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Meeting Abstracts

1554-P: Insights Into Insulin Synthesis and Turnover Using ¹³C₅¹⁵N-Valine to Label C-Peptide in Humans

AOIFE M. EGAN, ROY B. DYER, MARCELLO C. LAURENTI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2024;73(Supplement_1):1554-P

https://doi.org/10.2337/db24-1554-P

Published: 14 June 2024

View articletitled, 1554-P: Insights Into Insulin Synthesis and Turnover Using 13C515N-Valine to Label C-Peptide in Humans

Meeting Abstracts

1618-P: Progression to Glucose Intolerance Is Characterized by Glucagon Secretion Inappropriate for Circulating Glucose

SNEHA MOHAN, HANNAH E. CHRISTIE, MARCELLO C. LAURENTI, AOIFE M. EGAN, ADRIAN VELLA, CHIARA DALLA MAN

Diabetes 2024;73(Supplement_1):1618-P

https://doi.org/10.2337/db24-1618-P

Published: 14 June 2024

View articletitled, 1618-P: Progression to Glucose Intolerance Is Characterized by Glucagon Secretion Inappropriate for Circulating Glucose

Meeting Abstracts

1569-P: Quantification of Postprandial Hepatic Glucose Disposal in Roux-en-Y Gastric Bypass and Non-operated Controls Using Stable Isotope Labelling and Liver Metabolic Imaging

ALESSANDRO BRUNASSO, CHIARA DALLA MAN, SIMONE POLI, DAVID HERZIG, ROLAND KREIS, LIA BALLY, MICHELE SCHIAVON

Diabetes 2024;73(Supplement_1):1569-P

https://doi.org/10.2337/db24-1569-P

Published: 14 June 2024

View articletitled, 1569-P: Quantification of Postprandial Hepatic Glucose Disposal in Roux-en-Y Gastric Bypass and Non-operated Controls Using Stable Isotope Labelling and Liver Metabolic Imaging

Meeting Abstracts

1551-P: Impaired ß-Cell Responsiveness to Glucagon in Type 2 Diabetes Mellitus Assessed by a New C-Peptide Minimal Model

FEDERICA BOSCOLO, EDOARDO FAGGIONATO, ADRIAN VELLA, CHIARA DALLA MAN

Diabetes 2024;73(Supplement_1):1551-P

https://doi.org/10.2337/db24-1551-P

Published: 14 June 2024

View articletitled, 1551-P: Impaired ß-Cell Responsiveness to Glucagon in Type 2 Diabetes Mellitus Assessed by a New C-Peptide Minimal Model

Journal Articles

The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans

Maya Zeini, Marcello C. Laurenti, Aoife M. Egan, Kalpana Muthusamy, Anisha Ramar, Emma Vella, Kent R. Bailey, Claudio Cobelli, Chiara Dalla Man, Adrian Vella

Diabetes 2024;73(9):1440–1446

https://doi.org/10.2337/db24-0192

Published: 13 June 2024

View articletitled, The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans

Meeting Abstracts

36-OR: The Effect of Glucagon-Like Peptide-1 Receptor Blockade on the ß-Cell Response to Glucagon Bolus in People With and Without Type 2 Diabetes

AOIFE M. EGAN, MAYA ZEINI, ANDREW A. WELCH, RAHELE A. FARAHANI, MARCELLO C. LAURENTI, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2023;72(Supplement_1):36-OR

https://doi.org/10.2337/db23-36-OR

Published: 20 June 2023

View articletitled, 36-OR: The Effect of Glucagon-Like Peptide-1 Receptor Blockade on the ß-Cell Response to Glucagon Bolus in People With and Without Type 2 Diabetes

Meeting Abstracts

1564-P: Impaired Insulin Secretion Increases Glucagon Action on the Liver

ALESSIO TONELLO, MARCELLO C. LAURENTI, CLAUDIO COBELLI, ADRIAN VELLA, CHIARA DALLA MAN

Diabetes 2023;72(Supplement_1):1564-P

https://doi.org/10.2337/db23-1564-P

Published: 20 June 2023

View articletitled, 1564-P: Impaired Insulin Secretion Increases Glucagon Action on the Liver

