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Meeting Abstracts

1754-P: Investigating the Interplay between T-Cell Infiltration, ROS Detoxification, and Pancreatic Beta-cell Dysfunction in Type 1 Diabetes Pathogenesis

CHARLES LAZIMI, CLAYTON E. MATHEWS, EDWARD PHELPS

Diabetes 2024;73(Supplement_1):1754-P

https://doi.org/10.2337/db24-1754-P

Published: 14 June 2024

View article titled, 1754-P: Investigating the Interplay between T-Cell Infiltration, ROS Detoxification, and Pancreatic Beta-cell Dysfunction in Type 1 Diabetes Pathogenesis

Meeting Abstracts

98-OR: ß-Cell Dysfunction and Mitochondrial Loss Occur Independently of Insulitis in Type 1 Diabetes Pathogenesis

MOLLIE HUBER, ADRIENNE WIDENER, DYLAN SMURLICK, HELMUT HILLER, SR., MARIA BEERY, ELLEN VERNEY, IRINA KUSMARTSEVA, MARTHA CAMPBELL-THOMPSON, MARK A. ATKINSON, CLAYTON E. MATHEWS, EDWARD PHELPS

Diabetes 2024;73(Supplement_1):98-OR

https://doi.org/10.2337/db24-98-OR

Published: 14 June 2024

View article titled, 98-OR: ß-Cell Dysfunction and Mitochondrial Loss Occur Independently of Insulitis in Type 1 Diabetes Pathogenesis

Meeting Abstracts

136-OR: The MDA5627X Variant Is Associated with Type 1 Diabetes Protection via Attenuated Inflammatory Antiviral Responses

OPEOLUWA IWALOYE, LUCAS H. ARMITAGE, AMY M. MEACHAM, CLAYTON E. MATHEWS

Diabetes 2023;72(Supplement_1):136-OR

https://doi.org/10.2337/db23-136-OR

Published: 20 June 2023

View article titled, 136-OR: The MDA5627X Variant Is Associated with Type 1 Diabetes Protection via Attenuated Inflammatory Antiviral Responses

Meeting Abstracts

9-OR: ADA Presidents' Select Abstract: m6A mRNA Methylation Regulates the Innate Immune Response in Human Beta Cells

DARIO F. DE JESUS, ZIJIE ZHANG, NATALIE K. BROWN, GIORGIO BASILE, LING XIAO, SEVIM KAHRAMAN, CLAYTON E. MATHEWS, ALVIN C. POWERS, MARK A. ATKINSON, DECIO L. EIZIRIK, ROHIT KULKARNI

Diabetes 2022;71(Supplement_1):9-OR

https://doi.org/10.2337/db22-9-OR

Published: 01 June 2022

View article titled, 9-OR: ADA Presidents' Select Abstract: m6A mRNA Methylation Regulates the Innate Immune Response in Human Beta Cells

Meeting Abstracts

187-OR: Declines in ß-Cell Glucose Responsiveness Correlate with Loss of Glucose Metabolism during T1D Pathogenesis

MOLLIE HUBER, MARJAN SLAK RUPNIK, DENISE M. DROTAR, HELMUT HILLER, SR., MARIA BEERY, IRINA KUSMARTSEVA, MARK A. ATKINSON, EDWARD PHELPS, CLAYTON E. MATHEWS

Diabetes 2022;71(Supplement_1):187-OR

https://doi.org/10.2337/db22-187-OR

Published: 01 June 2022

View article titled, 187-OR: Declines in ß-Cell Glucose Responsiveness Correlate with Loss of Glucose Metabolism during T1D Pathogenesis

Meeting Abstracts

11-OR: Transcriptome Heterogeneity in Insulin-Positive Insulitic vs. Noninsulitic Human Islets in Type 1 Diabetes (T1D)

