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Dale L Greiner
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Journal Articles

An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes

Alan G. Derr, Adediwura Arowosegbe, Basanthi Satish, Sambra D. Redick, Natasha Qaisar, Zhiru Guo, Emma Vanderleeden, Melanie I. Trombly, Christina E. Baer, David M. Harlan, Dale L. Greiner, Manuel Garber, Jennifer P. Wang
Journal: Diabetes
Diabetes 2023;72(2):261–274
https://doi.org/10.2337/db22-0521
Published: 08 November 2022
View article titled, An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes
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Meeting Abstracts

255-OR: ADA Presidents’ Select Abstract: Glucagon Receptor Antagonism Stimulates Beta-Cell Proliferation in Mouse and Human Islets

KATIE C. COATE, ERICK SPEARS, CHUNHUA DAI, SCOTT WISNIEWSKI, GREG POFFENBERGER, LEONARD D. SHULTZ, DALE L. GREINER, DANIEL J. DRUCKER, HAI YAN, KYLE SLOOP, ALVIN C. POWERS, DANIELLE DEAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):255-OR
https://doi.org/10.2337/db20-255-OR
Published: 01 June 2020
View article titled, 255-OR: ADA Presidents’ Select Abstract: Glucagon Receptor Antagonism Stimulates Beta-Cell Proliferation in Mouse and Human Islets
Meeting Abstracts

Dapagliflozin Treatment Impacts ß, but Not a, Cell Function in Normal Human Islets

CHUNHUA DAI, ALENA SHOSTAK, YASIR H. BOUCHI, NATHANIEL HART, GREG POFFENBERGER, DIANE C. SAUNDERS, RACHANA HALIYUR, DANIELLE DEAN, RADHIKA ARAMANDLA, MARCELA BRISSOVA, MASAKAZU SHIOTA, DALE L. GREINER, LEONARD D. SHULTZ, RITA BOTTINO, ALVIN C. POWERS
Journal: Diabetes
Diabetes 2018;67(Supplement_1):323-OR
https://doi.org/10.2337/db18-323-OR
Published: 01 July 2018
View article titled, Dapagliflozin Treatment Impacts ß, but Not a, Cell Function in Normal Human Islets
Journal Articles

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

David M. Blodgett, Anetta Nowosielska, Shaked Afik, Susanne Pechhold, Anthony J. Cura, Norman J. Kennedy, Soyoung Kim, Alper Kucukural, Roger J. Davis, Sally C. Kent, Dale L. Greiner, Manuel G. Garber, David M. Harlan, Philip diIorio
Journal: Diabetes
Diabetes 2015;64(9):3172–3181
https://doi.org/10.2337/db15-0039
Published: 30 April 2015
View article titled, Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets
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Includes: Supplementary data
Journal Articles

GABA Promotes Human β-Cell Proliferation and Modulates Glucose Homeostasis

Indri Purwana, Juan Zheng, Xiaoming Li, Marielle Deurloo, Dong Ok Son, Zhaoyun Zhang, Christie Liang, Eddie Shen, Akshaya Tadkase, Zhong-Ping Feng, Yiming Li, Craig Hasilo, Steven Paraskevas, Rita Bortell, Dale L. Greiner, Mark Atkinson, Gerald J. Prud’homme, Qinghua Wang
Journal: Diabetes
Diabetes 2014;63(12):4197–4205
https://doi.org/10.2337/db14-0153
Published: 13 November 2014
View article titled, GABA Promotes Human β-Cell Proliferation and Modulates Glucose Homeostasis
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Includes: Supplementary data
Journal Articles

Viral Infection of Engrafted Human Islets Leads to Diabetes

Glen R. Gallagher, Michael A. Brehm, Robert W. Finberg, Bruce A. Barton, Leonard D. Shultz, Dale L. Greiner, Rita Bortell, Jennifer P. Wang
Journal: Diabetes
Diabetes 2015;64(4):1358–1369
https://doi.org/10.2337/db14-1020
Published: 12 November 2014
View article titled, Viral Infection of Engrafted Human Islets Leads to Diabetes
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Includes: Supplementary data
Journal Articles

Prevention of Type 1 Diabetes in the Rat With an Allele-Specific Anti–T-Cell Receptor Antibody: Vβ13 as a Therapeutic Target and Biomarker

