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Daniel A. Cunha
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Journal Articles

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

Baroj Abdulkarim, Marc Nicolino, Mariana Igoillo-Esteve, Mathilde Daures, Sophie Romero, Anne Philippi, Valérie Senée, Miguel Lopes, Daniel A. Cunha, Heather P. Harding, Céline Derbois, Nathalie Bendelac, Andrew T. Hattersley, Décio L. Eizirik, David Ron, Miriam Cnop, Cécile Julier
Journal: Diabetes
Diabetes 2015;64(11):3951–3962
https://doi.org/10.2337/db15-0477
Published: 09 July 2015
View article titled, A Missense Mutation in <em>PPP1R15B</em> Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly
Open the PDF for A Missense Mutation in <em>PPP1R15B</em> Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly in another window
Includes: Supplementary data
Journal Articles

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

Miriam Cnop, Baroj Abdulkarim, Guy Bottu, Daniel A. Cunha, Mariana Igoillo-Esteve, Matilde Masini, Jean-Valery Turatsinze, Thasso Griebel, Olatz Villate, Izortze Santin, Marco Bugliani, Laurence Ladriere, Lorella Marselli, Mark I. McCarthy, Piero Marchetti, Michael Sammeth, Décio L. Eizirik
Journal: Diabetes
Diabetes 2014;63(6):1978–1993
https://doi.org/10.2337/db13-1383
Published: 15 May 2014
View article titled, RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate
Open the PDF for RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate in another window
Includes: Supplementary data
Journal Articles

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

Daniel A. Cunha, Mariana Igoillo-Esteve, Esteban N. Gurzov, Carla M. Germano, Najib Naamane, Ihsane Marhfour, Makiko Fukaya, Jean-Marie Vanderwinden, Conny Gysemans, Chantal Mathieu, Lorella Marselli, Piero Marchetti, Heather P. Harding, David Ron, Décio L. Eizirik, Miriam Cnop
Journal: Diabetes
Diabetes 2012;61(11):2763–2775
https://doi.org/10.2337/db12-0123
Published: 16 October 2012
View article titled, Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis
Open the PDF for Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis in another window
Includes: Supplementary data
Journal Articles

Cytokines Interleukin-1β and Tumor Necrosis Factor-α Regulate Different Transcriptional and Alternative Splicing Networks in Primary β-Cells

Fernanda Ortis, Najib Naamane, Daisy Flamez, Laurence Ladrière, Fabrice Moore, Daniel A. Cunha, Maikel L. Colli, Thomas Thykjaer, Kasper Thorsen, Torben F. Ørntoft, Decio L. Eizirik
Journal: Diabetes
Diabetes 2010;59(2):358–374
https://doi.org/10.2337/db09-1159
Published: 23 November 2009
View article titled, Cytokines Interleukin-1β and Tumor Necrosis Factor-α Regulate Different Transcriptional and Alternative Splicing Networks in Primary β-Cells
Open the PDF for Cytokines Interleukin-1β and Tumor Necrosis Factor-α Regulate Different Transcriptional and Alternative Splicing Networks in Primary β-Cells in another window
Includes: Supplementary data
Journal Articles

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

Daniel A. Cunha, Laurence Ladrière, Fernanda Ortis, Mariana Igoillo-Esteve, Esteban N. Gurzov, Roberto Lupi, Piero Marchetti, Décio L. Eizirik, Miriam Cnop
Journal: Diabetes
Diabetes 2009;58(12):2851–2862
https://doi.org/10.2337/db09-0685
Published: 31 August 2009
View article titled, Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB
Open the PDF for Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB in another window
Includes: Supplementary data
Journal Articles

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis

Fabrice Moore, Maikel L. Colli, Miriam Cnop, Mariana Igoillo Esteve, Alessandra K. Cardozo, Daniel A. Cunha, Marco Bugliani, Piero Marchetti, Décio L. Eizirik
Journal: Diabetes
Diabetes 2009;58(6):1283–1291
https://doi.org/10.2337/db08-1510
Published: 26 March 2009
View article titled, PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis
Open the PDF for PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis in another window
Includes: Supplementary data