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Meeting Abstracts

1800-P: Cotadutide, a GLP-1/GCG Receptor Co-Agonist, Improves Insulin Sensitivity and Restores Normal Insulin Secretory Capacity in DIO Mice

RHIANNA C. LAKER, LOUISE LANTIER, OWEN MCGUINNESS, SARAH WILL, KYLE KUSZPIT, ALEX R. ALFARO, LUTZ JERMUTUS, CHRISTOPHER J. RHODES

Diabetes 2020;69(Supplement_1):1800-P

DOI: https://doi.org/10.2337/db20-1800-P

Published: 01 June 2020

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Meeting Abstracts

196-LB: Synergetic and Distinct Roles in the Control of Food Intake and Energy Balance for Subpopulations of NTS Neurons

WENWEN C. CHENG, ERMELINDA NDOKA, BASMA MAERZ, KAREN J. ROELOFS, CHRISTOPHER J. RHODES, RANDY J. SEELEY, DARLEEN A. SANDOVAL, DAVID OLSON, MARTIN G. MYERS, JR.

Diabetes 2020;69(Supplement_1):196-LB

DOI: https://doi.org/10.2337/db20-196-LB

Published: 01 June 2020

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Meeting Abstracts

1883-P: Phosphoproteomics Reveals Mechanistic Insight into Glucagon-Mediated Inhibition of Hepatic Lipogenesis and How MEDI0382, an Oxyntomodulin-Like Peptide with Targeted GLP-1/Glucagon Receptor Activity, Reverses Steatosis

RHIANNA C. LAKER, MICHELLE BOLAND, ARKADIUSZ NAWROCKI, KARLY M. MATHER, LUTZ JERMUTUS, MARTIN R. LARSEN, JAMES TREVASKIS, CHRISTOPHER J. RHODES

Diabetes 2019;68(Supplement_1):1883-P

DOI: https://doi.org/10.2337/db19-1883-P

Published: 01 June 2019

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Meeting Abstracts

2002-P: A Long-Acting GLP-1 and Y2-Receptor Dual Agonist Improves Body Weight and Glucose Control in Obese and Diabetic Rodent Models

STEPHANIE OLDHAM, VICTOR G. HOWARD, SARAH WILL, DAVID C. HORNIGOLD, CHRISTOPHER J. RHODES, SHIMONA MADALLI, ISABELLE SERMADIRAS, JACQUELINE NAYLOR, CHRSITAN RIVERA, SR.

Diabetes 2019;68(Supplement_1):2002-P

DOI: https://doi.org/10.2337/db19-2002-P

Published: 01 June 2019

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Meeting Abstracts

1086-P: Preclinical Development of an Ultralong-Acting Insulin for Once-Weekly Dosing

VICTOR G. HOWARD, CHRISTOPHER D. CHURCH, STEPHANIE OLDHAM, DAVID C. HORNIGOLD, JAMES TREVASKIS, DAVID BAKER, CHRISTOPHER J. RHODES, ALESSANDRA ROSSI, JACQUELINE NAYLOR, JATINDER DHILLON, ANDREW BUCHANAN, LIHUAN LIANG

Diabetes 2019;68(Supplement_1):1086-P

DOI: https://doi.org/10.2337/db19-1086-P

Published: 01 June 2019

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Journal Articles

Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes

Brandon B. Boland, Charles Brown, Jr., Michelle L. Boland, Jennifer Cann, Michal Sulikowski, Gitte Hansen, Rikke V. Grønlund, Wanda King, Cristina Rondinone, James Trevaskis, Christopher J. Rhodes, Joseph S. Grimsby

Diabetes 2019;68(1):131–140

DOI: https://doi.org/10.2337/db18-0304

Published: 10 October 2018

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Includes: Supplementary data

Meeting Abstracts

Coadministration of GLP-1 and Y2R Receptor Agonists Synergize to Promote Muscle Glucose Uptake and Induce Diabetic Remission

