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Meeting Abstracts

295-OR: The PNPLA3 G-allele Reduces the Beneficial Effects of a Healthy Diet on Hepatic Lipid Content in Type 2 Diabetes

KALLIOPI PAFILI, OANA P. ZAHARIA, KLAUS STRASSBURGER, BIRGIT KNEBEL, CHRISTIAN HERDER, MAXIMILIAN HUTTASCH, YANISLAVA KARUSHEVA, STEFAN KABISCH, ALEXANDER STROM, JULIA SZENDROEDI, MICHAEL RODEN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):295-OR
https://doi.org/10.2337/db24-295-OR
Published: 14 June 2024
View article titled, 295-OR: The PNPLA3 G-allele Reduces the Beneficial Effects of a Healthy Diet on Hepatic Lipid Content in Type 2 Diabetes
Meeting Abstracts

81-OR: High Throughput Proteomics Identifies Neurofilament Light Chain (NFL) as a Novel Blood Biomarker for Detection of Diabetic Sensorimotor Polyneuropathy

HAIFA MAALMI, ALEXANDER STROM, STEFANIE M. HAUCK, OANA P. ZAHARIA, KLAUS STRASSBURGER, GIDON J. BÖNHOF, WOLFGANG RATHMANN, SANDRA TRENKAMP, VOLKER BURKART, JULIA M. SZENDROEDI, DAN ZIEGLER, MICHAEL RODEN, CHRISTIAN HERDER
Journal: Diabetes
Diabetes 2022;71(Supplement_1):81-OR
https://doi.org/10.2337/db22-81-OR
Published: 01 June 2022
View article titled, 81-OR: High Throughput Proteomics Identifies Neurofilament Light Chain (NFL) as a Novel Blood Biomarker for Detection of Diabetic Sensorimotor Polyneuropathy
Meeting Abstracts

1412-P: Preexisting Nonalcoholic Steatohepatitis Attenuates Improvement of Adipose Tissue OXPHOS Capacity after Weight-Loss Surgery

SABINE KAHL, KLAUS STRASSBURGER, SOFIYA GANCHEVA, NINA SAATMANN, CESARE GRANATA, CHRISTIAN HERDER, KALLIOPI PAFILI, JENNIFER PUETZER-FURMANCZAK, THERESIA SARABHAI, GERONIMO HEILMANN, IRENE ESPOSITO, MATTHIAS SCHLENSAK, MICHAEL RODEN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1412-P
https://doi.org/10.2337/db22-1412-P
Published: 01 June 2022
View article titled, 1412-P: Preexisting Nonalcoholic Steatohepatitis Attenuates Improvement of Adipose Tissue OXPHOS Capacity after Weight-Loss Surgery
Journal Articles

Leukocyte Counts and T-Cell Frequencies Differ Between Novel Subgroups of Diabetes and Are Associated With Metabolic Parameters and Biomarkers of Inflammation

Jacqueline M. Ratter-Rieck, Haifa Maalmi, Sandra Trenkamp, Oana-Patricia Zaharia, Wolfgang Rathmann, Nanette C. Schloot, Klaus Straßburger, Julia Szendroedi, Christian Herder, Michael Roden
Journal: Diabetes
Diabetes 2021;70(11):2652–2662
https://doi.org/10.2337/db21-0364
Published: 30 August 2021
View article titled, Leukocyte Counts and T-Cell Frequencies Differ Between Novel Subgroups of Diabetes and Are Associated With Metabolic Parameters and Biomarkers of Inflammation
Open the PDF for Leukocyte Counts and T-Cell Frequencies Differ Between Novel Subgroups of Diabetes and Are Associated With Metabolic Parameters and Biomarkers of Inflammation in another window
Journal Articles

Differences in Biomarkers of Inflammation Between Novel Subgroups of Recent-Onset Diabetes