ALYSSA M. DYE, GRACE ASHBERY, NATALIYA I. LENCHIK, MARK A. ATKINSON, CLAYTON E. MATHEWS, MARTHA CAMPBELL-THOMPSON, IVAN C. GERLING

Diabetes 2022;71(Supplement_1):11-OR

https://doi.org/10.2337/db22-11-OR

Published: 01 June 2022

View article titled, 11-OR: Transcriptome Heterogeneity in Insulin-Positive Insulitic vs. Noninsulitic Human Islets in Type 1 Diabetes (T1D)

Meeting Abstracts

294-OR: The Type 1 Diabetes Protective Variant of Tyrosine Kinase 2 (TYK2) Protects ß-Cells from Autoimmunity

AYMEE RODRIGUEZ TAMAYO, MOLLIE HUBER, EDWARD J. BUTFILOSKI, CLAYTON E. MATHEWS

Diabetes 2022;71(Supplement_1):294-OR

https://doi.org/10.2337/db22-294-OR

Published: 01 June 2022

View article titled, 294-OR: The Type 1 Diabetes Protective Variant of Tyrosine Kinase 2 (TYK2) Protects ß-Cells from Autoimmunity

Journal Articles

ENTPD3 Marks Mature Stem Cell–Derived β-Cells Formed by Self-Aggregation In Vitro

Fiona M. Docherty, Kent A. Riemondy, Roberto Castro-Gutierrez, JaeAnn M. Dwulet, Ali H. Shilleh, Maria S. Hansen, Shane P.M. Williams, Lucas H. Armitage, Katherine E. Santostefano, Mark A. Wallet, Clayton E. Mathews, Taylor M. Triolo, Richard K.P. Benninger, Holger A. Russ

Diabetes 2021;70(11):2554–2567

https://doi.org/10.2337/db20-0873

Published: 11 August 2021

View article titled, ENTPD3 Marks Mature Stem Cell–Derived β-Cells Formed by Self-Aggregation In Vitro

Journal Articles

Erratum. NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8⁺ T-Cell Numbers. Diabetes 2020;69: 1749–1762

Andrew P. Trembath, Kelsey L. Krausz, Neekun Sharma, Ivan C. Gerling, Clayton E. Mathews, Mary A. Markiewicz

Diabetes 2021;70(9):2159

https://doi.org/10.2337/db21-er09a

Published: 08 July 2021

View article titled, Erratum. NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8<sup>+</sup> T-Cell Numbers. Diabetes 2020;69: 1749–1762

Meeting Abstracts

287-OR: M6A mRNA Methylation Regulates the Innate Immune Response in Human ß-Cells

DARIO F. DE JESUS, ZIJIE ZHANG, NATALIE K. BROWN, JIANG HU, SEVIM KAHRAMAN, CLAYTON E. MATHEWS, ALVIN C. POWERS, MARK A. ATKINSON, DECIO L. EIZIRIK, CHUAN HE, ROHIT KULKARNI

Diabetes 2021;70(Supplement_1):287-OR

https://doi.org/10.2337/db21-287-OR

Published: 01 June 2021

View article titled, 287-OR: M6A mRNA Methylation Regulates the Innate Immune Response in Human ß-Cells

Journal Articles

Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report

Andrea Lin, Jasmine A. Mack, Brittany Bruggeman, Laura M. Jacobsen, Amanda L. Posgai, Clive H. Wasserfall, Todd M. Brusko, Mark A. Atkinson, Stephen E. Gitelman, Peter A. Gottlieb, Matthew J. Gurka, Clayton E. Mathews, Desmond A. Schatz, Michael J. Haller

Diabetes 2021;70(5):1123–1129

https://doi.org/10.2337/db20-1103

Published: 25 February 2021

View article titled, Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report

Journal Articles

NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8⁺ T-Cell Numbers

Andrew P. Trembath, Kelsey L. Krausz, Neekun Sharma, Ivan C. Gerling, Clayton E. Mathews, Mary A. Markiewicz

