Heerschap, Bastiaan E. de Galan, Marinette van der Graaf

Diabetes 2016;65(6):1601–1605

https://doi.org/10.2337/db16-0068

Published: 18 March 2016

View article titled, Brain Lactate Concentration Falls in Response to Hypoglycemia in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia

Includes: Supplementary data

NARROW

Activation of the HPA Axis Does Not Explain Nonresponsiveness to GLP-1R Agonist Treatment in Individuals With Type 2 Diabetes

251-OR: The Impact of Identifying Sleep with a Fitbit on Calculated Rates of Nocturnal Hypoglycemia—The Hypo-Metrics Study

250-OR: Majority of Sensor Hypoglycemia Is Not Detected by People Living with Diabetes—Hypo-METRICS Study

392-P: Optimizing Duration and Threshold of Sensor Glucose for Identifying Symptomatic Hypoglycemia in Insulin-Treated Diabetes—Hypo-METRICS Study

391-P: Individualized Optimization of Duration and Threshold of Sensor Hypoglycemia Improves Identification of Symptomatic Hypoglycemia Episodes—Hypo-METRICS Study

388-P: The Impact of Routine CGM on Hypoglycemia Rates and Psychological Outcomes in the Hypo-METRICS Study

Monitoring β-Cell Survival After Intrahepatic Islet Transplantation Using Dynamic Exendin PET Imaging: A Proof-of-Concept Study in Individuals With Type 1 Diabetes

Sustained Proinflammatory Effects of Hypoglycemia in People With Type 2 Diabetes and in People Without Diabetes

233-OR: Impact of Nocturnal Hypoglycemia on Daily Sleep Quality, Mood, and Alertness among Adults with Type 1 Diabetes: The Hypo-METRICS (Hypoglycaemia Measurement, Thresholds, and Impacts) Study

238-OR: A Single Hypoglycemic Event Causes a Prolonged Immune Response

711-P: User Acceptability of Ecological Momentary Assessment to Report Hypoglycemia over Ten Weeks Using a Novel Smartphone Application in the Hypo-METRICS Study: Hypoglycemia Measurements, Thresholds and Impacts

689-P: Comparing the Rates of Sensor-Detected Hypoglycaemia and Patient-Reported Hypoglycaemia by Awareness of Hypoglycaemia Using Continuous Glucose Monitoring: The Hypo-METRICS Trial

688-P: Comparing Rates of Sensor-Detected Hypoglycaemia and Patient-Reported Hypoglycaemia by Method of Glucose Monitoring: The Hypo-METRICS Trial

373-P: A Systematic Review and Meta-analysis of the Impact of Acute Hypoglycemia on Cognitive Function in Adults with Type 1 Diabetes

46-OR: Hypoglycemia Increases the Left Ventricular Ejection Fraction in People with Diabetes and Healthy Controls

Prevalence of Impaired Awareness of Hypoglycemia and Severe Hypoglycemia among People with Type 2 Diabetes Treated with Insulin—The Dutch Diabetes Pearl Cohort

Effect of Exercise-Induced Lactate Elevation on Brain Lactate Levels During Hypoglycemia in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia

A Single Bout of High-Intensity Interval Training Reduces Awareness of Subsequent Hypoglycemia in Patients With Type 1 Diabetes

Proinflammatory Effects of Hypoglycemia in Humans With or Without Diabetes

Brain Lactate Concentration Falls in Response to Hypoglycemia in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia

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