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Daniel J Drucker
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Meeting Abstracts

362-OR: The Role of Intraislet Glucagon in Pulsatile Insulin Secretion

KINGA SUBA, YATEEN S. PATEL, ANNA ROBERTS, JED V. SHREWSBURY, SHIQIAN CHEN, RACHEL KWOK, VASILIKI KALOGIANNI, XIAOXUAN LIU, GUY A. RUTTER, BEN JONES, TRICIA M. TAN, BRYN OWEN, DANIEL J. DRUCKER, STEPHEN BLOOM, KEVIN MURPHY, VICTORIA SALEM
Journal: Diabetes
Diabetes 2022;71(Supplement_1):362-OR
https://doi.org/10.2337/db22-362-OR
Published: 01 June 2022
View article titled, 362-OR: The Role of Intraislet Glucagon in Pulsatile Insulin Secretion
Journal Articles

GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue

Jonathan E. Campbell, Jacqueline L. Beaudry, Berit Svendsen, Laurie L. Baggio, Andrew N. Gordon, John R. Ussher, Chi Kin Wong, Fiona M. Gribble, David A. D’Alessio, Frank Reimann, Daniel J. Drucker
Journal: Diabetes
Diabetes 2022;71(5):1115–1127
https://doi.org/10.2337/db21-1166
Published: 22 February 2022
View article titled, GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue
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Meeting Abstracts

255-OR: ADA Presidents’ Select Abstract: Glucagon Receptor Antagonism Stimulates Beta-Cell Proliferation in Mouse and Human Islets

KATIE C. COATE, ERICK SPEARS, CHUNHUA DAI, SCOTT WISNIEWSKI, GREG POFFENBERGER, LEONARD D. SHULTZ, DALE L. GREINER, DANIEL J. DRUCKER, HAI YAN, KYLE SLOOP, ALVIN C. POWERS, DANIELLE DEAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):255-OR
https://doi.org/10.2337/db20-255-OR
Published: 01 June 2020
View article titled, 255-OR: ADA Presidents’ Select Abstract: Glucagon Receptor Antagonism Stimulates Beta-Cell Proliferation in Mouse and Human Islets
Journal Articles

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

Mari Lilith Lund, Giovanni Sorrentino, Kristoffer Lihme Egerod, Chantal Kroone, Brynjulf Mortensen, Filip Krag Knop, Frank Reimann, Fiona M. Gribble, Daniel J. Drucker, Eelco J.P. de Koning, Kristina Schoonjans, Fredrik Bäckhed, Thue W. Schwartz, Natalia Petersen
Journal: Diabetes
Diabetes 2020;69(4):614–623
https://doi.org/10.2337/db19-0764
Published: 10 February 2020
View article titled, L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling
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Includes: Supplementary data
Journal Articles

Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents

Teayoun Kim, Cassie L. Holleman, Shelly Nason, Deanna M. Arble, Nickki Ottaway, Joseph Chabenne, Christine Loyd, Jeong-a Kim, Darleen Sandoval, Daniel J. Drucker, Richard DiMarchi, Diego Perez-Tilve, Kirk M. Habegger
Journal: Diabetes
Diabetes 2018;67(11):2157–2166
https://doi.org/10.2337/db18-0068
Published: 27 August 2018
View article titled, Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents
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Includes: Supplementary data
Journal Articles

The Ascending GLP-1 Road From Clinical Safety to Reduction of Cardiovascular Complications

Daniel J. Drucker
Journal: Diabetes
Diabetes 2018;67(9):1710–1719
https://doi.org/10.2337/dbi18-0008
Published: 15 August 2018
View article titled, The Ascending GLP-1 Road From Clinical Safety to Reduction of Cardiovascular Complications
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Journal Articles

Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21

Teayoun Kim, Shelly Nason, Cassie Holleman, Mark Pepin, Landon Wilson, Taylor F. Berryhill, Adam R. Wende, Chad Steele, Martin E. Young, Stephen Barnes, Daniel J. Drucker, Brian Finan, Richard DiMarchi, Diego Perez-Tilve, Matthias Tschöp, Kirk M. Habegger
Journal: Diabetes
Diabetes 2018;67(9):1773–1782
https://doi.org/10.2337/db17-1502
Published: 20 June 2018
View article titled, Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21
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Includes: Supplementary data
Journal Articles

