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Journal Articles

Advances in Cell Replacement Therapies for Diabetes

Free
Bernhard J. Hering, Michael R. Rickels, Melena D. Bellin, Jeffrey R. Millman, Alice A. Tomei, Andrés J. García, Haval Shirwan, Cherie L. Stabler, Minglin Ma, Peng Yi, Xunrong Luo, Qizhi Tang, Sabarinathan Ramachandran, Jose Oberholzer, Camillo Ricordi, Timothy J. Kieffer, A.M. James Shapiro
Journal: Diabetes
Diabetes db250037
https://doi.org/10.2337/db25-0037
Published: 24 April 2025
View articletitled, Advances in Cell Replacement Therapies for Diabetes
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Meeting Abstracts

2024-LB: Reversal of Diabetes by Human Stem Cell–Derived Islets Implanted with an Immunomodulatory Microgel in a Retrievable Site

Free
ARTHUR RECH TONDIN, ESMA S. YOLCU, SARAH K. HERRING, DENNIS M. HESTER, YELENA GADEA, GREYCY VEGA, JOEL SZUST, ARIEL REVEL, HAVAL SHIRWAN, ANDRÉS GARCIA, ANTHONY JAPOUR, MICHEL REVEL, KFIR MOLAKANDOV, CAMILLO RICORDI, GIACOMO LANZONI
Journal: Diabetes
Diabetes 2024;73(Supplement_1):2024-LB
https://doi.org/10.2337/db24-2024-LB
Published: 14 June 2024
View articletitled, 2024-LB: Reversal of Diabetes by Human Stem Cell–Derived Islets Implanted with an Immunomodulatory Microgel in a Retrievable Site
Journal Articles

Reversal of Experimental Autoimmune Diabetes With an sCD39/Anti-CD3 Treatment

Free
Carmen Fotino, R. Damaris Molano, Moufida Ben Nasr, Oliver Umland, Christopher A. Fraker, Ulisse Ulissi, Hari Baskar Balasubramanian, Maria Elena Lunati, Vera Usuelli, Andy Joe Seelam, Salma Ayman Khalefa, Christian La Sala, Jennifer Gimeno, Armando J. Mendez, Camillo Ricordi, Allison L. Bayer, Paolo Fiorina, Antonello Pileggi
Journal: Diabetes
Diabetes 2023;72(11):1641–1651
https://doi.org/10.2337/db23-0178
Published: 25 August 2023
View articletitled, Reversal of Experimental Autoimmune Diabetes With an sCD39/Anti-CD3 Treatment
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Meeting Abstracts

836-P: Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell–Derived, Fully Differentiated Islet Cells—Updated Data from the VX-880 Clinical Trial

Free
TREVOR W. REICHMAN, CAMILLO RICORDI, ALI NAJI, JAMES F. MARKMANN, BRUCE A. PERKINS, MARTIN WIJKSTROM, STEVEN PARASKEVAS, BOTE BRUINSMA, GAUTHAM MARIGOWDA, JUDY L. SHIH, CHENKUN WANG, DOUGLAS MELTON, FELICIA PAGLIUCA, BASTIANO SANNA, LESLIE S. KEAN, ANNE L. PETERS, PIOTR WITKOWSKI, MICHAEL R. RICKELS
Journal: Diabetes
Diabetes 2023;72(Supplement_1):836-P
https://doi.org/10.2337/db23-836-P
Published: 23 June 2023
View articletitled, 836-P: Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell–Derived, Fully Differentiated Islet Cells—Updated Data from the VX-880 Clinical Trial
Meeting Abstracts

251-LB: Tracking Beta-Cell Regeneration in Human Pancreatic Slices using Adenovirus Transduction

Free
SILVIA ALVAREZ-CUBELA, DAGMAR KLEIN, CHARLES G. ALVER, MIRZA MUHAMMAD FAHD QADIR, LUCIANA MATEUS GONCALVES, FARHAN QURESHI, JOANA ALMACA, CHRISTOPHER FRAKER, ALEJANDRO CAICEDO, ALBERTO PUGLIESE, CAMILLO RICORDI, ELISA OLTRA, ALBERTO PUGLIESE, ASHUTOSH G. AGARWAL, RICARDO PASTORI, JUAN DOMÍNGUEZ-BENDALA
Journal: Diabetes
Diabetes 2022;71(Supplement_1):251-LB
https://doi.org/10.2337/db22-251-LB
Published: 01 June 2022
View articletitled, 251-LB: Tracking Beta-Cell Regeneration in Human Pancreatic Slices using Adenovirus Transduction
Meeting Abstracts