Diabetes 2020;69(8):1749–1762

https://doi.org/10.2337/db19-0979

Published: 13 June 2020

View article titled, NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8<sup>+</sup> T-Cell Numbers

Meeting Abstracts

253-OR: Circulating Neutrophil Numbers Increase with Age, but Are Not a Biomarker of T1D Risk

ANDREA LIN, DANIEL J. PERRY, DESMOND SCHATZ, TODD M. BRUSKO, MARK A. ATKINSON, MICHAEL J. HALLER, CLAYTON E. MATHEWS

Diabetes 2020;69(Supplement_1):253-OR

https://doi.org/10.2337/db20-253-OR

Published: 01 June 2020

View article titled, 253-OR: Circulating Neutrophil Numbers Increase with Age, but Are Not a Biomarker of T1D Risk

Meeting Abstracts

201-LB: NKG2D Signaling within Pancreatic Islets Reduces NOD Diabetes and Is Associated with CD8+ Central Memory T-Cell Generation

ANDREW TREMBATH, NEEKUN SHARMA, IVAN C. GERLING, CLAYTON E. MATHEWS, MARY A. MARKIEWICZ

Diabetes 2020;69(Supplement_1):201-LB

https://doi.org/10.2337/db20-201-LB

Published: 01 June 2020

View article titled, 201-LB: NKG2D Signaling within Pancreatic Islets Reduces NOD Diabetes and Is Associated with CD8+ Central Memory T-Cell Generation

Meeting Abstracts

93-OR: Expression of Genes Associated with Host Viral Responses in Insulitic Islets

GRACE NELSON, NATALIYA I. LENCHIK, MARTHA CAMPBELL-THOMPSON, CLAYTON E. MATHEWS, MARK A. ATKINSON, IVAN C. GERLING

Diabetes 2019;68(Supplement_1):93-OR

https://doi.org/10.2337/db19-93-OR

Published: 01 June 2019

View article titled, 93-OR: Expression of Genes Associated with Host Viral Responses in Insulitic Islets

Meeting Abstracts

164-OR: Efficacy of New-Onset Type 1 Diabetes (T1D) Intervention Trials: Variation in 1-Year Outcomes

MICHAEL J. HALLER, MADISON N. GRECO, DESMOND SCHATZ, MARK A. ATKINSON, TODD M. BRUSKO, CLAYTON E. MATHEWS, LAURA M. JACOBSEN, KEVAN C. HEROLD, STEPHEN E. GITELMAN, JEFFREY KRISCHER, BRIAN N. BUNDY

Diabetes 2019;68(Supplement_1):164-OR

https://doi.org/10.2337/db19-164-OR

Published: 01 June 2019

View article titled, 164-OR: Efficacy of New-Onset Type 1 Diabetes (T1D) Intervention Trials: Variation in 1-Year Outcomes

Meeting Abstracts

Analysis of Transcriptome Data from 261 Individual Laser-Captured Islets from Nondiabetic, Autoantibody-Positive, and Type 1 Diabetic Organ Donors

MARTHA CAMPBELL-THOMPSON, ELIZABETH A. BUTTERWORTH, NATALIYA I. LENCHIK, MARK A. ATKINSON, CLAYTON E. MATHEWS, IVAN C. GERLING

Diabetes 2018;67(Supplement_1):308-LB

https://doi.org/10.2337/db18-308-LB

Published: 01 July 2018

View article titled, Analysis of Transcriptome Data from 261 Individual Laser-Captured Islets from Nondiabetic, Autoantibody-Positive, and Type 1 Diabetic Organ Donors

Meeting Abstracts

Sympathetic Innervation of Human Alpha Cells

ELIZABETH A. BUTTERWORTH, LITH H. NASIF, KAMAL NASIF, KATELYN N. CARTY, CLAYTON E. MATHEWS, MARK A. ATKINSON, IVAN C. GERLING, MARTHA CAMPBELL-THOMPSON

