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Journal Articles

Pharmacological Activation of PDC Flux Reverses Lipid-Induced Inhibition of Insulin Action in Muscle During Recovery From Exercise

Christian S. Carl, Marie M. Jensen, Kim A. Sjøberg, Dumitru Constantin-Teodosiu, Ian R. Hill, Rasmus Kjøbsted, Paul L. Greenhaff, Jørgen F.P. Wojtaszewski, Erik A. Richter, Andreas M. Fritzen, Bente Kiens
Journal: Diabetes
Diabetes 2024;73(7):1072–1083
https://doi.org/10.2337/db23-0879
Published: 12 April 2024
View articletitled, Pharmacological Activation of PDC Flux Reverses Lipid-Induced Inhibition of Insulin Action in Muscle During Recovery From Exercise
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Journal Articles

Insulin Sensitization Following a Single Exercise Bout Is Uncoupled to Glycogen in Human Skeletal Muscle: A Meta-analysis of 13 Single-Center Human Studies

Janne R. Hingst, Johan D. Onslev, Stephanie Holm, Rasmus Kjøbsted, Christian Frøsig, Kohei Kido, Dorte E. Steenberg, Magnus R. Larsen, Jonas M. Kristensen, Christian Strini Carl, Kim Sjøberg, Farah S.L. Thong, Wim Derave, Christian Pehmøller, Nina Brandt, Glenn McConell, Jørgen Jensen, Bente Kiens, Erik A. Richter, Jørgen F.P. Wojtaszewski
Journal: Diabetes
Diabetes 2022;71(11):2237–2250
https://doi.org/10.2337/db22-0015
Published: 13 October 2022
View articletitled, Insulin Sensitization Following a Single Exercise Bout Is Uncoupled to Glycogen in Human Skeletal Muscle: A Meta-analysis of 13 Single-Center Human Studies
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Journal Articles

Small Amounts of Dietary Medium-Chain Fatty Acids Protect Against Insulin Resistance During Caloric Excess in Humans

Anne-Marie Lundsgaard, Andreas M. Fritzen, Kim A. Sjøberg, Maximilian Kleinert, Erik A. Richter, Bente Kiens
Journal: Diabetes
Diabetes 2021;70(1):91–98
https://doi.org/10.2337/db20-0582
Published: 29 October 2020
View articletitled, Small Amounts of Dietary Medium-Chain Fatty Acids Protect Against Insulin Resistance During Caloric Excess in Humans
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Journal Articles

Mechanisms Underlying Absent Training-Induced Improvement in Insulin Action in Lean, Hyperandrogenic Women With Polycystic Ovary Syndrome

Solvejg L. Hansen, Kirstine N. Bojsen-Møller, Anne-Marie Lundsgaard, Frederikke L. Hendrich, Lisbeth Nilas, Kim A. Sjøberg, Janne R. Hingst, Annette K. Serup, Carlos Henríquez Olguín, Christian S. Carl, Louise F. Wernblad, Marie Henneberg, Katja M. Lustrup, Christine Hansen, Thomas E. Jensen, Sten Madsbad, Jørgen F. P. Wojtaszewski, Erik A. Richter, Bente Kiens
Journal: Diabetes
Diabetes 2020;69(11):2267–2280
https://doi.org/10.2337/db20-0062
Published: 01 September 2020
View articletitled, Mechanisms Underlying Absent Training-Induced Improvement in Insulin Action in Lean, Hyperandrogenic Women With Polycystic Ovary Syndrome
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Journal Articles

A Single Bout of One-Legged Exercise to Local Exhaustion Decreases Insulin Action in Nonexercised Muscle Leading to Decreased Whole-Body Insulin Action

Dorte E. Steenberg, Janne R. Hingst, Jesper B. Birk, Anette Thorup, Jonas M. Kristensen, Kim A. Sjøberg, Bente Kiens, Erik A. Richter, Jørgen F.P. Wojtaszewski
Journal: Diabetes
Diabetes 2020;69(4):578–590
https://doi.org/10.2337/db19-1010
Published: 23 January 2020
View articletitled, A Single Bout of One-Legged Exercise to Local Exhaustion Decreases Insulin Action in Nonexercised Muscle Leading to Decreased Whole-Body Insulin Action
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Journal Articles

ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations

Anne-Sofie Graae, Niels Grarup, Rasmus Ribel-Madsen, Sara H. Lystbæk, Trine Boesgaard, Harald Staiger, Andreas Fritsche, Niels Wellner, Karolina Sulek, Mads Kjolby, Marie Balslev Backe, Sabina Chubanava, Clara Prats, Annette K. Serup, Jesper B. Birk, Johanne Dubail, Linn Gillberg, Sara G. Vienberg, Anders Nykjær, Bente Kiens, Jørgen F.P. Wojtaszewski, Steen Larsen, Suneel S. Apte, Hans-Ulrich Häring, Allan Vaag, Björn Zethelius, Oluf Pedersen, Jonas T. Treebak, Torben Hansen, Birgitte Holst
Journal: Diabetes
Diabetes 2019;68(3):502–514
https://doi.org/10.2337/db18-0418
Published: 09 January 2019
View articletitled, ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations
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Includes: Supplementary data
Journal Articles