Christian Herder, Haifa Maalmi, Klaus Strassburger, Oana-Patricia Zaharia, Jacqueline M. Ratter, Yanislava Karusheva, Mohamed A. Elhadad, Kálmán Bódis, Brenda W.C. Bongaerts, Wolfgang Rathmann, Sandra Trenkamp, Melanie Waldenberger, Volker Burkart, Julia Szendroedi, Michael Roden, the GDS Group, Sue A. Brown, H. Al-Hasani, V. Burkart, A.E. Buyken, G. Geerling, C. Herder, A. Icks, K. Jandeleit-Dahm, J. Kotzka, O. Kuss, E. Lammert, W. Rathmann, V. Schrauwen-Hinderling, J. Szendroedi, S. Trenkamp, D. Ziegler, M. Roden
Journal: Diabetes
Diabetes 2021;70(5):1198–1208
https://doi.org/10.2337/db20-1054
Published: 19 February 2021
View article titled, Differences in Biomarkers of Inflammation Between Novel Subgroups of Recent-Onset Diabetes
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Meeting Abstracts

492-P: Associations between Novel Biomarkers of Inflammation and Estimated Glomerular Filtration Rate in Adults with Recent-Onset Type 1 and Type 2 Diabetes

HAIFA MAALMI, CHRISTIAN HERDER, KLAUS STRASSBURGER, SOFIA URNER, KARIN JANDELEIT-DAHM, OANA P. ZAHARIA, YANISLAVA KARUSHEVA, KALMAN BODIS, WOLFGANG RATHMANN, DANIEL F. MARKGRAF, VOLKER BURKART, JULIA SZENDROEDI, MICHAEL RODEN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):492-P
https://doi.org/10.2337/db20-492-P
Published: 01 June 2020
View article titled, 492-P: Associations between Novel Biomarkers of Inflammation and Estimated Glomerular Filtration Rate in Adults with Recent-Onset Type 1 and Type 2 Diabetes
Meeting Abstracts

1891-P: Palmitate-Enriched Lipid Ingestion Acutely Induces Insulin Resistance Associated with PKCγ Activation and Impaired Mitochondrial Function in Human Skeletal Muscle

THERESIA SARABHAI, CHRYSI KOLIAKI, SABINE KAHL, DOMINIK PESTA, LUCIA MASTROTOTARO, MARIA APOSTOLOPOULOU, DANIEL F. MARKGRAF, CHRISTIAN HERDER, MICHAEL RODEN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1891-P
https://doi.org/10.2337/db20-1891-P
Published: 01 June 2020
View article titled, 1891-P: Palmitate-Enriched Lipid Ingestion Acutely Induces Insulin Resistance Associated with PKCγ Activation and Impaired Mitochondrial Function in Human Skeletal Muscle
Meeting Abstracts

133-OR: Effects of Empagliflozin on Liver Fat Content in Type 2 Diabetes: The EMLIFA001 Trial

SABINE KAHL, SOFIYA GANCHEVA, KLAUS STRASSBURGER, CHRISTIAN HERDER, JÜRGEN MACHANN, HISAYUKI KATSUYAMA, STEFAN KABISCH, ELENA HENKEL, STEFAN KOPF, KONSTANTINOS KANTARTZIS, YULIYA KUPRIYANOVA, OLIVER KUSS, JONG-HEE HWANG, CHRISTIAN KASPERK, NORBERT STEFAN, ANDREAS F. PFEIFFER, ANDREAS L. BIRKENFELD, MICHAEL RODEN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):133-OR
https://doi.org/10.2337/db19-133-OR
Published: 01 June 2019
View article titled, 133-OR: Effects of Empagliflozin on Liver Fat Content in Type 2 Diabetes: The EMLIFA001 Trial
Journal Articles

A Systemic Inflammatory Signature Reflecting Cross Talk Between Innate and Adaptive Immunity Is Associated With Incident Polyneuropathy: KORA F4/FF4 Study

Christian Herder, Julia M. Kannenberg, Maren Carstensen-Kirberg, Alexander Strom, Gidon J. Bönhof, Wolfgang Rathmann, Cornelia Huth, Wolfgang Koenig, Margit Heier, Jan Krumsiek, Annette Peters, Christa Meisinger, Michael Roden, Barbara Thorand, Dan Ziegler
Journal: Diabetes
Diabetes 2018;67(11):2434–2442
https://doi.org/10.2337/db18-0060
Published: 16 August 2018
View article titled, A Systemic Inflammatory Signature Reflecting Cross Talk Between Innate and Adaptive Immunity Is Associated With Incident Polyneuropathy: KORA F4/FF4 Study
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Includes: Supplementary data
Meeting Abstracts

