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Journal Articles

Building the Glucagon-Like Peptide-1 Receptor Brick by Brick: Revisiting a 1993 Diabetes Classic by Thorens et al.

Bernard Thorens, David J. Hodson

Diabetes 2024;73(7):1027–1031

https://doi.org/10.2337/dbi24-0025

Published: 20 June 2024

View article titled, Building the Glucagon-Like Peptide-1 Receptor Brick by Brick: Revisiting a 1993 <em>Diabetes</em> Classic by Thorens et al.

Meeting Abstracts

121-OR: Safety, Tolerability, and Metabolic Effects of Once-Weekly GL0034 (Utreglutide) in Individuals with Obesity—A Multiple Ascending Dose Study

RAJAMANNAR THENNATI, VINOD S. BURADE, MUTHUKUMARAN NATARAJAN, PRADEEP SHAHI, RAVISHANKARA NAGARAJA, SUDEEP K. AGRAWAL, THIERRY DUVAUCHELLE, ADOLFO GARCIA-OCANA, GUY A. RUTTER, RICHARD E. PRATLEY, BERNARD THORENS, TINA VILSBØLL

Diabetes 2024;73(Supplement_1):121-OR

https://doi.org/10.2337/db24-121-OR

Published: 14 June 2024

View article titled, 121-OR: Safety, Tolerability, and Metabolic Effects of Once-Weekly GL0034 (Utreglutide) in Individuals with Obesity—A Multiple Ascending Dose Study

Meeting Abstracts

116-OR: GL0034 (Utreglutide), a Novel GLP-1RA, Increases Liver FGF-21 and Demonstrates Significant Efficacy on Weight Loss, HbA1c, and Triglycerides in db/db Mice

RAJAMANNAR THENNATI, VINOD S. BURADE, MUTHUKUMARAN NATARAJAN, ADOLFO GARCIA-OCANA, GUY A. RUTTER, RICHARD E. PRATLEY, BERNARD THORENS, TINA VILSBØLL

Diabetes 2024;73(Supplement_1):116-OR

https://doi.org/10.2337/db24-116-OR

Published: 14 June 2024

View article titled, 116-OR: GL0034 (Utreglutide), a Novel GLP-1RA, Increases Liver FGF-21 and Demonstrates Significant Efficacy on Weight Loss, HbA1c, and Triglycerides in db/db Mice

Meeting Abstracts

766-P: Safety and Tolerability of Once-Weekly GL0034 (Utreglutide) in Healthy Individuals—A Multiple Ascending Dose Study

RAJAMANNAR THENNATI, VINOD S. BURADE, MUTHUKUMARAN NATARAJAN, PRADEEP SHAHI, RAVISHANKARA NAGARAJA, SATISH T. PANCHAL, SUDEEP K. AGRAWAL, BERNARD JANDRAIN, THIERRY DUVAUCHELLE, ADOLFO GARCIA-OCANA, GUY A. RUTTER, RICHARD E. PRATLEY, BERNARD THORENS, TINA VILSBØLL

Diabetes 2023;72(Supplement_1):766-P

https://doi.org/10.2337/db23-766-P

Published: 20 June 2023

View article titled, 766-P: Safety and Tolerability of Once-Weekly GL0034 (Utreglutide) in Healthy Individuals—A Multiple Ascending Dose Study

Meeting Abstracts

765-P: A Single Ascending Dose Study of the Novel GLP-1 Receptor Agonist GL0034 (Utreglutide) in Obese Individuals without Diabetes

Diabetes 2023;72(Supplement_1):765-P

https://doi.org/10.2337/db23-765-P

Published: 20 June 2023

View article titled, 765-P: A Single Ascending Dose Study of the Novel GLP-1 Receptor Agonist GL0034 (Utreglutide) in Obese Individuals without Diabetes

Journal Articles

Susumu Seino, MD, DMSci (1948–2021): A Pioneer in the Biology of Insulin Secretion

Domenico Accili, Graeme I. Bell, Bernard Thorens

Diabetes 2022;71(12):2490–2495

https://doi.org/10.2337/dbi22-0011

Published: 21 November 2022

View article titled, Susumu Seino, MD, DMSci (1948–2021): A Pioneer in the Biology of Insulin Secretion

Meeting Abstracts

744-P: Effects of a Novel Long-Acting GIP/GLP-1/Glucagon Trireceptor Agonist, HISHS-3001, on HbA1c, Body Weight, and Lipid Metabolism

VINOD S. BURADE, ADOLFO GARCIA-OCANA, RICHARD E. PRATLEY, GUY A. RUTTER, TINA VILSBØLL, BERNARD THORENS, RAJAMANNAR THENNATI

