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Journal Articles

A Candidate-Gene Approach Identifies Novel Associations Between Common Variants in/Near Syndromic Obesity Genes and BMI in Pediatric and Adult European Populations

Dominic X. Wang, Yuvreet Kaur, Akram Alyass, David Meyre
Journal: Diabetes
Diabetes 2019;68(4):724–732
https://doi.org/10.2337/db18-0986
Published: 28 January 2019
View article titled, A Candidate-Gene Approach Identifies Novel Associations Between Common Variants in/Near Syndromic Obesity Genes and BMI in Pediatric and Adult European Populations
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Includes: Supplementary data
Journal Articles

Give GWAS a Chance

David Meyre
Journal: Diabetes
Diabetes 2017;66(11):2741–2742
https://doi.org/10.2337/dbi17-0026
Published: 13 October 2017
View article titled, Give GWAS a Chance
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Journal Articles

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

Antigone S. Dimas, Vasiliki Lagou, Adam Barker, Joshua W. Knowles, Reedik Mägi, Marie-France Hivert, Andrea Benazzo, Denis Rybin, Anne U. Jackson, Heather M. Stringham, Ci Song, Antje Fischer-Rosinsky, Trine Welløv Boesgaard, Niels Grarup, Fahim A. Abbasi, Themistocles L. Assimes, Ke Hao, Xia Yang, Cécile Lecoeur, Inês Barroso, Lori L. Bonnycastle, Yvonne Böttcher, Suzannah Bumpstead, Peter S. Chines, Michael R. Erdos, Jurgen Graessler, Peter Kovacs, Mario A. Morken, Narisu Narisu, Felicity Payne, Alena Stancakova, Amy J. Swift, Anke Tönjes, Stefan R. Bornstein, Stéphane Cauchi, Philippe Froguel, David Meyre, Peter E.H. Schwarz, Hans-Ulrich Häring, Ulf Smith, Michael Boehnke, Richard N. Bergman, Francis S. Collins, Karen L. Mohlke, Jaakko Tuomilehto, Thomas Quertemous, Lars Lind, Torben Hansen, Oluf Pedersen, Mark Walker, Andreas F.H. Pfeiffer, Joachim Spranger, Michael Stumvoll, James B. Meigs, Nicholas J. Wareham, Johanna Kuusisto, Markku Laakso, Claudia Langenberg, Josée Dupuis, Richard M. Watanabe, Jose C. Florez, Erik Ingelsson, Mark I. McCarthy, Inga Prokopenko, on behalf of the MAGIC Investigators
Journal: Diabetes
Diabetes 2014;63(6):2158–2171
https://doi.org/10.2337/db13-0949
Published: 15 May 2014
View article titled, Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity
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Includes: Supplementary data
Journal Articles

Genetic Dissection of Diabetes: Facing the Giant

David Meyre, Guillaume Pare
Journal: Diabetes
Diabetes 2013;62(10):3338–3340
https://doi.org/10.2337/db13-1154
Published: 17 September 2013
View article titled, Genetic Dissection of Diabetes: Facing the Giant
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Journal Articles

Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity

John W.M. Creemers, Hélène Choquet, Pieter Stijnen, Vincent Vatin, Marie Pigeyre, Sigri Beckers, Sandra Meulemans, Manuel E. Than, Loïc Yengo, Maithé Tauber, Beverley Balkau, Paul Elliott, Marjo-Riitta Jarvelin, Wim Van Hul, Luc Van Gaal, Fritz Horber, François Pattou, Philippe Froguel, David Meyre
Journal: Diabetes
Diabetes 2012;61(2):383–390
https://doi.org/10.2337/db11-0305
Published: 17 January 2012
View article titled, Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity
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Includes: Supplementary data
Journal Articles

Evaluation of A2BP1 as an Obesity Gene

Lijun Ma, Robert L. Hanson, Michael T. Traurig, Yunhua L. Muller, Bakhshish P. Kaur, Jessica M. Perez, David Meyre, Mao Fu, Antje Körner, Paul W. Franks, Wieland Kiess, Sayuko Kobes, William C. Knowler, Peter Kovacs, Philippe Froguel, Alan R. Shuldiner, Clifton Bogardus, Leslie J. Baier
Journal: Diabetes
Diabetes 2010;59(11):2837–2845
https://doi.org/10.2337/db09-1604
Published: 19 August 2010
View article titled, Evaluation of <em>A2BP1</em> as an Obesity Gene
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Includes: Supplementary data
Journal Articles