Meeting Abstracts

254-OR: Effects of Roux-en-Y Gastric Bypass on Postprandial Glucose Turnover Assessed through the Single-Tracer Oral Minimal Model

ALESSANDRO BRUNASSO, CHIARA DALLA MAN, DAVID HERZIG, LIA BALLY, MICHELE SCHIAVON

Diabetes 2023;72(Supplement_1):254-OR

https://doi.org/10.2337/db23-254-OR

Published: 20 June 2023

View articletitled, 254-OR: Effects of Roux-en-Y Gastric Bypass on Postprandial Glucose Turnover Assessed through the Single-Tracer Oral Minimal Model

Meeting Abstracts

254-LB: In Vivo Mapping of Postprandial Hepatic Glucose Metabolism Using Stable Isotope-Assisted Metabolic Imaging in Roux-en-Y Gastric Bypass Adults and Nonoperated Controls

NAOMI F. LANGE, SIMONE POLI, DAVID HERZIG, MICHELE SCHIAVON, CHIARA DALLA MAN, ROLAND KREIS, LIA BALLY

Diabetes 2023;72(Supplement_1):254-LB

https://doi.org/10.2337/db23-254-LB

Published: 20 June 2023

View articletitled, 254-LB: In Vivo Mapping of Postprandial Hepatic Glucose Metabolism Using Stable Isotope-Assisted Metabolic Imaging in Roux-en-Y Gastric Bypass Adults and Nonoperated Controls

Meeting Abstracts

1646-P: The Effect of Glucagon-Like Peptide-1 Receptor Blockade and Acute Insulin Resistance on Islet Function and Glucose Metabolism in People without Diabetes

MAYA ZEINI, RAHELE A. FARAHANI, ANDREW A. WELCH, MARCELLO C. LAURENTI, CLAUDIO COBELLI, CHIARA DALLA MAN, AOIFE M. EGAN, ADRIAN VELLA

Diabetes 2023;72(Supplement_1):1646-P

https://doi.org/10.2337/db23-1646-P

Published: 20 June 2023

View articletitled, 1646-P: The Effect of Glucagon-Like Peptide-1 Receptor Blockade and Acute Insulin Resistance on Islet Function and Glucose Metabolism in People without Diabetes

Meeting Abstracts

1645-P: Diabetes-Associated Variation in TCF7L2 Is Associated with a Longitudinal Decline in Glucose Tolerance Accompanied by Impaired Suppression of Postprandial Glucagon Secretion

MAYA ZEINI, KALPANA MUTHUSAMY, AOIFE M. EGAN, MARCELLO C. LAURENTI, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2023;72(Supplement_1):1645-P

https://doi.org/10.2337/db23-1645-P

Published: 20 June 2023

View articletitled, 1645-P: Diabetes-Associated Variation in TCF7L2 Is Associated with a Longitudinal Decline in Glucose Tolerance Accompanied by Impaired Suppression of Postprandial Glucagon Secretion

Meeting Abstracts

1547-P: The Differential Effect of Glucagon-Like Peptide-1 Receptor Blockade on Glucose Metabolism in People With and Without Type 2 Diabetes

ANDREW A. WELCH, RAHELE A. FARAHANI, MAYA ZEINI, AOIFE M. EGAN, MARCELLO C. LAURENTI, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2023;72(Supplement_1):1547-P

https://doi.org/10.2337/db23-1547-P

Published: 20 June 2023

View articletitled, 1547-P: The Differential Effect of Glucagon-Like Peptide-1 Receptor Blockade on Glucose Metabolism in People With and Without Type 2 Diabetes

Journal Articles

The Effect of Glucagon-Like Peptide 1 Receptor Blockade on Glucagon-Induced Stimulation of Insulin Secretion

