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D. Grahame Hardie
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Journal Articles

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels

Simon A. Hawley, Rebecca J. Ford, Brennan K. Smith, Graeme J. Gowans, Sarah J. Mancini, Ryan D. Pitt, Emily A. Day, Ian P. Salt, Gregory R. Steinberg, D. Grahame Hardie
Journal: Diabetes
Diabetes 2016;65(9):2784–2794
https://doi.org/10.2337/db16-0058
Published: 05 July 2016
View article titled, The Na<sup>+</sup>/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels
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Includes: Supplementary data
Journal Articles

Methotrexate Promotes Glucose Uptake and Lipid Oxidation in Skeletal Muscle via AMPK Activation

Sergej Pirkmajer, Sameer S. Kulkarni, Robby Z. Tom, Fiona A. Ross, Simon A. Hawley, D. Grahame Hardie, Juleen R. Zierath, Alexander V. Chibalin
Journal: Diabetes
Diabetes 2015;64(2):360–369
https://doi.org/10.2337/db14-0508
Published: 22 October 2014
View article titled, Methotrexate Promotes Glucose Uptake and Lipid Oxidation in Skeletal Muscle via AMPK Activation
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Journal Articles

AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer

D. Grahame Hardie
Journal: Diabetes
Diabetes 2013;62(7):2164–2172
https://doi.org/10.2337/db13-0368
Published: 14 June 2013
View article titled, AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer
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Journal Articles

5-Aminoimidazole-4-Carboxamide 1-β-d-Ribofuranoside Acutely Stimulates Skeletal Muscle 2-Deoxyglucose Uptake in Healthy Men

Daniel J. Cuthbertson, John A. Babraj, Kirsteen J.W. Mustard, Mhairi C. Towler, Kevin A. Green, Henning Wackerhage, Graeme P. Leese, Keith Baar, Michaela Thomason-Hughes, Calum Sutherland, D. Grahame Hardie, Michael J. Rennie
Journal: Diabetes
Diabetes 2007;56(8):2078–2084
https://doi.org/10.2337/db06-1716
Published: 01 August 2007
View article titled, 5-Aminoimidazole-4-Carboxamide 1-β-<sc>d</sc>-Ribofuranoside Acutely Stimulates Skeletal Muscle 2-Deoxyglucose Uptake in Healthy Men
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Journal Articles

The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading

Sebastian B. Jørgensen, Jakob N. Nielsen, Jesper B. Birk, Grith Skytte Olsen, Benoit Viollet, Fabrizio Andreelli, Peter Schjerling, Sophie Vaulont, D. Grahame Hardie, Bo F. Hansen, Erik A. Richter, Jørgen F.P. Wojtaszewski
Journal: Diabetes
Diabetes 2004;53(12):3074–3081
https://doi.org/10.2337/diabetes.53.12.3074
Published: 01 December 2004
View article titled, The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading
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Journal Articles

Increased Phosphorylation of Skeletal Muscle Glycogen Synthase at NH2-Terminal Sites During Physiological Hyperinsulinemia in Type 2 Diabetes

Kurt Højlund, Peter Stæhr, Bo Falck Hansen, Kevin A. Green, D. Grahame Hardie, Erik A. Richter, Henning Beck-Nielsen, Jørgen F.P. Wojtaszewski
Journal: Diabetes
Diabetes 2003;52(6):1393–1402
https://doi.org/10.2337/diabetes.52.6.1393
Published: 01 June 2003
View article titled, Increased Phosphorylation of Skeletal Muscle Glycogen Synthase at NH<sub>2</sub>-Terminal Sites During Physiological Hyperinsulinemia in Type 2 Diabetes
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Journal Articles

The Antidiabetic Drug Metformin Activates the AMP-Activated Protein Kinase Cascade via an Adenine Nucleotide-Independent Mechanism

Simon A. Hawley, Anne E. Gadalla, Grith Skytte Olsen, D. Grahame Hardie
Journal: Diabetes
Diabetes 2002;51(8):2420–2425
https://doi.org/10.2337/diabetes.51.8.2420
Published: 01 August 2002
View article titled, The Antidiabetic Drug Metformin Activates the AMP-Activated Protein Kinase Cascade via an Adenine Nucleotide-Independent Mechanism
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Journal Articles

Glycogen-Dependent Effects of 5-Aminoimidazole-4-Carboxamide (AICA)-Riboside on AMP-Activated Protein Kinase and Glycogen Synthase Activities in RatSkeletal Muscle

Jørgen F.P. Wojtaszewski, Sebastian B. Jørgensen, Ylva Hellsten, D. Grahame Hardie, Erik A. Richter
Journal: Diabetes
Diabetes 2002;51(2):284–292
https://doi.org/10.2337/diabetes.51.2.284
Published: 01 February 2002
View article titled, Glycogen-Dependent Effects of 5-Aminoimidazole-4-Carboxamide (AICA)-Riboside on AMP-Activated Protein Kinase and Glycogen Synthase Activities in RatSkeletal Muscle
Open the PDF for Glycogen-Dependent Effects of 5-Aminoimidazole-4-Carboxamide (AICA)-Riboside on AMP-Activated Protein Kinase and Glycogen Synthase Activities in RatSkeletal Muscle in another window