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Meeting Abstracts

1960-LB: A 3D Analysis of CD8+ Leukocytic Infiltration in Human Endocrine and Exocrine Pancreas at Type 1 Diabetes Onset

ALEXANDRA RIPPA, DENISE M. DROTAR, AMANDA POSGAI, MAIGAN A. HULME, CLIVE WASSERFALL, IRINA KUSMARTSEVA, MARTHA CAMPBELL-THOMPSON, MARK A. ATKINSON

Diabetes 2024;73(Supplement_1):1960-LB

https://doi.org/10.2337/db24-1960-LB

Published: 14 June 2024

View article titled, 1960-LB: A 3D Analysis of CD8+ Leukocytic Infiltration in Human Endocrine and Exocrine Pancreas at Type 1 Diabetes Onset

Meeting Abstracts

1997-LB: Curation of an AI-Ready Dataset Using Domain-Informed Features Derived from Type 1 Diabetes TrialNet Studies

ERIN M. TALLON, MELANIE R. SHAPIRO, AMEY SHRIKRISHNA WAGHMODE, RYAN MERRITT, CLIVE WASSERFALL, RHONDA BACHER, BRENT LOCKEE, CRAIG VANDERVELDEN, KELSEY PANFIL, WAYNE V. MOORE, MARK A. ATKINSON, TODD M. BRUSKO, MARK A. CLEMENTS

Diabetes 2024;73(Supplement_1):1997-LB

https://doi.org/10.2337/db24-1997-LB

Published: 14 June 2024

View article titled, 1997-LB: Curation of an AI-Ready Dataset Using Domain-Informed Features Derived from Type 1 Diabetes TrialNet Studies

Journal Articles

DNA Methylation–Based Assessment of Cell Composition in Human Pancreas and Islets

Zeina Drawshy, Daniel Neiman, Ori Fridlich, Ayelet Peretz, Judith Magenheim, Andrea V. Rozo, Nicolai M. Doliba, Doris A. Stoffers, Klaus H. Kaestner, Desmond A. Schatz, Clive Wasserfall, Martha Campbell-Thompson, James Shapiro, Tommy Kaplan, Ruth Shemer, Benjamin Glaser, Agnes Klochendler, Yuval Dor

Diabetes 2024;73(4):554–564

https://doi.org/10.2337/db23-0704

Published: 24 January 2024

View article titled, DNA Methylation–Based Assessment of Cell Composition in Human Pancreas and Islets

Meeting Abstracts

743-P: Delayed Diabetes with Proinsulin mRNA Vaccines in NOD Mice

TIMOTHY P. FOSTER, MICHAEL J. HALLER, DESMOND SCHATZ, CLIVE WASSERFALL, ELIAS SAYOUR

Diabetes 2023;72(Supplement_1):743-P

https://doi.org/10.2337/db23-743-P

Published: 20 June 2023

View article titled, 743-P: Delayed Diabetes with Proinsulin mRNA Vaccines in NOD Mice

Meeting Abstracts

195-LB: Metabolomic Characterization of Laron and Guevara-Rosenbloom Syndromes Using UHPLC-HRMS

VANESSA RUBIO, CASEY A. CHAMBERLAIN, CLIVE WASSERFALL, JAIME GUEVARA-AGUIRRE, ALEXANDRA GUEVARA, ARLAN L. ROSENBLOOM, MARK A. ATKINSON, RICHARD A. YOST, TIMOTHY J. GARRETT

Diabetes 2020;69(Supplement_1):195-LB

https://doi.org/10.2337/db20-195-LB

Published: 01 June 2020

View article titled, 195-LB: Metabolomic Characterization of Laron and Guevara-Rosenbloom Syndromes Using UHPLC-HRMS

Meeting Abstracts

1637-P: Role of mTORC1 Regulation in the T1D Organ Donor Pancreas

BRITTANY S. BRUGGEMAN, DAWN BEACHY, LAURA M. JACOBSEN, HARRY S. NICK, MARK A. ATKINSON, DESMOND SCHATZ, CLIVE WASSERFALL

Diabetes 2020;69(Supplement_1):1637-P

https://doi.org/10.2337/db20-1637-P

Published: 01 June 2020

View article titled, 1637-P: Role of mTORC1 Regulation in the T1D Organ Donor Pancreas

Meeting Abstracts

1729-P: Circadian Patterns of Autoimmune Components in the Blood of Persons with Type 1 Diabetes: Implications for the Timing of Blood Sampling

ELENI BELI, LINDA DIMEGLIO, STEPHANIE WOERNER, CARMELLA EVANS-MOLINA, KIERAN M. MCGRAIL, CLIVE WASSERFALL, MARK A. ATKINSON, CRAIG BEAM