The Molecular Role of WNT5A and Its Antagonist SFRP5 in Gluconeogenesis and Inflammation in Human Hepatocytes

MAREN CARSTENSEN-KIRBERG, CORINNA NIERSMANN, KARIN ROEHRIG, MICHAEL RODEN, CHRISTIAN HERDER
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1845-P
https://doi.org/10.2337/db18-1845-P
Published: 01 July 2018
View article titled, The Molecular Role of WNT5A and Its Antagonist SFRP5 in Gluconeogenesis and Inflammation in Human Hepatocytes
Meeting Abstracts

Mortality Risk of Noninsulin Glucose-Lowering Drugs in Type 2 Diabetes—A Network Meta-analysis of Observational Trials

BRENDA BONGAERTS, LENA M. LINDNER, ANNIKA HOYER, OLIVER KUSS, CHRISTIAN HERDER, HADI AL-HASANI, SR., KARSTEN MÜSSIG, MICHAEL RODEN, WOLFGANG RATHMANN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1139-P
https://doi.org/10.2337/db18-1139-P
Published: 01 July 2018
View article titled, Mortality Risk of Noninsulin Glucose-Lowering Drugs in Type 2 Diabetes—A Network Meta-analysis of Observational Trials
Meeting Abstracts

Differential Association of Inflammatory Markers and Growth Factors with Type 2 Diabetes and Polyneuropathy—A Multimarker Approach

GIDON J. BÖNHOF, ALEXANDER STROM, WOLFGANG RATHMANN, MARGIT HEIER, CHRISTA MEISINGER, ANNETTE PETERS, MICHAEL RODEN, BARBARA THORAND, CHRISTIAN HERDER, DAN ZIEGLER
Journal: Diabetes
Diabetes 2018;67(Supplement_1):63-OR
https://doi.org/10.2337/db18-63-OR
Published: 01 July 2018
View article titled, Differential Association of Inflammatory Markers and Growth Factors with Type 2 Diabetes and Polyneuropathy—A Multimarker Approach
Journal Articles

Erratum. Association Between Long-term Exposure to Air Pollution and Biomarkers Related to Insulin Resistance, Subclinical Inflammation, and Adipokines. Diabetes 2016;65: 3314–3326

Kathrin Wolf, Anita Popp, Alexandra Schneider, Susanne Breitner, Regina Hampel, Wolfgang Rathmann, Christian Herder, Michael Roden, Wolfgang Koenig, Christa Meisinger, Annette Peters
Journal: Diabetes
Diabetes 2017;66(10):2725
https://doi.org/10.2337/db17-er10b
Published: 11 August 2017
View article titled, Erratum. Association Between Long-term Exposure to Air Pollution and Biomarkers Related to Insulin Resistance, Subclinical Inflammation, and Adipokines. Diabetes 2016;65: 3314–3326
Open the PDF for Erratum. Association Between Long-term Exposure to Air Pollution and Biomarkers Related to Insulin Resistance, Subclinical Inflammation, and Adipokines. Diabetes 2016;65: 3314–3326 in another window
Journal Articles

Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues

Jonathan Adam, Stefan Brandmaier, Jörn Leonhardt, Markus F. Scheerer, Robert P. Mohney, Tao Xu, Jie Bi, Markus Rotter, Martina Troll, Shen Chi, Margit Heier, Christian Herder, Wolfgang Rathmann, Guido Giani, Jerzy Adamski, Thomas Illig, Konstantin Strauch, Yixue Li, Christian Gieger, Annette Peters, Karsten Suhre, Donna Ankerst, Thomas Meitinger, Martin Hrabĕ de Angelis, Michael Roden, Susanne Neschen, Gabi Kastenmüller, Rui Wang-Sattler
Journal: Diabetes
Diabetes 2016;65(12):3776–3785
https://doi.org/10.2337/db16-0512
Published: 12 September 2016
View article titled, Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues
Open the PDF for Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues in another window
Includes: Supplementary data
Journal Articles