259-OR: Stem Cell–Derived, Fully Differentiated Islet Cells for Type 1 Diabetes

Free
JAMES F. MARKMANN, ALI NAJI, MICHAEL R. RICKELS, MARIA ALBA, GAUTHAM MARIGOWDA, LEORAH ROSS, CHENKUN WANG, FELICIA PAGLIUCA, BASTIANO SANNA, LESLIE S. KEAN, ANNE L. PETERS, PIOTR WITKOWSKI, CAMILLO RICORDI
Journal: Diabetes
Diabetes 2022;71(Supplement_1):259-OR
https://doi.org/10.2337/db22-259-OR
Published: 01 June 2022
View articletitled, 259-OR: Stem Cell–Derived, Fully Differentiated Islet Cells for Type 1 Diabetes
Meeting Abstracts

118-OR: HLA Matching and Clinical Outcomes in Islet Transplantation

Free
VIRGINIA FUENMAYOR, CARMEN CHAVEZ, DAVID BAIDAL, ANA M. ALVAREZ, NATHALIA PADILLA, CAMILLO RICORDI, RODOLFO ALEJANDRO
Journal: Diabetes
Diabetes 2020;69(Supplement_1):118-OR
https://doi.org/10.2337/db20-118-OR
Published: 01 June 2020
View articletitled, 118-OR: HLA Matching and Clinical Outcomes in Islet Transplantation
Meeting Abstracts

206-LB: Survival after Islet Transplantation in Subjects with Type 1 Diabetes: 20-Year Follow-Up

Free
CAMILLO RICORDI, JOANA LEMOS, DAVID BAIDAL, ANA M. ALVAREZ, RODOLFO ALEJANDRO
Journal: Diabetes
Diabetes 2020;69(Supplement_1):206-LB
https://doi.org/10.2337/db20-206-LB
Published: 01 June 2020
View articletitled, 206-LB: Survival after Islet Transplantation in Subjects with Type 1 Diabetes: 20-Year Follow-Up
Meeting Abstracts

2290-PUB: Donor HLA-DR4 Positivity and Islet Transplantation Outcomes

Free
CARMEN CHAVEZ, VIRGINIA FUENMAYOR, DAVID BAIDAL, ANA M. ALVAREZ, NATHALIA PADILLA, CAMILLO RICORDI, RODOLFO ALEJANDRO
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2290-PUB
https://doi.org/10.2337/db20-2290-PUB
Published: 01 June 2020
View articletitled, 2290-PUB: Donor HLA-DR4 Positivity and Islet Transplantation Outcomes
Meeting Abstracts

259-LB: Stable Graft Function and Glycemic Control after Clinical Islet Transplantation on the Omentum

Free
DAVID BAIDAL, DORA M. BERMAN, CAMILLO RICORDI, ANA M. ALVAREZ GIL, NATHALIA PADILLA, GAETANO CIANCIO, ELINA LINETSKY, RODOLFO ALEJANDRO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):259-LB
https://doi.org/10.2337/db19-259-LB
Published: 01 June 2019
View articletitled, 259-LB: Stable Graft Function and Glycemic Control after Clinical Islet Transplantation on the Omentum
Meeting Abstracts

260-LB: Continuous Glucose Monitoring Metrics in Islet Transplant Recipients with Long-Term Insulin Independence

Free
DAVID BAIDAL, ANA M. ALVAREZ GIL, NATHALIA PADILLA, CAMILLO RICORDI, RODOLFO ALEJANDRO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):260-LB
https://doi.org/10.2337/db19-260-LB
Published: 01 June 2019
View articletitled, 260-LB: Continuous Glucose Monitoring Metrics in Islet Transplant Recipients with Long-Term Insulin Independence
Meeting Abstracts