Diabetes 2019;68(Supplement_1):1729-P

https://doi.org/10.2337/db19-1729-P

Published: 01 June 2019

View article titled, 1729-P: Circadian Patterns of Autoimmune Components in the Blood of Persons with Type 1 Diabetes: Implications for the Timing of Blood Sampling

Meeting Abstracts

Exocrine Pancreatic Function as a Novel Biomarker in Pre-T1D

JAMES J. ROSS, CLIVE WASSERFALL, DANIEL J. PERRY, KIERAN M. MCGRAIL, AMANDA L. POSGAI, TODD M. BRUSKO, DESMOND SCHATZ, MICHAEL J. HALLER, MARK A. ATKINSON

Diabetes 2018;67(Supplement_1):1543-P

https://doi.org/10.2337/db18-1543-P

Published: 01 July 2018

View article titled, Exocrine Pancreatic Function as a Novel Biomarker in Pre-T1D

Meeting Abstracts

Insulin-Like Growth-Factor Axis Collectively Identifies Pre–Type 1 Diabetes

MELANIE SHAPIRO, CLIVE WASSERFALL, ANDREW R. SCHULTZ, SEAN M. MCGRAIL, MICHAEL J. HALLER, DESMOND SCHATZ, MARK A. ATKINSON, TODD M. BRUSKO

Diabetes 2018;67(Supplement_1):1967-P

https://doi.org/10.2337/db18-1967-P

Published: 01 July 2018

View article titled, Insulin-Like Growth-Factor Axis Collectively Identifies Pre–Type 1 Diabetes

Journal Articles

Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles

Mia J. Smith, Marynette Rihanek, Clive Wasserfall, Clayton E. Mathews, Mark A. Atkinson, Peter A. Gottlieb, John C. Cambier

Diabetes 2018;67(4):697–703

https://doi.org/10.2337/db17-0937

Published: 17 January 2018

View article titled, Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles

Includes: Supplementary data

Journal Articles

Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?

Allison L. O’Kell, Clive Wasserfall, Brian Catchpole, Lucy J. Davison, Rebecka S. Hess, Jake A. Kushner, Mark A. Atkinson

Diabetes 2017;66(6):1443–1452

https://doi.org/10.2337/db16-1551

Published: 15 May 2017

View article titled, Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?

Journal Articles

Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10–Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells

Tatiana Takiishi, Dana Paulina Cook, Hannelie Korf, Guido Sebastiani, Francesca Mancarella, João Paulo Monteiro Carvalho Mori Cunha, Clive Wasserfall, Noelia Casares, Juan José Lasarte, Lothar Steidler, Pieter Rottiers, Francesco Dotta, Conny Gysemans, Chantal Mathieu

Diabetes 2017;66(2):448–459

https://doi.org/10.2337/db15-1625

Published: 08 November 2016

View article titled, Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10–Secreting <em>Lactococcus lactis</em> in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells

Includes: Supplementary data

Journal Articles

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

Martha Campbell-Thompson, Ann Fu, John S. Kaddis, Clive Wasserfall, Desmond A. Schatz, Alberto Pugliese, Mark A. Atkinson

Diabetes 2016;65(3):719–731

https://doi.org/10.2337/db15-0779

Published: 18 November 2015

View article titled, Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

Includes: Supplementary data

Journal Articles

Immunoproteomic Profiling of Antiviral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays

Xiaofang Bian, Garrick Wallstrom, Amy Davis, Jie Wang, Jin Park, Andrea Throop, Jason Steel, Xiaobo Yu, Clive Wasserfall, Desmond Schatz, Mark Atkinson, Ji Qiu, Joshua LaBaer

Diabetes 2016;65(1):285–296

https://doi.org/10.2337/db15-0179

Published: 08 October 2015

View article titled, Immunoproteomic Profiling of Antiviral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays

Includes: Supplementary data

Journal Articles

Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes

Clayton E. Mathews, Song Xue, Amanda Posgai, Yaima L. Lightfoot, Xia Li, Andrea Lin, Clive Wasserfall, Michael J. Haller, Desmond Schatz, Mark A. Atkinson

Diabetes 2015;64(11):3885–3890

https://doi.org/10.2337/db15-0449

Published: 27 July 2015

View article titled, Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes

Journal Articles

Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes

Song Xue, Amanda Posgai, Clive Wasserfall, Courtney Myhr, Martha Campbell-Thompson, Clayton E. Mathews, Todd Brusko, Alex Rabinovitch, Alexei Savinov, Manuela Battaglia, Desmond Schatz, Michael Haller, Mark A. Atkinson