β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation

Brandon L. Panaro, Grace B. Flock, Jonathan E. Campbell, Jacqueline L. Beaudry, Xiemin Cao, Daniel J. Drucker
Journal: Diabetes
Diabetes 2017;66(6):1626–1635
https://doi.org/10.2337/db17-0017
Published: 02 March 2017
View article titled, β-Cell Inactivation of <em>Gpr119</em> Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation
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Includes: Supplementary data
Journal Articles

The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice

Melissa A. Burmeister, Jennifer E. Ayala, Hannah Smouse, Adriana Landivar-Rocha, Jacob D. Brown, Daniel J. Drucker, Doris A. Stoffers, Darleen A. Sandoval, Randy J. Seeley, Julio E. Ayala
Journal: Diabetes
Diabetes 2017;66(2):372–384
https://doi.org/10.2337/db16-1102
Published: 01 December 2016
View article titled, The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice
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Includes: Supplementary data
Journal Articles

Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat–Fed Diabetic Mice

Erin E. Mulvihill, Elodie M. Varin, John R. Ussher, Jonathan E. Campbell, K.W. Annie Bang, Tahmid Abdullah, Laurie L. Baggio, Daniel J. Drucker
Journal: Diabetes
Diabetes 2016;65(3):742–754
https://doi.org/10.2337/db15-1224
Published: 15 December 2015
View article titled, Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat–Fed Diabetic Mice
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Includes: Supplementary data
Journal Articles

Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone

Daniel Oropeza, Nathalie Jouvet, Lionel Budry, Jonathan E. Campbell, Khalil Bouyakdan, Julie Lacombe, Gabrielle Perron, Valerie Bergeron, Joshua C. Neuman, Harpreet K. Brar, Rachel J. Fenske, Clemence Meunier, Sarah Sczelecki, Michelle E. Kimple, Daniel J. Drucker, Robert A. Screaton, Vincent Poitout, Mathieu Ferron, Thierry Alquier, Jennifer L. Estall
Journal: Diabetes
Diabetes 2015;64(11):3798–3807
https://doi.org/10.2337/db15-0272
Published: 07 July 2015
View article titled, Phenotypic Characterization of MIP-CreERT<sup>1Lphi</sup> Mice With Transgene-Driven Islet Expression of Human Growth Hormone
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Includes: Supplementary data
Journal Articles

GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R

Bernardo Yusta, Laurie L. Baggio, Jacqueline Koehler, Dianne Holland, Xiemin Cao, Lee J. Pinnell, Kathene C. Johnson-Henry, William Yeung, Michael G. Surette, K.W. Annie Bang, Philip M. Sherman, Daniel J. Drucker
Journal: Diabetes
Diabetes 2015;64(7):2537–2549
https://doi.org/10.2337/db14-1577
Published: 03 March 2015
View article titled, GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R
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Includes: Supplementary data
Journal Articles

Deciphering Metabolic Messages From the Gut Drives Therapeutic Innovation: The 2014 Banting Lecture

Daniel J. Drucker
Journal: Diabetes
Diabetes 2015;64(2):317–326
https://doi.org/10.2337/db14-1514
Published: 13 January 2015
View article titled, Deciphering Metabolic Messages From the Gut Drives Therapeutic Innovation: The 2014 Banting Lecture
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Journal Articles

Ghrelin Is a Novel Regulator of GLP-1 Secretion

Jeffrey Gagnon, Laurie L. Baggio, Daniel J. Drucker, Patricia L. Brubaker
Journal: Diabetes
Diabetes 2015;64(5):1513–1521
https://doi.org/10.2337/db14-1176
Published: 20 November 2014
View article titled, Ghrelin Is a Novel Regulator of GLP-1 Secretion
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Journal Articles

Glucagon-Like Peptide-1 Receptor Agonists Increase Pancreatic Mass by Induction of Protein Synthesis

