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Meeting Abstracts

257-OR: Short-Term Hyperglucagonemia Induces Adipose Tissue Insulin Resistance and Inflammation In Vivo

XI CHEN, MARCEL FOURCAUDOT, LUKE NORTON, RALPH A. DEFRONZO, DEVJIT TRIPATHY

Diabetes 2021;70(Supplement_1):257-OR

DOI: https://doi.org/10.2337/db21-257-OR

Published: 01 June 2021

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Journal Articles

Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects

Aurora Merovci, Devjit Tripathy, Xi Chen, Ivan Valdez, Muhammad Abdul-Ghani, Carolina Solis-Herrera, Amalia Gastaldelli, Ralph A. DeFronzo

Diabetes 2021;70(1):204–213

DOI: https://doi.org/10.2337/db20-0039

Published: 08 October 2020

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Meeting Abstracts

1707-P: Differential Effect of Prolonged Glucagon Infusion on Plasma Lipidome in Humans

XI CHEN, XIANLIN HAN, JONATHAN TREJO, EMINA CASE, RALPH A. DEFRONZO, DEVJIT TRIPATHY

Diabetes 2020;69(Supplement_1):1707-P

DOI: https://doi.org/10.2337/db20-1707-P

Published: 01 June 2020

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Meeting Abstracts

1914-P: Prolonged (12-Hour) Glucagon Infusion Stimulates Adipocyte Lipolysis and Inflammation In Vivo in Humans

DEVJIT TRIPATHY, MARCEL FOURCAUDOT, LUKE NORTON, RALPH A. DEFRONZO, XI CHEN

Diabetes 2020;69(Supplement_1):1914-P

DOI: https://doi.org/10.2337/db20-1914-P

Published: 01 June 2020

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Meeting Abstracts

1465-P: Application of the New Cluster-Based Classification of Adult-Onset Diabetes in a South Texas Veteran Population, Increased Incidence of Diabetic Nephropathy in Veterans with Severe Insulin Resistance

JONATHAN TREJO, SHEILA PINKSON, LYAN GONDIN, LUCY ESTEVE, XI CHEN, DEVJIT TRIPATHY

Diabetes 2020;69(Supplement_1):1465-P

DOI: https://doi.org/10.2337/db20-1465-P

Published: 01 June 2020

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Meeting Abstracts

1840-P: Pioglitazone Increases Metabolic Insulin Clearance (MCRI) in IGT Subjects: The ACT NOW Study

AMALIA GASTALDELLI, DEVJIT TRIPATHY, RALPH A. DEFRONZO, NOW ACT INVESTIGATORS

Diabetes 2019;68(Supplement_1):1840-P

DOI: https://doi.org/10.2337/db19-1840-P

Published: 01 June 2019

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Meeting Abstracts

1951-P: Prolonged (12-Hour) Glucagon Infusion Leads to Transient Elevation of Plasma Glucose but Sustained Elevation of Hepatic Glucose Production

XI CHEN, AURORA MEROVCI, EMINA CASE, RALPH A. DEFRONZO, DEVJIT TRIPATHY

Diabetes 2019;68(Supplement_1):1951-P

DOI: https://doi.org/10.2337/db19-1951-P

Published: 01 June 2019

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Meeting Abstracts

1967-P: Mild Physiologic Hyperglycemia Impairs Insulin-Mediated Suppression of Plasma Glucagon in Healthy Normal Glucose Tolerant Subjects

AURORA MEROVCI, XI CHEN, RALPH A. DEFRONZO, DEVJIT TRIPATHY

Diabetes 2019;68(Supplement_1):1967-P

DOI: https://doi.org/10.2337/db19-1967-P

Published: 01 June 2019

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Meeting Abstracts

1935-P: Decoupling between ATP Utilization and Replenishment in Insulin Resistant Skeletal Muscle

JUAN A. VASQUEZ, JR., CAROLINA SOLIS-HERRERA, DEVJIT TRIPATHY, MUHAMMAD ABDUL-GHANI, RALPH A. DEFRONZO, GEOFFREY D. CLARKE

