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Christopher B. Newgard
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Meeting Abstracts

1728-P: Transcriptional Activation of Myc by Glucose Requires Recruitment of ChREBP to the Pvt1 Promoter Regulating Proliferation in ß-Cells

LIORA S. KATZ, PENG WANG, GABRIEL BRILL, PILI ZHANG, JONATHAN HALDEMAN, CHRISTOPHER B. NEWGARD, ANDREW F. STEWART, ADOLFO GARCIA-OCANA, DONALD SCOTT
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1728-P
https://doi.org/10.2337/db23-1728-P
Published: 20 June 2023
View article titled, 1728-P: Transcriptional Activation of Myc by Glucose Requires Recruitment of ChREBP to the Pvt1 Promoter Regulating Proliferation in ß-Cells
Meeting Abstracts

1562-P: Hepatic ChREBP-ß Overexpression Enhances Peripheral Glucose and Lipid Homeostasis Independently of FGF21

SARAH HANNOU, ASHOT SARGSYAN, WENXIN TONG, JIE AN, CHRISTOPHER B. NEWGARD, INNA ASTAPOVA, MARK A. HERMAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1562-P
https://doi.org/10.2337/db23-1562-P
Published: 20 June 2023
View article titled, 1562-P: Hepatic ChREBP-ß Overexpression Enhances Peripheral Glucose and Lipid Homeostasis Independently of FGF21
Journal Articles

Maternal Exercise and Paternal Exercise Induce Distinct Metabolite Signatures in Offspring Tissues

Diego Hernández-Saavedra, Christina Markunas, Hirokazu Takahashi, Lisa A. Baer, Johan E. Harris, Michael F. Hirshman, Olga Ilkayeva, Christopher B. Newgard, Kristin I. Stanford, Laurie J. Goodyear
Journal: Diabetes
Diabetes 2022;71(10):2094–2105
https://doi.org/10.2337/db22-0341
Published: 15 July 2022
View article titled, Maternal Exercise and Paternal Exercise Induce Distinct Metabolite Signatures in Offspring Tissues
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Meeting Abstracts

146-OR: Specific Metabolomic Signatures Associate with Diabetes Remission after Weight Loss

LYDIA C. KWEE, OLGA ILKAYEVA, MICHAEL MUEHLBAUER, BRUCE M. WOLFE, JONATHAN Q. PURNELL, XAVIER PI-SUNYER, HAIYING CHEN, CHRISTOPHER B. NEWGARD, SVATI H. SHAH, BLANDINE LAFERRERE
Journal: Diabetes
Diabetes 2020;69(Supplement_1):146-OR
https://doi.org/10.2337/db20-146-OR
Published: 01 June 2020
View article titled, 146-OR: Specific Metabolomic Signatures Associate with Diabetes Remission after Weight Loss
Meeting Abstracts

1344-P: Metabolomics Reveals Broad Scale Metabolic Changes in Gestational Diabetes

YU LIU, ALAN KUANG, JAMES R. BAIN, TABITHA GEORGE, OLGA ILKAYEVA, ADAM MINCEY, MICHAEL MUEHLBAUER, LYNN P. LOWE, BOYD E. METZGER, CHRISTOPHER B. NEWGARD, DENISE SCHOLTENS, WILLIAM LOWE, JR.
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1344-P
https://doi.org/10.2337/db20-1344-P
Published: 01 June 2020
View article titled, 1344-P: Metabolomics Reveals Broad Scale Metabolic Changes in Gestational Diabetes
Meeting Abstracts

Integration of BCAA and Lipid Metabolism by the BCKDH Kinase and Phosphatase

PHILLIP J. WHITE, ROBERT W. MCGARRAH, III, PAUL A. GRIMSRUD, WEN-HSUAN YANG, GUO-FANG ZHANG, JONATHAN M. HALDEMAN, MICHELLE ARLOTTO, OLGA ILKAYEVA, RICHARD M. WYNN, DAVID T. CHUANG, CHRISTOPHER B. NEWGARD
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1874-P
https://doi.org/10.2337/db18-1874-P
Published: 01 July 2018
View article titled, Integration of BCAA and Lipid Metabolism by the BCKDH Kinase and Phosphatase
Journal Articles

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction

Jianyang Fu, Xiaoqing Dai, Gregory Plummer, Kunimasa Suzuki, Austin Bautista, John M. Githaka, Laura Senior, Mette Jensen, Dafna Greitzer-Antes, Jocelyn E. Manning Fox, Herbert Y. Gaisano, Christopher B. Newgard, Nicolas Touret, Patrick E. MacDonald
Journal: Diabetes
Diabetes 2017;66(7):1890–1900
https://doi.org/10.2337/db16-1170
Published: 15 June 2017
View article titled, Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction
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Includes: Supplementary data
Journal Articles

Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism

Jami M. Gurley, Olga Ilkayeva, Robert M. Jackson, Beth A. Griesel, Phillip White, Satochi Matsuzaki, Rizwan Qaisar, Holly Van Remmen, Kenneth M. Humphries, Christopher B. Newgard, Ann Louise Olson
Journal: Diabetes
Diabetes 2016;65(12):3585–3597
https://doi.org/10.2337/db16-0709
Published: 27 September 2016
View article titled, Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism
Open the PDF for Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism in another window
Journal Articles

Metabolic Networks and Metabolites Underlie Associations Between Maternal Glucose During Pregnancy and Newborn Size at Birth

Denise M. Scholtens, James R. Bain, Anna C. Reisetter, Michael J. Muehlbauer, Michael Nodzenski, Robert D. Stevens, Olga Ilkayeva, Lynn P. Lowe, Boyd E. Metzger, Christopher B. Newgard, William L. Lowe, Jr.
Journal: Diabetes
Diabetes 2016;65(7):2039–2050
https://doi.org/10.2337/db15-1748
Published: 05 April 2016
View article titled, Metabolic Networks and Metabolites Underlie Associations Between Maternal Glucose During Pregnancy and Newborn Size at Birth
Open the PDF for Metabolic Networks and Metabolites Underlie Associations Between Maternal Glucose During Pregnancy and Newborn Size at Birth in another window
Includes: Supplementary data
Journal Articles

Compartmentalized Acyl-CoA Metabolism in Skeletal Muscle Regulates Systemic Glucose Homeostasis

Lei O. Li, Trisha J. Grevengoed, David S. Paul, Olga Ilkayeva, Timothy R. Koves, Florencia Pascual, Christopher B. Newgard, Deborah M. Muoio, Rosalind A. Coleman
Journal: Diabetes
Diabetes 2015;64(1):23–35
https://doi.org/10.2337/db13-1070
Published: 28 July 2014
View article titled, Compartmentalized Acyl-CoA Metabolism in Skeletal Muscle Regulates Systemic Glucose Homeostasis
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Includes: Supplementary data
Journal Articles

BMI, RQ, Diabetes, and Sex Affect the Relationships Between Amino Acids and Clamp Measures of Insulin Action in Humans

Anna E. Thalacker-Mercer, Katherine H. Ingram, Fangjian Guo, Olga Ilkayeva, Christopher B. Newgard, W. Timothy Garvey
Journal: Diabetes
Diabetes 2014;63(2):791–800
https://doi.org/10.2337/db13-0396
Published: 16 January 2014
View article titled, BMI, RQ, Diabetes, and Sex Affect the Relationships Between Amino Acids and Clamp Measures of Insulin Action in Humans
Open the PDF for BMI, RQ, Diabetes, and Sex Affect the Relationships Between Amino Acids and Clamp Measures of Insulin Action in Humans in another window
Includes: Supplementary data
Journal Articles

Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation

Enxuan Jing, Brian T. O’Neill, Matthew J. Rardin, André Kleinridders, Olga R. Ilkeyeva, Siegfried Ussar, James R. Bain, Kevin Y. Lee, Eric M. Verdin, Christopher B. Newgard, Bradford W. Gibson, C. Ronald Kahn
Journal: Diabetes
Diabetes 2013;62(10):3404–3417
https://doi.org/10.2337/db12-1650
Published: 17 September 2013
View article titled, Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation
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Includes: Supplementary data
Journal Articles

Effect of Roux-en-Y Gastric Bypass and Laparoscopic Adjustable Gastric Banding on Branched-Chain Amino Acid Metabolism

Faidon Magkos, David Bradley, George G. Schweitzer, Brian N. Finck, J. Christopher Eagon, Olga Ilkayeva, Christopher B. Newgard, Samuel Klein
Journal: Diabetes
Diabetes 2013;62(8):2757–2761
https://doi.org/10.2337/db13-0185
Published: 17 July 2013
View article titled, Effect of Roux-en-Y Gastric Bypass and Laparoscopic Adjustable Gastric Banding on Branched-Chain Amino Acid Metabolism
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Includes: Supplementary data
Journal Articles

Pathogenesis of A−β+ Ketosis-Prone Diabetes

Sanjeet G. Patel, Jean W. Hsu, Farook Jahoor, Ivonne Coraza, James R. Bain, Robert D. Stevens, Dinakar Iyer, Ramaswami Nalini, Kerem Ozer, Christiane S. Hampe, Christopher B. Newgard, Ashok Balasubramanyam
Journal: Diabetes
Diabetes 2013;62(3):912–922
https://doi.org/10.2337/db12-0624
Published: 14 February 2013
View article titled, Pathogenesis of A<sup>−</sup>β<sup>+</sup> Ketosis-Prone Diabetes
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Journal Articles

