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Journal Articles

Revisiting the pattern of loss of β-cell function in preclinical Type 1 Diabetes.

Mariangela Martino, MD, Alfonso Galderisi, MD, PhD, Carmella Evans-Molina, MD, PhD, Colin Dayan, MA MBBS, FRCP, PhD

Diabetes db240163

https://doi.org/10.2337/db24-0163

Published: 06 August 2024

View article titled, Revisiting the pattern of loss of β-cell function in preclinical Type 1 Diabetes.

Meeting Abstracts

1443-P: Natural History of Type 1 Diabetes (T1D)—Contrasting Adult vs. Pediatric At-Risk Populations

ERIN TEMPLEMAN, LAURIC A. FERRAT, NICHOLAS THOMAS, CATE SPEAKE, DIANE K. WHERRETT, JENNIFER L. SHERR, MARIA J. REDONDO, CARMELLA EVANS-MOLINA, JAY SOSENKO, EMILY K. SIMS, RICHARD A. ORAM

Diabetes 2024;73(Supplement_1):1443-P

https://doi.org/10.2337/db24-1443-P

Published: 14 June 2024

View article titled, 1443-P: Natural History of Type 1 Diabetes (T1D)—Contrasting Adult vs. Pediatric At-Risk Populations

Journal Articles

A Golden Hour and Golden Opportunity for β-Cell Preservation

Carmella Evans-Molina, Richard A. Oram

Diabetes 2024;73(6):834–836

https://doi.org/10.2337/dbi24-0019

Published: 20 May 2024

View article titled, A Golden Hour and Golden Opportunity for β-Cell Preservation

Journal Articles

The Ailing β-Cell in Diabetes: Insights From a Trip to the ER: The 2023 Outstanding Scientific Achievement Award Lecture

Carmella Evans-Molina

Diabetes 2024;73(4):545–553

https://doi.org/10.2337/dbi23-0030

Published: 20 March 2024

View article titled, The Ailing β-Cell in Diabetes: Insights From a Trip to the ER: The 2023 Outstanding Scientific Achievement Award Lecture

Journal Articles

Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein–Coupled Estrogen Receptor 1 Signaling

Paul Sohn, Madeline R. McLaughlin, Preethi Krishnan, Wenting Wu, Marjan Slak Rupnik, Akira Takasu, Toshiya Senda, Chih-Chun Lee, Tatsuyoshi Kono, Carmella Evans-Molina

Diabetes 2023;72(10):1433–1445

https://doi.org/10.2337/db22-0988

Published: 21 July 2023

View article titled, Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein–Coupled Estrogen Receptor 1 Signaling

Journal Articles

β-Cell Glucose Sensitivity to Assess Changes in β-Cell Function in Recent-Onset Stage 3 Type 1 Diabetes

Stephen E. Gitelman, Carmella Evans-Molina, Annamaria Guolo, Andrea Mari, Ele Ferrannini

Diabetes 2023;72(9):1289–1296

https://doi.org/10.2337/db23-0196

Published: 27 June 2023

View article titled, β-Cell Glucose Sensitivity to Assess Changes in β-Cell Function in Recent-Onset Stage 3 Type 1 Diabetes

Meeting Abstracts

296-LB: Loss of SERCA2 Induces Mitochondrial Dysfunction, Increases ß-Cell Senescence, and Accelerates Type 1 Diabetes Development

STACI A. WEAVER, ROBERT N. BONE, DOMINIC J. ACRI, JUNGSU KIM, TATSUYOSHI KONO, RUSSELL DAHL, DECIO L. EIZIRIK, FAROOQ SYED, CARMELLA EVANS-MOLINA

Diabetes 2023;72(Supplement_1):296-LB

https://doi.org/10.2337/db23-296-LB

Published: 20 June 2023

View article titled, 296-LB: Loss of SERCA2 Induces Mitochondrial Dysfunction, Increases ß-Cell Senescence, and Accelerates Type 1 Diabetes Development

Meeting Abstracts

1725-P: The Role of miR-146a-5p on Cytokine-Induced ß-Cell Mitochondrial Dysfunction and Death

PREETHI KRISHNAN, RENATO C.S. BRANCO, STACI A. WEAVER, CHIH-CHUN LEE, FAROOQ SYED, CARMELLA EVANS-MOLINA

Diabetes 2023;72(Supplement_1):1725-P

https://doi.org/10.2337/db23-1725-P

Published: 20 June 2023

View article titled, 1725-P: The Role of miR-146a-5p on Cytokine-Induced ß-Cell Mitochondrial Dysfunction and Death

Meeting Abstracts

232-OR: STIM1 Interacts with G Protein–Coupled Estrogen Receptor Signaling to Maintain ß-Cell Identity in Female Mice

MADELINE MCLAUGHLIN, PAUL SOHN, PREETHI KRISHNAN, CHIH-CHUN LEE, TATSUYOSHI KONO, CARMELLA EVANS-MOLINA

Diabetes 2023;72(Supplement_1):232-OR

https://doi.org/10.2337/db23-232-OR

Published: 20 June 2023

View article titled, 232-OR: STIM1 Interacts with G Protein–Coupled Estrogen Receptor Signaling to Maintain ß-Cell Identity in Female Mice