Rahele A. Farahani, Aoife M. Egan, Andrew A. Welch, Marcello C. Laurenti, Claudio Cobelli, Chiara Dalla Man, Adrian Vella

Diabetes 2023;72(4):449–454

https://doi.org/10.2337/db22-0709

Published: 23 December 2022

View articletitled, The Effect of Glucagon-Like Peptide 1 Receptor Blockade on Glucagon-Induced Stimulation of Insulin Secretion

Journal Articles

Impaired Diurnal Pattern of Meal Tolerance and Insulin Sensitivity in Type 2 Diabetes: Implications for Therapy

Yogesh Yadav, Davide Romeres, Claudio Cobelli, Chiara Dalla Man, Rickey Carter, Ananda Basu, Rita Basu

Diabetes 2023;72(2):223–232

https://doi.org/10.2337/db22-0238

Published: 08 November 2022

View articletitled, Impaired Diurnal Pattern of Meal Tolerance and Insulin Sensitivity in Type 2 Diabetes: Implications for Therapy

Meeting Abstracts

1377-P: Pramlintide Lowers Postprandial Glucagon Concentrations by Inhibiting Glucagon Secretion without Altering Clearance in Type 1 Diabetes: A [13C15N]-Glucagon Study

FNU RUCHI, DAVIDE ROMERES, MICHELE SCHIAVON, SANTOSH RENUSE, AKHILESH PANDEY, CHIARA DALLA MAN, CLAUDIO COBELLI, RITA BASU, ANANDA BASU

Diabetes 2022;71(Supplement_1):1377-P

https://doi.org/10.2337/db22-1377-P

Published: 01 June 2022

View articletitled, 1377-P: Pramlintide Lowers Postprandial Glucagon Concentrations by Inhibiting Glucagon Secretion without Altering Clearance in Type 1 Diabetes: A [13C15N]-Glucagon Study

Meeting Abstracts

1376-P: Comparison of a-Cell Response to Intravenous or Oral Glucose in Nondiabetic Humans

MARCELLO C. LAURENTI, ARMANDO MANDUCA, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2022;71(Supplement_1):1376-P

https://doi.org/10.2337/db22-1376-P

Published: 01 June 2022

View articletitled, 1376-P: Comparison of a-Cell Response to Intravenous or Oral Glucose in Nondiabetic Humans

Meeting Abstracts

1325-P: Modulation of Overnight Free Fatty Acid and Glucose Concentrations and Their Effect on Postprandial Islet Function and Glucose Metabolism

ANDREW A. WELCH, DANIEL SCHEMBRI WISMAYER, AOIFE M. EGAN, RAHELE A. FARAHANI, MARCELLO C. LAURENTI, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2022;71(Supplement_1):1325-P

https://doi.org/10.2337/db22-1325-P

Published: 01 June 2022

View articletitled, 1325-P: Modulation of Overnight Free Fatty Acid and Glucose Concentrations and Their Effect on Postprandial Islet Function and Glucose Metabolism

Meeting Abstracts

684-P: Tracking Type 2 Diabetes Progression Using CGM Systems

MICHELE SCHIAVON, CHIARA DALLA MAN

Diabetes 2022;71(Supplement_1):684-P

https://doi.org/10.2337/db22-684-P

Published: 01 June 2022

View articletitled, 684-P: Tracking Type 2 Diabetes Progression Using CGM Systems

Meeting Abstracts

1426-P: Increased Insulin Secretion and Glucose Effectiveness Result in Improved Glucose Tolerance in Obese Subjects Two Months after Gastric Bypass and Sleeve

ROBERTO VISENTIN, KATRINE BRODERSEN, BJØRN RICHELSEN, NIELS MOLLER, CHIARA DALLA MAN, MICHAEL F. NIELSEN

Diabetes 2022;71(Supplement_1):1426-P

https://doi.org/10.2337/db22-1426-P

Published: 01 June 2022

View articletitled, 1426-P: Increased Insulin Secretion and Glucose Effectiveness Result in Improved Glucose Tolerance in Obese Subjects Two Months after Gastric Bypass and Sleeve

