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Journal Articles

β-Cell Function and Sensitivity to Incretins Before and After Roux-en-Y Gastric Bypass in Individuals With Type 2 Diabetes

Available to Purchase
Maria S. Svane, Morten Hindsø, Christoffer Martinussen, Carsten Dirksen, Nils B. Jørgensen, Nora Hedbäck, Bolette Hartmann, Viggo B. Kristiansen, Jens J. Holst, Kirstine N. Bojsen-Møller, Sten Madsbad
Journal: Diabetes
Diabetes db241054
https://doi.org/10.2337/db24-1054
Published: 03 July 2025
View articletitled, β-Cell Function and Sensitivity to Incretins Before and After Roux-en-Y Gastric Bypass in Individuals With Type 2 Diabetes
Open the PDF for β-Cell Function and Sensitivity to Incretins Before and After Roux-en-Y Gastric Bypass in Individuals With Type 2 Diabetes in another window
Meeting Abstracts

94-OR: The Glucagonotropic Effect of Glucose-Dependent Insulinotropic Polypeptide Is Negated during Insulin-Induced Hypoglycemia in Persons with Type 1 Diabetes

Free
NIKOLAJ E. SØRUM, JULIE WARNØE, JENS J. HOLST, BOLETTE HARTMANN, LÆRKE S. GASBJERG, JOACHIM STØRLING, THOMAS F. DEJGAARD, MIKKEL B. CHRISTENSEN, FILIP KRAG K. KNOP, ASGER B. LUND
Journal: Diabetes
Diabetes 2025;74(Supplement_1):94-OR
https://doi.org/10.2337/db25-94-OR
Published: 20 June 2025
View articletitled, 94-OR: The Glucagonotropic Effect of Glucose-Dependent Insulinotropic Polypeptide Is Negated during Insulin-Induced Hypoglycemia in Persons with Type 1 Diabetes
Meeting Abstracts

1770-P: Secretin Infusion Has Little or No Effect on Circulating Markers of Bone Remodelling, Incretin Hormones, and Glucagon in Healthy Males

Free
SEBASTIAN M. NGUYEN HEIMBÜRGER, MARIA J. BENTZEN, BOLETTE HARTMANN, JENS J. HOLST, ASGER B. LUND, MIKKEL B. CHRISTENSEN, FILIP KRAG K. KNOP
Journal: Diabetes
Diabetes 2025;74(Supplement_1):1770-P
https://doi.org/10.2337/db25-1770-P
Published: 20 June 2025
View articletitled, 1770-P: Secretin Infusion Has Little or No Effect on Circulating Markers of Bone Remodelling, Incretin Hormones, and Glucagon in Healthy Males
Meeting Abstracts

1661-P: Exogenous Oxytocin Has No Effect on Ad Libitum Food Intake or Postprandial Plasma Glucose Concentrations in Individuals with Obesity

Free
IDA MARIE GETHER, PETUR T. OLAFSSON, VIVIAN KLIIM-HANSEN, CASPER K. NIELSEN, MIRIAM G. PEDERSEN, JENS J. HOLST, BOLETTE HARTMANN, JENS F. REHFELD, MIKKEL B. CHRISTENSEN, FILIP K. KNOP, LÆRKE S. GASBJERG, ASGER B. LUND
Journal: Diabetes
Diabetes 2025;74(Supplement_1):1661-P
https://doi.org/10.2337/db25-1661-P
Published: 20 June 2025
View articletitled, 1661-P: Exogenous Oxytocin Has No Effect on Ad Libitum Food Intake or Postprandial Plasma Glucose Concentrations in Individuals with Obesity
Meeting Abstracts

1659-P: Oxytocin Is Robustly Expressed throughout the Small Intestine in Individuals with and without Type 2 Diabetes and Serum Neurophysin I Levels Are Reduced after Roux-en-y Gastric Bypass

Free
IDA MARIE GETHER, HANNAH GILLIAM-VIGH, VIVIAN KLIIM-HANSEN, BOLETTE HARTMANN, JENS J. HOLST, ASGER B. LUND, LÆRKE S. GASBJERG, FILIP K. KNOP
Journal: Diabetes
Diabetes 2025;74(Supplement_1):1659-P
https://doi.org/10.2337/db25-1659-P
Published: 20 June 2025
View articletitled, 1659-P: Oxytocin Is Robustly Expressed throughout the Small Intestine in Individuals with and without Type 2 Diabetes and Serum Neurophysin I Levels Are Reduced after Roux-en-y Gastric Bypass
Meeting Abstracts

