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Chul-Ho Lee
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Journal Articles

Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis

Free
Younghoon Go, Ji Yun Jeong, Nam Ho Jeoung, Jae-Han Jeon, Bo-Yoon Park, Hyeon-Ji Kang, Chae-Myeong Ha, Young-Keun Choi, Sun Joo Lee, Hye Jin Ham, Byung-Gyu Kim, Keun-Gyu Park, So Young Park, Chul-Ho Lee, Cheol Soo Choi, Tae-Sik Park, W.N. Paul Lee, Robert A. Harris, In-Kyu Lee
Journal: Diabetes
Diabetes 2016;65(10):2876–2887
https://doi.org/10.2337/db16-0223
Published: 06 July 2016
View articletitled, Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis
Open the PDF for Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis in another window
Includes: Supplementary data
Journal Articles

O-GlcNAcylation of Orphan Nuclear Receptor Estrogen-Related Receptor γ Promotes Hepatic Gluconeogenesis

Free
Jagannath Misra, Don-Kyu Kim, Yoon Seok Jung, Han Byeol Kim, Yong-Hoon Kim, Eun-Kyung Yoo, Byung Gyu Kim, Sunghoon Kim, In-Kyu Lee, Robert A. Harris, Jeong-Sun Kim, Chul-Ho Lee, Jin Won Cho, Hueng-Sik Choi
Journal: Diabetes
Diabetes 2016;65(10):2835–2848
https://doi.org/10.2337/db15-1523
Published: 22 June 2016
View articletitled, O-GlcNAcylation of Orphan Nuclear Receptor Estrogen-Related Receptor γ Promotes Hepatic Gluconeogenesis
Open the PDF for O-GlcNAcylation of Orphan Nuclear Receptor Estrogen-Related Receptor γ Promotes Hepatic Gluconeogenesis in another window
Includes: Supplementary data
Journal Articles

Glucose-6-Phosphate Dehydrogenase Deficiency Improves Insulin Resistance With Reduced Adipose Tissue Inflammation in Obesity

Free
Mira Ham, Sung Sik Choe, Kyung Cheul Shin, Goun Choi, Ji-Won Kim, Jung-Ran Noh, Yong-Hoon Kim, Je-won Ryu, Kun-Ho Yoon, Chul-Ho Lee, Jae Bum Kim
Journal: Diabetes
Diabetes 2016;65(9):2624–2638
https://doi.org/10.2337/db16-0060
Published: 09 June 2016
View articletitled, Glucose-6-Phosphate Dehydrogenase Deficiency Improves Insulin Resistance With Reduced Adipose Tissue Inflammation in Obesity
Open the PDF for Glucose-6-Phosphate Dehydrogenase Deficiency Improves Insulin Resistance With Reduced Adipose Tissue Inflammation in Obesity in another window
Includes: Supplementary data
Journal Articles

Insulin-Inducible SMILE Inhibits Hepatic Gluconeogenesis

Free
Ji-Min Lee, Woo-Young Seo, Hye-Sook Han, Kyoung-Jin Oh, Yong-Soo Lee, Don-Kyu Kim, Seri Choi, Byeong Hun Choi, Robert A. Harris, Chul-Ho Lee, Seung-Hoi Koo, Hueng-Sik Choi
Journal: Diabetes
Diabetes 2016;65(1):62–73
https://doi.org/10.2337/db15-0249
Published: 04 September 2015
View articletitled, Insulin-Inducible SMILE Inhibits Hepatic Gluconeogenesis
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Includes: Supplementary data
Journal Articles

SIK2 Is Critical in the Regulation of Lipid Homeostasis and Adipogenesis In Vivo

Free
Jinyoung Park, Young-Sil Yoon, Hye-Sook Han, Yong-Hoon Kim, Yoshihiro Ogawa, Keun-Gyu Park, Chul-Ho Lee, Seong-Tae Kim, Seung-Hoi Koo
Journal: Diabetes
Diabetes 2014;63(11):3659–3673
https://doi.org/10.2337/db13-1423
Published: 13 October 2014
View articletitled, SIK2 Is Critical in the Regulation of Lipid Homeostasis and Adipogenesis In Vivo
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Includes: Supplementary data
Journal Articles