Association Between Long-term Exposure to Air Pollution and Biomarkers Related to Insulin Resistance, Subclinical Inflammation, and Adipokines

Kathrin Wolf, Anita Popp, Alexandra Schneider, Susanne Breitner, Regina Hampel, Wolfgang Rathmann, Christian Herder, Michael Roden, Wolfgang Koenig, Christa Meisinger, Annette Peters, for the KORA-Study Group
Journal: Diabetes
Diabetes 2016;65(11):3314–3326
https://doi.org/10.2337/db15-1567
Published: 07 September 2016
View article titled, Association Between Long-term Exposure to Air Pollution and Biomarkers Related to Insulin Resistance, Subclinical Inflammation, and Adipokines
Open the PDF for Association Between Long-term Exposure to Air Pollution and Biomarkers Related to Insulin Resistance, Subclinical Inflammation, and Adipokines in another window
Includes: Supplementary data
Journal Articles

Variants in Genes Controlling Oxidative Metabolism Contribute to Lower Hepatic ATP Independent of Liver Fat Content in Type 1 Diabetes

Sofiya Gancheva, Alessandra Bierwagen, Kirti Kaul, Christian Herder, Peter Nowotny, Sabine Kahl, Guido Giani, Birgit Klueppelholz, Birgit Knebel, Paul Begovatz, Klaus Strassburger, Hadi Al-Hasani, Jesper Lundbom, Julia Szendroedi, Michael Roden, for the German Diabetes Study (GDS) Group
Journal: Diabetes
Diabetes 2016;65(7):1849–1857
https://doi.org/10.2337/db16-0162
Published: 19 April 2016
View article titled, Variants in Genes Controlling Oxidative Metabolism Contribute to Lower Hepatic ATP Independent of Liver Fat Content in Type 1 Diabetes
Open the PDF for Variants in Genes Controlling Oxidative Metabolism Contribute to Lower Hepatic ATP Independent of Liver Fat Content in Type 1 Diabetes in another window
Includes: Supplementary data
Journal Articles

Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors

Tove Fall, Sara Hägg, Alexander Ploner, Reedik Mägi, Krista Fischer, Harmen H.M. Draisma, Antti-Pekka Sarin, Beben Benyamin, Claes Ladenvall, Mikael Åkerlund, Mart Kals, Tõnu Esko, Christopher P. Nelson, Marika Kaakinen, Ville Huikari, Massimo Mangino, Aline Meirhaeghe, Kati Kristiansson, Marja-Liisa Nuotio, Michael Kobl, Harald Grallert, Abbas Dehghan, Maris Kuningas, Paul S. de Vries, Renée F.A.G. de Bruijn, Sara M. Willems, Kauko Heikkilä, Karri Silventoinen, Kirsi H. Pietiläinen, Vanessa Legry, Vilmantas Giedraitis, Louisa Goumidi, Ann-Christine Syvänen, Konstantin Strauch, Wolfgang Koenig, Peter Lichtner, Christian Herder, Aarno Palotie, Cristina Menni, André G. Uitterlinden, Kari Kuulasmaa, Aki S. Havulinna, Luis A. Moreno, Marcela Gonzalez-Gross, Alun Evans, David-Alexandre Tregouet, John W.G. Yarnell, Jarmo Virtamo, Jean Ferrières, Giovanni Veronesi, Markus Perola, Dominique Arveiler, Paolo Brambilla, Lars Lind, Jaakko Kaprio, Albert Hofman, Bruno H. Stricker, Cornelia M. van Duijn, M. Arfan Ikram, Oscar H. Franco, Dominique Cottel, Jean Dallongeville, Alistair S. Hall, Antti Jula, Martin D. Tobin, Brenda W. Penninx, Annette Peters, Christian Gieger, Nilesh J. Samani, Grant W. Montgomery, John B. Whitfield, Nicholas G. Martin, Leif Groop, Tim D. Spector, Patrik K. Magnusson, Philippe Amouyel, Dorret I. Boomsma, Peter M. Nilsson, Marjo-Riitta Järvelin, Valeriya Lyssenko, Andres Metspalu, David P. Strachan, Veikko Salomaa, Samuli Ripatti, Nancy L. Pedersen, Inga Prokopenko, Mark I. McCarthy, Erik Ingelsson
Journal: Diabetes
Diabetes 2015;64(5):1841–1852
https://doi.org/10.2337/db14-0988
Published: 23 February 2015
View article titled, Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors
Open the PDF for Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors in another window
Includes: Supplementary data
Journal Articles