Zhijun Liu, Laura Cort, Ryan Eberwine, Thomas Herrmann, Jean H. Leif, Dale L. Greiner, Barak Yahalom, Elizabeth P. Blankenhorn, John P. Mordes
Journal: Diabetes
Diabetes 2012;61(5):1160–1168
https://doi.org/10.2337/db11-0867
Published: 13 April 2012
View article titled, Prevention of Type 1 Diabetes in the Rat With an Allele-Specific Anti–T-Cell Receptor Antibody: <subtitle>Vβ13 as a Therapeutic Target and Biomarker</subtitle>
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Includes: Supplementary data
Journal Articles

Prevention of “Humanized” Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach

Marijke Niens, Alexandra E. Grier, Michele Marron, Thomas W.H. Kay, Dale L. Greiner, David V. Serreze
Journal: Diabetes
Diabetes 2011;60(4):1229–1236
https://doi.org/10.2337/db10-1523
Published: 22 March 2011
View article titled, Prevention of “Humanized” Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach
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Journal Articles

Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1null IL2rγnull Ins2Akita Mice

Michael A. Brehm, Rita Bortell, Philip diIorio, Jean Leif, Joseph Laning, Amy Cuthbert, Chaoxing Yang, Mary Herlihy, Lisa Burzenski, Bruce Gott, Oded Foreman, Alvin C. Powers, Dale L. Greiner, Leonard D. Shultz
Journal: Diabetes
Diabetes 2010;59(9):2265–2270
https://doi.org/10.2337/db10-0323
Published: 22 June 2010
View article titled, Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-<em>Rag1<sup>null</sup> IL2r</em>γ<sup><em>null</em></sup> <em>Ins2<sup>Akita</sup></em> Mice
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Includes: Supplementary data
Journal Articles

Infection With Viruses From Several Families Triggers Autoimmune Diabetes in LEW.1WR1 Rats: Prevention of Diabetes by Maternal Immunization

Rebecca S. Tirabassi, Dennis L. Guberski, Elizabeth P. Blankenhorn, Jean H. Leif, Bruce A. Woda, Zhijun Liu, Donald Winans, Dale L. Greiner, John P. Mordes
Journal: Diabetes
Diabetes 2010;59(1):110–118
https://doi.org/10.2337/db09-0255
Published: 30 September 2009
View article titled, Infection With Viruses From Several Families Triggers Autoimmune Diabetes in LEW.1WR1 Rats: <subtitle>Prevention of Diabetes by Maternal Immunization</subtitle>
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Includes: Supplementary data
Journal Articles

Virus-Induced Autoimmune Diabetes in the LEW.1WR1 Rat Requires Iddm14 and a Genetic Locus Proximal to the Major Histocompatibility Complex

Elizabeth P. Blankenhorn, Laura Cort, Dale L. Greiner, Dennis L. Guberski, John P. Mordes
Journal: Diabetes
Diabetes 2009;58(12):2930–2938
https://doi.org/10.2337/db09-0387
Published: 31 August 2009
View article titled, Virus-Induced Autoimmune Diabetes in the LEW.1WR1 Rat Requires <em>Iddm14</em> and a Genetic Locus Proximal to the Major Histocompatibility Complex
Open the PDF for Virus-Induced Autoimmune Diabetes in the LEW.1WR1 Rat Requires <em>Iddm14</em> and a Genetic Locus Proximal to the Major Histocompatibility Complex in another window
Includes: Supplementary data
Journal Articles

Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice

Julie Mangada, Todd Pearson, Michael A. Brehm, Linda S. Wicker, Laurence B. Peterson, Leonard D. Shultz, David V. Serreze, Aldo A. Rossini, Dale L. Greiner
Journal: Diabetes
Diabetes 2009;58(1):165–173
https://doi.org/10.2337/db08-0275
Published: 01 January 2009
View article titled, <em>Idd</em> Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice
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Journal Articles

LEW.1WR1 Rats Develop Autoimmune Diabetes Spontaneously and in Response to Environmental Perturbation

John P. Mordes, Dennis L. Guberski, Jean H. Leif, Bruce A. Woda, Joan F. Flanagan, Dale L. Greiner, Edward H. Kislauskis, Rebecca S. Tirabassi
Journal: Diabetes
Diabetes 2005;54(9):2727–2733
https://doi.org/10.2337/diabetes.54.9.2727
Published: 01 September 2005
View article titled, LEW.1WR1 Rats Develop Autoimmune Diabetes Spontaneously and in Response to Environmental Perturbation
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Includes: Supplementary data
Journal Articles

The Rat Diabetes Susceptibility Locus Iddm4 and at Least One Additional Gene Are Required for Autoimmune Diabetes Induced by Viral Infection

