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Carl D. Langefeld
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Meeting Abstracts

1673-P: Metaboepigenetic Regulation of Gene Expression in Obesity and Insulin Resistance

SWAPAN K. DAS, MARY COMEAU, CARL D. LANGEFELD
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1673-P
https://doi.org/10.2337/db24-1673-P
Published: 14 June 2024
View article titled, 1673-P: Metaboepigenetic Regulation of Gene Expression in Obesity and Insulin Resistance
Meeting Abstracts

140-OR: Machine Learning for Metabolite Estimation to Examine Contributors to Glucose Homeostasis and Adiposity: The GUARDIAN Consortium

NICHOLETTE ALLRED, HANNAH C. AINSWORTH, XIUQING GUO, ADRIENNE W. MACKAY, FESTUS NYASIMI, OWEN MELIA, YANYU LIANG, DONALD W. BOWDEN, KENT TAYLOR, LESLIE J. RAFFEL, THOMAS A. BUCHANAN, RICHARD M. WATANABE, JEROME I. ROTTER, LYNNE E. WAGENKNECHT, CARL D. LANGEFELD, IV, HAE K. IM
Journal: Diabetes
Diabetes 2022;71(Supplement_1):140-OR
https://doi.org/10.2337/db22-140-OR
Published: 01 June 2022
View article titled, 140-OR: Machine Learning for Metabolite Estimation to Examine Contributors to Glucose Homeostasis and Adiposity: The GUARDIAN Consortium
Journal Articles

Integrative Analysis of Glucometabolic Traits, Adipose Tissue DNA Methylation, and Gene Expression Identifies Epigenetic Regulatory Mechanisms of Insulin Resistance and Obesity in African Americans

Neeraj K. Sharma, Mary E. Comeau, Dennis Montoya, Matteo Pellegrini, Timothy D. Howard, Carl D. Langefeld, Swapan K. Das
Journal: Diabetes
Diabetes 2020;69(12):2779–2793
https://doi.org/10.2337/db20-0117
Published: 14 September 2020
View article titled, Integrative Analysis of Glucometabolic Traits, Adipose Tissue DNA Methylation, and Gene Expression Identifies Epigenetic Regulatory Mechanisms of Insulin Resistance and Obesity in African Americans
Open the PDF for Integrative Analysis of Glucometabolic Traits, Adipose Tissue DNA Methylation, and Gene Expression Identifies Epigenetic Regulatory Mechanisms of Insulin Resistance and Obesity in African Americans in another window
Meeting Abstracts

1640-P: Common and Ethnic-Specific Molecular Networks and Drivers of Insulin Resistance in African and European Ancestry Individuals

PENG XU, MINGHUI WANG, NEERAJ K. SHARMA, MARY COMEAU, METE CIVELEK, CARL D. LANGEFELD, IV, BIN ZHANG, SWAPAN K. DAS
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1640-P
https://doi.org/10.2337/db20-1640-P
Published: 01 June 2020
View article titled, 1640-P: Common and Ethnic-Specific Molecular Networks and Drivers of Insulin Resistance in African and European Ancestry Individuals
Meeting Abstracts

243-OR: Integrative Multiomics Analysis of Glucometabolic Traits, Adipose Tissue DNA Methylation, and Gene Expression Identifies Epigenetic Regulatory Mechanisms of Insulin Resistance and Obesity in African Americans

NEERAJ K. SHARMA, MARY COMEAU, DENNIS J. MONTOYA, MATTEO PELLEGRINI, TIMOTHY HOWARD, CARL D. LANGEFELD, IV, SWAPAN K. DAS
Journal: Diabetes
Diabetes 2020;69(Supplement_1):243-OR
https://doi.org/10.2337/db20-243-OR
Published: 01 June 2020
View article titled, 243-OR: Integrative Multiomics Analysis of Glucometabolic Traits, Adipose Tissue DNA Methylation, and Gene Expression Identifies Epigenetic Regulatory Mechanisms of Insulin Resistance and Obesity in African Americans
Meeting Abstracts

1703-P: Altered DNA-Methylation Modulates Adipose Tissue Gene Expression and Is Associated with Insulin Resistance in African Americans