1979-LB: GIP Alone or with GLP-1RA Had No Detectable Effect on Glucose Levels in Individuals with Type 2 Diabetes

Free
MADS M. HELSTED, CHRISTIANE C. FONNESBECH-WULFF, NINA L. SCHALTZ, INGRID W. LUND, JULIE FORMAN, CASPER K. NIELSEN, ANDERS ENGLUND, BOLETTE HARTMANN, TINA VILSBØLL, JENS J. HOLST, ASGER B. LUND, MIKKEL B. CHRISTENSEN, FILIP K. KNOP, LÆRKE S. GASBJERG
Journal: Diabetes
Diabetes 2025;74(Supplement_1):1979-LB
https://doi.org/10.2337/db25-1979-LB
Published: 20 June 2025
View articletitled, 1979-LB: GIP Alone or with GLP-1RA Had No Detectable Effect on Glucose Levels in Individuals with Type 2 Diabetes
Journal Articles

Glucose-Dependent Insulinotropic Polypeptide Is Involved in Postprandial Regulation of Splanchnic Blood Supply

Available to Purchase
Rasmus S. Rasmussen, Ludvig S. Langberg, Frederikke Østergaard, Sophie W. Nielsen, Mark B. Vestergaard, Kirsa Skov-Jeppesen, Bolette Hartmann, Helle Hjorth Johannesen, Jens J. Holst, Bryan Haddock, Henrik B. W. Larsson, Mette M. Rosenkilde, Ali Asmar, Ulrik B. Andersen, Lærke S. Gasbjerg
Journal: Diabetes
Diabetes db250149
https://doi.org/10.2337/db25-0149
Published: 30 May 2025
View articletitled, Glucose-Dependent Insulinotropic Polypeptide Is Involved in Postprandial Regulation of Splanchnic Blood Supply
Open the PDF for Glucose-Dependent Insulinotropic Polypeptide Is Involved in Postprandial Regulation of Splanchnic Blood Supply in another window
Journal Articles

Glucagon Clearance Is Decreased in Chronic Kidney Disease but Preserved in Liver Cirrhosis

Free
Magnus F.G. Grøndahl, Andreas H. Lange, Malte P. Suppli, Jonatan I. Bagger, Mira Thing, Lise L. Gluud, Dea H. Kofod, Mads Hornum, Gerrit van Hall, Samuel A.J. Trammell, Trisha J. Grevengoed, Bolette Hartmann, Jens J. Holst, Tina Vilsbøll, Mikkel B. Christensen, Asger B. Lund, Filip K. Knop
Journal: Diabetes
Diabetes 2024;73(10):1641–1647
https://doi.org/10.2337/db24-0305
Published: 25 July 2024
View articletitled, Glucagon Clearance Is Decreased in Chronic Kidney Disease but Preserved in Liver Cirrhosis
Open the PDF for Glucagon Clearance Is Decreased in Chronic Kidney Disease but Preserved in Liver Cirrhosis in another window
Meeting Abstracts

1619-P: Insulin Resistance Stimulates Intraislet GLP-1 Secretion from a-Cells in Diet-Induced Obese Mice

Free
GIANFRANCO DI GIUSEPPE, SARA L. JEPSEN, JON VERGARA UCIN, BOLETTE HARTMANN, ANDREA GIACCARI, JENS J. HOLST, TERESA MEZZA
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1619-P
https://doi.org/10.2337/db24-1619-P
Published: 14 June 2024
View articletitled, 1619-P: Insulin Resistance Stimulates Intraislet GLP-1 Secretion from a-Cells in Diet-Induced Obese Mice
Meeting Abstracts

73-PUB: Endogenous GIP Lowers Plasma Glucose during Fasting in Obese Individuals

Free
FREDERIKKE KOEFOED-HANSEN, HÜSÜN SHEYMA KIZILKAYA, MADS M. HELSTED, NIKOLAJ E. SØRUM, BOLETTE HARTMANN, FILIP KRAG K. KNOP, LÆRKE S. GASBJERG
Journal: Diabetes
Diabetes 2024;73(Supplement_1):73-PUB
https://doi.org/10.2337/db24-73-PUB
Published: 14 June 2024
View articletitled, 73-PUB: Endogenous GIP Lowers Plasma Glucose during Fasting in Obese Individuals
Journal Articles

