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Meeting Abstracts

260-LB: Elucidating the Role of NTPDase3 and Purinergic Signaling in Islet Hormone Secretion

TIFFANY M. RICHARDSON, CHUNHUA DAI, RADHIKA ARAMANDLA, HEATHER H. DURAI, CONRAD REIHSMANN, COREY DAVIS, SHAOJUN MEI, DANNIELLE GIBSON, SHRISTI SHRESTHA, DIANE C. SAUNDERS, KATIE C. COATE, SIMON C. ROBSON, ALVIN C. POWERS, MARCELA BRISSOVA

Diabetes 2022;71(Supplement_1):260-LB

DOI: https://doi.org/10.2337/db22-260-LB

Published: 01 June 2022

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Meeting Abstracts

369-OR: Defining the Role of RIPK3 in Beta Cells and the Mechanism of Its Activation by ER Stress

LIU YANG, BINGYUAN YANG, XIN TONG, CHUNHUA DAI, ZIHAN TANG, WENBIAO CHEN

Diabetes 2022;71(Supplement_1):369-OR

DOI: https://doi.org/10.2337/db22-369-OR

Published: 01 June 2022

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Meeting Abstracts

367-OR: Elucidating Mechanisms of α-Cell Dysfunction in T1D

YASMINYE D. PETTWAY, CHUNHUA DAI, TIFFANY M. RICHARDSON, JOHN T. WALKER, RADHIKA ARAMANDLA, GREG POFFENBERGER, AMBER BRADLEY, ALVIN C. POWERS, MARCELA BRISSOVA

Diabetes 2022;71(Supplement_1):367-OR

DOI: https://doi.org/10.2337/db22-367-OR

Published: 01 June 2022

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Meeting Abstracts

365-OR: Interruption of Glucagon Signaling Increases Delta-Cell Proliferation in Mouse and Human Islets

CHUNHUA DAI, AMBER BRADLEY, ERICK SPEARS, AJAY K. SINGH, FAVOUR O. OLADIPUPO, REGINA JENKINS, KATIE C. COATE, ALVIN C. POWERS

Diabetes 2022;71(Supplement_1):365-OR

DOI: https://doi.org/10.2337/db22-365-OR

Published: 01 June 2022

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Journal Articles

Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health

Xin Tong, Chunhua Dai, John T. Walker, Gopika G. Nair, Arion Kennedy, Rotonya M. Carr, Matthias Hebrok, Alvin C. Powers, Roland Stein

Diabetes 2020;69(3):342–354

DOI: https://doi.org/10.2337/db19-0281

Published: 13 December 2020

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Includes: Supplementary data

Meeting Abstracts

255-OR: ADA Presidents’ Select Abstract: Glucagon Receptor Antagonism Stimulates Beta-Cell Proliferation in Mouse and Human Islets

KATIE C. COATE, ERICK SPEARS, CHUNHUA DAI, SCOTT WISNIEWSKI, GREG POFFENBERGER, LEONARD D. SHULTZ, DALE L. GREINER, DANIEL J. DRUCKER, HAI YAN, KYLE SLOOP, ALVIN C. POWERS, DANIELLE DEAN

Diabetes 2020;69(Supplement_1):255-OR

DOI: https://doi.org/10.2337/db20-255-OR

Published: 01 June 2020

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Meeting Abstracts

1894-P: Interruption of Glucagon Signaling Increases Pancreas Mass

CHUNHUA DAI, AMBER BRADLEY, KATIE C. COATE, GREG POFFENBERGER, ERICK SPEARS, JORDAN J. WRIGHT, SHRISTI SHRESTHA, DANIELLE DEAN, MARCELA BRISSOVA, ALVIN C. POWERS

Diabetes 2020;69(Supplement_1):1894-P

DOI: https://doi.org/10.2337/db20-1894-P

Published: 01 June 2020

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Meeting Abstracts

198-OR: Role for the Cationic Amino Acid Transporter Slc7a2 in Alpha-Cell Proliferation and Islet Hormone Secretion

ERICK SPEARS, MATTHEW SHOU, WALTER A. SIV, CHUNHUA DAI, WENBIAO CHEN, ALVIN C. POWERS, DANIELLE DEAN

Diabetes 2019;68(Supplement_1):198-OR

DOI: https://doi.org/10.2337/db19-198-OR

Published: 01 June 2019

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Meeting Abstracts

Dapagliflozin Treatment Impacts ß, but Not a, Cell Function in Normal Human Islets