Rapid and Weight-Independent Improvement of Glucose Tolerance Induced by a Peptide Designed to Elicit Apoptosis in Adipose Tissue Endothelium

Dong-Hoon Kim, Maureen A. Sartor, James R. Bain, Darleen Sandoval, Robert D. Stevens, Mario Medvedovic, Christopher B. Newgard, Stephen C. Woods, Randy J. Seeley
Journal: Diabetes
Diabetes 2012;61(9):2299–2310
https://doi.org/10.2337/db11-1579
Published: 17 August 2012
View article titled, Rapid and Weight-Independent Improvement of Glucose Tolerance Induced by a Peptide Designed to Elicit Apoptosis in Adipose Tissue Endothelium
Open the PDF for Rapid and Weight-Independent Improvement of Glucose Tolerance Induced by a Peptide Designed to Elicit Apoptosis in Adipose Tissue Endothelium in another window
Includes: Supplementary data
Journal Articles

Metabolomics Applied to Diabetes Research: Moving From Information to Knowledge

James R. Bain, Robert D. Stevens, Brett R. Wenner, Olga Ilkayeva, Deborah M. Muoio, Christopher B. Newgard
Journal: Diabetes
Diabetes 2009;58(11):2429–2443
https://doi.org/10.2337/db09-0580
Published: 01 November 2009
View article titled, Metabolomics Applied to Diabetes Research: <subtitle>Moving From Information to Knowledge</subtitle>
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Journal Articles

Insulin Resistance and Altered Systemic Glucose Metabolism in Mice Lacking Nur77

Lily C. Chao, Kevin Wroblewski, Zidong Zhang, Liming Pei, Laurent Vergnes, Olga R. Ilkayeva, Shi Ying Ding, Karen Reue, Matthew J. Watt, Christopher B. Newgard, Paul F. Pilch, Andrea L. Hevener, Peter Tontonoz
Journal: Diabetes
Diabetes 2009;58(12):2788–2796
https://doi.org/10.2337/db09-0763
Published: 09 September 2009
View article titled, Insulin Resistance and Altered Systemic Glucose Metabolism in Mice Lacking Nur77
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Includes: Supplementary data
Journal Articles

Restoration of Hepatic Glucokinase Expression Corrects Hepatic Glucose Flux and Normalizes Plasma Glucose in Zucker Diabetic Fatty Rats

Tracy P. Torres, ReEtta L. Catlin, Robert Chan, Yuka Fujimoto, Noriyasu Sasaki, Richard L. Printz, Christopher B. Newgard, Masakazu Shiota
Journal: Diabetes
Diabetes 2009;58(1):78–86
https://doi.org/10.2337/db08-1119
Published: 01 January 2009
View article titled, Restoration of Hepatic Glucokinase Expression Corrects Hepatic Glucose Flux and Normalizes Plasma Glucose in Zucker Diabetic Fatty Rats
Open the PDF for Restoration of Hepatic Glucokinase Expression Corrects Hepatic Glucose Flux and Normalizes Plasma Glucose in Zucker Diabetic Fatty Rats in another window
Includes: Supplementary data
Journal Articles

Fatty Acid Oxidation and Insulin Action: When Less Is More

Deborah M. Muoio, Christopher B. Newgard
Journal: Diabetes
Diabetes 2008;57(6):1455–1456
https://doi.org/10.2337/db08-0281
Published: 01 June 2008
View article titled, Fatty Acid Oxidation and Insulin Action: <subtitle>When Less Is More</subtitle>
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Journal Articles

Pro- and Antiapoptotic Proteins Regulate Apoptosis but Do Not Protect Against Cytokine-Mediated Cytotoxicity in Rat Islets and β-Cell Lines

J. Jason Collier, Patrick T. Fueger, Hans E. Hohmeier, Christopher B. Newgard
Journal: Diabetes
Diabetes 2006;55(5):1398–1406
https://doi.org/10.2337/db05-1000
Published: 01 May 2006
View article titled, Pro- and Antiapoptotic Proteins Regulate Apoptosis but Do Not Protect Against Cytokine-Mediated Cytotoxicity in Rat Islets and β-Cell Lines
Open the PDF for Pro- and Antiapoptotic Proteins Regulate Apoptosis but Do Not Protect Against Cytokine-Mediated Cytotoxicity in Rat Islets and β-Cell Lines in another window