Diabetes 2019;68(Supplement_1):1935-P

DOI: https://doi.org/10.2337/db19-1935-P

Published: 01 June 2019

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Meeting Abstracts

1770-P: Further Evidence Supporting a Potential Role for ADH1B in Obesity

CHRIS JENKINSON, LIZA D. MORALES, DEVJIT TRIPATHY, SHIRLEY L. HU, JUAN C. LOPEZ-ALVARENGA, RAVINDRANATH DUGGIRALA, RALPH A. DEFRONZO, SRINIVAS MUMMIDI, RECTOR ARYA, LUKE NORTON, JOHN BLANGERO, ALVARO DIAZ-BADILLO

Diabetes 2019;68(Supplement_1):1770-P

DOI: https://doi.org/10.2337/db19-1770-P

Published: 01 June 2019

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Meeting Abstracts

274-OR: Beta-Cell Dysfunction Is Associated with Impaired Insulin-Mediated Suppression of Glucagon in Obese Hispanic Americans

XI CHEN, ENRIQUE R. MALDONADO CORCHADO, AURORA MEROVCI, EMINA CASE, DEVJIT TRIPATHY, RALPH A. DEFRONZO

Diabetes 2019;68(Supplement_1):274-OR

DOI: https://doi.org/10.2337/db19-274-OR

Published: 01 June 2019

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Journal Articles

Effect of Chronic Hyperglycemia on Glucose Metabolism in Subjects With Normal Glucose Tolerance

Chris Shannon, Aurora Merovci, Juan Xiong, Devjit Tripathy, Felipe Lorenzo, Donald McClain, Muhammad Abdul-Ghani, Luke Norton, Ralph A. DeFronzo

Diabetes 2018;67(12):2507–2517

DOI: https://doi.org/10.2337/db18-0439

Published: 13 September 2018

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Includes: Supplementary data

Meeting Abstracts

Mild Physiologic Hyperglycemia Induces Hepatic Insulin Resistance in Healthy Normal Glucose Tolerant Subjects–Role of Glucagon and Gluconeogenic Substrates

DEVJIT TRIPATHY, AURORA MEROVCI, ENRIQUE R. MALDONADO CORCHADO, BASU RITA, RALPH A. DEFRONZO

Diabetes 2018;67(Supplement_1):41-OR

DOI: https://doi.org/10.2337/db18-41-OR

Published: 01 July 2018

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Meeting Abstracts

Mild Physiologic Hyperglycemia Impairs Beta-Cell Function and Induces Insulin Resistance in Healthy Normal Glucose Tolerant Subjects

AURORA MEROVCI, ENRIQUE R. MALDONADO CORCHADO, DEVJIT TRIPATHY, RALPH A. DEFRONZO

Diabetes 2018;67(Supplement_1):1827-P

DOI: https://doi.org/10.2337/db18-1827-P

Published: 01 July 2018

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Meeting Abstracts

Effects of Hyperglycemia on Skeletal Muscle Glucose Metabolism in Healthy Subjects

CHRIS SHANNON, AURORA MEROVCI, DEVJIT TRIPATHY, MUHAMMAD ABDUL-GHANI, LUKE NORTON, RALPH A. DEFRONZO

Diabetes 2018;67(Supplement_1):1920-P

DOI: https://doi.org/10.2337/db18-1920-P

Published: 01 July 2018

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Journal Articles

Exenatide Regulates Cerebral Glucose Metabolism in Brain Areas Associated With Glucose Homeostasis and Reward System

Giuseppe Daniele, Patricia Iozzo, Marjorie Molina-Carrion, Jack Lancaster, Demetrio Ciociaro, Eugenio Cersosimo, Devjit Tripathy, Curtis Triplitt, Peter Fox, Nicolas Musi, Ralph DeFronzo, Amalia Gastaldelli

Diabetes 2015;64(10):3406–3412

DOI: https://doi.org/10.2337/db14-1718

Published: 26 June 2015

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Includes: Supplementary data

Journal Articles

Chronic Reduction of Plasma Free Fatty Acid Improves Mitochondrial Function and Whole-Body Insulin Sensitivity in Obese and Type 2 Diabetic Individuals

Giuseppe Daniele, Roy Eldor, Aurora Merovci, Geoffrey D. Clarke, Juan Xiong, Devjit Tripathy, Anna Taranova, Muhammad Abdul-Ghani, Ralph A. DeFronzo

Diabetes 2014;63(8):2812–2820

DOI: https://doi.org/10.2337/db13-1130

Published: 17 July 2014

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Includes: Supplementary data