Inverse Agonist of Nuclear Receptor ERRγ Mediates Antidiabetic Effect Through Inhibition of Hepatic Gluconeogenesis

Open Access
Don-Kyu Kim, Gil-Tae Gang, Dongryeol Ryu, Minseob Koh, Yo-Na Kim, Su Sung Kim, Jinyoung Park, Yong-Hoon Kim, Taebo Sim, In-Kyu Lee, Cheol Soo Choi, Seung Bum Park, Chul-Ho Lee, Seung-Hoi Koo, Hueng-Sik Choi
Journal: Diabetes
Diabetes 2013;62(9):3093–3102
https://doi.org/10.2337/db12-0946
Published: 15 August 2013
View articletitled, Inverse Agonist of Nuclear Receptor ERRγ Mediates Antidiabetic Effect Through Inhibition of Hepatic Gluconeogenesis
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Includes: Supplementary data
Journal Articles

Metformin Inhibits Growth Hormone–Mediated Hepatic PDK4 Gene Expression Through Induction of Orphan Nuclear Receptor Small Heterodimer Partner

Open Access
Yong Deuk Kim, Yong-Hoon Kim, Surendar Tadi, Ji Hoon Yu, Yong-Hyeon Yim, Nam Ho Jeoung, Minho Shong, Lothar Hennighausen, Robert A. Harris, In-Kyu Lee, Chul-Ho Lee, Hueng-Sik Choi
Journal: Diabetes
Diabetes 2012;61(10):2484–2494
https://doi.org/10.2337/db11-1665
Published: 13 September 2012
View articletitled, Metformin Inhibits Growth Hormone–Mediated Hepatic PDK4 Gene Expression Through Induction of Orphan Nuclear Receptor Small Heterodimer Partner
Open the PDF for Metformin Inhibits Growth Hormone–Mediated Hepatic PDK4 Gene Expression Through Induction of Orphan Nuclear Receptor Small Heterodimer Partner in another window
Includes: Supplementary data
Journal Articles

Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP

Free
Yong Deuk Kim, Keun-Gyu Park, Yong-Soo Lee, Yun-Yong Park, Don-Kyu Kim, Balachandar Nedumaran, Won Gu Jang, Won-Jea Cho, Joohun Ha, In-Kyu Lee, Chul-Ho Lee, Hueng-Sik Choi
Journal: Diabetes
Diabetes 2008;57(2):306–314
https://doi.org/10.2337/db07-0381
Published: 01 February 2008
View articletitled, Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP
Open the PDF for Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP in another window
Includes: Supplementary data
Journal Articles

Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: II. Immunologic Analysis

Free
Chul-Ho Lee, Yi-Guang Chen, Jing Chen, Peter C. Reifsnyder, David V. Serreze, Michael Clare-Salzler, Michelle Rodriguez, Clive Wasserfall, Mark A. Atkinson, Edward H. Leiter
Journal: Diabetes
Diabetes 2006;55(1):171–178
https://doi.org/10.2337/diabetes.55.01.06.db05-1129
Published: 01 January 2006
View articletitled, Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: II. Immunologic Analysis
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Journal Articles

Mouse Models and the Genetics of Diabetes: Is There Evidence for Genetic Overlap Between Type 1 and Type 2 Diabetes?

Free
Edward H. Leiter, Chul-Ho Lee
Journal: Diabetes
Diabetes 2005;54(suppl_2):S151–S158
https://doi.org/10.2337/diabetes.54.suppl_2.S151
Published: 01 December 2005
View articletitled, Mouse Models and the Genetics of Diabetes: Is There Evidence for Genetic Overlap Between Type 1 and Type 2 Diabetes?
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Journal Articles

Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: I. Pathophysiological Analysis

Free
Chul-Ho Lee, Peter C. Reifsnyder, Jürgen K. Naggert, Clive Wasserfall, Mark A. Atkinson, Jing Chen, Edward H. Leiter
Journal: Diabetes
Diabetes 2005;54(9):2525–2532
https://doi.org/10.2337/diabetes.54.9.2525
Published: 01 September 2005
View articletitled, Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: I. Pathophysiological Analysis
Open the PDF for Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: I. Pathophysiological Analysis in another window