In Vivo Inhibition of Dipeptidyl Peptidase 4 Allows Measurement of GLP-1 Secretion in Mice

Free
Mark M. Smits, Katrine D. Galsgaard, Sara Lind Jepsen, Nicolai Wewer Albrechtsen, Bolette Hartmann, Jens J. Holst
Journal: Diabetes
Diabetes 2024;73(5):671–681
https://doi.org/10.2337/db23-0848
Published: 31 January 2024
View articletitled, In Vivo Inhibition of Dipeptidyl Peptidase 4 Allows Measurement of GLP-1 Secretion in Mice
Open the PDF for In Vivo Inhibition of Dipeptidyl Peptidase 4 Allows Measurement of GLP-1 Secretion in Mice in another window
Meeting Abstracts

1651-P: Elevated FGF21 Levels after Total Pancreatectomy and in Response to Single-Dose Glucagon Receptor Antagonism in Humans

Free
MAGNUS F.G. GRØNDAHL, CAROLINE T. JUEL, ASGER LUND, SOFIE HAEDERSDAL, MARIA M. ANDERSEN, JENS S. SVENNINGSEN, MATTHEW GILLUM, BOLETTE HARTMANN, JENS J. HOLST, TINA VILSBØLL, FILIP K. KNOP
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1651-P
https://doi.org/10.2337/db23-1651-P
Published: 20 June 2023
View articletitled, 1651-P: Elevated FGF21 Levels after Total Pancreatectomy and in Response to Single-Dose Glucagon Receptor Antagonism in Humans
Journal Articles

The Importance of Endogenously Secreted GLP-1 and GIP for Postprandial Glucose Tolerance and β-Cell Function After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Surgery

Free
Morten Hindsø, Nora Hedbäck, Maria S. Svane, Andreas Møller, Christoffer Martinussen, Nils B. Jørgensen, Carsten Dirksen, Lærke S. Gasbjerg, Viggo B. Kristiansen, Bolette Hartmann, Mette M. Rosenkilde, Jens J. Holst, Sten Madsbad, Kirstine N. Bojsen-Møller
Journal: Diabetes
Diabetes 2023;72(3):336–347
https://doi.org/10.2337/db22-0568
Published: 07 December 2022
View articletitled, The Importance of Endogenously Secreted GLP-1 and GIP for Postprandial Glucose Tolerance and β-Cell Function After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Surgery
Open the PDF for The Importance of Endogenously Secreted GLP-1 and GIP for Postprandial Glucose Tolerance and β-Cell Function After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Surgery in another window
Journal Articles

Endogenous Glucose-Dependent Insulinotropic Polypeptide Contributes to Sitagliptin-Mediated Improvement in β-Cell Function in Patients With Type 2 Diabetes

Free
Signe Stensen, Lærke S. Gasbjerg, Mette M. Rosenkilde, Tina Vilsbøll, Jens J. Holst, Bolette Hartmann, Mikkel B. Christensen, Filip K. Knop
Journal: Diabetes
Diabetes 2022;71(10):2209–2221
https://doi.org/10.2337/db22-0059
Published: 07 July 2022
View articletitled, Endogenous Glucose-Dependent Insulinotropic Polypeptide Contributes to Sitagliptin-Mediated Improvement in β-Cell Function in Patients With Type 2 Diabetes
Open the PDF for Endogenous Glucose-Dependent Insulinotropic Polypeptide Contributes to Sitagliptin-Mediated Improvement in β-Cell Function in Patients With Type 2 Diabetes in another window
Meeting Abstracts

357-OR: Improved Glycemic Control in Persons with Type 2 Diabetes Improves Beta-Cell Actions of Endogenous Glucose-Dependent Insulinotropic Polypeptide

Free
BJØRN HOE, MADS B. LYNGGAARD, LÆRKE S. GASBJERG, MADS M. HELSTED, SIGNE STENSEN, BOLETTE HARTMANN, JENS J. HOLST, MIKKEL B. CHRISTENSEN, TINA VILSBØLL, FILIP K. KNOP
Journal: Diabetes
Diabetes 2022;71(Supplement_1):357-OR
https://doi.org/10.2337/db22-357-OR
Published: 01 June 2022
View articletitled, 357-OR: Improved Glycemic Control in Persons with Type 2 Diabetes Improves Beta-Cell Actions of Endogenous Glucose-Dependent Insulinotropic Polypeptide
Meeting Abstracts

