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Meeting Abstracts

41-OR: Insulin Regulates Exosomal MicroRNA Secretion from Adipocytes Completing a Novel Feedback Loop

MARSEL LINO, RUBEN GARCIA MARTIN, VITOR MUÑOZ, BRUNA B. BRANDAO, C. RONALD KAHN

Diabetes 2024;73(Supplement_1):41-OR

https://doi.org/10.2337/db24-41-OR

Published: 14 June 2024

View article titled, 41-OR: Insulin Regulates Exosomal MicroRNA Secretion from Adipocytes Completing a Novel Feedback Loop

Meeting Abstracts

44-OR: Cell Intrinsic Alterations in miRNA Expression and Secretion in Muscle in Type 2 Diabetes

ALLAH NAWAZ, MARSEL LINO, ARIJEET GATTU, NIDA HAIDER, C. RONALD KAHN

Diabetes 2024;73(Supplement_1):44-OR

https://doi.org/10.2337/db24-44-OR

Published: 14 June 2024

View article titled, 44-OR: Cell Intrinsic Alterations in miRNA Expression and Secretion in Muscle in Type 2 Diabetes

Meeting Abstracts

1517-P: Rev-Erba as an Intermediate between Regulation of Circadian Rhythm and Skeletal Muscle Insulin Sensitivity

VITOR R. MUÑOZ, ANA PAULA S.R. PINTO, MARSEL LINO, ADELINO S.R. SILVA, C. RONALD KAHN

Diabetes 2024;73(Supplement_1):1517-P

https://doi.org/10.2337/db24-1517-P

Published: 14 June 2024

View article titled, 1517-P: Rev-Erba as an Intermediate between Regulation of Circadian Rhythm and Skeletal Muscle Insulin Sensitivity

Meeting Abstracts

219-OR: Loss of Insulin Signaling in Microglia Impairs Cellular Uptake of Aß and Neuroinflammatory Response Exacerbating Alzheimer-Like Neuropathology

WENQIANG CHEN, VITOR R. MUÑOZ, C. RONALD KAHN

Diabetes 2024;73(Supplement_1):219-OR

https://doi.org/10.2337/db24-219-OR

Published: 14 June 2024

View article titled, 219-OR: Loss of Insulin Signaling in Microglia Impairs Cellular Uptake of Aß and Neuroinflammatory Response Exacerbating Alzheimer-Like Neuropathology

Meeting Abstracts

292-OR: High-Fat Diets Containing Sucrose and Fructose, but Not Glucose, Induce Obesity and Hepatic Insulin Resistance via Accumulation of Diacylglycerols

SE-HYUNG PARK, TAGHREED I. FADHUL, C. RONALD KAHN, SAMIR SOFTIC

Diabetes 2023;72(Supplement_1):292-OR

https://doi.org/10.2337/db23-292-OR

Published: 20 June 2023

View article titled, 292-OR: High-Fat Diets Containing Sucrose and Fructose, but Not Glucose, Induce Obesity and Hepatic Insulin Resistance via Accumulation of Diacylglycerols

Meeting Abstracts

289-OR: Defining Pathway-Selective Insulin Resistance in Type 2 Diabetes Using iPS Cell-Derived Hepatocytes

ARIJEET GATTU, ANNA KROOK, JULEEN R. ZIERATH, MATTHIAS MANN, C. RONALD KAHN

Diabetes 2023;72(Supplement_1):289-OR

https://doi.org/10.2337/db23-289-OR

Published: 20 June 2023

View article titled, 289-OR: Defining Pathway-Selective Insulin Resistance in Type 2 Diabetes Using iPS Cell-Derived Hepatocytes

Meeting Abstracts

190-OR: Lrtm1, a Novel Regulator of Insulin Signaling and Metabolism

GUOXIAO WANG, YINGYING YU, WENQIANG CHEN, WEIKANG CAI, XIANGYU LIU, C. RONALD KAHN

Diabetes 2023;72(Supplement_1):190-OR

https://doi.org/10.2337/db23-190-OR

Published: 20 June 2023

View article titled, 190-OR: Lrtm1, a Novel Regulator of Insulin Signaling and Metabolism

Meeting Abstracts

290-OR: FoxK1-Associated Gene Regulatory Network—A New Transcriptional Regulator of Hepatic Insulin Action

PRASANNA ALLU, HUI PAN, JONATHAN DREYFUSS, C. RONALD KAHN

Diabetes 2023;72(Supplement_1):290-OR

https://doi.org/10.2337/db23-290-OR

Published: 20 June 2023

View article titled, 290-OR: FoxK1-Associated Gene Regulatory Network—A New Transcriptional Regulator of Hepatic Insulin Action

Meeting Abstracts

1503-P: Insulin Regulates Expression and Secretion of Exosomal MicroRNAs in Adipocytes