Hepatic Insulin Clearance in Regulation of Systemic Insulin Concentrations—Role of Carbohydrate and Energy Availability

Kirstine N. Bojsen-Møller, Anne-Marie Lundsgaard, Sten Madsbad, Bente Kiens, Jens Juul Holst
Journal: Diabetes
Diabetes 2018;67(11):2129–2136
https://doi.org/10.2337/db18-0539
Published: 11 October 2018
View articletitled, Hepatic Insulin Clearance in Regulation of Systemic Insulin Concentrations—Role of Carbohydrate and Energy Availability
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Journal Articles

Opposite Regulation of Insulin Sensitivity by Dietary Lipid Versus Carbohydrate Excess

Anne-Marie Lundsgaard, Kim A. Sjøberg, Louise D. Høeg, Jacob Jeppesen, Andreas B. Jordy, Annette K. Serup, Andreas M. Fritzen, Henriette Pilegaard, Lene S. Myrmel, Lise Madsen, Jørgen F.P. Wojtaszewski, Erik A. Richter, Bente Kiens
Journal: Diabetes
Diabetes 2017;66(10):2583–2595
https://doi.org/10.2337/db17-0046
Published: 02 August 2017
View articletitled, Opposite Regulation of Insulin Sensitivity by Dietary Lipid Versus Carbohydrate Excess
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Includes: Supplementary data
Journal Articles

Exercise Increases Human Skeletal Muscle Insulin Sensitivity via Coordinated Increases in Microvascular Perfusion and Molecular Signaling

Kim A. Sjøberg, Christian Frøsig, Rasmus Kjøbsted, Lykke Sylow, Maximilian Kleinert, Andrew C. Betik, Christopher S. Shaw, Bente Kiens, Jørgen F.P. Wojtaszewski, Stephen Rattigan, Erik A. Richter, Glenn K. McConell
Journal: Diabetes
Diabetes 2017;66(6):1501–1510
https://doi.org/10.2337/db16-1327
Published: 14 March 2017
View articletitled, Exercise Increases Human Skeletal Muscle Insulin Sensitivity via Coordinated Increases in Microvascular Perfusion and Molecular Signaling
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Journal Articles

Partial Disruption of Lipolysis Increases Postexercise Insulin Sensitivity in Skeletal Muscle Despite Accumulation of DAG

Annette Karen Serup, Thomas Junker Alsted, Andreas Børsting Jordy, Peter Schjerling, Cecilia Holm, Bente Kiens
Journal: Diabetes
Diabetes 2016;65(10):2932–2942
https://doi.org/10.2337/db16-0655
Published: 03 August 2016
View articletitled, Partial Disruption of Lipolysis Increases Postexercise Insulin Sensitivity in Skeletal Muscle Despite Accumulation of DAG
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Includes: Supplementary data
Journal Articles

Early Enhancements of Hepatic and Later of Peripheral Insulin Sensitivity Combined With Increased Postprandial Insulin Secretion Contribute to Improved Glycemic Control After Roux-en-Y Gastric Bypass

Kirstine N. Bojsen-Møller, Carsten Dirksen, Nils B. Jørgensen, Siv H. Jacobsen, Annette K. Serup, Peter H. Albers, Dorte L. Hansen, Dorte Worm, Lars Naver, Viggo B. Kristiansen, Jørgen F.P. Wojtaszewski, Bente Kiens, Jens J. Holst, Erik A. Richter, Sten Madsbad
Journal: Diabetes
Diabetes 2014;63(5):1725–1737
https://doi.org/10.2337/db13-1307
Published: 12 April 2014
View articletitled, Early Enhancements of Hepatic and Later of Peripheral Insulin Sensitivity Combined With Increased Postprandial Insulin Secretion Contribute to Improved Glycemic Control After Roux-en-Y Gastric Bypass
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Journal Articles

Rac1 Signaling Is Required for Insulin-Stimulated Glucose Uptake and Is Dysregulated in Insulin-Resistant Murine and Human Skeletal Muscle

Lykke Sylow, Thomas E. Jensen, Maximilian Kleinert, Kurt Højlund, Bente Kiens, Jørgen Wojtaszewski, Clara Prats, Peter Schjerling, Erik A. Richter
Journal: Diabetes
Diabetes 2013;62(6):1865–1875
https://doi.org/10.2337/db12-1148
Published: 17 May 2013
View articletitled, Rac1 Signaling Is Required for Insulin-Stimulated Glucose Uptake and Is Dysregulated in Insulin-Resistant Murine and Human Skeletal Muscle
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Includes: Supplementary data
Journal Articles

