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Christopher L. Axelrod
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Meeting Abstracts

1605-P: Skeletal Muscle Ubiquitin Protease Function Governs Mitochondrial Quality Control and Insulin Sensitivity in Type 2 Diabetes

CHRISTOPHER L. AXELROD, WAGNER S. DANTAS, ELIZABETH C. HEINTZ, ELIZABETH R.M. ZUNICA, GANGARAO DAVULURI, JOHN P. KIRWAN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1605-P
https://doi.org/10.2337/db24-1605-P
Published: 14 June 2024
View article titled, 1605-P: Skeletal Muscle Ubiquitin Protease Function Governs Mitochondrial Quality Control and Insulin Sensitivity in Type 2 Diabetes
Meeting Abstracts

1602-P: Exercise Training Reverses Skeletal Muscle DRP1 Hyperactivation and Improves Respiratory Capacity in Patients with Type 2 Diabetes

ELIZABETH C. HEINTZ, WAGNER S. DANTAS, ELIZABETH R.M. ZUNICA, KATHRYN BELMONT, JACOB T. MEY, ROBBIE A. BEYL, DANIEL S. HSIA, HAILEY A. PARRY, BRIAN GLANCY, CHARLES L. HOPPEL, CHRISTOPHER L. AXELROD, JOHN P. KIRWAN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1602-P
https://doi.org/10.2337/db24-1602-P
Published: 14 June 2024
View article titled, 1602-P: Exercise Training Reverses Skeletal Muscle DRP1 Hyperactivation and Improves Respiratory Capacity in Patients with Type 2 Diabetes
Meeting Abstracts

265-LB: Human Skeletal Muscle Mitochondrial Dynamics across the Insulin-Sensitivity Spectrum

CHRISTOPHER L. AXELROD, WAGNER S. DANTAS, ELIZABETH R.M. ZUNICA, KATHRYN BELMONT, ELIZABETH C. HEINTZ, GANGARAO DAVULURI, JACOB T. MEY, MELISSA ERICKSON, HISASHI FUJIOKA, CIARAN FEALY, CHARLES L. HOPPEL, JOHN P. KIRWAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):265-LB
https://doi.org/10.2337/db23-265-LB
Published: 20 June 2023
View article titled, 265-LB: Human Skeletal Muscle Mitochondrial Dynamics across the Insulin-Sensitivity Spectrum
Meeting Abstracts

264-LB: Aerobic Exercise Training Reorganizes Skeletal Muscle Mitochondrial and Lipid Droplet Architecture

HAILEY A. PARRY, CHRISTOPHER L. AXELROD, VALENTINA BAENA, WAGNER S. DANTAS, JOHN P. KIRWAN, BRIAN GLANCY
Journal: Diabetes
Diabetes 2023;72(Supplement_1):264-LB
https://doi.org/10.2337/db23-264-LB
Published: 20 June 2023
View article titled, 264-LB: Aerobic Exercise Training Reorganizes Skeletal Muscle Mitochondrial and Lipid Droplet Architecture
Meeting Abstracts

730-P: Effects of Obstructive Sleep Apnea Treatment on Whole-Body and Adipose Tissue Insulin Sensitivity—Role of Senescence and Mitigation by Adjuvant Metformin Therapy

SARA RODRIGUES, WAGNER S. DANTAS, ROBBIE A. BEYL, REBEKAH C. HEBERT, ISABELLA GRIFFITH, MAKAYLA TANKSLEY, EDWARD C. MADER, JOHN P. KIRWAN, CHRISTOPHER L. AXELROD, ERIC RAVUSSIN, PRACHI SINGH
Journal: Diabetes
Diabetes 2023;72(Supplement_1):730-P
https://doi.org/10.2337/db23-730-P
Published: 20 June 2023
View article titled, 730-P: Effects of Obstructive Sleep Apnea Treatment on Whole-Body and Adipose Tissue Insulin Sensitivity—Role of Senescence and Mitigation by Adjuvant Metformin Therapy
Meeting Abstracts

582-P: Exercise Training Reverses NAFLD in Mice with Obesity Independent of Changes in Hepatic Mitochondrial Oxidative Capacity

ELIZABETH C. HEINTZ, WAGNER S. DANTAS, JAMES E. STAMPLEY, GREGORY M. DAVIS, BRIAN A. IRVING, CHRISTOPHER L. AXELROD, JOHN P. KIRWAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):582-P
https://doi.org/10.2337/db23-582-P
Published: 20 June 2023
View article titled, 582-P: Exercise Training Reverses NAFLD in Mice with Obesity Independent of Changes in Hepatic Mitochondrial Oxidative Capacity
Journal Articles

GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion

Hui Zhang, Anny Mulya, Stephan Nieuwoudt, Bolormaa Vandanmagsar, Ruth McDowell, Elizabeth C. Heintz, Elizabeth R.M. Zunica, J. Jason Collier, Nadejda Bozadjieva-Kramer, Randy J. Seeley, Christopher L. Axelrod, John P. Kirwan
Journal: Diabetes
Diabetes 2023;72(8):1070–1082
https://doi.org/10.2337/db22-0019
Published: 24 May 2023
View article titled, GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion
Open the PDF for GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion in another window
Meeting Abstracts

1436-P: Metformin Increases Skeletal Muscle Mitochondrial Function and Acute Phase Insulin Sensitivity in Obstructive Sleep Apnea

ELIZABETH R.M. ZUNICA, ELIZABETH C. HEINTZ, REBEKAH C. HEBERT, MAKAYLA C. TANKSLEY, EDWARD C. MADER, JOHN P. KIRWAN, CHRISTOPHER L. AXELROD, PRACHI SINGH
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1436-P
https://doi.org/10.2337/db22-1436-P
Published: 01 June 2022
View article titled, 1436-P: Metformin Increases Skeletal Muscle Mitochondrial Function and Acute Phase Insulin Sensitivity in Obstructive Sleep Apnea
Meeting Abstracts

237-LB: Weight-Independent Effects of Roux-en-Y Gastric Bypass Surgery on Remission of Nonalcoholic Fatty Liver Disease in Mice

CHRISTOPHER L. AXELROD, INGEBORG M. LANGOHR, WAGNER S. DANTAS, R. LEIGH TOWNSEND, VANCE L. ALBAUGH, JOHN P. KIRWAN, HANS-RUDOLF BERTHOUD
Journal: Diabetes
Diabetes 2022;71(Supplement_1):237-LB
https://doi.org/10.2337/db22-237-LB
Published: 01 June 2022
View article titled, 237-LB: Weight-Independent Effects of Roux-en-Y Gastric Bypass Surgery on Remission of Nonalcoholic Fatty Liver Disease in Mice
Journal Articles

Erratum. Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling. Diabetes 2020;69: 1675–1691

Wagner S. Dantas, Hamilton Roschel, Igor H. Murai, Saulo Gil, Gangarao Davuluri, Christopher L. Axelrod, Sujoy Ghosh, Susan S. Newman, Hui Zhang, Samuel K. Shinjo, Willian das Neves, Carlos Merege-Filho, Walcy R. Teodoro, Vera L. Capelozzi, Rosa Maria Pereira, Fabiana B. Benatti, Ana L. de Sá-Pinto, Roberto de Cleva, Marco A. Santo, John P. Kirwan, Bruno Gualano
Journal: Diabetes
Diabetes 2021;70(6):1415
https://doi.org/10.2337/db21-er06b
Published: 02 July 2021
View article titled, Erratum. Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling. Diabetes 2020;69: 1675–1691
Open the PDF for Erratum. Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling. Diabetes 2020;69: 1675–1691 in another window
Meeting Abstracts

238-LB: Dietary Protein Restriction Induces Myocardial Dysfunction Despite Reducing Body Weight in Aged C57BL/6J Mice

CHRISTOPHER L. AXELROD, WAGNER S. DANTAS, GANGARAO DAVULURI, WILLIAM T. KING, CRISTAL M. HILL, CHRISTOPHER MORRISON, JOHN P. KIRWAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):238-LB
https://doi.org/10.2337/db20-238-LB
Published: 01 June 2020
View article titled, 238-LB: Dietary Protein Restriction Induces Myocardial Dysfunction Despite Reducing Body Weight in Aged C57BL/6J Mice
Meeting Abstracts

1904-P: Metabolomic Fingerprints after Metabolic Surgery: The STAMPEDE Trial

WAGNER S. DANTAS, CHRISTOPHER L. AXELROD, ADITHYA HARI, SANGEETA KASHYAP, PHILIP SCHAUER, JOHN P. KIRWAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1904-P
https://doi.org/10.2337/db20-1904-P
Published: 01 June 2020
View article titled, 1904-P: Metabolomic Fingerprints after Metabolic Surgery: The STAMPEDE Trial
Meeting Abstracts