Diabetes 2018;67(Supplement_1):1799-P

https://doi.org/10.2337/db18-1799-P

Published: 01 July 2018

View article titled, Sympathetic Innervation of Human Alpha Cells

Meeting Abstracts

Costimulatory Molecules CD226 and TIGIT Impact CD8+ T-Cell Activity and Function during Type 1 Diabetes

WEN-I YEH, HOWARD SEAY, CLAYTON E. MATHEWS, TODD M. BRUSKO

Diabetes 2018;67(Supplement_1):96-OR

https://doi.org/10.2337/db18-96-OR

Published: 01 July 2018

View article titled, Costimulatory Molecules CD226 and TIGIT Impact CD8+ T-Cell Activity and Function during Type 1 Diabetes

Meeting Abstracts

Supramolecular Biomaterials as a Biomimetic Platform for Investigating Immunopathological Processes of Human Type 1 Diabetes

MATTHEW BECKER, DILLON SEROSKI, SCOTT STIMPSON, CLAYTON E. MATHEWS, GREG HUDALLA, EDWARD A. PHELPS

Diabetes 2018;67(Supplement_1):99-OR

https://doi.org/10.2337/db18-99-OR

Published: 01 July 2018

View article titled, Supramolecular Biomaterials as a Biomimetic Platform for Investigating Immunopathological Processes of Human Type 1 Diabetes

NARROW

1754-P: Investigating the Interplay between T-Cell Infiltration, ROS Detoxification, and Pancreatic Beta-cell Dysfunction in Type 1 Diabetes Pathogenesis

98-OR: ß-Cell Dysfunction and Mitochondrial Loss Occur Independently of Insulitis in Type 1 Diabetes Pathogenesis

136-OR: The MDA5627X Variant Is Associated with Type 1 Diabetes Protection via Attenuated Inflammatory Antiviral Responses

9-OR: ADA Presidents' Select Abstract: m6A mRNA Methylation Regulates the Innate Immune Response in Human Beta Cells

187-OR: Declines in ß-Cell Glucose Responsiveness Correlate with Loss of Glucose Metabolism during T1D Pathogenesis

11-OR: Transcriptome Heterogeneity in Insulin-Positive Insulitic vs. Noninsulitic Human Islets in Type 1 Diabetes (T1D)

294-OR: The Type 1 Diabetes Protective Variant of Tyrosine Kinase 2 (TYK2) Protects ß-Cells from Autoimmunity

ENTPD3 Marks Mature Stem Cell–Derived β-Cells Formed by Self-Aggregation In Vitro

Erratum. NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8⁺ T-Cell Numbers. Diabetes 2020;69: 1749–1762

287-OR: M6A mRNA Methylation Regulates the Innate Immune Response in Human ß-Cells

Low-Dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report

NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8⁺ T-Cell Numbers

253-OR: Circulating Neutrophil Numbers Increase with Age, but Are Not a Biomarker of T1D Risk

201-LB: NKG2D Signaling within Pancreatic Islets Reduces NOD Diabetes and Is Associated with CD8+ Central Memory T-Cell Generation

93-OR: Expression of Genes Associated with Host Viral Responses in Insulitic Islets

164-OR: Efficacy of New-Onset Type 1 Diabetes (T1D) Intervention Trials: Variation in 1-Year Outcomes

Analysis of Transcriptome Data from 261 Individual Laser-Captured Islets from Nondiabetic, Autoantibody-Positive, and Type 1 Diabetic Organ Donors

Sympathetic Innervation of Human Alpha Cells

Costimulatory Molecules CD226 and TIGIT Impact CD8+ T-Cell Activity and Function during Type 1 Diabetes

Supramolecular Biomaterials as a Biomimetic Platform for Investigating Immunopathological Processes of Human Type 1 Diabetes

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