NEERAJ K. SHARMA, MARY E. COMEAU, CARL D. LANGEFELD, SWAPAN K. DAS
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1703-P
https://doi.org/10.2337/db19-1703-P
Published: 01 June 2019
View article titled, 1703-P: Altered DNA-Methylation Modulates Adipose Tissue Gene Expression and Is Associated with Insulin Resistance in African Americans
Journal Articles

Genetic Regulation of Enoyl-CoA Hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans

Neeraj K. Sharma, Chia-Chi Chuang Key, Mete Civelek, Martin Wabitsch, Mary E. Comeau, Carl D. Langefeld, John S. Parks, Swapan K. Das
Journal: Diabetes
Diabetes 2019;68(7):1508–1522
https://doi.org/10.2337/db18-1229
Published: 22 April 2019
View article titled, Genetic Regulation of Enoyl-CoA Hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans
Open the PDF for Genetic Regulation of Enoyl-CoA Hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans in another window
Includes: Supplementary data
Meeting Abstracts

Adipose Tissue Transferrin and Insulin Resistance

DON MCCLAIN, NEERAJ K. SHARMA, FELIPE LORENZO, SHALINI JAIN, CARL D. LANGEFELD, MARY E. COMEAU, LIPIKA SALAYE, SWAPAN K. DAS
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1760-P
https://doi.org/10.2337/db18-1760-P
Published: 01 July 2018
View article titled, Adipose Tissue Transferrin and Insulin Resistance
Meeting Abstracts

Genetically-Regulated Mechanisms of Insulin Resistance in Adipose Tissue

NEERAJ K. SHARMA, CHIA-CHI C. KEY, MARY E. COMEAU, CARL D. LANGEFELD, JOHN S. PARKS, SWAPAN K. DAS
Journal: Diabetes
Diabetes 2018;67(Supplement_1):19-OR
https://doi.org/10.2337/db18-19-OR
Published: 01 July 2018
View article titled, Genetically-Regulated Mechanisms of Insulin Resistance in Adipose Tissue
Journal Articles

Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium

Nicholette D. Palmer, Lynne E. Wagenknecht, Carl D. Langefeld, Nan Wang, Thomas A. Buchanan, Anny H. Xiang, Hooman Allayee, Richard N. Bergman, Leslie J. Raffel, Yii-Der Ida Chen, Talin Haritunians, Tasha Fingerlin, Mark O. Goodarzi, Kent D. Taylor, Jerome I. Rotter, Richard M. Watanabe, Donald W. Bowden
Journal: Diabetes
Diabetes 2016;65(7):2072–2080
https://doi.org/10.2337/db15-1543
Published: 03 May 2016
View article titled, Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium
Open the PDF for Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium in another window
Includes: Supplementary data
Journal Articles

Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium

Nicholette D. Palmer, Mark O. Goodarzi, Carl D. Langefeld, Nan Wang, Xiuqing Guo, Kent D. Taylor, Tasha E. Fingerlin, Jill M. Norris, Thomas A. Buchanan, Anny H. Xiang, Talin Haritunians, Julie T. Ziegler, Adrienne H. Williams, Darko Stefanovski, Jinrui Cui, Adrienne W. Mackay, Leora F. Henkin, Richard N. Bergman, Xiaoyi Gao, James Gauderman, Rohit Varma, Craig L. Hanis, Nancy J. Cox, Heather M. Highland, Jennifer E. Below, Amy L. Williams, Noel P. Burtt, Carlos A. Aguilar-Salinas, Alicia Huerta-Chagoya, Clicerio Gonzalez-Villalpando, Lorena Orozco, Christopher A. Haiman, Michael Y. Tsai, W. Craig Johnson, Jie Yao, Laura Rasmussen-Torvik, James Pankow, Beverly Snively, Rebecca D. Jackson, Simin Liu, Jerry L. Nadler, Fouad Kandeel, Yii-Der I. Chen, Donald W. Bowden, Stephen S. Rich, Leslie J. Raffel, Jerome I. Rotter, Richard M. Watanabe, Lynne E. Wagenknecht
Journal: Diabetes
Diabetes 2015;64(5):1853–1866
https://doi.org/10.2337/db14-0732
Published: 18 December 2014
View article titled, Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium
Open the PDF for Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium in another window
Includes: Supplementary data
Journal Articles