Meeting Abstracts

25-OR: ADA Presidents' Select Abstract: Preclinical Evaluation of TYK2 Inhibitors in Type 1 Diabetes

FAROOQ SYED, OLIVIA BALLEW, CHIH-CHUN LEE, JYOTI RANA, ANGELA CASTELA, STACI A. WEAVER, SOFIA THOMAIDOU, STÉPHANE DEMINE, ALEXANDRA COOMANS DE BRACHÈNE, MARIA I. ALVELOS, GARRICK CHANG, KARA ORR, KENTARO YAMADA, JING LIU, ARNAUD ZALDUMBIDE, DONALYN SCHEUNER, DECIO L. EIZIRIK, CARMELLA EVANS-MOLINA

Diabetes 2023;72(Supplement_1):25-OR

https://doi.org/10.2337/db23-25-OR

Published: 20 June 2023

View article titled, 25-OR: ADA Presidents' Select Abstract: Preclinical Evaluation of TYK2 Inhibitors in Type 1 Diabetes

Meeting Abstracts

20-OR: Loss of Characteristic ß-Cell Function in Autoantibody-Positive (Ab+) Individuals during the Progression to Type 1 Diabetes (T1D)

HEBA M. ISMAIL, DAVID D. CUTHBERTSON, JAY S. SKYLER, CARMELLA EVANS-MOLINA, JAY SOSENKO

Diabetes 2023;72(Supplement_1):20-OR

https://doi.org/10.2337/db23-20-OR

Published: 20 June 2023

View article titled, 20-OR: Loss of Characteristic ß-Cell Function in Autoantibody-Positive (Ab+) Individuals during the Progression to Type 1 Diabetes (T1D)

Meeting Abstracts

1751-P: SERCA2 Regulates ER Lipid Composition and Proinsulin Processing

MARYALICE HARTLEY, MACKENZIE J. PEARSON, FAROOQ SYED, HAI BUI, TATSUYOSHI KONO, KENNETH D. ROTH, CARMELLA EVANS-MOLINA

Diabetes 2023;72(Supplement_1):1751-P

https://doi.org/10.2337/db23-1751-P

Published: 20 June 2023

View article titled, 1751-P: SERCA2 Regulates ER Lipid Composition and Proinsulin Processing

Meeting Abstracts

1131-P: Gut Microbial Differences in Youth with Obesity and Type 1 Diabetes (T1D)

HEBA M. ISMAIL, DIMUTHU PERERA, RABINDRA K. MANDAL, SARA JAVORNIK CREGEEN, LINDA DIMEGLIO, TAMARA S. HANNON, CARMELLA EVANS-MOLINA, NATHAN SCHMIDT

Diabetes 2023;72(Supplement_1):1131-P

https://doi.org/10.2337/db23-1131-P

Published: 20 June 2023

View article titled, 1131-P: Gut Microbial Differences in Youth with Obesity and Type 1 Diabetes (T1D)

Meeting Abstracts

1441-P: Index60 Stratification Enhances Current Staging for Type 1 Diabetes by Identifying At-Risk Single Islet Autoantibody Positive (Ab+) Individuals

EMILY K. SIMS, DAVID D. CUTHBERTSON, EMANUELE BOSI, CARMELLA EVANS-MOLINA, MARIA J. REDONDO, BRANDON M. NATHAN, HEBA M. ISMAIL, LAURA M. JACOBSEN, JAY SOSENKO

Diabetes 2023;72(Supplement_1):1441-P

https://doi.org/10.2337/db23-1441-P

Published: 20 June 2023

View article titled, 1441-P: Index60 Stratification Enhances Current Staging for Type 1 Diabetes by Identifying At-Risk Single Islet Autoantibody Positive (Ab+) Individuals

Meeting Abstracts

1440-P: Single Islet Antigen 2 Antibody–Positive (IA2A Ab+) Children Exhibit Significant Metabolic Abnormalities and 5-Year Type 1 Diabetes (T1D) Risk

EMILY K. SIMS, DAVID D. CUTHBERTSON, EMANUELE BOSI, CARMELLA EVANS-MOLINA, MARIA J. REDONDO, BRANDON M. NATHAN, HEBA M. ISMAIL, LAURA M. JACOBSEN, JAY SOSENKO

Diabetes 2023;72(Supplement_1):1440-P

https://doi.org/10.2337/db23-1440-P

Published: 20 June 2023

View article titled, 1440-P: Single Islet Antigen 2 Antibody–Positive (IA2A Ab+) Children Exhibit Significant Metabolic Abnormalities and 5-Year Type 1 Diabetes (T1D) Risk

Meeting Abstracts

217-LB: Heterogeneity of Single Cells Obtained from Peripheral Blood Mononuclear Cells Collected from Youth with Recent-Onset Type 1 Diabetes

