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Meeting Abstracts

314-OR: A Randomized Study of a GPR119 Agonist on Glucagon Counterregulation during Hypoglycemia in Type 1 Diabetes Mellitus (T1DM)

ANIKA BILAL, ANNA CASU, FANCHAO YI, JUSTINE M. MUCINSKI, GINA MERCOUFFER, DAVID E. KELLEY, RICHARD E. PRATLEY

Diabetes 2024;73(Supplement_1):314-OR

https://doi.org/10.2337/db24-314-OR

Published: 14 June 2024

View article titled, 314-OR: A Randomized Study of a GPR119 Agonist on Glucagon Counterregulation during Hypoglycemia in Type 1 Diabetes Mellitus (T1DM)

Journal Articles

GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia

Nina Xiaoyan Li, Stacey Brown, Tim Kowalski, Margaret Wu, Liming Yang, Ge Dai, Aleksandr Petrov, Yuyan Ding, Tamara Dlugos, Harold B. Wood, Liangsu Wang, Mark Erion, Robert Sherwin, David E. Kelley

Diabetes 2018;67(7):1401–1413

https://doi.org/10.2337/db18-0031

Published: 18 April 2018

View article titled, GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia

Includes: Supplementary data

Journal Articles

Native Oxyntomodulin Has Significant Glucoregulatory Effects Independent of Weight Loss in Obese Humans With and Without Type 2 Diabetes

Sudha S. Shankar, R. Ravi Shankar, Lori A. Mixson, Deborah L. Miller, Barnali Pramanik, Amy K. O’Dowd, Donna M. Williams, Clay B. Frederick, Chan R. Beals, S. Aubrey Stoch, Helmut O. Steinberg, David E. Kelley

Diabetes 2018;67(6):1105–1112

https://doi.org/10.2337/db17-1331

Published: 15 March 2018

View article titled, Native Oxyntomodulin Has Significant Glucoregulatory Effects Independent of Weight Loss in Obese Humans With and Without Type 2 Diabetes

Journal Articles

Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts

Mary Courtney Moore, David E. Kelley, Raul C. Camacho, Peter Zafian, Tian Ye, Songnian Lin, Niels C. Kaarsholm, Ravi Nargund, Terri M. Kelly, Margaret Van Heek, Stephen F. Previs, Christopher Moyes, Marta S. Smith, Ben Farmer, Phil Williams, Alan D. Cherrington

Diabetes 2018;67(6):1173–1181

https://doi.org/10.2337/db18-0099

Published: 14 March 2018

View article titled, Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts

Includes: Supplementary data

Journal Articles

Erratum. Engineering Glucose Responsiveness Into Insulin. Diabetes 2018;67: 299–308

Diabetes 2018;67(5):1030

https://doi.org/10.2337/db18-er05a

Published: 27 February 2018

View article titled, Erratum. Engineering Glucose Responsiveness Into Insulin. Diabetes 2018;67: 299–308

Journal Articles

Engineering Glucose Responsiveness Into Insulin

Diabetes 2018;67(2):299–308

https://doi.org/10.2337/db17-0577

Published: 02 November 2017

View article titled, Engineering Glucose Responsiveness Into Insulin

Includes: Supplementary data

Journal Articles

Stewing in Not-So-Good Juices: Interactions of Skeletal Muscle With Adipose Secretions

David E. Kelley, Bret H. Goodpaster

Diabetes 2015;64(9):3055–3057

https://doi.org/10.2337/db15-0403

Published: 13 August 2015

View article titled, Stewing in Not-So-Good Juices: Interactions of Skeletal Muscle With Adipose Secretions

Journal Articles

Using Oral Challenge Testing to Assess Insulin Action and Secretion With Mathematical Modeling

Myrlene A. Staten, David E. Kelley

Diabetes 2014;63(4):1188–1190

https://doi.org/10.2337/db13-1839

Published: 13 March 2014

View article titled, Using Oral Challenge Testing to Assess Insulin Action and Secretion With Mathematical Modeling

Journal Articles

Interactions Among Glucose Delivery, Transport, and Phosphorylation That Underlie Skeletal Muscle Insulin Resistance in Obesity and Type 2 Diabetes: Studies With Dynamic PET Imaging

Bret H. Goodpaster, Alessandra Bertoldo, Jason M. Ng, Koichiro Azuma, R. Richard Pencek, Carol Kelley, Julie C. Price, Claudio Cobelli, David E. Kelley