Transferability and Fine Mapping of Type 2 Diabetes Loci in African Americans: The Candidate Gene Association Resource Plus Study

Maggie C.Y. Ng, Richa Saxena, Jiang Li, Nicholette D. Palmer, Latchezar Dimitrov, Jianzhao Xu, Laura J. Rasmussen-Torvik, Joseph M. Zmuda, David S. Siscovick, Sanjay R. Patel, Errol D. Crook, Mario Sims, Yii-Der I. Chen, Alain G. Bertoni, Mingyao Li, Struan F.A. Grant, Josée Dupuis, James B. Meigs, Bruce M. Psaty, James S. Pankow, Carl D. Langefeld, Barry I. Freedman, Jerome I. Rotter, James G. Wilson, Donald W. Bowden
Journal: Diabetes
Diabetes 2013;62(3):965–976
https://doi.org/10.2337/db12-0266
Published: 14 February 2013
View article titled, Transferability and Fine Mapping of Type 2 Diabetes Loci in African Americans: <subtitle>The Candidate Gene Association Resource Plus Study</subtitle>
Open the PDF for Transferability and Fine Mapping of Type 2 Diabetes Loci in African Americans: <subtitle>The Candidate Gene Association Resource Plus Study</subtitle> in another window
Includes: Supplementary data
Journal Articles

Resequencing and Analysis of Variation in the TCF7L2 Gene in African Americans Suggests That SNP rs7903146 Is the Causal Diabetes Susceptibility Variant

Nicholette D. Palmer, Jessica M. Hester, S. Sandy An, Adebowale Adeyemo, Charles Rotimi, Carl D. Langefeld, Barry I. Freedman, Maggie C.Y. Ng, Donald W. Bowden
Journal: Diabetes
Diabetes 2011;60(2):662–668
https://doi.org/10.2337/db10-0134
Published: 21 January 2011
View article titled, Resequencing and Analysis of Variation in the <em>TCF7L2</em> Gene in African Americans Suggests That SNP rs7903146 Is the Causal Diabetes Susceptibility Variant
Open the PDF for Resequencing and Analysis of Variation in the <em>TCF7L2</em> Gene in African Americans Suggests That SNP rs7903146 Is the Causal Diabetes Susceptibility Variant in another window
Includes: Supplementary data
Journal Articles

Association of SSTR2 Polymorphisms and Glucose Homeostasis Phenotypes: The Insulin Resistance Atherosclerosis Family Study

Beth S. Sutton, Nicholette D. Palmer, Carl D. Langefeld, Bingzhong Xue, Alexandria Proctor, Julie T. Ziegler, Steven M. Haffner, Jill M. Norris, Donald W. Bowden
Journal: Diabetes
Diabetes 2009;58(6):1457–1462
https://doi.org/10.2337/db08-0189
Published: 26 March 2009
View article titled, Association of <em>SSTR2</em> Polymorphisms and Glucose Homeostasis Phenotypes: <subtitle>The Insulin Resistance Atherosclerosis Family Study</subtitle>
Open the PDF for Association of <em>SSTR2</em> Polymorphisms and Glucose Homeostasis Phenotypes: <subtitle>The Insulin Resistance Atherosclerosis Family Study</subtitle> in another window
Includes: Supplementary data
Journal Articles

Association of Adiponectin Gene Polymorphisms With Type 2 Diabetes in an African American Population Enriched for Nephropathy

Meredith A. Bostrom, Barry I. Freedman, Carl D. Langefeld, Lingyi Liu, Pamela J. Hicks, Donald W. Bowden
Journal: Diabetes
Diabetes 2009;58(2):499–504
https://doi.org/10.2337/db08-0598
Published: 01 February 2009
View article titled, Association of Adiponectin Gene Polymorphisms With Type 2 Diabetes in an African American Population Enriched for Nephropathy
Open the PDF for Association of Adiponectin Gene Polymorphisms With Type 2 Diabetes in an African American Population Enriched for Nephropathy in another window
Includes: Supplementary data
Journal Articles

Genome-Wide Linkage Scan in Gullah-Speaking African American Families With Type 2 Diabetes: The Sea Islands Genetic African American Registry (Project SuGAR)

