1-20 of 31
Christopher J. Rhodes
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Meeting Abstracts

1800-P: Cotadutide, a GLP-1/GCG Receptor Co-Agonist, Improves Insulin Sensitivity and Restores Normal Insulin Secretory Capacity in DIO Mice

Free
RHIANNA C. LAKER, LOUISE LANTIER, OWEN MCGUINNESS, SARAH WILL, KYLE KUSZPIT, ALEX R. ALFARO, LUTZ JERMUTUS, CHRISTOPHER J. RHODES
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1800-P
https://doi.org/10.2337/db20-1800-P
Published: 01 June 2020
View articletitled, 1800-P: Cotadutide, a GLP-1/GCG Receptor Co-Agonist, Improves Insulin Sensitivity and Restores Normal Insulin Secretory Capacity in DIO Mice
Meeting Abstracts

196-LB: Synergetic and Distinct Roles in the Control of Food Intake and Energy Balance for Subpopulations of NTS Neurons

Free
WENWEN C. CHENG, ERMELINDA NDOKA, BASMA MAERZ, KAREN J. ROELOFS, CHRISTOPHER J. RHODES, RANDY J. SEELEY, DARLEEN A. SANDOVAL, DAVID OLSON, MARTIN G. MYERS, JR.
Journal: Diabetes
Diabetes 2020;69(Supplement_1):196-LB
https://doi.org/10.2337/db20-196-LB
Published: 01 June 2020
View articletitled, 196-LB: Synergetic and Distinct Roles in the Control of Food Intake and Energy Balance for Subpopulations of NTS Neurons
Meeting Abstracts

1883-P: Phosphoproteomics Reveals Mechanistic Insight into Glucagon-Mediated Inhibition of Hepatic Lipogenesis and How MEDI0382, an Oxyntomodulin-Like Peptide with Targeted GLP-1/Glucagon Receptor Activity, Reverses Steatosis

Free
RHIANNA C. LAKER, MICHELLE BOLAND, ARKADIUSZ NAWROCKI, KARLY M. MATHER, LUTZ JERMUTUS, MARTIN R. LARSEN, JAMES TREVASKIS, CHRISTOPHER J. RHODES
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1883-P
https://doi.org/10.2337/db19-1883-P
Published: 01 June 2019
View articletitled, 1883-P: Phosphoproteomics Reveals Mechanistic Insight into Glucagon-Mediated Inhibition of Hepatic Lipogenesis and How MEDI0382, an Oxyntomodulin-Like Peptide with Targeted GLP-1/Glucagon Receptor Activity, Reverses Steatosis
Meeting Abstracts

2002-P: A Long-Acting GLP-1 and Y2-Receptor Dual Agonist Improves Body Weight and Glucose Control in Obese and Diabetic Rodent Models

Free
STEPHANIE OLDHAM, VICTOR G. HOWARD, SARAH WILL, DAVID C. HORNIGOLD, CHRISTOPHER J. RHODES, SHIMONA MADALLI, ISABELLE SERMADIRAS, JACQUELINE NAYLOR, CHRSITAN RIVERA, SR.
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2002-P
https://doi.org/10.2337/db19-2002-P
Published: 01 June 2019
View articletitled, 2002-P: A Long-Acting GLP-1 and Y2-Receptor Dual Agonist Improves Body Weight and Glucose Control in Obese and Diabetic Rodent Models
Meeting Abstracts

1086-P: Preclinical Development of an Ultralong-Acting Insulin for Once-Weekly Dosing

Free
VICTOR G. HOWARD, CHRISTOPHER D. CHURCH, STEPHANIE OLDHAM, DAVID C. HORNIGOLD, JAMES TREVASKIS, DAVID BAKER, CHRISTOPHER J. RHODES, ALESSANDRA ROSSI, JACQUELINE NAYLOR, JATINDER DHILLON, ANDREW BUCHANAN, LIHUAN LIANG
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1086-P
https://doi.org/10.2337/db19-1086-P
Published: 01 June 2019
View articletitled, 1086-P: Preclinical Development of an Ultralong-Acting Insulin for Once-Weekly Dosing
Journal Articles

Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes

Free
Brandon B. Boland, Charles Brown, Jr., Michelle L. Boland, Jennifer Cann, Michal Sulikowski, Gitte Hansen, Rikke V. Grønlund, Wanda King, Cristina Rondinone, James Trevaskis, Christopher J. Rhodes, Joseph S. Grimsby
Journal: Diabetes
Diabetes 2019;68(1):131–140
https://doi.org/10.2337/db18-0304
Published: 10 October 2018
View articletitled, Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes
Open the PDF for Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes in another window
Includes: Supplementary data
Meeting Abstracts

Coadministration of GLP-1 and Y2R Receptor Agonists Synergize to Promote Muscle Glucose Uptake and Induce Diabetic Remission