163-OR: Metabolically Unhealthy Obese Is Transient and Improves with Aerobic Exercise

KRISTIN K. HODDY, CHRISTOPHER L. AXELROD, JACOB T. MEY, ADITHYA HARI, ROBBIE A. BEYL, JOHN P. KIRWAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):163-OR
https://doi.org/10.2337/db20-163-OR
Published: 01 June 2020
View article titled, 163-OR: Metabolically Unhealthy Obese Is Transient and Improves with Aerobic Exercise
Journal Articles

Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling

Wagner S. Dantas, Hamilton Roschel, Igor H. Murai, Saulo Gil, Gangarao Davuluri, Christopher L. Axelrod, Sujoy Ghosh, Susan S. Newman, Hui Zhang, Samuel K. Shinjo, Willian das Neves, Carlos Merege-Filho, Walcy R. Teodoro, Vera L. Capelozzi, Rosa Maria Pereira, Fabiana B. Benatti, Ana L. de Sá-Pinto, Roberto de Cleva, Marco A. Santo, John P. Kirwan, Bruno Gualano
Journal: Diabetes
Diabetes 2020;69(8):1675–1691
https://doi.org/10.2337/db19-1180
Published: 14 May 2020
View article titled, Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling
Open the PDF for Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling in another window
Meeting Abstracts

276-OR: Rethinking Metabolically Healthy Obesity: What Is the Underlying Risk?

CHRISTOPHER L. AXELROD, ADITHYA HARI, JACOB T. MEY, ROBBIE A. BEYL, JOHN P. KIRWAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):276-OR
https://doi.org/10.2337/db19-276-OR
Published: 01 June 2019
View article titled, 276-OR: Rethinking Metabolically Healthy Obesity: What Is the Underlying Risk?
Meeting Abstracts

190-OR: Weight-Loss after Exercise Increases Non-Insulin-Dependent Glucose Clearance in Adults with Metabolic Syndrome

ADITHYA HARI, CHRISTOPHER L. AXELROD, JACOB T. MEY, JOHN P. KIRWAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):190-OR
https://doi.org/10.2337/db19-190-OR
Published: 01 June 2019
View article titled, 190-OR: Weight-Loss after Exercise Increases Non-Insulin-Dependent Glucose Clearance in Adults with Metabolic Syndrome
Meeting Abstracts

1928-P: GDF15 Protects against Insulin Resistance in Individuals with Type 2 Diabetes

HUI ZHANG, WAGNER DANTAS, WILLIAM T. KING, CHRISTOPHER L. AXELROD, SAULO GIL, IGOR MURAI, HAMILTON ROSCHEL, BRUNO GUALANO, JOHN P. KIRWAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1928-P
https://doi.org/10.2337/db19-1928-P
Published: 01 June 2019
View article titled, 1928-P: GDF15 Protects against Insulin Resistance in Individuals with Type 2 Diabetes
Meeting Abstracts

1945-P: The Mitochondrial Protein DRP1 Is Required for Endogenous Fatty Acid Oxidation

WILLIAM T. KING, CHRISTOPHER L. AXELROD, GANGARAO DAVULURI, ROBERT C. NOLAND, JOHN P. KIRWAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1945-P
https://doi.org/10.2337/db19-1945-P
Published: 01 June 2019
View article titled, 1945-P: The Mitochondrial Protein DRP1 Is Required for Endogenous Fatty Acid Oxidation
Meeting Abstracts

Mitochondrial Adaptation in Insulin Resistant Human Skeletal Muscle

CHRISTOPHER L. AXELROD, CIARAN E. FEALY, ANNY MULYA, EMILY HUANG, HISASHI FUJIOKA, BARTOLOME BURGUERA, CHARLES L. HOPPEL, JOHN P. KIRWAN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1915-P
https://doi.org/10.2337/db18-1915-P
Published: 01 July 2018
View article titled, Mitochondrial Adaptation in Insulin Resistant Human Skeletal Muscle
Meeting Abstracts

Pharmacologic Uncoupling of Skeletal Muscle Mitochondria Promotes Glucose Metabolism

MICHAELA E. HULL, CHRISTOPHER L. AXELROD, KELLY M. FITZGERALD, JESSICA SACKS, JOHN P. KIRWAN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1778-P
https://doi.org/10.2337/db18-1778-P
Published: 01 July 2018
View article titled, Pharmacologic Uncoupling of Skeletal Muscle Mitochondria Promotes Glucose Metabolism