CHUNHUA DAI, ALENA SHOSTAK, YASIR H. BOUCHI, NATHANIEL HART, GREG POFFENBERGER, DIANE C. SAUNDERS, RACHANA HALIYUR, DANIELLE DEAN, RADHIKA ARAMANDLA, MARCELA BRISSOVA, MASAKAZU SHIOTA, DALE L. GREINER, LEONARD D. SHULTZ, RITA BOTTINO, ALVIN C. POWERS

Diabetes 2018;67(Supplement_1):323-OR

DOI: https://doi.org/10.2337/db18-323-OR

Published: 01 July 2018

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Journal Articles

Tshz1 Regulates Pancreatic β-Cell Maturation

Jeffrey C. Raum, Scott A. Soleimanpour, David N. Groff, Nathalie Coré, Laurent Fasano, Alistair N. Garratt, Chunhua Dai, Alvin C. Powers, Doris A. Stoffers

Diabetes 2015;64(8):2905–2914

DOI: https://doi.org/10.2337/db14-1443

Published: 27 April 2015

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Includes: Supplementary data

Journal Articles

Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but Not Insulin Action, in High-Fat–Fed Mice

Li Kang, Chunhua Dai, Mary E. Lustig, Jeffrey S. Bonner, Wesley H. Mayes, Shilpa Mokshagundam, Freyja D. James, Courtney S. Thompson, Chien-Te Lin, Christopher G.R. Perry, Ethan J. Anderson, P. Darrell Neufer, David H. Wasserman, Alvin C. Powers

Diabetes 2014;63(11):3699–3710

DOI: https://doi.org/10.2337/db13-1845

Published: 13 October 2014

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Journal Articles

Vascular Endothelial Growth Factor-A and Islet Vascularization Are Necessary in Developing, but Not Adult, Pancreatic Islets

Rachel B. Reinert, Marcela Brissova, Alena Shostak, Fong Cheng Pan, Greg Poffenberger, Qing Cai, Gregory L. Hundemer, Jeannelle Kantz, Courtney S. Thompson, Chunhua Dai, Owen P. McGuinness, Alvin C. Powers

Diabetes 2013;62(12):4154–4164

DOI: https://doi.org/10.2337/db13-0071

Published: 16 November 2013

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Includes: Supplementary data

Journal Articles

Pancreatic Islet Vasculature Adapts to Insulin Resistance Through Dilation and Not Angiogenesis

Chunhua Dai, Marcela Brissova, Rachel B. Reinert, Lara Nyman, Eric H. Liu, Courtney Thompson, Alena Shostak, Masakazu Shiota, Takamune Takahashi, Alvin C. Powers

Diabetes 2013;62(12):4144–4153

DOI: https://doi.org/10.2337/db12-1657

Published: 16 November 2013

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Includes: Supplementary data

Journal Articles

Liver-Specific Disruption of the Murine Glucagon Receptor Produces α-Cell Hyperplasia: Evidence for a Circulating α-Cell Growth Factor

Christine Longuet, Ana M. Robledo, E. Danielle Dean, Chunhua Dai, Safina Ali, Ian McGuinness, Vincent de Chavez, Patricia M. Vuguin, Maureen J. Charron, Alvin C. Powers, Daniel J. Drucker

Diabetes 2013;62(4):1196–1205

DOI: https://doi.org/10.2337/db11-1605

Published: 14 March 2013

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Includes: Supplementary data

NARROW

260-LB: Elucidating the Role of NTPDase3 and Purinergic Signaling in Islet Hormone Secretion

369-OR: Defining the Role of RIPK3 in Beta Cells and the Mechanism of Its Activation by ER Stress

367-OR: Elucidating Mechanisms of α-Cell Dysfunction in T1D

365-OR: Interruption of Glucagon Signaling Increases Delta-Cell Proliferation in Mouse and Human Islets

Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health

255-OR: ADA Presidents’ Select Abstract: Glucagon Receptor Antagonism Stimulates Beta-Cell Proliferation in Mouse and Human Islets

1894-P: Interruption of Glucagon Signaling Increases Pancreas Mass

198-OR: Role for the Cationic Amino Acid Transporter Slc7a2 in Alpha-Cell Proliferation and Islet Hormone Secretion

Dapagliflozin Treatment Impacts ß, but Not a, Cell Function in Normal Human Islets

Tshz1 Regulates Pancreatic β-Cell Maturation

Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but Not Insulin Action, in High-Fat–Fed Mice

Vascular Endothelial Growth Factor-A and Islet Vascularization Are Necessary in Developing, but Not Adult, Pancreatic Islets

Pancreatic Islet Vasculature Adapts to Insulin Resistance Through Dilation and Not Angiogenesis

Liver-Specific Disruption of the Murine Glucagon Receptor Produces α-Cell Hyperplasia: Evidence for a Circulating α-Cell Growth Factor

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