Meeting Abstracts

1359-P: Effect of Fat Content on Postprandial Gastric Retention and Glucose Absorption in Subjects with Type 1 Diabetes during Daily Life Conditions: Assessment through a Computational Model

EDOARDO FAGGIONATO, MICHELE SCHIAVON, BRUCE A. BUCKINGHAM, LAYA EKHLASPOUR, CHIARA DALLA MAN

Diabetes 2022;71(Supplement_1):1359-P

https://doi.org/10.2337/db22-1359-P

Published: 01 June 2022

View articletitled, 1359-P: Effect of Fat Content on Postprandial Gastric Retention and Glucose Absorption in Subjects with Type 1 Diabetes during Daily Life Conditions: Assessment through a Computational Model

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1554-P: Insights Into Insulin Synthesis and Turnover Using ¹³C₅¹⁵N-Valine to Label C-Peptide in Humans

1618-P: Progression to Glucose Intolerance Is Characterized by Glucagon Secretion Inappropriate for Circulating Glucose

1569-P: Quantification of Postprandial Hepatic Glucose Disposal in Roux-en-Y Gastric Bypass and Non-operated Controls Using Stable Isotope Labelling and Liver Metabolic Imaging

1551-P: Impaired ß-Cell Responsiveness to Glucagon in Type 2 Diabetes Mellitus Assessed by a New C-Peptide Minimal Model

The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans

36-OR: The Effect of Glucagon-Like Peptide-1 Receptor Blockade on the ß-Cell Response to Glucagon Bolus in People With and Without Type 2 Diabetes

1564-P: Impaired Insulin Secretion Increases Glucagon Action on the Liver

254-OR: Effects of Roux-en-Y Gastric Bypass on Postprandial Glucose Turnover Assessed through the Single-Tracer Oral Minimal Model

254-LB: In Vivo Mapping of Postprandial Hepatic Glucose Metabolism Using Stable Isotope-Assisted Metabolic Imaging in Roux-en-Y Gastric Bypass Adults and Nonoperated Controls

1646-P: The Effect of Glucagon-Like Peptide-1 Receptor Blockade and Acute Insulin Resistance on Islet Function and Glucose Metabolism in People without Diabetes

1645-P: Diabetes-Associated Variation in TCF7L2 Is Associated with a Longitudinal Decline in Glucose Tolerance Accompanied by Impaired Suppression of Postprandial Glucagon Secretion

1547-P: The Differential Effect of Glucagon-Like Peptide-1 Receptor Blockade on Glucose Metabolism in People With and Without Type 2 Diabetes

The Effect of Glucagon-Like Peptide 1 Receptor Blockade on Glucagon-Induced Stimulation of Insulin Secretion

Impaired Diurnal Pattern of Meal Tolerance and Insulin Sensitivity in Type 2 Diabetes: Implications for Therapy

1377-P: Pramlintide Lowers Postprandial Glucagon Concentrations by Inhibiting Glucagon Secretion without Altering Clearance in Type 1 Diabetes: A [13C15N]-Glucagon Study

1376-P: Comparison of a-Cell Response to Intravenous or Oral Glucose in Nondiabetic Humans

1325-P: Modulation of Overnight Free Fatty Acid and Glucose Concentrations and Their Effect on Postprandial Islet Function and Glucose Metabolism

684-P: Tracking Type 2 Diabetes Progression Using CGM Systems

1426-P: Increased Insulin Secretion and Glucose Effectiveness Result in Improved Glucose Tolerance in Obese Subjects Two Months after Gastric Bypass and Sleeve

1359-P: Effect of Fat Content on Postprandial Gastric Retention and Glucose Absorption in Subjects with Type 1 Diabetes during Daily Life Conditions: Assessment through a Computational Model

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