Diabetes 2014;63(3):1058–1068

https://doi.org/10.2337/db13-1249

Published: 13 February 2014

View article titled, Interactions Among Glucose Delivery, Transport, and Phosphorylation That Underlie Skeletal Muscle Insulin Resistance in Obesity and Type 2 Diabetes: Studies With Dynamic PET Imaging

Includes: Supplementary data

Journal Articles

Metabolic Changes Following a 1-Year Diet and Exercise Intervention in Patients With Type 2 Diabetes

Jeanine B. Albu, Leonie K. Heilbronn, David E. Kelley, Steven R. Smith, Koichiro Azuma, Evan S. Berk, F. Xavier Pi-Sunyer, Eric Ravussin, the Look AHEAD Adipose Research Group

Diabetes 2010;59(3):627–633

https://doi.org/10.2337/db09-1239

Published: 22 December 2009

View article titled, Metabolic Changes Following a 1-Year Diet and Exercise Intervention in Patients With Type 2 Diabetes

Journal Articles

Metabolic Flexibility in Response to Glucose Is Not Impaired in People With Type 2 Diabetes After Controlling for Glucose Disposal Rate

Jose E. Galgani, Leonie K. Heilbronn, Koichiro Azuma, David E. Kelley, Jeanine B. Albu, Xavier Pi-Sunyer, Steven R. Smith, Eric Ravussin, and the Look AHEAD Adipose Research Group

Diabetes 2008;57(4):841–845

https://doi.org/10.2337/db08-0043

Published: 01 April 2008

View article titled, Metabolic Flexibility in Response to Glucose Is Not Impaired in People With Type 2 Diabetes After Controlling for Glucose Disposal Rate

Journal Articles

Mitochondrial Capacity in Skeletal Muscle Is Not Stimulated by Weight Loss Despite Increases in Insulin Action and Decreases in Intramyocellular Lipid Content

Frederico G.S. Toledo, Elizabeth V. Menshikova, Koichiro Azuma, Zofia Radiková, Carol A. Kelley, Vladimir B. Ritov, David E. Kelley

Diabetes 2008;57(4):987–994

https://doi.org/10.2337/db07-1429

Published: 01 April 2008

View article titled, Mitochondrial Capacity in Skeletal Muscle Is Not Stimulated by Weight Loss Despite Increases in Insulin Action and Decreases in Intramyocellular Lipid Content

Journal Articles

Effects of Physical Activity and Weight Loss on Skeletal Muscle Mitochondria and Relationship With Glucose Control in Type 2 Diabetes

Frederico G.S. Toledo, Elizabeta V. Menshikova, Vladimir B. Ritov, Koichiro Azuma, Zofia Radikova, James DeLany, David E. Kelley

Diabetes 2007;56(8):2142–2147

https://doi.org/10.2337/db07-0141

Published: 01 August 2007

View article titled, Effects of Physical Activity and Weight Loss on Skeletal Muscle Mitochondria and Relationship With Glucose Control in Type 2 Diabetes

Journal Articles

Interleukin-6 Regulation of AMP-Activated Protein Kinase: Potential Role in the Systemic Response to Exercise and Prevention of the Metabolic Syndrome

Neil B. Ruderman, Charlotte Keller, Ann-Marie Richard, Asish K. Saha, Zhijun Luo, Xiaoqin Xiang, Mercedes Giralt, Vladimir B. Ritov, Elizabeth V. Menshikova, David E. Kelley, Juan Hidalgo, Bente K. Pedersen, Meghan Kelly

Diabetes 2006;55(Supplement_2):S48–S54

https://doi.org/10.2337/db06-S007

Published: 01 December 2006

View article titled, Interleukin-6 Regulation of AMP-Activated Protein Kinase: <subtitle>Potential Role in the Systemic Response to Exercise and Prevention of the Metabolic Syndrome</subtitle>

Journal Articles

Interactions Between Delivery, Transport, and Phosphorylation of Glucose in Governing Uptake Into Human Skeletal Muscle

Alessandra Bertoldo, R. Richard Pencek, Koichiro Azuma, Julie C. Price, Carol Kelley, Claudio Cobelli, David E. Kelley

Diabetes 2006;55(11):3028–3037

https://doi.org/10.2337/db06-0762

Published: 01 November 2006

View article titled, Interactions Between Delivery, Transport, and Phosphorylation of Glucose in Governing Uptake Into Human Skeletal Muscle

