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Conny Gysemans
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Journal Articles

A Plasma miR-193b-365 Signature Combined With Age and Glycemic Status Predicts Response to Lactococcus lactis–Based Antigen-Specific Immunotherapy in New-Onset Type 1 Diabetes

Gabriele Sassi, Giada Licata, Giuliana Ventriglia, Amber Wouters, Pierre Lemaitre, Ruth Seurinck, Alessia Mori, Giuseppina Emanuela Grieco, Samal Bissenova, Darcy Ellis, Silvia Caluwaerts, Pieter Rottiers, Niels Vandamme, Chantal Mathieu, Francesco Dotta, Conny Gysemans, Guido Sebastiani
Journal: Diabetes
Diabetes 2023;72(10):1470–1482
https://doi.org/10.2337/db22-0852
Published: 26 July 2023
View articletitled, A Plasma miR-193b-365 Signature Combined With Age and Glycemic Status Predicts Response to Lactococcus lactis–Based Antigen-Specific Immunotherapy in New-Onset Type 1 Diabetes
Open the PDF for A Plasma miR-193b-365 Signature Combined With Age and Glycemic Status Predicts Response to Lactococcus lactis–Based Antigen-Specific Immunotherapy in New-Onset Type 1 Diabetes in another window
Journal Articles

PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes

Bernat Elvira, Valerie Vandenbempt, Julia Bauzá-Martinez, Raphaël Crutzen, Javier Negueruela, Hazem Ibrahim, Matthew L. Winder, Manoja K. Brahma, Beata Vekeriotaite, Pieter-Jan Martens, Sumeet Pal Singh, Fernando Rossello, Pascale Lybaert, Timo Otonkoski, Conny Gysemans, Wei Wu, Esteban N. Gurzov
Journal: Diabetes
Diabetes 2022;71(4):653–668
https://doi.org/10.2337/db21-0443
Published: 19 January 2022
View articletitled, PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes
Open the PDF for PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes in another window
Journal Articles

Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10–Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells

Tatiana Takiishi, Dana Paulina Cook, Hannelie Korf, Guido Sebastiani, Francesca Mancarella, João Paulo Monteiro Carvalho Mori Cunha, Clive Wasserfall, Noelia Casares, Juan José Lasarte, Lothar Steidler, Pieter Rottiers, Francesco Dotta, Conny Gysemans, Chantal Mathieu
Journal: Diabetes
Diabetes 2017;66(2):448–459
https://doi.org/10.2337/db15-1625
Published: 08 November 2016
View articletitled, Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10–Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells
Open the PDF for Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10–Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells in another window
Includes: Supplementary data
Journal Articles

Oral Delivery of Glutamic Acid Decarboxylase (GAD)-65 and IL10 by Lactococcus lactis Reverses Diabetes in Recent-Onset NOD Mice

Sofie Robert, Conny Gysemans, Tatiana Takiishi, Hannelie Korf, Isabella Spagnuolo, Guido Sebastiani, Karolien Van Huynegem, Lothar Steidler, Silvia Caluwaerts, Pieter Demetter, Clive H. Wasserfall, Mark A. Atkinson, Francesco Dotta, Pieter Rottiers, Tom L. Van Belle, Chantal Mathieu
Journal: Diabetes
Diabetes 2014;63(8):2876–2887
https://doi.org/10.2337/db13-1236
Published: 17 July 2014
View articletitled, Oral Delivery of Glutamic Acid Decarboxylase (GAD)-65 and IL10 by Lactococcus lactis Reverses Diabetes in Recent-Onset NOD Mice
Open the PDF for Oral Delivery of Glutamic Acid Decarboxylase (GAD)-65 and IL10 by Lactococcus lactis Reverses Diabetes in Recent-Onset NOD Mice in another window
Includes: Supplementary data
Journal Articles

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

Daniel A. Cunha, Mariana Igoillo-Esteve, Esteban N. Gurzov, Carla M. Germano, Najib Naamane, Ihsane Marhfour, Makiko Fukaya, Jean-Marie Vanderwinden, Conny Gysemans, Chantal Mathieu, Lorella Marselli, Piero Marchetti, Heather P. Harding, David Ron, Décio L. Eizirik, Miriam Cnop
Journal: Diabetes
Diabetes 2012;61(11):2763–2775
https://doi.org/10.2337/db12-0123
Published: 16 October 2012
View articletitled, Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis
Open the PDF for Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis in another window
Includes: Supplementary data
Journal Articles

Increased β-Cell Mass by Islet Transplantation and PLAG1 Overexpression Causes Hyperinsulinemic Normoglycemia and Hepatic Insulin Resistance in Mice

Jeroen Declercq, Anujith Kumar, Janna A. Van Diepen, Irene O.C.M. Vroegrijk, Conny Gysemans, Caterina Di Pietro, Peter J. Voshol, Chantal Mathieu, Nadine Ectors, Wim J.M. Van de Ven, Catherine M. Verfaillie
Journal: Diabetes
Diabetes 2010;59(8):1957–1965
https://doi.org/10.2337/db09-1446
Published: 03 June 2010
View articletitled, Increased β-Cell Mass by Islet Transplantation and PLAG1 Overexpression Causes Hyperinsulinemic Normoglycemia and Hepatic Insulin Resistance in Mice
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Includes: Supplementary data
Journal Articles

Pancreatic Duct Cells in Human Islet Cell Preparations Are a Source of Angiogenic Cytokines Interleukin-8 and Vascular Endothelial Growth Factor

Babak Movahedi, Conny Gysemans, Daniel Jacobs-Tulleneers-Thevissen, Chantal Mathieu, Daniel Pipeleers
Journal: Diabetes
Diabetes 2008;57(8):2128–2136
https://doi.org/10.2337/db07-1705
Published: 01 August 2008
View articletitled, Pancreatic Duct Cells in Human Islet Cell Preparations Are a Source of Angiogenic Cytokines Interleukin-8 and Vascular Endothelial Growth Factor
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Journal Articles

Double-Stranded RNA Induces Pancreatic β-Cell Apoptosis by Activation of the Toll-Like Receptor 3 and Interferon Regulatory Factor 3 Pathways

Zeynep Dogusan, Mónica García, Daisy Flamez, Lena Alexopoulou, Michel Goldman, Conny Gysemans, Chantal Mathieu, Claude Libert, Decio L. Eizirik, Joanne Rasschaert
Journal: Diabetes
Diabetes 2008;57(5):1236–1245
https://doi.org/10.2337/db07-0844
Published: 01 May 2008
View articletitled, Double-Stranded RNA Induces Pancreatic β-Cell Apoptosis by Activation of the Toll-Like Receptor 3 and Interferon Regulatory Factor 3 Pathways
Open the PDF for Double-Stranded RNA Induces Pancreatic β-Cell Apoptosis by Activation of the Toll-Like Receptor 3 and Interferon Regulatory Factor 3 Pathways in another window
Includes: Supplementary data
Journal Articles

Unaltered Diabetes Presentation in NOD Mice Lacking the Vitamin D Receptor

Conny Gysemans, Evelyne van Etten, Lutgart Overbergh, Annapaula Giulietti, Guy Eelen, Mark Waer, Annemieke Verstuyf, Roger Bouillon, Chantal Mathieu
Journal: Diabetes
Diabetes 2008;57(1):269–275
https://doi.org/10.2337/db07-1095
Published: 01 January 2008
View articletitled, Unaltered Diabetes Presentation in NOD Mice Lacking the Vitamin D Receptor
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Includes: Supplementary data