Diabetes 2022;71(Supplement_1):744-P

https://doi.org/10.2337/db22-744-P

Published: 01 June 2022

View article titled, 744-P: Effects of a Novel Long-Acting GIP/GLP-1/Glucagon Trireceptor Agonist, HISHS-3001, on HbA1c, Body Weight, and Lipid Metabolism

Journal Articles

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study

Diabetes 2021;70(11):2683–2693

https://doi.org/10.2337/db20-1281

Published: 10 August 2021

View article titled, Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study

Meeting Abstracts

638-P: A Novel, Long-Acting Dual Agonist for GIPR/GLP-1R, HISHS-2001, Demonstrates Effects on HbA1c and Weight Loss in the db/db Mouse Model of Type 2 Diabetes

VINOD S. BURADE, ADOLFO GARCIA-OCANA, RICHARD E. PRATLEY, GUY A. RUTTER, TINA VILSBØLL, BERNARD THORENS, RAJAMANNAR THENNATI

Diabetes 2021;70(Supplement_1):638-P

https://doi.org/10.2337/db21-638-P

Published: 01 June 2021

View article titled, 638-P: A Novel, Long-Acting Dual Agonist for GIPR/GLP-1R, HISHS-2001, Demonstrates Effects on HbA1c and Weight Loss in the db/db Mouse Model of Type 2 Diabetes

Journal Articles

Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis

Alexandre Picard, Salima Metref, David Tarussio, Wanda Dolci, Xavier Berney, Sophie Croizier, Gwenaël Labouebe, Bernard Thorens

Diabetes 2021;70(7):1443–1457

https://doi.org/10.2337/db20-1121

Published: 21 April 2021

View article titled, Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis

Journal Articles

Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation

Simon Quenneville, Gwenaël Labouèbe, Davide Basco, Salima Metref, Benoit Viollet, Marc Foretz, Bernard Thorens

Diabetes 2020;69(11):2253–2266

https://doi.org/10.2337/db20-0577

Published: 24 August 2020

View article titled, Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation

Meeting Abstracts

350-OR: A Novel Long-Acting GLP-1 Agonist (GL0034) Demonstrates Remarkable Efficacy on HbA1c, Weight Loss, and Triglycerides in a Model of Type 2 Diabetes, the db/db Mouse

RAJAMANNAR THENNATI, VINOD S. BURADE, TINA VILSBØLL, BERNARD THORENS, GUY A. RUTTER

Diabetes 2020;69(Supplement_1):350-OR

https://doi.org/10.2337/db20-350-OR

Published: 01 June 2020

View article titled, 350-OR: A Novel Long-Acting GLP-1 Agonist (GL0034) Demonstrates Remarkable Efficacy on HbA1c, Weight Loss, and Triglycerides in a Model of Type 2 Diabetes, the db/db Mouse

Meeting Abstracts

946-P: The GLP-1 Receptor Agonist GL0034 Activates Central Regions Controlling Glucose Homeostasis and Feeding Behavior

ALEXANDRE PICARD, DAVID TARUSSIO, RAJAMANNAR THENNATI, VINOD S. BURADE, BERNARD THORENS

Diabetes 2020;69(Supplement_1):946-P

https://doi.org/10.2337/db20-946-P

Published: 01 June 2020

View article titled, 946-P: The GLP-1 Receptor Agonist GL0034 Activates Central Regions Controlling Glucose Homeostasis and Feeding Behavior

Journal Articles

Targeting the Brain to Cure Type 2 Diabetes

Bernard Thorens

Diabetes 2019;68(3):476–478

https://doi.org/10.2337/dbi18-0051

Published: 13 February 2019

View article titled, Targeting the Brain to Cure Type 2 Diabetes

Journal Articles

Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase

Laura K.M. Steinbusch, Alexandre Picard, Marion S. Bonnet, Davide Basco, Gwenaël Labouèbe, Bernard Thorens

Diabetes 2016;65(10):2920–2931

https://doi.org/10.2337/db15-1514

Published: 15 July 2016

View article titled, Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase

Includes: Supplementary data

Journal Articles

Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca²⁺ Stores

Alice Marmugi, Julia Parnis, Xi Chen, LeAnne Carmichael, Julie Hardy, Naila Mannan, Piero Marchetti, Lorenzo Piemonti, Domenico Bosco, Paul Johnson, James A.M. Shapiro, Céline Cruciani-Guglielmacci, Christophe Magnan, Mark Ibberson, Bernard Thorens, Héctor H. Valdivia, Guy A. Rutter, Isabelle Leclerc