Includes: Supplementary data

Journal Articles

Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes

Vladimir B. Ritov, Elizabeth V. Menshikova, Jing He, Robert E. Ferrell, Bret H. Goodpaster, David E. Kelley

Diabetes 2005;54(1):8–14

https://doi.org/10.2337/diabetes.54.1.8

Published: 01 January 2005

View article titled, Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes

Journal Articles

Enhanced Fat Oxidation Through Physical Activity Is Associated With Improvements in Insulin Sensitivity in Obesity

Bret H. Goodpaster, Andreas Katsiaras, David E. Kelley

Diabetes 2003;52(9):2191–2197

https://doi.org/10.2337/diabetes.52.9.2191

Published: 01 September 2003

View article titled, Enhanced Fat Oxidation Through Physical Activity Is Associated With Improvements in Insulin Sensitivity in Obesity

Journal Articles

Weight Loss-Induced Plasticity of Glucose Transport and Phosphorylation in the Insulin Resistance of Obesity and Type 2 Diabetes

Katherine V. Williams, Alessandra Bertoldo, Paul Kinahan, Claudio Cobelli, David E. Kelley

Diabetes 2003;52(7):1619–1626

https://doi.org/10.2337/diabetes.52.7.1619

Published: 01 July 2003

View article titled, Weight Loss-Induced Plasticity of Glucose Transport and Phosphorylation in the Insulin Resistance of Obesity and Type 2 Diabetes

Journal Articles

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

David E. Kelley, Jing He, Elizabeth V. Menshikova, Vladimir B. Ritov

Diabetes 2002;51(10):2944–2950

https://doi.org/10.2337/diabetes.51.10.2944

Published: 01 October 2002

View article titled, Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

Journal Articles

Interactions of Impaired Glucose Transport and Phosphorylation in Skeletal Muscle Insulin Resistance: A Dose-Response Assessment Using Positron Emission Tomography

Katherine V. Williams, Julie C. Price, David E. Kelley

Diabetes 2001;50(9):2069–2079

https://doi.org/10.2337/diabetes.50.9.2069

Published: 01 September 2001

View article titled, Interactions of Impaired Glucose Transport and Phosphorylation in Skeletal Muscle Insulin Resistance: <subtitle>A Dose-Response Assessment Using Positron Emission Tomography</subtitle>

NARROW

314-OR: A Randomized Study of a GPR119 Agonist on Glucagon Counterregulation during Hypoglycemia in Type 1 Diabetes Mellitus (T1DM)

GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia

Native Oxyntomodulin Has Significant Glucoregulatory Effects Independent of Weight Loss in Obese Humans With and Without Type 2 Diabetes

Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts

Erratum. Engineering Glucose Responsiveness Into Insulin. Diabetes 2018;67: 299–308

Engineering Glucose Responsiveness Into Insulin

Stewing in Not-So-Good Juices: Interactions of Skeletal Muscle With Adipose Secretions

Using Oral Challenge Testing to Assess Insulin Action and Secretion With Mathematical Modeling

Interactions Among Glucose Delivery, Transport, and Phosphorylation That Underlie Skeletal Muscle Insulin Resistance in Obesity and Type 2 Diabetes: Studies With Dynamic PET Imaging

Metabolic Changes Following a 1-Year Diet and Exercise Intervention in Patients With Type 2 Diabetes

Metabolic Flexibility in Response to Glucose Is Not Impaired in People With Type 2 Diabetes After Controlling for Glucose Disposal Rate

Mitochondrial Capacity in Skeletal Muscle Is Not Stimulated by Weight Loss Despite Increases in Insulin Action and Decreases in Intramyocellular Lipid Content

Effects of Physical Activity and Weight Loss on Skeletal Muscle Mitochondria and Relationship With Glucose Control in Type 2 Diabetes

Interleukin-6 Regulation of AMP-Activated Protein Kinase: Potential Role in the Systemic Response to Exercise and Prevention of the Metabolic Syndrome

Interactions Between Delivery, Transport, and Phosphorylation of Glucose in Governing Uptake Into Human Skeletal Muscle

Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes

Enhanced Fat Oxidation Through Physical Activity Is Associated With Improvements in Insulin Sensitivity in Obesity

Weight Loss-Induced Plasticity of Glucose Transport and Phosphorylation in the Insulin Resistance of Obesity and Type 2 Diabetes

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

Interactions of Impaired Glucose Transport and Phosphorylation in Skeletal Muscle Insulin Resistance: A Dose-Response Assessment Using Positron Emission Tomography

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