Journal Articles

Prevention of Diabetes With Pioglitazone in ACT NOW: Physiologic Correlates

Ralph A. DeFronzo, Devjit Tripathy, Dawn C. Schwenke, MaryAnn Banerji, George A. Bray, Thomas A. Buchanan, Stephen C. Clement, Amalia Gastaldelli, Robert R. Henry, Abbas E. Kitabchi, Sunder Mudaliar, Robert E. Ratner, Frankie B. Stentz, Nicolas Musi, Peter D. Reaven, for the ACT NOW Study

Diabetes 2013;62(11):3920–3926

DOI: https://doi.org/10.2337/db13-0265

Published: 18 October 2013

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Includes: Supplementary data

Journal Articles

Insulin Secretion and Action in Subjects With Impaired Fasting Glucose and Impaired Glucose Tolerance : Results From the Veterans Administration Genetic Epidemiology Study

Muhammad A. Abdul-Ghani, Christopher P. Jenkinson, Dawn K. Richardson, Devjit Tripathy, Ralph A. DeFronzo

Diabetes 2006;55(5):1430–1435

DOI: https://doi.org/10.2337/db05-1200

Published: 01 May 2006

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Journal Articles

Elevation of Free Fatty Acids Induces Inflammation and Impairs Vascular Reactivity in Healthy Subjects

Devjit Tripathy, Priya Mohanty, Sandeep Dhindsa, Tufail Syed, Husam Ghanim, Ahmad Aljada, Paresh Dandona

Diabetes 2003;52(12):2882–2887

DOI: https://doi.org/10.2337/diabetes.52.12.2882

Published: 01 December 2003

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NARROW

257-OR: Short-Term Hyperglucagonemia Induces Adipose Tissue Insulin Resistance and Inflammation In Vivo

Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects

1707-P: Differential Effect of Prolonged Glucagon Infusion on Plasma Lipidome in Humans

1914-P: Prolonged (12-Hour) Glucagon Infusion Stimulates Adipocyte Lipolysis and Inflammation In Vivo in Humans

1465-P: Application of the New Cluster-Based Classification of Adult-Onset Diabetes in a South Texas Veteran Population, Increased Incidence of Diabetic Nephropathy in Veterans with Severe Insulin Resistance

1840-P: Pioglitazone Increases Metabolic Insulin Clearance (MCRI) in IGT Subjects: The ACT NOW Study

1951-P: Prolonged (12-Hour) Glucagon Infusion Leads to Transient Elevation of Plasma Glucose but Sustained Elevation of Hepatic Glucose Production

1967-P: Mild Physiologic Hyperglycemia Impairs Insulin-Mediated Suppression of Plasma Glucagon in Healthy Normal Glucose Tolerant Subjects

1935-P: Decoupling between ATP Utilization and Replenishment in Insulin Resistant Skeletal Muscle

1770-P: Further Evidence Supporting a Potential Role for ADH1B in Obesity

274-OR: Beta-Cell Dysfunction Is Associated with Impaired Insulin-Mediated Suppression of Glucagon in Obese Hispanic Americans

Effect of Chronic Hyperglycemia on Glucose Metabolism in Subjects With Normal Glucose Tolerance

Mild Physiologic Hyperglycemia Induces Hepatic Insulin Resistance in Healthy Normal Glucose Tolerant Subjects–Role of Glucagon and Gluconeogenic Substrates

Mild Physiologic Hyperglycemia Impairs Beta-Cell Function and Induces Insulin Resistance in Healthy Normal Glucose Tolerant Subjects

Effects of Hyperglycemia on Skeletal Muscle Glucose Metabolism in Healthy Subjects

Exenatide Regulates Cerebral Glucose Metabolism in Brain Areas Associated With Glucose Homeostasis and Reward System

Chronic Reduction of Plasma Free Fatty Acid Improves Mitochondrial Function and Whole-Body Insulin Sensitivity in Obese and Type 2 Diabetic Individuals

Prevention of Diabetes With Pioglitazone in ACT NOW: Physiologic Correlates

Insulin Secretion and Action in Subjects With Impaired Fasting Glucose and Impaired Glucose Tolerance : Results From the Veterans Administration Genetic Epidemiology Study

Elevation of Free Fatty Acids Induces Inflammation and Impairs Vascular Reactivity in Healthy Subjects

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