LKB1 Regulates Lipid Oxidation During Exercise Independently of AMPK

Jacob Jeppesen, Stine J. Maarbjerg, Andreas B. Jordy, Andreas M. Fritzen, Christian Pehmøller, Lykke Sylow, Annette Karen Serup, Niels Jessen, Kasper Thorsen, Clara Prats, Klaus Qvortrup, Jason R.B. Dyck, Roger W. Hunter, Kei Sakamoto, David M. Thomson, Peter Schjerling, Jørgen F.P. Wojtaszewski, Erik A. Richter, Bente Kiens
Journal: Diabetes
Diabetes 2013;62(5):1490–1499
https://doi.org/10.2337/db12-1160
Published: 16 April 2013
View articletitled, LKB1 Regulates Lipid Oxidation During Exercise Independently of AMPK
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Includes: Supplementary data
Journal Articles

Exercise Alleviates Lipid-Induced Insulin Resistance in Human Skeletal Muscle–Signaling Interaction at the Level of TBC1 Domain Family Member 4

Christian Pehmøller, Nina Brandt, Jesper B. Birk, Louise D. Høeg, Kim A. Sjøberg, Laurie J. Goodyear, Bente Kiens, Erik A. Richter, Jørgen F.P. Wojtaszewski
Journal: Diabetes
Diabetes 2012;61(11):2743–2752
https://doi.org/10.2337/db11-1572
Published: 16 October 2012
View articletitled, Exercise Alleviates Lipid-Induced Insulin Resistance in Human Skeletal Muscle–Signaling Interaction at the Level of TBC1 Domain Family Member 4
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Includes: Supplementary data
Journal Articles

Response to Comment on: Høeg et al. Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling. Diabetes 2011;60:64–73

Bente Kiens, Louise D. Høeg, Kim A. Sjøberg
Journal: Diabetes
Diabetes 2011;60(9):e24
https://doi.org/10.2337/db11-0879
Published: 20 August 2011
View articletitled, Response to Comment on: Høeg et al. Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling. Diabetes 2011;60:64–73
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Journal Articles

Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling

Louise D. Høeg, Kim A. Sjøberg, Jacob Jeppesen, Thomas E. Jensen, Christian Frøsig, Jesper B. Birk, Bruno Bisiani, Natalie Hiscock, Henriette Pilegaard, Jørgen F.P. Wojtaszewski, Erik A. Richter, Bente Kiens
Journal: Diabetes
Diabetes 2011;60(1):64–73
https://doi.org/10.2337/db10-0698
Published: 18 October 2010
View articletitled, Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling
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Includes: Supplementary data
Journal Articles

Hormone-Sensitive Lipase Serine Phosphorylation and Glycerol Exchange Across Skeletal Muscle in Lean and Obese Subjects : Effect of β-Adrenergic Stimulation

Johan W.E. Jocken, Carsten Roepstorff, Gijs H. Goossens, Paula van der Baan, Marleen van Baak, Wim H.M. Saris, Bente Kiens, Ellen E. Blaak
Journal: Diabetes
Diabetes 2008;57(7):1834–1841
https://doi.org/10.2337/db07-0857
Published: 01 July 2008
View articletitled, Hormone-Sensitive Lipase Serine Phosphorylation and Glycerol Exchange Across Skeletal Muscle in Lean and Obese Subjects : Effect of β-Adrenergic Stimulation
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Journal Articles

Effects of Endurance Exercise Training on Insulin Signaling in Human Skeletal Muscle: Interactions at the Level of Phosphatidylinositol 3-Kinase, Akt, and AS160

Christian Frøsig, Adam J. Rose, Jonas T. Treebak, Bente Kiens, Erik A. Richter, Jørgen F.P. Wojtaszewski
Journal: Diabetes
Diabetes 2007;56(8):2093–2102
https://doi.org/10.2337/db06-1698
Published: 01 August 2007
View articletitled, Effects of Endurance Exercise Training on Insulin Signaling in Human Skeletal Muscle: Interactions at the Level of Phosphatidylinositol 3-Kinase, Akt, and AS160
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Journal Articles

Caffeine-Induced Impairment of Insulin Action but Not Insulin Signaling in Human Skeletal Muscle Is Reduced by Exercise

Farah S.L. Thong, Wim Derave, Bente Kiens, Terry E. Graham, Birgitte Ursø, Jørgen F.P. Wojtaszewski, Bo F. Hansen, Erik A. Richter
Journal: Diabetes
Diabetes 2002;51(3):583–590
https://doi.org/10.2337/diabetes.51.3.583
Published: 01 March 2002
View articletitled, Caffeine-Induced Impairment of Insulin Action but Not Insulin Signaling in Human Skeletal Muscle Is Reduced by Exercise
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Journal Articles

Regulation of Glycogen Synthase Kinase-3 in Human Skeletal Muscle: Effects of Food Intake and Bicycle Exercise

Jørgen F.P. Wojtaszewski, Pernille Nielsen, Bente Kiens, Erik A. Richter
Journal: Diabetes
Diabetes 2001;50(2):265–269
https://doi.org/10.2337/diabetes.50.2.265
Published: 01 February 2001
View articletitled, Regulation of Glycogen Synthase Kinase-3 in Human Skeletal Muscle: Effects of Food Intake and Bicycle Exercise
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