Diabetes 2016;65(4):1009–1021

https://doi.org/10.2337/db15-1334

Published: 28 January 2016

View article titled, Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca<sup>2+</sup> Stores

Includes: Supplementary data

Journal Articles

Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function

Honey Modi, Cecile Jacovetti, David Tarussio, Salima Metref, Ole D. Madsen, Fu-Ping Zhang, Pia Rantakari, Matti Poutanen, Serge Nef, Tracy Gorman, Romano Regazzi, Bernard Thorens

Diabetes 2015;64(12):4148–4157

https://doi.org/10.2337/db14-1735

Published: 17 September 2015

View article titled, Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function

Includes: Supplementary data

Journal Articles

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

Fabrizio Thorel, Nicolas Damond, Simona Chera, Andreas Wiederkehr, Bernard Thorens, Paolo Meda, Claes B. Wollheim, Pedro L. Herrera

Diabetes 2011;60(11):2872–2882

https://doi.org/10.2337/db11-0876

Published: 17 October 2011

View article titled, Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

Includes: Supplementary data

Journal Articles

Oxidative Phosphorylation Flexibility in the Liver of Mice Resistant to High-Fat Diet–Induced Hepatic Steatosis

Carinne Poussin, Mark Ibberson, Diana Hall, Jun Ding, Jamie Soto, E. Dale Abel, Bernard Thorens

Diabetes 2011;60(9):2216–2224

https://doi.org/10.2337/db11-0338

Published: 20 August 2011

View article titled, Oxidative Phosphorylation Flexibility in the Liver of Mice Resistant to High-Fat Diet–Induced Hepatic Steatosis

Includes: Supplementary data

Journal Articles

In Vivo Conditional Pax4 Overexpression in Mature Islet β-Cells Prevents Stress-Induced Hyperglycemia in Mice

Kai Hui Hu He, Petra I. Lorenzo, Thierry Brun, Carmen M. Jimenez Moreno, Deborah Aeberhard, Jorge Vallejo Ortega, Marion Cornu, Fabrizio Thorel, Asllan Gjinovci, Bernard Thorens, Pedro L. Herrera, Paolo Meda, Claes B. Wollheim, Benoit R. Gauthier

Diabetes 2011;60(6):1705–1715

https://doi.org/10.2337/db10-1102

Published: 21 May 2011

View article titled, In Vivo Conditional Pax4 Overexpression in Mature Islet β-Cells Prevents Stress-Induced Hyperglycemia in Mice

Includes: Supplementary data

NARROW

Building the Glucagon-Like Peptide-1 Receptor Brick by Brick: Revisiting a 1993 Diabetes Classic by Thorens et al.

121-OR: Safety, Tolerability, and Metabolic Effects of Once-Weekly GL0034 (Utreglutide) in Individuals with Obesity—A Multiple Ascending Dose Study

116-OR: GL0034 (Utreglutide), a Novel GLP-1RA, Increases Liver FGF-21 and Demonstrates Significant Efficacy on Weight Loss, HbA1c, and Triglycerides in db/db Mice

766-P: Safety and Tolerability of Once-Weekly GL0034 (Utreglutide) in Healthy Individuals—A Multiple Ascending Dose Study

765-P: A Single Ascending Dose Study of the Novel GLP-1 Receptor Agonist GL0034 (Utreglutide) in Obese Individuals without Diabetes

Susumu Seino, MD, DMSci (1948–2021): A Pioneer in the Biology of Insulin Secretion

744-P: Effects of a Novel Long-Acting GIP/GLP-1/Glucagon Trireceptor Agonist, HISHS-3001, on HbA1c, Body Weight, and Lipid Metabolism

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study

638-P: A Novel, Long-Acting Dual Agonist for GIPR/GLP-1R, HISHS-2001, Demonstrates Effects on HbA1c and Weight Loss in the db/db Mouse Model of Type 2 Diabetes

Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis

Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation

350-OR: A Novel Long-Acting GLP-1 Agonist (GL0034) Demonstrates Remarkable Efficacy on HbA1c, Weight Loss, and Triglycerides in a Model of Type 2 Diabetes, the db/db Mouse

946-P: The GLP-1 Receptor Agonist GL0034 Activates Central Regions Controlling Glucose Homeostasis and Feeding Behavior

Targeting the Brain to Cure Type 2 Diabetes

Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase

Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca²⁺ Stores

Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

Oxidative Phosphorylation Flexibility in the Liver of Mice Resistant to High-Fat Diet–Induced Hepatic Steatosis

In Vivo Conditional Pax4 Overexpression in Mature Islet β-Cells Prevents Stress-Induced Hyperglycemia in Mice

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