Genetic Determinants of Circulating Interleukin-1 Receptor Antagonist Levels and Their Association With Glycemic Traits

Christian Herder, Marja-Liisa Nuotio, Sonia Shah, Stefan Blankenberg, Eric J. Brunner, Maren Carstensen, Christian Gieger, Harald Grallert, Antti Jula, Mika Kähönen, Johannes Kettunen, Mika Kivimäki, Wolfgang Koenig, Kati Kristiansson, Claudia Langenberg, Terho Lehtimäki, Kari Luotola, Carola Marzi, Christian Müller, Annette Peters, Holger Prokisch, Olli Raitakari, Wolfgang Rathmann, Michael Roden, Marko Salmi, Katharina Schramm, Daniel Swerdlow, Adam G. Tabak, Barbara Thorand, Nick Wareham, Philipp S. Wild, Tanja Zeller, Aroon D. Hingorani, Daniel R. Witte, Meena Kumari, Markus Perola, Veikko Salomaa
Journal: Diabetes
Diabetes 2014;63(12):4343–4359
https://doi.org/10.2337/db14-0731
Published: 13 November 2014
View article titled, Genetic Determinants of Circulating Interleukin-1 Receptor Antagonist Levels and Their Association With Glycemic Traits
Open the PDF for Genetic Determinants of Circulating Interleukin-1 Receptor Antagonist Levels and Their Association With Glycemic Traits in another window
Includes: Supplementary data
Journal Articles

Mechanisms Underlying the Onset of Oral Lipid–Induced Skeletal Muscle Insulin Resistance in Humans

Bettina Nowotny, Lejla Zahiragic, Dorothea Krog, Peter J. Nowotny, Christian Herder, Maren Carstensen, Toru Yoshimura, Julia Szendroedi, Esther Phielix, Peter Schadewaldt, Nanette C. Schloot, Gerald I. Shulman, Michael Roden
Journal: Diabetes
Diabetes 2013;62(7):2240–2248
https://doi.org/10.2337/db12-1179
Published: 14 June 2013
View article titled, Mechanisms Underlying the Onset of Oral Lipid–Induced Skeletal Muscle Insulin Resistance in Humans
Open the PDF for Mechanisms Underlying the Onset of Oral Lipid–Induced Skeletal Muscle Insulin Resistance in Humans in another window
Includes: Supplementary data
Journal Articles

Accelerated Increase in Serum Interleukin-1 Receptor Antagonist Starts 6 Years Before Diagnosis of Type 2 Diabetes: Whitehall II Prospective Cohort Study

Maren Carstensen, Christian Herder, Mika Kivimäki, Markus Jokela, Michael Roden, Martin J. Shipley, Daniel R. Witte, Eric J. Brunner, Adam G. Tabák
Journal: Diabetes
Diabetes 2010;59(5):1222–1227
https://doi.org/10.2337/db09-1199
Published: 25 February 2010
View article titled, Accelerated Increase in Serum Interleukin-1 Receptor Antagonist Starts 6 Years Before Diagnosis of Type 2 Diabetes: <subtitle>Whitehall II Prospective Cohort Study</subtitle>
Open the PDF for Accelerated Increase in Serum Interleukin-1 Receptor Antagonist Starts 6 Years Before Diagnosis of Type 2 Diabetes: <subtitle>Whitehall II Prospective Cohort Study</subtitle> in another window
Includes: Supplementary data