Free
BRANDON BOLAND, VICTOR G. HOWARD, MICHELLE BEATON, SARAH WILL, STEPHANIE OLDHAM, JAMES TREVASKIS, CHRISTOPHER J. RHODES, JOE GRIMSBY
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1909-P
https://doi.org/10.2337/db18-1909-P
Published: 01 July 2018
View articletitled, Coadministration of GLP-1 and Y2R Receptor Agonists Synergize to Promote Muscle Glucose Uptake and Induce Diabetic Remission
Meeting Abstracts

MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, Dramatically Reduces Hepatic Collagen in a Mouse Model of NASH

Free
MICHELLE BEATON, SILVIA GUIONAUD, JAMES P. CONWAY, JOE GRIMSBY, CHRISTOPHER J. RHODES, LUTZ JERMUTUS, JAMES TREVASKIS
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1841-P
https://doi.org/10.2337/db18-1841-P
Published: 01 July 2018
View articletitled, MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, Dramatically Reduces Hepatic Collagen in a Mouse Model of NASH
Journal Articles

Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats

Free
James L. Trevaskis, Chester Bittencourt Sacramento, Hani Jouihan, Safina Ali, John Le Lay, Stephanie Oldham, Nicholas Bhagroo, Brandon B. Boland, Jennifer Cann, Yuan Chang, Terrence O’Day, Victor Howard, Christina Reers, Maria Sorhede Winzell, David M. Smith, Michael Feigh, Pernille Barkholt, Kay Schreiter, Matthias Austen, Uwe Andag, Simon Thompson, Lutz Jermutus, Matthew P. Coghlan, Joseph Grimsby, Cord Dohrmann, Christopher J. Rhodes, Cristina M. Rondinone, Arun Sharma
Journal: Diabetes
Diabetes 2017;66(7):2007–2018
https://doi.org/10.2337/db16-0916
Published: 13 April 2017
View articletitled, Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats
Open the PDF for Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats in another window
Includes: Supplementary data
Journal Articles

The Brain–to–Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions

Free
Wilfredo Rosario, Inderroop Singh, Arnaud Wautlet, Christa Patterson, Jonathan Flak, Thomas C. Becker, Almas Ali, Natalia Tamarina, Louis H. Philipson, Lynn W. Enquist, Martin G. Myers, Jr., Christopher J. Rhodes
Journal: Diabetes
Diabetes 2016;65(9):2711–2723
https://doi.org/10.2337/db15-0629
Published: 12 April 2016
View articletitled, The Brain–to–Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions
Open the PDF for The Brain–to–Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions in another window
Includes: Supplementary data
Journal Articles

Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function

Free
Cristina Alarcon, Brandon B. Boland, Yuji Uchizono, Patrick C. Moore, Bryan Peterson, Suryalekha Rajan, Olivia S. Rhodes, Andrew B. Noske, Leena Haataja, Peter Arvan, Bradly J. Marsh, Jotham Austin, Christopher J. Rhodes
Journal: Diabetes
Diabetes 2016;65(2):438–450
https://doi.org/10.2337/db15-0792
Published: 28 August 2015
View articletitled, Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function
Open the PDF for Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function in another window
Includes: Multimedia, Supplementary data
Journal Articles

Direct Autocrine Action of Insulin on β-Cells: Does It Make Physiological Sense?

Open Access
Christopher J. Rhodes, Morris F. White, John L. Leahy, Steven E. Kahn
Journal: Diabetes
Diabetes 2013;62(7):2157–2163
https://doi.org/10.2337/db13-0246
Published: 14 June 2013
View articletitled, Direct Autocrine Action of Insulin on β-Cells: Does It Make Physiological Sense?
Open the PDF for Direct Autocrine Action of Insulin on β-Cells: Does It Make Physiological Sense? in another window
Journal Articles

Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca2+-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells

Open Access
Damien Demozay, Shin Tsunekawa, Isabelle Briaud, Ramila Shah, Christopher J. Rhodes
Journal: Diabetes
Diabetes 2011;60(11):2892–2902
https://doi.org/10.2337/db11-0341
Published: 17 October 2011
View articletitled, Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca2+-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells
Open the PDF for Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca2+-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells in another window
Includes: Supplementary data
Journal Articles

Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets: Role of Rac1–JNK1/2 Signaling Pathway in Mitochondrial Dysregulation in the Diabetic Islet

Open Access
Ismail Syed, Chandrashekara N. Kyathanahalli, Bhavaani Jayaram, Sudha Govind, Christopher J. Rhodes, Renu A. Kowluru, Anjaneyulu Kowluru
Journal: Diabetes
Diabetes 2011;60(11):2843–2852
https://doi.org/10.2337/db11-0809
Published: 17 October 2011
View articletitled, Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets: Role of Rac1–JNK1/2 Signaling Pathway in Mitochondrial Dysregulation in the Diabetic Islet
Open the PDF for Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets: Role of Rac1–JNK1/2 Signaling Pathway in Mitochondrial Dysregulation in the Diabetic Islet in another window
Journal Articles

FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic β-Cells Is Distinct From That in Hepatocytes

Open Access
Shin Tsunekawa, Damien Demozay, Isabelle Briaud, Jill McCuaig, Domenico Accili, Roland Stein, Christopher J. Rhodes
Journal: Diabetes
Diabetes 2011;60(11):2883–2891
https://doi.org/10.2337/db11-0340
Published: 17 October 2011
View articletitled, FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic β-Cells Is Distinct From That in Hepatocytes
Open the PDF for FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic β-Cells Is Distinct From That in Hepatocytes in another window
Includes: Supplementary data
Journal Articles

How Does Type 1 Diabetes Develop?: The Notion of Homicide or β-Cell Suicide Revisited

Open Access
Mark A. Atkinson, Jeffrey A. Bluestone, George S. Eisenbarth, Matthias Hebrok, Kevan C. Herold, Domenico Accili, Massimo Pietropaolo, Peter R. Arvan, Matthias Von Herrath, Dorene S. Markel, Christopher J. Rhodes
Journal: Diabetes
Diabetes 2011;60(5):1370–1379
https://doi.org/10.2337/db10-1797
Published: 23 April 2011
View articletitled, How Does Type 1 Diabetes Develop?: The Notion of Homicide or β-Cell Suicide Revisited
Open the PDF for How Does Type 1 Diabetes Develop?: The Notion of Homicide or β-Cell Suicide Revisited in another window
Journal Articles

Protein Farnesylation–Dependent Raf/Extracellular Signal–Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic β-Cells

Open Access
Anjaneyulu Kowluru, Rajakrishnan Veluthakal, Christopher J. Rhodes, Vasudeva Kamath, Ismail Syed, Brandon J. Koch
Journal: Diabetes
Diabetes 2010;59(4):967–977
https://doi.org/10.2337/db09-1334
Published: 13 January 2010
View articletitled, Protein Farnesylation–Dependent Raf/Extracellular Signal–Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic β-Cells
Open the PDF for Protein Farnesylation–Dependent Raf/Extracellular Signal–Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic β-Cells in another window
Journal Articles

Involvement of Per-Arnt-Sim Kinase and Extracellular-Regulated Kinases-1/2 in Palmitate Inhibition of Insulin Gene Expression in Pancreatic β-Cells

Open Access
Ghislaine Fontés, Meriem Semache, Derek K. Hagman, Caroline Tremblay, Ramila Shah, Christopher J. Rhodes, Jared Rutter, Vincent Poitout
Journal: Diabetes
Diabetes 2009;58(9):2048–2058
https://doi.org/10.2337/db08-0579
Published: 05 June 2009
View articletitled, Involvement of Per-Arnt-Sim Kinase and Extracellular-Regulated Kinases-1/2 in Palmitate Inhibition of Insulin Gene Expression in Pancreatic β-Cells
Open the PDF for Involvement of Per-Arnt-Sim Kinase and Extracellular-Regulated Kinases-1/2 in Palmitate Inhibition of Insulin Gene Expression in Pancreatic β-Cells in another window
Includes: Supplementary data
Journal Articles

β-Cell Regeneration: Epithelial Mesenchymal Transition Pre-EMTpted by Lineage Tracing?

Free
Larry G. Moss, Christopher J. Rhodes
Journal: Diabetes
Diabetes 2007;56(1):281–282
https://doi.org/10.2337/db07-9901
Published: 01 January 2007
View articletitled, β-Cell Regeneration: Epithelial Mesenchymal Transition Pre-EMTpted by Lineage Tracing?
Open the PDF for β-Cell Regeneration: Epithelial Mesenchymal Transition Pre-EMTpted by Lineage Tracing? in another window
Journal Articles

Impaired NH2-Terminal Processing of Human Proislet Amyloid Polypeptide by the Prohormone Convertase PC2 Leads to Amyloid Formation and Cell Death

Free
Lucy Marzban, Christopher J. Rhodes, Donald F. Steiner, Leena Haataja, Philippe A. Halban, C. Bruce Verchere
Journal: Diabetes
Diabetes 2006;55(8):2192–2201
https://doi.org/10.2337/db05-1566
Published: 01 August 2006
View articletitled, Impaired NH2-Terminal Processing of Human Proislet Amyloid Polypeptide by the Prohormone Convertase PC2 Leads to Amyloid Formation and Cell Death
Open the PDF for Impaired NH2-Terminal Processing of Human Proislet Amyloid Polypeptide by the Prohormone Convertase PC2 Leads to Amyloid Formation and Cell Death in another window