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David A. Jacobson
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Journal Articles

Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid

Available to Purchase
Mahircan Yagan, Sadia Najam, Ruiying Hu, Yu Wang, Mathew T. Dickerson, Prasanna K. Dadi, Yanwen Xu, Alan J. Simmons, Roland Stein, Christopher M. Adams, David A. Jacobson, Ken S. Lau, Qi Liu, Guoqiang Gu
Journal: Diabetes
Diabetes 2025;74(5):838–849
https://doi.org/10.2337/db24-0360
Published: 03 February 2025
View articletitled, Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid
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Journal Articles

Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function

Free
Rebecca Cheung, Grazia Pizza, Pauline Chabosseau, Delphine Rolando, Alejandra Tomas, Thomas Burgoyne, Zhiyi Wu, Anna Salowka, Anusha Thapa, Annabel Macklin, Yufei Cao, Marie-Sophie Nguyen-Tu, Matthew T. Dickerson, David A. Jacobson, Piero Marchetti, James Shapiro, Lorenzo Piemonti, Eelco de Koning, Isabelle Leclerc, Karim Bouzakri, Kei Sakamoto, David M. Smith, Guy A. Rutter, Aida Martinez-Sanchez
Journal: Diabetes
Diabetes 2022;71(7):1525–1545
https://doi.org/10.2337/db21-0803
Published: 27 April 2022
View articletitled, Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function
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Journal Articles

Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response

Free
Xiaodun Yang, Sarah M. Graff, Cody N. Heiser, Kung-Hsien Ho, Bob Chen, Alan J. Simmons, Austin N. Southard-Smith, Gregory David, David A. Jacobson, Irina Kaverina, Christopher V.E. Wright, Ken S. Lau, Guoqiang Gu
Journal: Diabetes
Diabetes 2020;69(6):1219–1231
https://doi.org/10.2337/db19-0721
Published: 03 April 2020
View articletitled, Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response
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Journal Articles

Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion

Free
Nicholas H.F. Fine, Craig L. Doig, Yasir S. Elhassan, Nicholas C. Vierra, Piero Marchetti, Marco Bugliani, Rita Nano, Lorenzo Piemonti, Guy A. Rutter, David A. Jacobson, Gareth G. Lavery, David J. Hodson
Journal: Diabetes
Diabetes 2018;67(2):278–290
https://doi.org/10.2337/db16-1356
Published: 04 December 2017
View articletitled, Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion
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Includes: Supplementary data
Journal Articles

Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca2+-Regulated Genes

Free
Jennifer S. Stancill, Jean-Philippe Cartailler, Hannah W. Clayton, James T. O’Connor, Matthew T. Dickerson, Prasanna K. Dadi, Anna B. Osipovich, David A. Jacobson, Mark A. Magnuson
Journal: Diabetes
Diabetes 2017;66(8):2175–2187
https://doi.org/10.2337/db16-1355
Published: 26 May 2017
View articletitled, Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca2+-Regulated Genes
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Includes: Supplementary data
Journal Articles

Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion

Free
Maria L. Golson, Jennifer C. Dunn, Matthew F. Maulis, Prasanna K. Dadi, Anna B. Osipovich, Mark A. Magnuson, David A. Jacobson, Maureen Gannon
Journal: Diabetes
Diabetes 2015;64(11):3829–3838
https://doi.org/10.2337/db15-0465
Published: 06 August 2015
View articletitled, Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion
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Includes: Supplementary data
Journal Articles

Type 2 Diabetes–Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis

Free
Nicholas C. Vierra, Prasanna K. Dadi, Imju Jeong, Matthew Dickerson, David R. Powell, David A. Jacobson
Journal: Diabetes
Diabetes 2015;64(11):3818–3828
https://doi.org/10.2337/db15-0280
Published: 03 August 2015
View articletitled, Type 2 Diabetes–Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis
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Includes: Supplementary data
Journal Articles

G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion

Open Access
Lynley D. Pound, James K. Oeser, Tracy P. O’Brien, Yingda Wang, Chandler J. Faulman, Prasanna K. Dadi, David A. Jacobson, John C. Hutton, Owen P. McGuinness, Masakazu Shiota, Richard M. O’Brien
Journal: Diabetes
Diabetes 2013;62(5):1547–1556
https://doi.org/10.2337/db12-1067
Published: 16 April 2013
View articletitled, G6PC2: A Negative Regulator of Basal Glucose-Stimulated Insulin Secretion
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Journal Articles

β-Cell–Specific Protein Kinase A Activation Enhances the Efficiency of Glucose Control by Increasing Acute-Phase Insulin Secretion

Open Access
Kelly A. Kaihara, Lorna M. Dickson, David A. Jacobson, Natalia Tamarina, Michael W. Roe, Louis H. Philipson, Barton Wicksteed
Journal: Diabetes
Diabetes 2013;62(5):1527–1536
https://doi.org/10.2337/db12-1013
Published: 16 April 2013
View articletitled, β-Cell–Specific Protein Kinase A Activation Enhances the Efficiency of Glucose Control by Increasing Acute-Phase Insulin Secretion
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Includes: Supplementary data
Journal Articles

The α-Cell Conundrum: ATP-Sensitive K+ Channels and Glucose Sensing

Free
David A. Jacobson, Barton L. Wicksteed, Louis H. Philipson
Journal: Diabetes
Diabetes 2009;58(2):304–306
https://doi.org/10.2337/db08-1618
Published: 01 February 2009
View articletitled, The α-Cell Conundrum: ATP-Sensitive K+ Channels and Glucose Sensing
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