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D. Ross Laybutt
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Journal Articles

Contribution of the Long Noncoding RNA H19 to β-Cell Mass Expansion in Neonatal and Adult Rodents

Clara Sanchez-Parra, Cécile Jacovetti, Olivier Dumortier, Kailun Lee, Marie-Line Peyot, Claudiane Guay, Marc Prentki, D. Ross Laybutt, Emmanuel Van Obberghen, Romano Regazzi
Journal: Diabetes
Diabetes 2018;67(11):2254–2267
https://doi.org/10.2337/db18-0201
Published: 16 August 2018
View article titled, Contribution of the Long Noncoding RNA H19 to β-Cell Mass Expansion in Neonatal and Adult Rodents
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Includes: Supplementary data
Journal Articles

A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?

Terence P. Herbert, D. Ross Laybutt
Journal: Diabetes
Diabetes 2016;65(6):1472–1480
https://doi.org/10.2337/db15-1633
Published: 18 May 2016
View article titled, A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?
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Journal Articles

Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in β-Cell Gene Expression and Progression to Diabetes

Jeng Yie Chan, Jude Luzuriaga, Mohammed Bensellam, Trevor J. Biden, D. Ross Laybutt
Journal: Diabetes
Diabetes 2013;62(5):1557–1568
https://doi.org/10.2337/db12-0701
Published: 16 April 2013
View article titled, Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in β-Cell Gene Expression and Progression to Diabetes
Open the PDF for Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in β-Cell Gene Expression and Progression to Diabetes in another window
Includes: Supplementary data
Journal Articles

Inhibition of Id1 Augments Insulin Secretion and Protects Against High-Fat Diet–Induced Glucose Intolerance

Mia C. Åkerfeldt, D. Ross Laybutt
Journal: Diabetes
Diabetes 2011;60(10):2506–2514
https://doi.org/10.2337/db11-0083
Published: 16 September 2011
View article titled, Inhibition of Id1 Augments Insulin Secretion and Protects Against High-Fat Diet–Induced Glucose Intolerance
Open the PDF for Inhibition of Id1 Augments Insulin Secretion and Protects Against High-Fat Diet–Induced Glucose Intolerance in another window
Includes: Supplementary data
Journal Articles

Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling

Mia C. Åkerfeldt, Jennifer Howes, Jeng Yie Chan, Veronica A. Stevens, Nacer Boubenna, Helen M. McGuire, Cecile King, Trevor J. Biden, D. Ross Laybutt
Journal: Diabetes
Diabetes 2008;57(11):3034–3044
https://doi.org/10.2337/db07-1802
Published: 01 November 2008
View article titled, Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling
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Includes: Supplementary data
Journal Articles

Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction

Pascal Lovis, Elodie Roggli, D. Ross Laybutt, Sonia Gattesco, Jiang-Yan Yang, Christian Widmann, Amar Abderrahmani, Romano Regazzi
Journal: Diabetes
Diabetes 2008;57(10):2728–2736
https://doi.org/10.2337/db07-1252
Published: 01 October 2008
View article titled, Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction
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Includes: Supplementary data
Journal Articles

Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion : A New Mechanism for Fat-Induced Impairment of β-Cell Function

Melkam Kebede, Jenny Favaloro, Jenny E. Gunton, D. Ross Laybutt, Margaret Shaw, Nicole Wong, Barbara C. Fam, Kathryn Aston-Mourney, Christian Rantzau, Anthony Zulli, Joseph Proietto, Sofianos Andrikopoulos
Journal: Diabetes
Diabetes 2008;57(7):1887–1895
https://doi.org/10.2337/db07-1326
Published: 01 July 2008
View article titled, Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion : <subtitle>A New Mechanism for Fat-Induced Impairment of β-Cell Function</subtitle>
Open the PDF for Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion : <subtitle>A New Mechanism for Fat-Induced Impairment of β-Cell Function</subtitle> in another window
Journal Articles

Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia: Possible Contribution to Impaired Incretin Effects in Diabetes