Diabetes 2015;64(11):3873–3884

https://doi.org/10.2337/db15-0164

Published: 16 July 2015

View article titled, Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes

Journal Articles

Nardilysin-Dependent Proteolysis of Cell-Associated VTCN1 (B7-H4) Marks Type 1 Diabetes Development

Ilian A. Radichev, Lilia V. Maneva-Radicheva, Christina Amatya, Camille Parker, Jacob Ellefson, Clive Wasserfall, Mark Atkinson, Paul Burn, Alexei Y. Savinov

Diabetes 2014;63(10):3470–3482

https://doi.org/10.2337/db14-0213

Published: 15 September 2014

View article titled, Nardilysin-Dependent Proteolysis of Cell-Associated VTCN1 (B7-H4) Marks Type 1 Diabetes Development

Includes: Supplementary data

Journal Articles

Inhibition of VEGFR-2 Reverses Type 1 Diabetes in NOD Mice by Abrogating Insulitis and Restoring Islet Function

S. Armando Villalta, Jiena Lang, Samantha Kubeck, Beniwende Kabre, Gregory L. Szot, Boris Calderon, Clive Wasserfall, Mark A. Atkinson, Rolf A. Brekken, Nick Pullen, Robert H. Arch, Jeffrey A. Bluestone

Diabetes 2013;62(8):2870–2878

https://doi.org/10.2337/db12-1619

Published: 17 July 2013

View article titled, Inhibition of VEGFR-2 Reverses Type 1 Diabetes in NOD Mice by Abrogating Insulitis and Restoring Islet Function

Includes: Supplementary data

Journal Articles

Loss of Intra-Islet CD20 Expression May Complicate Efficacy of B-Cell–Directed Type 1 Diabetes Therapies

David V. Serreze, Harold D. Chapman, Marijke Niens, Robert Dunn, Marilyn R. Kehry, John P. Driver, Michael Haller, Clive Wasserfall, Mark A. Atkinson

Diabetes 2011;60(11):2914–2921

https://doi.org/10.2337/db11-0705

Published: 17 October 2011

View article titled, Loss of Intra-Islet CD20 Expression May Complicate Efficacy of B-Cell–Directed Type 1 Diabetes Therapies

Includes: Supplementary data

Journal Articles

Reduced Serum Vitamin D–Binding Protein Levels Are Associated With Type 1 Diabetes

Dustin Blanton, Zhao Han, Lindsey Bierschenk, M.V. Prasad Linga-Reddy, Hongjie Wang, Michael Clare-Salzler, Michael Haller, Desmond Schatz, Courtney Myhr, Jin-Xiong She, Clive Wasserfall, Mark Atkinson

Diabetes 2011;60(10):2566–2570

https://doi.org/10.2337/db11-0576

Published: 16 September 2011

View article titled, Reduced Serum Vitamin D–Binding Protein Levels Are Associated With Type 1 Diabetes

Includes: Supplementary data

NARROW

1960-LB: A 3D Analysis of CD8+ Leukocytic Infiltration in Human Endocrine and Exocrine Pancreas at Type 1 Diabetes Onset

1997-LB: Curation of an AI-Ready Dataset Using Domain-Informed Features Derived from Type 1 Diabetes TrialNet Studies

DNA Methylation–Based Assessment of Cell Composition in Human Pancreas and Islets

743-P: Delayed Diabetes with Proinsulin mRNA Vaccines in NOD Mice

195-LB: Metabolomic Characterization of Laron and Guevara-Rosenbloom Syndromes Using UHPLC-HRMS

1637-P: Role of mTORC1 Regulation in the T1D Organ Donor Pancreas

1729-P: Circadian Patterns of Autoimmune Components in the Blood of Persons with Type 1 Diabetes: Implications for the Timing of Blood Sampling

Exocrine Pancreatic Function as a Novel Biomarker in Pre-T1D

Insulin-Like Growth-Factor Axis Collectively Identifies Pre–Type 1 Diabetes

Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles

Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?

Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10–Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

Immunoproteomic Profiling of Antiviral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays

Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes

Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes

Nardilysin-Dependent Proteolysis of Cell-Associated VTCN1 (B7-H4) Marks Type 1 Diabetes Development

Inhibition of VEGFR-2 Reverses Type 1 Diabetes in NOD Mice by Abrogating Insulitis and Restoring Islet Function

Loss of Intra-Islet CD20 Expression May Complicate Efficacy of B-Cell–Directed Type 1 Diabetes Therapies

Reduced Serum Vitamin D–Binding Protein Levels Are Associated With Type 1 Diabetes

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