2139-P: Real-Time Monitoring and High-Resolution Analysis of Human Pancreatic Ductal Plasticity

Free
MIRZA MUHAMMAD FAHD QADIR, SILVIA ALVAREZ-CUBELA, JASMIJN VAN DIJK, JONATHAN WEITZ, SIRLENE CECHIN, DAGMAR KLEIN, ALEJANDRO M. TAMAYO, JOANA ALMACA, ALEJANDRO CAICEDO, IRINA KUSMARTSEVA, HELMUT HILLER, SR., MARIA BEERY, KEVIN B. JOHNSON, YAISA B. MORENO HERNANDEZ, MARIA B. NAVARRO RUBIO, SAAD SADIQ, CAMILLO RICORDI, ALBERTO PUGLIESE, CHRISTOPHER FRAKER, RICARDO PASTORI, JUAN DOMÍNGUEZ-BENDALA
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2139-P
https://doi.org/10.2337/db19-2139-P
Published: 01 June 2019
View articletitled, 2139-P: Real-Time Monitoring and High-Resolution Analysis of Human Pancreatic Ductal Plasticity
Journal Articles

Islet-Derived eATP Fuels Autoreactive CD8+ T Cells and Facilitates the Onset of Type 1 Diabetes

Free
Sara Tezza, Moufida Ben Nasr, Francesca D’Addio, Andrea Vergani, Vera Usuelli, Simonetta Falzoni, Roberto Bassi, Sergio Dellepiane, Carmen Fotino, Chiara Rossi, Anna Maestroni, Anna Solini, Domenico Corradi, Elisa Giani, Chiara Mameli, Federico Bertuzzi, Marcus G. Pezzolesi, Clive H. Wasserfall, Mark A. Atkinson, Ernst-Martin Füchtbauer, Camillo Ricordi, Franco Folli, Francesco Di Virgilio, Antonello Pileggi, Sirano Dhe-Paganon, Gian Vincenzo Zuccotti, Paolo Fiorina
Journal: Diabetes
Diabetes 2018;67(10):2038–2053
https://doi.org/10.2337/db17-1227
Published: 31 July 2018
View articletitled, Islet-Derived eATP Fuels Autoreactive CD8+ T Cells and Facilitates the Onset of Type 1 Diabetes
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Meeting Abstracts

Use of Live Murine Pancreatic Slices for the Study of ß-Cell Regeneration

Free
FAHD QADIR, JONATHAN WEITZ, SILVIA ALVAREZ-CUBELA, DAGMAR KLEIN, GIACOMO LANZONI, CARLOS A. GARCIA-SANTANA, ABELARDO MONTALVO, CAMILLO RICORDI, LUCA INVERARDI, ALEJANDRO CAICEDO, RICARDO PASTORI, JUAN DOMÍNGUEZ-BENDALA
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2118-P
https://doi.org/10.2337/db18-2118-P
Published: 01 July 2018
View articletitled, Use of Live Murine Pancreatic Slices for the Study of ß-Cell Regeneration
Meeting Abstracts

Persistence of Allosensitization after Islet Allograft Failure

Free
PAOLA RIOS, DAVID BAIDAL, NATHALIA PADILLA, ANA M. ALVAREZ GIL, SRIGITA MADIRAJU, JONATHAN AMBUT, ALEJANDRO M. MANTERO, CAMILLO RICORDI, RODOLFO ALEJANDRO
Journal: Diabetes
Diabetes 2018;67(Supplement_1):142-OR
https://doi.org/10.2337/db18-142-OR
Published: 01 July 2018
View articletitled, Persistence of Allosensitization after Islet Allograft Failure
Meeting Abstracts

Long-Term Function of Islet Allografts Transplanted on the Omentum Using a Biological Scaffold

Free
DAVID BAIDAL, CAMILLO RICORDI, DORA M. BERMAN, ANTONELLO PILEGGI, ANA M. ALVAREZ GIL, NATHALIA PADILLA, GAETANO CIANCIO, ELINA LINETSKY, RODOLFO ALEJANDRO
Journal: Diabetes
Diabetes 2018;67(Supplement_1):140-OR
https://doi.org/10.2337/db18-140-OR
Published: 01 July 2018
View articletitled, Long-Term Function of Islet Allografts Transplanted on the Omentum Using a Biological Scaffold
Journal Articles