BRANDON BOLAND, VICTOR G. HOWARD, MICHELLE BEATON, SARAH WILL, STEPHANIE OLDHAM, JAMES TREVASKIS, CHRISTOPHER J. RHODES, JOE GRIMSBY

Diabetes 2018;67(Supplement_1):1909-P

DOI: https://doi.org/10.2337/db18-1909-P

Published: 01 July 2018

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Meeting Abstracts

MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, Dramatically Reduces Hepatic Collagen in a Mouse Model of NASH

MICHELLE BEATON, SILVIA GUIONAUD, JAMES P. CONWAY, JOE GRIMSBY, CHRISTOPHER J. RHODES, LUTZ JERMUTUS, JAMES TREVASKIS

Diabetes 2018;67(Supplement_1):1841-P

DOI: https://doi.org/10.2337/db18-1841-P

Published: 01 July 2018

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Journal Articles

Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats

Diabetes 2017;66(7):2007–2018

DOI: https://doi.org/10.2337/db16-0916

Published: 13 April 2017

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Includes: Supplementary data

Journal Articles

The Brain–to–Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions

Wilfredo Rosario, Inderroop Singh, Arnaud Wautlet, Christa Patterson, Jonathan Flak, Thomas C. Becker, Almas Ali, Natalia Tamarina, Louis H. Philipson, Lynn W. Enquist, Martin G. Myers, Jr., Christopher J. Rhodes

Diabetes 2016;65(9):2711–2723

DOI: https://doi.org/10.2337/db15-0629

Published: 12 April 2016

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Includes: Supplementary data

Journal Articles

Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function

Cristina Alarcon, Brandon B. Boland, Yuji Uchizono, Patrick C. Moore, Bryan Peterson, Suryalekha Rajan, Olivia S. Rhodes, Andrew B. Noske, Leena Haataja, Peter Arvan, Bradly J. Marsh, Jotham Austin, Christopher J. Rhodes

Diabetes 2016;65(2):438–450

DOI: https://doi.org/10.2337/db15-0792

Published: 28 August 2015

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Includes: Multimedia, Supplementary data

Journal Articles

Direct Autocrine Action of Insulin on β-Cells: Does It Make Physiological Sense?

Christopher J. Rhodes, Morris F. White, John L. Leahy, Steven E. Kahn

Diabetes 2013;62(7):2157–2163

DOI: https://doi.org/10.2337/db13-0246

Published: 14 June 2013

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Journal Articles

Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca²⁺-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells

Damien Demozay, Shin Tsunekawa, Isabelle Briaud, Ramila Shah, Christopher J. Rhodes

Diabetes 2011;60(11):2892–2902

DOI: https://doi.org/10.2337/db11-0341

Published: 17 October 2011

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Includes: Supplementary data

Journal Articles

Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets: Role of Rac1–JNK1/2 Signaling Pathway in Mitochondrial Dysregulation in the Diabetic Islet

Ismail Syed, Chandrashekara N. Kyathanahalli, Bhavaani Jayaram, Sudha Govind, Christopher J. Rhodes, Renu A. Kowluru, Anjaneyulu Kowluru

Diabetes 2011;60(11):2843–2852

DOI: https://doi.org/10.2337/db11-0809

Published: 17 October 2011

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Journal Articles

FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic β-Cells Is Distinct From That in Hepatocytes

Shin Tsunekawa, Damien Demozay, Isabelle Briaud, Jill McCuaig, Domenico Accili, Roland Stein, Christopher J. Rhodes

Diabetes 2011;60(11):2883–2891

DOI: https://doi.org/10.2337/db11-0340

Published: 17 October 2011

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Includes: Supplementary data

Journal Articles

How Does Type 1 Diabetes Develop?: The Notion of Homicide or β-Cell Suicide Revisited

Mark A. Atkinson, Jeffrey A. Bluestone, George S. Eisenbarth, Matthias Hebrok, Kevan C. Herold, Domenico Accili, Massimo Pietropaolo, Peter R. Arvan, Matthias Von Herrath, Dorene S. Markel, Christopher J. Rhodes