Michèle M. Sale, Lingyi Lu, Ida J. Spruill, Jyotika K. Fernandes, Kerry H. Lok, Jasmin Divers, Carl D. Langefeld, W. Timothy Garvey
Journal: Diabetes
Diabetes 2009;58(1):260–267
https://doi.org/10.2337/db08-0198
Published: 01 January 2009
View article titled, Genome-Wide Linkage Scan in Gullah-Speaking African American Families With Type 2 Diabetes: <subtitle>The Sea Islands Genetic African American Registry (Project SuGAR)</subtitle>
Open the PDF for Genome-Wide Linkage Scan in Gullah-Speaking African American Families With Type 2 Diabetes: <subtitle>The Sea Islands Genetic African American Registry (Project SuGAR)</subtitle> in another window
Includes: Supplementary data
Journal Articles

Association Analysis in African Americans of European-Derived Type 2 Diabetes Single Nucleotide Polymorphisms From Whole-Genome Association Studies

Joshua P. Lewis, Nicholette D. Palmer, Pamela J. Hicks, Michele M. Sale, Carl D. Langefeld, Barry I. Freedman, Jasmin Divers, Donald W. Bowden
Journal: Diabetes
Diabetes 2008;57(8):2220–2225
https://doi.org/10.2337/db07-1319
Published: 01 August 2008
View article titled, Association Analysis in African Americans of European-Derived Type 2 Diabetes Single Nucleotide Polymorphisms From Whole-Genome Association Studies
Open the PDF for Association Analysis in African Americans of European-Derived Type 2 Diabetes Single Nucleotide Polymorphisms From Whole-Genome Association Studies in another window
Includes: Supplementary data
Journal Articles

Quantitative Trait Analysis of Type 2 Diabetes Susceptibility Loci Identified From Whole Genome Association Studies in the Insulin Resistance Atherosclerosis Family Study

Nicholette D. Palmer, Mark O. Goodarzi, Carl D. Langefeld, Julie Ziegler, Jill M. Norris, Steven M. Haffner, Michael Bryer-Ash, Richard N. Bergman, Lynne E. Wagenknecht, Kent D. Taylor, Jerome I. Rotter, Donald W. Bowden
Journal: Diabetes
Diabetes 2008;57(4):1093–1100
https://doi.org/10.2337/db07-1169
Published: 01 April 2008
View article titled, Quantitative Trait Analysis of Type 2 Diabetes Susceptibility Loci Identified From Whole Genome Association Studies in the Insulin Resistance Atherosclerosis Family Study
Open the PDF for Quantitative Trait Analysis of Type 2 Diabetes Susceptibility Loci Identified From Whole Genome Association Studies in the Insulin Resistance Atherosclerosis Family Study in another window
Includes: Supplementary data
Journal Articles

Association of the Distal Region of the Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene With Type 2 Diabetes in an African-American Population Enriched for Nephropathy

Keith L. Keene, Josyf C. Mychaleckyj, Shelly G. Smith, Tennille S. Leak, Peter S. Perlegas, Carl D. Langefeld, Barry I. Freedman, Stephen S. Rich, Donald W. Bowden, Michèle M. Sale
Journal: Diabetes
Diabetes 2008;57(4):1057–1062
https://doi.org/10.2337/db07-0886
Published: 01 April 2008
View article titled, Association of the Distal Region of the Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene With Type 2 Diabetes in an African-American Population Enriched for Nephropathy
Open the PDF for Association of the Distal Region of the Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene With Type 2 Diabetes in an African-American Population Enriched for Nephropathy in another window
Includes: Supplementary data
Journal Articles

Association of NOS1AP Genetic Variants With QT Interval Duration in Families From the Diabetes Heart Study

Allison B. Lehtinen, Christopher Newton-Cheh, Julie T. Ziegler, Carl D. Langefeld, Barry I. Freedman, Kurt R. Daniel, David M. Herrington, Donald W. Bowden
Journal: Diabetes
Diabetes 2008;57(4):1108–1114
https://doi.org/10.2337/db07-1365
Published: 01 April 2008
View article titled, Association of <em>NOS1AP</em> Genetic Variants With QT Interval Duration in Families From the Diabetes Heart Study
Open the PDF for Association of <em>NOS1AP</em> Genetic Variants With QT Interval Duration in Families From the Diabetes Heart Study in another window
Includes: Supplementary data