MARSEL LINO, HUI PAN, JONATHAN DREYFUSS, C. RONALD KAHN

Diabetes 2023;72(Supplement_1):1503-P

https://doi.org/10.2337/db23-1503-P

Published: 20 June 2023

View article titled, 1503-P: Insulin Regulates Expression and Secretion of Exosomal MicroRNAs in Adipocytes

Meeting Abstracts

21-OR: Insulin and Glucagon Regulate a Novel Bidirectional Long Noncoding RNA/Protein-Coding Gene Pair That Control Cell Sensitivity to Metabolic Stress

XIANGYU LIU, C. RONALD KAHN

Diabetes 2023;72(Supplement_1):21-OR

https://doi.org/10.2337/db23-21-OR

Published: 20 June 2023

View article titled, 21-OR: Insulin and Glucagon Regulate a Novel Bidirectional Long Noncoding RNA/Protein-Coding Gene Pair That Control Cell Sensitivity to Metabolic Stress

Meeting Abstracts

223-OR: ADA Presidents' Select Abstract: Novel Ligand and Kinase-Independent Signaling by the Insulin Receptor

HIROFUMI NAGAO, WEIKANG CAI, HUI PAN, THIAGO M. BATISTA, BRUNA BRANDAO, C. RONALD KAHN

Diabetes 2022;71(Supplement_1):223-OR

https://doi.org/10.2337/db22-223-OR

Published: 01 June 2022

View article titled, 223-OR: ADA Presidents' Select Abstract: Novel Ligand and Kinase-Independent Signaling by the Insulin Receptor

Journal Articles

Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones

Khyati Girdhar, Marion Soto, Qian Huang, Lucie Orliaguet, Carly Cederquist, Bharathi Sundaresh, Jiang Hu, Maximilian Figura, Amol Raisingani, Emanuel E. Canfora, Ercument Dirice, Shiho Fujisaka, Gijs H. Goossens, Ellen E. Blaak, Rohit N. Kulkarni, C. Ronald Kahn, Emrah Altindis

Diabetes 2022;71(5):945–960

https://doi.org/10.2337/db21-0382

Published: 25 February 2022

View article titled, Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones

Meeting Abstracts

1178-P: Portal Vein Metabolites as Intermediate Regulators of the Gut Microbiome in Insulin Resistance

FRANCOIS MOREAU, BRUNA B. BRANDAO, JULIAN AVILA, HUI PAN, JONATHAN DREYFUSS, ALEKSANDAR KOSTIC, CLARY B. CLISH, C. RONALD KAHN

Diabetes 2021;70(Supplement_1):1178-P

https://doi.org/10.2337/db21-1178-P

Published: 01 June 2021

View article titled, 1178-P: Portal Vein Metabolites as Intermediate Regulators of the Gut Microbiome in Insulin Resistance

Meeting Abstracts

938-P: A Human Gut Commensal, Parabacteroides Distasonis, Enhances Type 1 Diabetes Autoimmunity via Molecular Mimicry

KHYATI GIRDHAR, QIAN HUANG, I-TING CHOW, CLAUDIA BRADY, AMOL RAISINGANI, TU TRAN, WILLIAM KWOK, MARK A. ATKINSON, C. RONALD KAHN, EMRAH ALTINDIS

Diabetes 2021;70(Supplement_1):938-P

https://doi.org/10.2337/db21-938-P

Published: 01 June 2021

View article titled, 938-P: A Human Gut Commensal, Parabacteroides Distasonis, Enhances Type 1 Diabetes Autoimmunity via Molecular Mimicry

Meeting Abstracts

334-OR: Sex Differences in Protein Phosphorylation in Insulin Resistance in Humans at the Cellular Level

NIDA HAIDER, JASMIN LEBASTCHI, THIAGO M. BATISTA, HUI PAN, JONATHAN DREYFUSS, IVAN CARCAMO-ORIVE, JOSH KNOWLES, C. RONALD KAHN

Diabetes 2021;70(Supplement_1):334-OR

https://doi.org/10.2337/db21-334-OR

Published: 01 June 2021

View article titled, 334-OR: Sex Differences in Protein Phosphorylation in Insulin Resistance in Humans at the Cellular Level

Journal Articles

Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens

Weikang Cai, Xuemei Zhang, Thiago M. Batista, Rubén García-Martín, Samir Softic, Guoxiao Wang, Alfred K. Ramirez, Masahiro Konishi, Brian T. O’Neill, Jong Hun Kim, Jason K. Kim, C. Ronald Kahn