Diabetes 2011;60(5):1370–1379

DOI: https://doi.org/10.2337/db10-1797

Published: 23 April 2011

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Journal Articles

Protein Farnesylation–Dependent Raf/Extracellular Signal–Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic β-Cells

Anjaneyulu Kowluru, Rajakrishnan Veluthakal, Christopher J. Rhodes, Vasudeva Kamath, Ismail Syed, Brandon J. Koch

Diabetes 2010;59(4):967–977

DOI: https://doi.org/10.2337/db09-1334

Published: 13 January 2010

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Journal Articles

Involvement of Per-Arnt-Sim Kinase and Extracellular-Regulated Kinases-1/2 in Palmitate Inhibition of Insulin Gene Expression in Pancreatic β-Cells

Ghislaine Fontés, Meriem Semache, Derek K. Hagman, Caroline Tremblay, Ramila Shah, Christopher J. Rhodes, Jared Rutter, Vincent Poitout

Diabetes 2009;58(9):2048–2058

DOI: https://doi.org/10.2337/db08-0579

Published: 05 June 2009

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Includes: Supplementary data

Journal Articles

β-Cell Regeneration: Epithelial Mesenchymal Transition Pre-EMTpted by Lineage Tracing?

Larry G. Moss, Christopher J. Rhodes

Diabetes 2007;56(1):281–282

DOI: https://doi.org/10.2337/db07-9901

Published: 01 January 2007

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Journal Articles

Impaired NH₂-Terminal Processing of Human Proislet Amyloid Polypeptide by the Prohormone Convertase PC2 Leads to Amyloid Formation and Cell Death

Lucy Marzban, Christopher J. Rhodes, Donald F. Steiner, Leena Haataja, Philippe A. Halban, C. Bruce Verchere

Diabetes 2006;55(8):2192–2201

DOI: https://doi.org/10.2337/db05-1566

Published: 01 August 2006

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NARROW

1800-P: Cotadutide, a GLP-1/GCG Receptor Co-Agonist, Improves Insulin Sensitivity and Restores Normal Insulin Secretory Capacity in DIO Mice

196-LB: Synergetic and Distinct Roles in the Control of Food Intake and Energy Balance for Subpopulations of NTS Neurons

1883-P: Phosphoproteomics Reveals Mechanistic Insight into Glucagon-Mediated Inhibition of Hepatic Lipogenesis and How MEDI0382, an Oxyntomodulin-Like Peptide with Targeted GLP-1/Glucagon Receptor Activity, Reverses Steatosis

2002-P: A Long-Acting GLP-1 and Y2-Receptor Dual Agonist Improves Body Weight and Glucose Control in Obese and Diabetic Rodent Models

1086-P: Preclinical Development of an Ultralong-Acting Insulin for Once-Weekly Dosing

Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes

Coadministration of GLP-1 and Y2R Receptor Agonists Synergize to Promote Muscle Glucose Uptake and Induce Diabetic Remission

MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, Dramatically Reduces Hepatic Collagen in a Mouse Model of NASH

Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats

The Brain–to–Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions

Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function

Direct Autocrine Action of Insulin on β-Cells: Does It Make Physiological Sense?

Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca²⁺-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells

Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets: Role of Rac1–JNK1/2 Signaling Pathway in Mitochondrial Dysregulation in the Diabetic Islet

FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic β-Cells Is Distinct From That in Hepatocytes

How Does Type 1 Diabetes Develop?: The Notion of Homicide or β-Cell Suicide Revisited

Protein Farnesylation–Dependent Raf/Extracellular Signal–Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic β-Cells

Involvement of Per-Arnt-Sim Kinase and Extracellular-Regulated Kinases-1/2 in Palmitate Inhibition of Insulin Gene Expression in Pancreatic β-Cells

β-Cell Regeneration: Epithelial Mesenchymal Transition Pre-EMTpted by Lineage Tracing?

Impaired NH₂-Terminal Processing of Human Proislet Amyloid Polypeptide by the Prohormone Convertase PC2 Leads to Amyloid Formation and Cell Death

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