Elizabeth P. Blankenhorn, Lucy Rodemich, Cristina Martin-Fernandez, Jean Leif, Dale L. Greiner, John P. Mordes
Journal: Diabetes
Diabetes 2005;54(4):1233–1237
https://doi.org/10.2337/diabetes.54.4.1233
Published: 01 April 2005
View article titled, The Rat Diabetes Susceptibility Locus <em>Iddm4</em> and at Least One Additional Gene Are Required for Autoimmune Diabetes Induced by Viral Infection
Open the PDF for The Rat Diabetes Susceptibility Locus <em>Iddm4</em> and at Least One Additional Gene Are Required for Autoimmune Diabetes Induced by Viral Infection in another window
Includes: Supplementary data
Journal Articles

Autoimmune Diabetes and Resistance to Xenograft Transplantation Tolerance in NOD Mice

Ethel J. Gordon, Linda S. Wicker, Laurence B. Peterson, David V. Serreze, Thomas G. Markees, Leonard D. Shultz, Aldo A. Rossini, Dale L. Greiner, John P. Mordes
Journal: Diabetes
Diabetes 2005;54(1):107–115
https://doi.org/10.2337/diabetes.54.1.107
Published: 01 January 2005
View article titled, Autoimmune Diabetes and Resistance to Xenograft Transplantation Tolerance in NOD Mice
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Journal Articles

Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice Is Controlled by Allelic Variants of Idd3

Todd Pearson, Peter Weiser, Thomas G. Markees, David V. Serreze, Linda S. Wicker, Laurence B. Peterson, Anne-Marie Cumisky, Leonard D. Shultz, John P. Mordes, Aldo A. Rossini, Dale L. Greiner
Journal: Diabetes
Diabetes 2004;53(8):1972–1978
https://doi.org/10.2337/diabetes.53.8.1972
Published: 01 August 2004
View article titled, Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice Is Controlled by Allelic Variants of <em>Idd3</em>
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Journal Articles

NOD Congenic Mice Genetically Protected From Autoimmune Diabetes Remain Resistant to Transplantation Tolerance Induction

Todd Pearson, Thomas G. Markees, Linda S. Wicker, David V. Serreze, Laurence B. Peterson, John P. Mordes, Aldo A. Rossini, Dale L. Greiner
Journal: Diabetes
Diabetes 2003;52(2):321–326
https://doi.org/10.2337/diabetes.52.2.321
Published: 01 February 2003
View article titled, NOD Congenic Mice Genetically Protected From Autoimmune Diabetes Remain Resistant to Transplantation Tolerance Induction
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Journal Articles

The iddm4 Locus Segregates With Diabetes Susceptibility in Congenic WF.iddm4 Rats

John P. Mordes, Jean Leif, Stephen Novak, Cheryl DeScipio, Dale L. Greiner, Elizabeth P. Blankenhorn
Journal: Diabetes
Diabetes 2002;51(11):3254–3262
https://doi.org/10.2337/diabetes.51.11.3254
Published: 01 November 2002
View article titled, The <em>iddm4</em> Locus Segregates With Diabetes Susceptibility in Congenic WF.<em>iddm4</em> Rats
Open the PDF for The <em>iddm4</em> Locus Segregates With Diabetes Susceptibility in Congenic WF.<em>iddm4</em> Rats in another window
Journal Articles

BB Rat Thymocytes Cultured in the Presence of Islets Lose Their Ability to Transfer Autoimmune Diabetes

Barbara J. Whalen, Jan Marounek, Peter Weiser, Michael C. Appel, Dale L. Greiner, John P. Mordes, Aldo A. Rossini
Journal: Diabetes
Diabetes 2001;50(5):972–979
https://doi.org/10.2337/diabetes.50.5.972
Published: 01 May 2001
View article titled, BB Rat Thymocytes Cultured in the Presence of Islets Lose Their Ability to Transfer Autoimmune Diabetes
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Journal Articles

Prolonged Survival of Rat Islet and Skin Xenografts in Mice Treated with Donor Splenocytes and Anti-CD154 Monoclonal Antibody

Ethel J Gordon, Thomas G Markees, Nancy E Phillips, Randolph J Noelle, Leonard D Shultz, John P Mordes, Aldo A Rossini, Dale L Greiner
Journal: Diabetes
Diabetes 1998;47(8):1199–1206
https://doi.org/10.2337/diab.47.8.1199
Published: 01 August 1998
View article titled, Prolonged Survival of Rat Islet and Skin Xenografts in Mice Treated with Donor Splenocytes and Anti-CD154 Monoclonal Antibody
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