Genetic and Functional Assessment of the Role of the rs13431652-A and rs573225-A Alleles in the G6PC2 Promoter That Are Strongly Associated With Elevated Fasting Glucose Levels

Nabila Bouatia-Naji, Amélie Bonnefond, Devin A. Baerenwald, Marion Marchand, Marco Bugliani, Piero Marchetti, François Pattou, Richard L. Printz, Brian P. Flemming, Obi C. Umunakwe, Nicholas L. Conley, Martine Vaxillaire, Olivier Lantieri, Beverley Balkau, Michel Marre, Claire Lévy-Marchal, Paul Elliott, Marjo-Riitta Jarvelin, David Meyre, Christian Dina, James K. Oeser, Philippe Froguel, Richard M. O'Brien
Journal: Diabetes
Diabetes 2010;59(10):2662–2671
https://doi.org/10.2337/db10-0389
Published: 09 July 2010
View article titled, Genetic and Functional Assessment of the Role of the rs13431652-A and rs573225-A Alleles in the <em>G6PC2</em> Promoter That Are Strongly Associated With Elevated Fasting Glucose Levels
Open the PDF for Genetic and Functional Assessment of the Role of the rs13431652-A and rs573225-A Alleles in the <em>G6PC2</em> Promoter That Are Strongly Associated With Elevated Fasting Glucose Levels in another window
Includes: Supplementary data
Journal Articles

MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans

Ehm A. Andersson, Birgitte Holst, Thomas Sparsø, Niels Grarup, Karina Banasik, Johan Holmkvist, Torben Jørgensen, Knut Borch-Johnsen, Kristoffer L. Egerod, Torsten Lauritzen, Thorkild I.A. Sørensen, Amélie Bonnefond, David Meyre, Philippe Froguel, Thue W. Schwartz, Oluf Pedersen, Torben Hansen
Journal: Diabetes
Diabetes 2010;59(6):1539–1548
https://doi.org/10.2337/db09-1757
Published: 03 March 2010
View article titled, <em>MTNR1B</em> G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans
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Includes: Supplementary data
Journal Articles

Prevalence of Loss-of-Function FTO Mutations in Lean and Obese Individuals

David Meyre, Karine Proulx, Hiroko Kawagoe-Takaki, Vincent Vatin, Ruth Gutiérrez-Aguilar, Debbie Lyon, Marcella Ma, Helene Choquet, Fritz Horber, Wim Van Hul, Luc Van Gaal, Beverley Balkau, Sophie Visvikis-Siest, François Pattou, I. Sadaf Farooqi, Vladimir Saudek, Stephen O'Rahilly, Philippe Froguel, Barbara Sedgwick, Giles S.H. Yeo
Journal: Diabetes
Diabetes 2010;59(1):311–318
https://doi.org/10.2337/db09-0703
Published: 15 October 2009
View article titled, Prevalence of Loss-of-Function <em>FTO</em> Mutations in Lean and Obese Individuals
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Includes: Supplementary data
Journal Articles

Genetic Variant in HK1 Is Associated With a Proanemic State and A1C but Not Other Glycemic Control–Related Traits

Amélie Bonnefond, Martine Vaxillaire, Yann Labrune, Cécile Lecoeur, Jean-Claude Chèvre, Nabila Bouatia-Naji, Stéphane Cauchi, Beverley Balkau, Michel Marre, Jean Tichet, Jean-Pierre Riveline, Samy Hadjadj, Yves Gallois, Sébastien Czernichow, Serge Hercberg, Marika Kaakinen, Susanne Wiesner, Guillaume Charpentier, Claire Lévy-Marchal, Paul Elliott, Marjo-Riitta Jarvelin, Fritz Horber, Christian Dina, Oluf Pedersen, Robert Sladek, David Meyre, Philippe Froguel
Journal: Diabetes
Diabetes 2009;58(11):2687–2697
https://doi.org/10.2337/db09-0652
Published: 03 August 2009
View article titled, Genetic Variant in <em>HK1</em> Is Associated With a Proanemic State and A1C but Not Other Glycemic Control–Related Traits
Open the PDF for Genetic Variant in <em>HK1</em> Is Associated With a Proanemic State and A1C but Not Other Glycemic Control–Related Traits in another window
Includes: Supplementary data
Journal Articles