WENTING WU, CORINNE PARKS-SCHENCK, TINGBO GUO, CHI ZHANG, RAGHAVENDRA G. MIRMIRA, CARMELLA EVANS-MOLINA

Diabetes 2023;72(Supplement_1):217-LB

https://doi.org/10.2337/db23-217-LB

Published: 20 June 2023

View article titled, 217-LB: Heterogeneity of Single Cells Obtained from Peripheral Blood Mononuclear Cells Collected from Youth with Recent-Onset Type 1 Diabetes

Meeting Abstracts

1771-P: STIM1 Maintains Beta-Cell Identity and Function

TATSUYOSHI KONO, PAUL SOHN, MADELINE MCLAUGHLIN, WENTING WU, SANDRA POSTIC, PREETHI KRISHNAN, CHIH-CHUN LEE, MARJAN SLAK RUPNIK, CARMELLA EVANS-MOLINA, MARJAN SLAK RUPNIK, PREETHI KRISHNAN

Diabetes 2023;72(Supplement_1):1771-P

https://doi.org/10.2337/db23-1771-P

Published: 20 June 2023

View article titled, 1771-P: STIM1 Maintains Beta-Cell Identity and Function

Journal Articles

The Chd4 Helicase Regulates Chromatin Accessibility and Gene Expression Critical for β-Cell Function In Vivo

Rebecca K. Davidson, Sukrati Kanojia, Wenting Wu, Tatsuyoshi Kono, Jerry Xu, Meredith Osmulski, Robert N. Bone, Nolan Casey, Carmella Evans-Molina, Emily K. Sims, Jason M. Spaeth

Diabetes 2023;72(6):746–757

https://doi.org/10.2337/db22-0939

Published: 13 March 2023

View article titled, The Chd4 Helicase Regulates Chromatin Accessibility and Gene Expression Critical for β-Cell Function In Vivo

Journal Articles

Hypothesis: Induction of Autoimmunity in Type 1 Diabetes—A Lipid Focus

Barbara E. Corkey, Laurie E. Kilpatrick, Carmella Evans-Molina

Diabetes 2022;71(10):2067–2074

https://doi.org/10.2337/db22-0240

Published: 12 September 2022

View article titled, Hypothesis: Induction of Autoimmunity in Type 1 Diabetes—A Lipid Focus

Journal Articles

Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

Mei-Ling Yang, Sean E. Connolly, Renelle J. Gee, TuKiet T. Lam, Jean Kanyo, Jian Peng, Perrin Guyer, Farooq Syed, Hubert M. Tse, Steven G. Clarke, Catherine F. Clarke, Eddie A. James, Cate Speake, Carmella Evans-Molina, Peter Arvan, Kevan C. Herold, Li Wen, Mark J. Mamula

Diabetes 2022;71(9):1979–1993

https://doi.org/10.2337/db21-0989

Published: 22 June 2022

View article titled, Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

NARROW

Revisiting the pattern of loss of β-cell function in preclinical Type 1 Diabetes.

1443-P: Natural History of Type 1 Diabetes (T1D)—Contrasting Adult vs. Pediatric At-Risk Populations

A Golden Hour and Golden Opportunity for β-Cell Preservation

The Ailing β-Cell in Diabetes: Insights From a Trip to the ER: The 2023 Outstanding Scientific Achievement Award Lecture

Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein–Coupled Estrogen Receptor 1 Signaling

β-Cell Glucose Sensitivity to Assess Changes in β-Cell Function in Recent-Onset Stage 3 Type 1 Diabetes

296-LB: Loss of SERCA2 Induces Mitochondrial Dysfunction, Increases ß-Cell Senescence, and Accelerates Type 1 Diabetes Development

1725-P: The Role of miR-146a-5p on Cytokine-Induced ß-Cell Mitochondrial Dysfunction and Death

232-OR: STIM1 Interacts with G Protein–Coupled Estrogen Receptor Signaling to Maintain ß-Cell Identity in Female Mice

25-OR: ADA Presidents' Select Abstract: Preclinical Evaluation of TYK2 Inhibitors in Type 1 Diabetes

20-OR: Loss of Characteristic ß-Cell Function in Autoantibody-Positive (Ab+) Individuals during the Progression to Type 1 Diabetes (T1D)

1751-P: SERCA2 Regulates ER Lipid Composition and Proinsulin Processing

1131-P: Gut Microbial Differences in Youth with Obesity and Type 1 Diabetes (T1D)

1441-P: Index60 Stratification Enhances Current Staging for Type 1 Diabetes by Identifying At-Risk Single Islet Autoantibody Positive (Ab+) Individuals

1440-P: Single Islet Antigen 2 Antibody–Positive (IA2A Ab+) Children Exhibit Significant Metabolic Abnormalities and 5-Year Type 1 Diabetes (T1D) Risk

217-LB: Heterogeneity of Single Cells Obtained from Peripheral Blood Mononuclear Cells Collected from Youth with Recent-Onset Type 1 Diabetes

1771-P: STIM1 Maintains Beta-Cell Identity and Function

The Chd4 Helicase Regulates Chromatin Accessibility and Gene Expression Critical for β-Cell Function In Vivo

Hypothesis: Induction of Autoimmunity in Type 1 Diabetes—A Lipid Focus

Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

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