Jacqueline A. Koehler, Laurie L. Baggio, Xiemin Cao, Tahmid Abdulla, Jonathan E. Campbell, Thomas Secher, Jacob Jelsing, Brett Larsen, Daniel J. Drucker
Journal: Diabetes
Diabetes 2015;64(3):1046–1056
https://doi.org/10.2337/db14-0883
Published: 01 October 2014
View article titled, Glucagon-Like Peptide-1 Receptor Agonists Increase Pancreatic Mass by Induction of Protein Synthesis
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Includes: Supplementary data
Journal Articles

Lipopolysaccharides-Mediated Increase in Glucose-Stimulated Insulin Secretion: Involvement of the GLP-1 Pathway

Anh Thoai Nguyen, Stéphane Mandard, Cédric Dray, Valérie Deckert, Philippe Valet, Philippe Besnard, Daniel J. Drucker, Laurent Lagrost, Jacques Grober
Journal: Diabetes
Diabetes 2014;63(2):471–482
https://doi.org/10.2337/db13-0903
Published: 16 January 2014
View article titled, Lipopolysaccharides-Mediated Increase in Glucose-Stimulated Insulin Secretion: Involvement of the GLP-1 Pathway
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Journal Articles

Incretin Action in the Pancreas: Potential Promise, Possible Perils, and Pathological Pitfalls

Daniel J. Drucker
Journal: Diabetes
Diabetes 2013;62(10):3316–3323
https://doi.org/10.2337/db13-0822
Published: 17 September 2013
View article titled, Incretin Action in the Pancreas: Potential Promise, Possible Perils, and Pathological Pitfalls
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Includes: Supplementary data
Journal Articles

Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency

Hilary E. Wilson-Pérez, Adam P. Chambers, Karen K. Ryan, Bailing Li, Darleen A. Sandoval, Doris Stoffers, Daniel J. Drucker, Diego Pérez-Tilve, Randy J. Seeley
Journal: Diabetes
Diabetes 2013;62(7):2380–2385
https://doi.org/10.2337/db12-1498
Published: 14 June 2013
View article titled, Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency
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Includes: Supplementary data
Journal Articles

Liver-Specific Disruption of the Murine Glucagon Receptor Produces α-Cell Hyperplasia: Evidence for a Circulating α-Cell Growth Factor

Christine Longuet, Ana M. Robledo, E. Danielle Dean, Chunhua Dai, Safina Ali, Ian McGuinness, Vincent de Chavez, Patricia M. Vuguin, Maureen J. Charron, Alvin C. Powers, Daniel J. Drucker
Journal: Diabetes
Diabetes 2013;62(4):1196–1205
https://doi.org/10.2337/db11-1605
Published: 14 March 2013
View article titled, Liver-Specific Disruption of the Murine Glucagon Receptor Produces α-Cell Hyperplasia: <subtitle>Evidence for a Circulating α-Cell Growth Factor</subtitle>
Open the PDF for Liver-Specific Disruption of the Murine Glucagon Receptor Produces α-Cell Hyperplasia: <subtitle>Evidence for a Circulating α-Cell Growth Factor</subtitle> in another window
Includes: Supplementary data
Journal Articles

Ectopic Expression of GIP in Pancreatic β-Cells Maintains Enhanced Insulin Secretion in Mice With Complete Absence of Proglucagon-Derived Peptides

Ayako Fukami, Yusuke Seino, Nobuaki Ozaki, Michiyo Yamamoto, Chisato Sugiyama, Eriko Sakamoto-Miura, Tatsuhito Himeno, Yoshiko Takagishi, Shin Tsunekawa, Safina Ali, Daniel J. Drucker, Yoshiharu Murata, Yutaka Seino, Yutaka Oiso, Yoshitaka Hayashi
Journal: Diabetes
Diabetes 2013;62(2):510–518
https://doi.org/10.2337/db12-0294
Published: 17 January 2013
View article titled, Ectopic Expression of GIP in Pancreatic β-Cells Maintains Enhanced Insulin Secretion in Mice With Complete Absence of Proglucagon-Derived Peptides
Open the PDF for Ectopic Expression of GIP in Pancreatic β-Cells Maintains Enhanced Insulin Secretion in Mice With Complete Absence of Proglucagon-Derived Peptides in another window
Includes: Supplementary data