1385-P: Impact of Preanalytical and Analytical Factors on Glucagon and GLP-1 Levels in Humans

Free
CHRISTINE RASMUSSEN, SASHA KJELDSEN, NICOLE J. JENSEN, NIKLAS HEINZ, BOLETTE HARTMANN, JENS J. HOLST, NICOLAI J. WEWER ALBRECHTSEN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1385-P
https://doi.org/10.2337/db22-1385-P
Published: 01 June 2022
View articletitled, 1385-P: Impact of Preanalytical and Analytical Factors on Glucagon and GLP-1 Levels in Humans
Meeting Abstracts

1362-P: Endogenous Glucose-Dependent Insulinotropic Polypeptide Facilitates Postprandial Intestinal Lipid Uptake in Healthy Men, but Not in Patients with Type 2 Diabetes

Free
LÆRKE S. GASBJERG, MADS M. HELSTED, SIGNE STENSEN, LIVA S.L. KROGH, ALEXANDER H. SPARRE-ULRICH, BOLETTE HARTMANN, TINA VILSBØLL, MIKKEL B. CHRISTENSEN, JENS J. HOLST, CHRISTINA CHRISTOFFERSEN, FILIP K. KNOP, METTE M. ROSENKILDE
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1362-P
https://doi.org/10.2337/db22-1362-P
Published: 01 June 2022
View articletitled, 1362-P: Endogenous Glucose-Dependent Insulinotropic Polypeptide Facilitates Postprandial Intestinal Lipid Uptake in Healthy Men, but Not in Patients with Type 2 Diabetes
Meeting Abstracts

1192-P: Robust Arginine-Stimulated Glucagon Secretion in Patients with Type 1 Diabetes Independent of Diabetes Duration, Age, HbA1c, and Beta-Cell Secretory Capacity

Free
JULIE WARNØE, NICKLAS J. JOHANSEN, ASGER LUND, JONATAN I. BAGGER, NICOLAI J. WEWER ALBRECHTSEN, SR., BOLETTE HARTMANN, JENS J. HOLST, TINA VILSBØLL, HENRIK U. ANDERSEN, THOMAS F. DEJGAARD, FILIP K. KNOP
Journal: Diabetes
Diabetes 2021;70(Supplement_1):1192-P
https://doi.org/10.2337/db21-1192-P
Published: 01 June 2021
View articletitled, 1192-P: Robust Arginine-Stimulated Glucagon Secretion in Patients with Type 1 Diabetes Independent of Diabetes Duration, Age, HbA1c, and Beta-Cell Secretory Capacity
Meeting Abstracts

1224-P: Exogenous Secretin Decreases Energy Intake and Exerts a Bimodular Effect on Postprandial Brown Adipose Tissue Activation in Man

Free
SEBASTIAN M. NGUYEN HEIMBÜRGER, MARIA J. BENTZEN, BOLETTE HARTMANN, JENS J. HOLST, MIKKEL B. CHRISTENSEN, FILIP K. KNOP
Journal: Diabetes
Diabetes 2021;70(Supplement_1):1224-P
https://doi.org/10.2337/db21-1224-P
Published: 01 June 2021
View articletitled, 1224-P: Exogenous Secretin Decreases Energy Intake and Exerts a Bimodular Effect on Postprandial Brown Adipose Tissue Activation in Man
Meeting Abstracts

1215-P: Effects of Exogenous Secretin on Postprandial Plasma Glucose and Lipids and Gallbladder Motility and Hemodynamics in Man

Free
MARIA J. BENTZEN, SEBASTIAN M. NGUYEN HEIMBÜRGER, BOLETTE HARTMANN, JENS J. HOLST, MIKKEL B. CHRISTENSEN, FILIP K. KNOP
Journal: Diabetes
Diabetes 2021;70(Supplement_1):1215-P
https://doi.org/10.2337/db21-1215-P
Published: 01 June 2021
View articletitled, 1215-P: Effects of Exogenous Secretin on Postprandial Plasma Glucose and Lipids and Gallbladder Motility and Hemodynamics in Man