Gang Xu, Hideaki Kaneto, D. Ross Laybutt, Valerie F. Duvivier-Kali, Nitin Trivedi, Kiyoshi Suzuma, George L. King, Gordon C. Weir, Susan Bonner-Weir
Journal: Diabetes
Diabetes 2007;56(6):1551–1558
https://doi.org/10.2337/db06-1033
Published: 01 June 2007
View article titled, Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia: <subtitle>Possible Contribution to Impaired Incretin Effects in Diabetes</subtitle>
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Journal Articles

Increased Fatty Acid Desaturation and Enhanced Expression of Stearoyl Coenzyme A Desaturase Protects Pancreatic β-Cells from Lipoapoptosis

Anna K. Busch, Ebru Gurisik, Damien V. Cordery, Michelle Sudlow, Gareth S. Denyer, D. Ross Laybutt, William E. Hughes, Trevor J. Biden
Journal: Diabetes
Diabetes 2005;54(10):2917–2924
https://doi.org/10.2337/diabetes.54.10.2917
Published: 01 October 2005
View article titled, Increased Fatty Acid Desaturation and Enhanced Expression of Stearoyl Coenzyme A Desaturase Protects Pancreatic β-Cells from Lipoapoptosis
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Journal Articles

Chronic Hyperglycemia, Independent of Plasma Lipid Levels, Is Sufficient for the Loss of β-Cell Differentiation and Secretory Function in the db/db Mouse Model of Diabetes

Cecilie Kjørholt, Mia C. Åkerfeldt, Trevor J. Biden, D. Ross Laybutt
Journal: Diabetes
Diabetes 2005;54(9):2755–2763
https://doi.org/10.2337/diabetes.54.9.2755
Published: 01 September 2005
View article titled, Chronic Hyperglycemia, Independent of Plasma Lipid Levels, Is Sufficient for the Loss of β-Cell Differentiation and Secretory Function in the <em>db/db</em> Mouse Model of Diabetes
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Journal Articles

Overexpression of c-Myc in β-Cells of Transgenic Mice Causes Proliferation and Apoptosis, Downregulation of Insulin Gene Expression, and Diabetes

D. Ross Laybutt, Gordon C. Weir, Hideaki Kaneto, Judith Lebet, Richard D. Palmiter, Arun Sharma, Susan Bonner-Weir
Journal: Diabetes
Diabetes 2002;51(6):1793–1804
https://doi.org/10.2337/diabetes.51.6.1793
Published: 01 June 2002
View article titled, Overexpression of c-Myc in β-Cells of Transgenic Mice Causes Proliferation and Apoptosis, Downregulation of Insulin Gene Expression, and Diabetes
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Journal Articles

Increased Expression of Antioxidant and Antiapoptotic Genes in Islets That May Contribute to β-Cell Survival During Chronic Hyperglycemia

D. Ross Laybutt, Hideaki Kaneto, Wendy Hasenkamp, Shane Grey, Jean-Christophe Jonas, Dennis C. Sgroi, Adam Groff, Christiane Ferran, Susan Bonner-Weir, Arun Sharma, Gordon C. Weir
Journal: Diabetes
Diabetes 2002;51(2):413–423
https://doi.org/10.2337/diabetes.51.2.413
Published: 01 February 2002
View article titled, Increased Expression of Antioxidant and Antiapoptotic Genes in Islets That May Contribute to β-Cell Survival During Chronic Hyperglycemia
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Journal Articles

A New Antidiabetic Agent, BRL 49653, Reduces Lipid Availability and Improves Insulin Action and Glucoregulation in the Rat

Nicholas D Oakes, Catherine J Kennedy, Arthur B Jenkins, D Ross Laybutt, Donald J Chisholm, Edward W Kraegen
Journal: Diabetes
Diabetes 1994;43(10):1203–1210
https://doi.org/10.2337/diab.43.10.1203
Published: 01 October 1994
View article titled, A New Antidiabetic Agent, BRL 49653, Reduces Lipid Availability and Improves Insulin Action and Glucoregulation in the Rat
Open the PDF for A New Antidiabetic Agent, BRL 49653, Reduces Lipid Availability and Improves Insulin Action and Glucoregulation in the Rat in another window