Erratum. National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65: 3418–3428

Free
Camillo Ricordi, Julia S. Goldstein, A.N. Balamurugan, Gregory L. Szot, Tatsuya Kin, Chengyang Liu, Christine W. Czarniecki, Barbara Barbaro, Nancy D. Bridges, Jose Cano, William R. Clarke, Thomas L. Eggerman, Lawrence G. Hunsicker, Dixon B. Kaufman, Aisha Khan, David-Erick Lafontant, Elina Linetsky, Xunrong Luo, James F. Markmann, Ali Naji, Olle Korsgren, Jose Oberholzer, Nicole A. Turgeon, Daniel Brandhorst, Andrew S. Friberg, Ji Lei, Ling-jia Wang, Joshua J. Wilhelm, Jamie Willits, Xiaomin Zhang, Bernhard J. Hering, Andrew M. Posselt, Peter G. Stock, A.M. James Shapiro
Journal: Diabetes
Diabetes 2017;66(9):2531
https://doi.org/10.2337/db17-er09a
Published: 29 June 2017
View articletitled, Erratum. National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65: 3418–3428
Open the PDF for Erratum. National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65: 3418–3428 in another window
Journal Articles

National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities

Free
Camillo Ricordi, Julia S. Goldstein, A.N. Balamurugan, Gregory L. Szot, Tatsuya Kin, Chengyang Liu, Christine W. Czarniecki, Barbara Barbaro, Nancy D. Bridges, Jose Cano, William R. Clarke, Thomas L. Eggerman, Lawrence G. Hunsicker, Dixon B. Kaufman, Aisha Khan, David-Erick Lafontant, Elina Linetsky, Xunrong Luo, James F. Markmann, Ali Naji, Olle Korsgren, Jose Oberholzer, Nicole A. Turgeon, Daniel Brandhorst, Xiaojuan Chen, Andrew S. Friberg, Ji Lei, Ling-jia Wang, Joshua J. Wilhelm, Jamie Willits, Xiaomin Zhang, Bernhard J. Hering, Andrew M. Posselt, Peter G. Stock, A.M. James Shapiro
Journal: Diabetes
Diabetes 2016;65(11):3418–3428
https://doi.org/10.2337/db16-0234
Published: 27 July 2016
View articletitled, National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities
Open the PDF for National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities in another window
Includes: Supplementary data
Journal Articles

Bioengineering the Endocrine Pancreas: Intraomental Islet Transplantation Within a Biologic Resorbable Scaffold

Free
Dora M. Berman, R. Damaris Molano, Carmen Fotino, Ulisse Ulissi, Jennifer Gimeno, Armando J. Mendez, Norman M. Kenyon, Norma S. Kenyon, David M. Andrews, Camillo Ricordi, Antonello Pileggi
Journal: Diabetes
Diabetes 2016;65(5):1350–1361
https://doi.org/10.2337/db15-1525
Published: 25 February 2016
View articletitled, Bioengineering the Endocrine Pancreas: Intraomental Islet Transplantation Within a Biologic Resorbable Scaffold
Open the PDF for Bioengineering the Endocrine Pancreas: Intraomental Islet Transplantation Within a Biologic Resorbable Scaffold in another window
Journal Articles

BMP-7 Induces Adult Human Pancreatic Exocrine-to-Endocrine Conversion

Free
Dagmar Klein, Silvia Álvarez-Cubela, Giacomo Lanzoni, Nancy Vargas, Kamalaveni R. Prabakar, Maria Boulina, Camillo Ricordi, Luca Inverardi, Ricardo L. Pastori, Juan Domínguez-Bendala
Journal: Diabetes
Diabetes 2015;64(12):4123–4134
https://doi.org/10.2337/db15-0688
Published: 25 August 2015
View articletitled, BMP-7 Induces Adult Human Pancreatic Exocrine-to-Endocrine Conversion
Open the PDF for BMP-7 Induces Adult Human Pancreatic Exocrine-to-Endocrine Conversion in another window
Includes: Supplementary data