Common Variation in SIM1 Is Reproducibly Associated With BMI in Pi ma Indians

Michael Traurig, Janel Mack, Robert L. Hanson, Maya Ghoussaini, David Meyre, William C. Knowler, Sayuko Kobes, Philippe Froguel, Clifton Bogardus, Leslie J. Baier
Journal: Diabetes
Diabetes 2009;58(7):1682–1689
https://doi.org/10.2337/db09-0028
Published: 28 April 2009
View article titled, Common Variation in <em>SIM1</em> Is Reproducibly Associated With BMI in Pi ma Indians
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Includes: Supplementary data
Journal Articles

Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees

Fanny Stutzmann, Karen Tan, Vincent Vatin, Christian Dina, Béatrice Jouret, Jean Tichet, Beverley Balkau, Natascha Potoczna, Fritz Horber, Stephen O'Rahilly, I. Sadaf Farooqi, Philippe Froguel, David Meyre
Journal: Diabetes
Diabetes 2008;57(9):2511–2518
https://doi.org/10.2337/db08-0153
Published: 01 September 2008
View article titled, Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees
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Includes: Supplementary data
Journal Articles

Association Analysis Indicates That a Variant GATA-Binding Site in the PIK3CB Promoter Is a Cis-Acting Expression Quantitative Trait Locus for This Gene and Attenuates Insulin Resistance in Obese Children

Catherine Le Stunff, Agnès Dechartres, Virginie Mariot, Chantal Lotton, Cecelia Trainor, Emanuele Miraglia Del Giudice, David Meyre, Ivan Bieche, Ingrid Laurendeau, Philippe Froguel, Diana Zelenika, Dani Fallin, Mark Lathrop, Paul-Henri Roméo, Pierre Bougnères
Journal: Diabetes
Diabetes 2008;57(2):494–502
https://doi.org/10.2337/db07-1273
Published: 01 February 2008
View article titled, Association Analysis Indicates That a Variant GATA-Binding Site in the <em>PIK3CB</em> Promoter Is a Cis-Acting Expression Quantitative Trait Locus for This Gene and Attenuates Insulin Resistance in Obese Children
Open the PDF for Association Analysis Indicates That a Variant GATA-Binding Site in the <em>PIK3CB</em> Promoter Is a Cis-Acting Expression Quantitative Trait Locus for This Gene and Attenuates Insulin Resistance in Obese Children in another window
Journal Articles

Impact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study

Martine Vaxillaire, Jacques Veslot, Christian Dina, Christine Proença, Stéphane Cauchi, Guillaume Charpentier, Jean Tichet, Frédéric Fumeron, Michel Marre, David Meyre, Beverley Balkau, Philippe Froguel, for the DESIR Study Group
Journal: Diabetes
Diabetes 2008;57(1):244–254
https://doi.org/10.2337/db07-0615
Published: 01 January 2008
View article titled, Impact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study
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Includes: Supplementary data
Journal Articles

TCF7L2 Variation Predicts Hyperglycemia Incidence in a French General Population : The Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study

Stéphane Cauchi, David Meyre, Hélène Choquet, Christian Dina, Catherine Born, Michel Marre, Beverley Balkau, Philippe Froguel, for the DESIR Study Group
Journal: Diabetes
Diabetes 2006;55(11):3189–3192
https://doi.org/10.2337/db06-0692
Published: 01 November 2006
View article titled, <em>TCF7L2</em> Variation Predicts Hyperglycemia Incidence in a French General Population : <subtitle>The Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study</subtitle>
Open the PDF for <em>TCF7L2</em> Variation Predicts Hyperglycemia Incidence in a French General Population : <subtitle>The Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study</subtitle> in another window
Includes: Supplementary data
Journal Articles

Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human β-Cells and Adipose Tissue and Strong Association With Type 2 Diabetes