Diabetes 2021;70(8):1857–1873

https://doi.org/10.2337/db20-1119

Published: 24 May 2021

View article titled, Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens

Journal Articles

Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance

Guoxiao Wang, Yingying Yu, Weikang Cai, Thiago M. Batista, Sujin Suk, Hye Lim Noh, Michael Hirshman, Pasquale Nigro, Mengyao Ella Li, Samir Softic, Laurie Goodyear, Jason K. Kim, C. Ronald Kahn

Diabetes 2020;69(11):2294–2309

https://doi.org/10.2337/db20-0439

Published: 31 August 2020

View article titled, Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance

Meeting Abstracts

1737-P: Defining Distinct Actions of Insulin and IGF1 Receptors and Their Extra and Intracellular Domains at the Level of the Phosphoproteome

HIROFUMI NAGAO, WEIKANG CAI, THIAGO M. BATISTA, HUI PAN, JONATHAN DREYFUSS, C. RONALD KAHN

Diabetes 2020;69(Supplement_1):1737-P

https://doi.org/10.2337/db20-1737-P

Published: 01 June 2020

View article titled, 1737-P: Defining Distinct Actions of Insulin and IGF1 Receptors and Their Extra and Intracellular Domains at the Level of the Phosphoproteome

Meeting Abstracts

1733-P: Phosphoproteomic Analysis of Insulin Action Using Human IPS-Derived Myoblasts Reveals Important Interactions between Differences Based on Insulin Sensitivity and Sex

NIDA HAIDER, JASMIN LEBASTCHI, THIAGO M. BATISTA, JOSH KNOWLES, HUI PAN, JONATHAN DREYFUSS, C. RONALD KAHN

Diabetes 2020;69(Supplement_1):1733-P

https://doi.org/10.2337/db20-1733-P

Published: 01 June 2020

View article titled, 1733-P: Phosphoproteomic Analysis of Insulin Action Using Human IPS-Derived Myoblasts Reveals Important Interactions between Differences Based on Insulin Sensitivity and Sex

Meeting Abstracts

1725-P: Viral Insulins as Agonists and Antagonists on Insulin/IGF-1 Receptors

FRANCOIS MOREAU, BRUNA BRANDAO, ESQ., CARLY CEDERQUIST, THIAGO M. BATISTA, RICHARD DIMARCHI, EMRAH ALTINDIS, C. RONALD KAHN

Diabetes 2020;69(Supplement_1):1725-P

https://doi.org/10.2337/db20-1725-P

Published: 01 June 2020

View article titled, 1725-P: Viral Insulins as Agonists and Antagonists on Insulin/IGF-1 Receptors

NARROW

41-OR: Insulin Regulates Exosomal MicroRNA Secretion from Adipocytes Completing a Novel Feedback Loop

44-OR: Cell Intrinsic Alterations in miRNA Expression and Secretion in Muscle in Type 2 Diabetes

1517-P: Rev-Erba as an Intermediate between Regulation of Circadian Rhythm and Skeletal Muscle Insulin Sensitivity

219-OR: Loss of Insulin Signaling in Microglia Impairs Cellular Uptake of Aß and Neuroinflammatory Response Exacerbating Alzheimer-Like Neuropathology

292-OR: High-Fat Diets Containing Sucrose and Fructose, but Not Glucose, Induce Obesity and Hepatic Insulin Resistance via Accumulation of Diacylglycerols

289-OR: Defining Pathway-Selective Insulin Resistance in Type 2 Diabetes Using iPS Cell-Derived Hepatocytes

190-OR: Lrtm1, a Novel Regulator of Insulin Signaling and Metabolism

290-OR: FoxK1-Associated Gene Regulatory Network—A New Transcriptional Regulator of Hepatic Insulin Action

1503-P: Insulin Regulates Expression and Secretion of Exosomal MicroRNAs in Adipocytes

21-OR: Insulin and Glucagon Regulate a Novel Bidirectional Long Noncoding RNA/Protein-Coding Gene Pair That Control Cell Sensitivity to Metabolic Stress

223-OR: ADA Presidents' Select Abstract: Novel Ligand and Kinase-Independent Signaling by the Insulin Receptor

Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones

1178-P: Portal Vein Metabolites as Intermediate Regulators of the Gut Microbiome in Insulin Resistance

938-P: A Human Gut Commensal, Parabacteroides Distasonis, Enhances Type 1 Diabetes Autoimmunity via Molecular Mimicry

334-OR: Sex Differences in Protein Phosphorylation in Insulin Resistance in Humans at the Cellular Level

Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens

Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance

1737-P: Defining Distinct Actions of Insulin and IGF1 Receptors and Their Extra and Intracellular Domains at the Level of the Phosphoproteome

1733-P: Phosphoproteomic Analysis of Insulin Action Using Human IPS-Derived Myoblasts Reveals Important Interactions between Differences Based on Insulin Sensitivity and Sex

1725-P: Viral Insulins as Agonists and Antagonists on Insulin/IGF-1 Receptors

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