Stéphane Cauchi, David Meyre, Christian Dina, Hélène Choquet, Chantal Samson, Sophie Gallina, Beverley Balkau, Guillaume Charpentier, François Pattou, Volodymyr Stetsyuk, Raphaël Scharfmann, Bart Staels, Gema Frühbeck, Philippe Froguel
Journal: Diabetes
Diabetes 2006;55(10):2903–2908
https://doi.org/10.2337/db06-0474
Published: 01 October 2006
View article titled, Transcription Factor <em>TCF7L2</em> Genetic Study in the French Population: <subtitle>Expression in Human β-Cells and Adipose Tissue and Strong Association With Type 2 Diabetes</subtitle>
Open the PDF for Transcription Factor <em>TCF7L2</em> Genetic Study in the French Population: <subtitle>Expression in Human β-Cells and Adipose Tissue and Strong Association With Type 2 Diabetes</subtitle> in another window
Includes: Supplementary data
Journal Articles

Bardet-Biedl Syndrome Gene Variants Are Associated With Both Childhood and Adult Common Obesity in French Caucasians

Michael Benzinou, Andrew Walley, Stephan Lobbens, Marie-Aline Charles, Béatrice Jouret, Frédéric Fumeron, Beverley Balkau, David Meyre, Philippe Froguel
Journal: Diabetes
Diabetes 2006;55(10):2876–2882
https://doi.org/10.2337/db06-0337
Published: 01 October 2006
View article titled, Bardet-Biedl Syndrome Gene Variants Are Associated With Both Childhood and Adult Common Obesity in French Caucasians
Open the PDF for Bardet-Biedl Syndrome Gene Variants Are Associated With Both Childhood and Adult Common Obesity in French Caucasians in another window
Includes: Supplementary data
Journal Articles

ACDC/Adiponectin Polymorphisms Are Associated With Severe Childhood and Adult Obesity

Nabila Bouatia-Naji, David Meyre, Stéphane Lobbens, Karin Séron, Frédéric Fumeron, Beverley Balkau, Barbara Heude, Béatrice Jouret, Philipp E. Scherer, Christian Dina, Jacques Weill, Philippe Froguel
Journal: Diabetes
Diabetes 2006;55(2):545–550
https://doi.org/10.2337/diabetes.55.02.06.db05-0971
Published: 01 February 2006
View article titled, ACDC/Adiponectin Polymorphisms Are Associated With Severe Childhood and Adult Obesity
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Includes: Supplementary data
Journal Articles

Association of Melanin-Concentrating Hormone Receptor 1 5′ Polymorphism With Early-Onset Extreme Obesity

Christopher G. Bell, David Meyre, Chantal Samson, Cliona Boyle, Cécile Lecoeur, Maïte Tauber, Béatrice Jouret, Delphine Jaquet, Claire Levy-Marchal, Marie Aline Charles, Jacques Weill, Fernando Gibson, Charles A. Mein, Philippe Froguel, Andrew J. Walley
Journal: Diabetes
Diabetes 2005;54(10):3049–3055
https://doi.org/10.2337/diabetes.54.10.3049
Published: 01 October 2005
View article titled, Association of Melanin-Concentrating Hormone Receptor 1 5′ Polymorphism With Early-Onset Extreme Obesity
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Journal Articles

Polymorphisms in the Amino Acid Transporter Solute Carrier Family 6 (Neurotransmitter Transporter) Member 14 Gene Contribute to Polygenic Obesity in French Caucasians

Emmanuelle Durand, Philippe Boutin, David Meyre, M. Aline Charles, Karine Clement, Christian Dina, Philippe Froguel
Journal: Diabetes
Diabetes 2004;53(9):2483–2486
https://doi.org/10.2337/diabetes.53.9.2483
Published: 01 September 2004
View article titled, Polymorphisms in the Amino Acid Transporter Solute Carrier Family 6 (Neurotransmitter Transporter) Member 14 Gene Contribute to Polygenic Obesity in French Caucasians
Open the PDF for Polymorphisms in the Amino Acid Transporter Solute Carrier Family 6 (Neurotransmitter Transporter) Member 14 Gene Contribute to Polygenic Obesity in French Caucasians in another window